Gereau Lab Publications

2007  
Zhao, Z, Gao, YJ, Sun, YG, Zhao, C, Gereau, RW, and Chen, Z (2007) Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward. PNAS 104(36): 14519-14524. pdf
Chiechio, S, Copani, A, Gereau, R.W, and Nicoletti, F. (2007) Acetyl-L-carnitine in neuropathic pain.  CNS Drugs, 21 Suppl 1:31-8.  
Zhao, Z, Chiechio, S, Sun, Y, Zhang, K, Zhao, CS, Scott, M, Johnson, RL, Deneris, ES, Renner, KJ, Gereau, RW, and Chen, ZF (2007) Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs. Journal of Neuroscience. 27(22): 6045-53. pdf
Carrasquillo, Y., and Gereau, R.W. (2007) Activation of the Extracellular Signal Regulated Kinase in the Amygdala Modulates Pain Perception. Journal of Neuroscience, 27(7): 1543-1551. pdf
2006  
Zhao, Z.Q., Scott, M., Chiechio, S., Wang, J.-S., Renner, K.J., Gereau, R.W., Johnson, R.L., Deneris, E.S., and Chen, Z.F. (2006) Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system show normal locomotor activity. Journal of Neuroscience , 26(49):12781-12788.  pdf
Chiechio, S, Copani, A, Nicoletti, F, and Gereau, RW (2006) L-Acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies.  Current Neuropharmacology 4(3): 233-237. pdf
Chiechio, S, Copani, A, De Petris, L, Morales, M.E., Nicoletti, F, and Gereau, RW (2006) Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-Acetylcarnitine. Molecular Pain 2:20 link
Story, GM, and Gereau, RW. (2006) Numbing the senses: Role of TRPA1 in mechanical and cold sensation. Neuron.  50(2): 277-89. pdf
Hu, HJ., Carrasquillo, Y., Karim, F., Jung, WE., Nerbonne, JM., Schwarz, TL., and Gereau, RW (2006) The Kv4.2 potassium channel subunit is required for pain plasticity. Neuron  50: 89-100. pdf
Jin, X.J. and Gereau, R.W. (2005) Acute p38-mediated modulation of TTX-resistant sodium channels in mouse sensory neurons by tumor necrosis factor alpha.  Journal of Neuroscience. 26(1): 246-255. pdf
Karim, F., Hu, HJ.,Adwanikar, H., Kaplan, DR., and Gereau, R.W. (2006) Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK).  Molecular Pain 2:2. link

 

2005  
Gereau, R.W. (2005) Neurofibromatosis Pain is in the Membrane.  Focus on "Sensory Neurons from Nf1 Haploinsufficient Mice Exhibit Increased Excitability." Journal of Neurophysiology. 94:3659. pdf
Alagarsamy, S., Saugstad, J., Warren, L., Mansuy, I., Gereau, R.W., and Conn, P.J. (2005) NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin. Neuropharmacology. 49 Suppl. 1: 135-145. pdf

2004

 

Carrasquillo, Y. and Gereau, R.W. (2004) Rodent models clarify the role of cells expression the substance P receptor in pain.  Drug Discovery Today: Disease Models, 1(2), 107-113. pdf
Bhave, G., and Gereau, R.W. (2004) Post-translational mechanisms of peripheral sensitization. Journal of Neurobiology. 61(1): 88-106. pdf
Adwanikar, H., Karim, F., and Gereau, R. W. (2004) Inflammation persistently enhances nocifensive behaviors induced by spinal group I mGluR activation through sustained ERK activation. Pain 111:125-35. pdf

Yang, D. and Gereau, R.W. (2004) Group II metabotropic glutamate receptors inhibit cAMP-dependent protein kinase-mediated enhancement of tetrodotoxin-resistant sodium currents in mouse dorsal root ganglion neurons.  Neuroscience Letters 357: 159-162.

  pdf

2003

 

Yang, D. and Gereau, R.W. (2003) Peripheral group II mGluRs mediate endogenous anti-allodynia in inflammation.  Pain. 106: 411–417.

pdf

Bhave, G., Hu, H.-J., Glauner, K.S., Zhu, W., Wang, H., Brasier, D.J., Oxford, G.S. and Gereau, R.W. (2003) Protein kinase C sensitizes but does not activate the capsaicin receptor TRPV1.  Proceedings of the National Academy of Sciences, USA.  100(21): 12480-12485.

pdf

Bhave, G. and Gereau, R.W. (2003) Growing Pains: The cytoskeleton as a critical regulator of pain plasticity.  Neuron. 39: 577-589.

pdf

Hu, H.-J., Glauner, K.S., and Gereau, R.W. (2003) ERK Integrates PKA and PKC Signaling in Superficial Dorsal Horn Neurons I: Modulation of A-Type K+ Currents.  J. Neurophysiol.  90:1 671-1679.

pdf

Hu, H.-J. and Gereau, R.W.  (2003) ERK Integrates PKA and PKC Signaling in Superficial Dorsal Horn Neurons II: Modulation of Neuronal Excitability. J. Neurophysiol.  90: 1680-1688.

pdf

Bhave, G., Nadin, B., Brasier, D.J., Glauner, K.S., Shah, R.D., Heinemann, S.F., Karim, F. and Gereau, R.W. (2003) Analysis of the membrane topology of a metabotropic glutamate receptor. Journal of Biological Chemistry.  278(32): 30294-30301.

pdf

Neugebauer, V, Li, W., Bird, G.C., Bhave, G., and Gereau, R.W. (2003) Synaptic Plasticity in the Amygdala in Prolonged Pain: Differential Roles of mGluR1 and mGluR5.  Journal of Neuroscience. 23:52-63.

pdf

2002

 

Bhave, G., Zhu, W., Wang, H., Brasier, D.J., Oxford, G. and Gereau, R.W. (2002) cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by Direct Phosphorylation.  Neuron.  35: 721-731.

pdf

Hu, H.-J., Bhave, G. and Gereau, R.W. (2002) Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia.  Journal of Neuroscience. 22: 7444-7452.

 pdf

Yang, D. and Gereau, R.W. (2002) Peripheral group II metabotropic glutamate receptors (mGlu2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception. Journal of Neuroscience. 22(15): 6388-6393.

pdf

Faas, G., Adwanikar, H., Gereau, R.W., and Saggau, P. (2002) Modulation of presynaptic calcium transients by metabotropic glutamate receptor activation: a differential role in acute depression of synaptic transmission and long-term depression. Journal of Neuroscience. 22(16): 6885-5890.

pdf

Varney, M. and Gereau, R.W. (2002) Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospect for the development of novel analgesics. Current Drug Targets: CNS and Neurologic Disorders. 1: 283-296.

pdf

2001

 

Bhave, G., Karim, F., Carlton, S. and Gereau, R.W. (2001) Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nature Neuroscience.  4(4): 417-423.

pdf

Karim, F., Wang, C.-C., and Gereau, R.W. (2001) Metabotropic glutamate receptor subtypes 1 and 5 are activators of ERK signaling required for inflammatory pain in mice. Journal of Neuroscience 21: 3771-3779.

pdf

Karim, F., Bhave, G., and Gereau, R.W. (2001) Metabotropic glutamate receptors on peripheral sensory neuron terminals as targets for the development of novel analgesics. Molecular Psychiatry. 6: 615-617.

pdf

©2004, Robert W. Gereau IV, Ph.D.,
Washington University Pain Center
660 S Euclid Ave., St Louis, MO 63110 (314) 362-8312 Fax (314)362-8334
URL: http:// elysium.wustl.edu/rglab  (Modified: 9/27/07)