A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System.

Massaly N, Morón JA, Al-Hasani R (2016) A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System. Frontiers in neuroscience, 10():480.

 PubMed


Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities

Cabanero D, Irie T, Celorrio M, Trousdale C, Owens DM, Virley D, Albrecht PH, Caterina MJ, Rice FL, Moron JA (2016) Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities PAIN Reports, ():.

 PubMed


Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons.

Fakira AK, Massaly N, Cohensedgh O, Berman A, Morón JA (2016) Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, ():.

 PubMed


Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J. (2016) Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Science signaling, 9(410):ra5.

 PubMed


Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors.

Hipólito L, Wilson-Poe A, Campos-Jurado Y, Zhong E, Gonzalez-Romero J, Virag L, Whittington R, Comer SD, Carlton SM, Walker BM (2015) Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(35):12217-31.

 PubMed


Evidence of CNIH3 involvement in opioid dependence.

Nelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH.,Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, Gordon S, Henders AK, Hesselbrock V, Kapoor M, Lynskey MT, Madden PA, Moron JA, Rice JP, Saccone NL, Schwab SG, Shand FL, Todorov AA, Wallace L, Wang T, Wray NR, Zhou X, Degenhardt L, Martin NG, Hariri AR, Kranzler HR, Gelernter J, Bierut LJ, Clark DJ, Montgomery GW. (2015) Evidence of CNIH3 involvement in opioid dependence. Molecular psychiatry, ():.

 PubMed


Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.

Gallo EF, Salling MC, Feng B, Morón JA, Harrison NL, Javitch JA, Kellendonk C (2015) Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(7):1609-18.

 PubMed


In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.

Hipólito L, Fakira AK, Cabañero D, Blandón R, Carlton SM, Morón JA, Melyan Z (2015) In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model. Pain, 156(5):849-58.

 PubMed


Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain.

Beaudry H, Gendron L, Morón JA (2015) Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain. The European journal of neuroscience, 41(7):901--7.

 PubMed


Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine.

Fakira AK, Portugal GS, Carusillo B, Melyan Z, Morón JA (2014) Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine. Biological psychiatry, 75(2):105-14.

 PubMed


Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference.

Portugal GS, Al-Hasani R, Fakira AK, Gonzalez-Romero JL, Melyan Z, McCall JG, Bruchas MR, Morón JA (2014) Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(2):527-38.

 PubMed


Systemic morphine treatment induces changes in firing patterns and responses of nociceptive afferent fibers in mouse glabrous skin.

Hogan D, Baker AL, Morón JA, Carlton SM (2013) Systemic morphine treatment induces changes in firing patterns and responses of nociceptive afferent fibers in mouse glabrous skin. Pain, 154(11):2297-309.

 PubMed


Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord.

Cabañero D, Baker A, Zhou S, Hargett GL, Irie T, Xia Y, Beaudry H, Gendron L, Melyan Z, Carlton SM (2013) Pain after discontinuation of morphine treatment is associated with synaptic increase of GluA4-containing AMPAR in the dorsal horn of the spinal cord. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(8):1472-84.

 PubMed


Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine.

Xia Y, Portugal GS, Fakira AK, Melyan Z, Neve R, Lee HT, Russo SJ, Liu J, Morón JA (2011) Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(45):16279-91.

 PubMed


Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse.

Billa SK, Xia Y, Morón JA (2010) Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse. The European journal of neuroscience, 32(4):625-31.

 PubMed


Increased insertion of glutamate receptor 2-lacking alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors at hippocampal synapses upon repeated morphine administration.

Billa SK, Liu J, Bjorklund NL, Sinha N, Fu Y, Shinnick-Gallagher P, Morón JA (2010) Increased insertion of glutamate receptor 2-lacking alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors at hippocampal synapses upon repeated morphine administration. Molecular pharmacology, 77(5):874-83.

 PubMed


Extinction of morphine-dependent conditioned behavior is associated with increased phosphorylation of the GluR1 subunit of AMPA receptors at hippocampal synapses.

Billa SK, Sinha N, Rudrabhatla SR, Morón JA (2009) Extinction of morphine-dependent conditioned behavior is associated with increased phosphorylation of the GluR1 subunit of AMPA receptors at hippocampal synapses. The European journal of neuroscience, 29(1):55-64.

 PubMed