DBR Publications


Effect of HAART on Brain Organization and Function in HIV-Negative Subjects.

Brier MR, Wu Q, Tanenbaum AB, Westerhaus ET, Kharasch ED, Ances BM (2015) Effect of HAART on Brain Organization and Function in HIV-Negative Subjects. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 10(4):517-21.

Kharasch Lab  PubMed


Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.

Martinez-Espinosa PL, Wu J, Yang C, Gonzalez-Perez V, Zhou H, Liang H, Xia XM, Lingle CJ (2015) Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. eLife, 4():.

Lingle Lab  PubMed


Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices.

Tadepalli S, Kuang Z, Jiang Q, Liu KK, Fisher MA, Morrissey JJ, Kharasch ED, Slocik JM, Naik RR, Singamaneni S (2015) Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices. Scientific reports, 5():16206.

Kharasch Lab  PubMed


Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics.

Park SI, Brenner DS, Shin G, Morgan CD, Copits BA, Chung HU, Pullen MY, Noh KN, Davidson S, Oh SJ, Yoon J, Jank KI, Samineni VK, Norman M, Grajales-Reyes JG, Vogt SK, Sundaram SS, Wilson KM, Ha JS, Xu R, Pan T, Kim TI, Huan Y, Montana MC, Golden JP, Bruchas MR, Gereau RW, Rogers JA (2015) Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics. Nature Biotechnology, 33(12):1280-1286.

Gereau Lab Bruchas Lab  PubMed


Imaging Apoptosis in Sepsis--A Technology We Would Die for!

Hotchkiss RS, Crouser E (2015) Imaging Apoptosis in Sepsis--A Technology We Would Die for! Critical care medicine, 43(11):2506-8.

Hotchkiss Lab  PubMed


The authors reply.

Drewry AM, Fuller BM, Skrupky LP, Hotchkiss RS (2015) The authors reply. Critical care medicine, 43(11):e529-30.

Hotchkiss Lab  PubMed


Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism.

Kharasch ED, Regina KJ, Blood J, Friedel C (2015) Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism. Anesthesiology, 123(5):1142-53.

Kharasch Lab  PubMed


Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows.

Schilling B, MacLean B, Held JM, Sahu AK, Rardin MJ, Sorensen DJ, Peters T, Wolfe AJ, Hunter CL, MacCoss MJ (2015) Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows. Analytical chemistry, 87(20):10222-9.

Held Lab  PubMed


Ultraminiaturized photovoltaic and radio frequency powered optoelectronic systems for wireless optogenetics.

Park SI, Shin G, Banks A, McCall JG, Siuda ER, Schmidt MJ, Chung HU, Noh KN, Mun JG, Rhodes J (2015) Ultraminiaturized photovoltaic and radio frequency powered optoelectronic systems for wireless optogenetics. Journal of neural engineering, 12(5):056002.

Bruchas Lab  PubMed


Optodynamic simulation of β-adrenergic receptor signalling.

Siuda ER, McCall JG, Al-Hasani R, Shin G, Il Park S, Schmidt MJ, Anderson SL, Planer WJ, Rogers JA, Bruchas MR (2015) Optodynamic simulation of β-adrenergic receptor signalling. Nature communications, 6():8480.

Bruchas Lab  PubMed


Optimizing optogenetic constructs for control over signaling and cell behaviours.

O'Neill PR, Gautam N (2015) Optimizing optogenetic constructs for control over signaling and cell behaviours. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 14(9):1578-85.

Gautam Lab  PubMed


Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating.

Gonzalez-Perez V, Xia XM, Lingle CJ (2015) Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating. Nature communications, 6():8341.

Lingle Lab  PubMed


Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.

Eaton MM, Cao LQ, Chen Z, Franks NP, Evers AS, Akk G (2015) Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors. Molecular pharmacology, 88(4):736-45.

Akk Lab Evers Lab  PubMed


Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward.

Al-Hasani R, McCall JG, Shin G, Gomez AM, Schmitz GP, Bernardi JM, Pyo CO, Park SI, Marcinkiewcz CM, Crowley NA (2015) Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward. Neuron, 87(5):1063-77.

Bruchas Lab  PubMed


Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors.

Hipólito L, Wilson-Poe A, Campos-Jurado Y, Zhong E, Gonzalez-Romero J, Virag L, Whittington R, Comer SD, Carlton SM, Walker BM (2015) Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(35):12217-31.

Moron-Concepcion Lab  PubMed


Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking.

Mickle AD, Shepherd AJ, Loo L, Mohapatra DP (2015) Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking. Pain, 156(9):1620-36.

Mohapatra Lab  PubMed


Effectiveness of Minocycline and Rifampin vs Chlorhexidine and Silver Sulfadiazine-Impregnated Central Venous Catheters in Preventing Central Line-Associated Bloodstream Infection in a High-Volume Academic Intensive Care Unit: A Before and after Trial.

Bonne S, Mazuski JE, Sona C, Schallom M, Boyle W, Buchman TG, Bochicchio GV, Coopersmith CM, Schuerer DJ (2015) Effectiveness of Minocycline and Rifampin vs Chlorhexidine and Silver Sulfadiazine-Impregnated Central Venous Catheters in Preventing Central Line-Associated Bloodstream Infection in a High-Volume Academic Intensive Care Unit: A Before and after Trial. Journal of the American College of Surgeons, 221(3):739-47.

Boyle Lab  PubMed


Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor.

Chang SD, Mascarella SW, Spangler SM, Gurevich VV, Navarro HA, Carroll FI, Bruchas MR (2015) Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor. Molecular pharmacology, 88(3):502-11.

Bruchas Lab  PubMed


CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety.

McCall JG, Al-Hasani R, Siuda ER, Hong DY, Norris AJ, Ford CP, Bruchas MR (2015) CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety. Neuron, 87(3):605-20.

Bruchas Lab  PubMed


Evidence of CNIH3 involvement in opioid dependence.

Nelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH.,Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, Gordon S, Henders AK, Hesselbrock V, Kapoor M, Lynskey MT, Madden PA, Moron JA, Rice JP, Saccone NL, Schwab SG, Shand FL, Todorov AA, Wallace L, Wang T, Wray NR, Zhou X, Degenhardt L, Martin NG, Hariri AR, Kranzler HR, Gelernter J, Bierut LJ, Clark DJ, Montgomery GW. (2015) Evidence of CNIH3 involvement in opioid dependence. Molecular psychiatry, ():.

Moron-Concepcion Lab  PubMed


Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics.

Jeong JW, McCall JG, Shin G, Zhang Y, Al-Hasani R, Kim M, Li S, Sim JY, Jang KI, Shi Y (2015) Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics. Cell, 162(3):662-74.

Bruchas Lab  PubMed


Animal Models of Urologic Chronic Pelvic Pain Syndromes: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network.

Lai H, Gereau RW 4th, Luo Y, O'Donnell M, Rudick CN, Pontari M, Mullins C, Klumpp DJ. (2015) Animal Models of Urologic Chronic Pelvic Pain Syndromes: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network. Urology, 85(6):1454-65.

Gereau Lab  PubMed


Bio-Enabled Gold Superstructures with Built-In and Accessible Electromagnetic Hotspots.

Tian L, Fei M, Tadepalli S, Morrissey JJ, Kharasch ED, Singamaneni S (2015) Bio-Enabled Gold Superstructures with Built-In and Accessible Electromagnetic Hotspots. Advanced healthcare materials, 4(10):1502-9, 1423.

Kharasch Lab  PubMed


Differences in Methadone Metabolism by CYP2B6 Variants.

Gadel S, Friedel C, Kharasch ED (2015) Differences in Methadone Metabolism by CYP2B6 Variants. Drug metabolism and disposition: the biological fate of chemicals, 43(7):994-1001.

Kharasch Lab  PubMed


Function and postnatal changes of dural afferent fibers expressing TRPM8 channels.

Ren L, Dhaka A, Cao YQ (2015) Function and postnatal changes of dural afferent fibers expressing TRPM8 channels. Molecular pain, 11(1):37.

Cao Lab  PubMed


ERK2 Alone Drives Inflammatory Pain But Cooperates with ERK1 in Sensory Neuron Survival.

O'Brien DE, Alter BJ, Satomoto M, Morgan CD, Davidson S, Vogt SK, Norman ME, Gereau GB, Demaro JA 3rd, Landreth GE, Golden JG, Gereau RW 4th (2015) ERK2 Alone Drives Inflammatory Pain But Cooperates with ERK1 in Sensory Neuron Survival. The Journal of Neuroscience, 35(25):9491-507.

Gereau Lab  PubMed


The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia.

Drewry AM, Fuller BM, Skrupky LP, Hotchkiss RS (2015) The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia. Critical care medicine, 43(6):1165-9.

Hotchkiss Lab  PubMed


Sepsis: Revising definitions of sepsis.

Drewry AM, Hotchkiss RS (2015) Sepsis: Revising definitions of sepsis. Nature reviews. Nephrology, 11(6):326-8.

Hotchkiss Lab  PubMed


The hematological effects of nitrous oxide anesthesia in pediatric patients.

Duma A, Cartmill C, Blood J, Sharma A, Kharasch ED, Nagele P (2015) The hematological effects of nitrous oxide anesthesia in pediatric patients. Anesthesia and analgesia, 120(6):1325-30.

Kharasch Lab  PubMed


Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.

Gallo EF, Salling MC, Feng B, Morón JA, Harrison NL, Javitch JA, Kellendonk C (2015) Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(7):1609-18.

Moron-Concepcion Lab  PubMed


Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.

Gallo EF, Salling MC, Feng B, Morón JA, Harrison NL, Javitch JA, Kellendonk C (2015) Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(7):1609-18.

 PubMed


Influence of HIV antiretrovirals on methadone N-demethylation and transport.

Campbell SD, Gadel S, Friedel C, Crafford A, Regina KJ, Kharasch ED (2015) Influence of HIV antiretrovirals on methadone N-demethylation and transport. Biochemical pharmacology, 95(2):115-25.

Kharasch Lab  PubMed


Opioid Half-lives and Hemlines: The Long and Short of Fashion.

Kharasch ED, {Authors/Author/Name#2} (2015) Opioid Half-lives and Hemlines: The Long and Short of Fashion. Anesthesiology, 122(5):969-70.

Kharasch Lab  PubMed


Steroid Anesthesia Revisited: Again.

Kharasch ED, Hollmann MW (2015) Steroid Anesthesia Revisited: Again. Anesthesia and analgesia, 120(5):983-4.

Kharasch Lab  PubMed


Evaluation of Urine Aquaporin-1 and Perilipin-2 Concentrations as Biomarkers to Screen for Renal Cell Carcinoma: A Prospective Cohort Study.

Morrissey JJ, Mellnick VM, Luo J, Siegel MJ, Figenshau RS, Bhayani S, Kharasch ED (2015) Evaluation of Urine Aquaporin-1 and Perilipin-2 Concentrations as Biomarkers to Screen for Renal Cell Carcinoma: A Prospective Cohort Study. JAMA oncology, 1(2):204-12.

Kharasch Lab  PubMed


In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.

Hipólito L, Fakira AK, Cabañero D, Blandón R, Carlton SM, Morón JA, Melyan Z (2015) In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model. Pain, 156(5):849-58.

Moron-Concepcion Lab  PubMed


In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.

Hipólito L, Fakira AK, Cabañero D, Blandón R, Carlton SM, Morón JA, Melyan Z (2015) In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model. Pain, 156(5):849-58.

 PubMed


Synaptic-type α1β2γ2L GABAA receptors produce large persistent currents in the presence of ambient GABA and anesthetic drugs.

Li P, Akk G (2015) Synaptic-type α1β2γ2L GABAA receptors produce large persistent currents in the presence of ambient GABA and anesthetic drugs. Molecular pharmacology, 87(5):776-81.

Akk Lab  PubMed


Spatiotemporal Control of Opioid Signaling and Behavior.

Siuda ER, Copits BA, Schmidt MJ, Baird MA, Al-Hasani R, Planer WJ, Funderburk SC, McCall JG, Gereau RW 4th, Bruchas MR (2015) Spatiotemporal Control of Opioid Signaling and Behavior. Neuron, epub ahead of print():.

 PubMed


Spatiotemporal Control of Opioid Signaling and Behavior.

Siuda ER, Copits BA, Schmidt MJ, Baird MA, Al-Hasani R, Planer WJ, Funderburk SC, McCall JG, Gereau RW 4th, Bruchas MR (2015) Spatiotemporal Control of Opioid Signaling and Behavior. Neuron, 86(4):923-35.

Gereau Lab Bruchas Lab  PubMed


Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications.

Zhou Y, Xia XM, Lingle CJ (2015) Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implications. Proceedings of the National Academy of Sciences of the United States of America, 112(16):5237-42.

Lingle Lab  PubMed


Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression.

Shindo Y, Unsinger J, Burnham CA, Green JM, Hotchkiss RS (2015) Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression. Shock (Augusta, Ga.), 43(4):334-43.

Hotchkiss Lab  PubMed


Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain.

Beaudry H, Gendron L, Morón JA (2015) Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain. The European journal of neuroscience, 41(7):901--7.

Moron-Concepcion Lab  PubMed


A simple and inexpensive method for determining cold sensitivity and adaptation in mice.

Brenner DS, Golden JP, Vogt SK, Gereau RW 4th (2015) A simple and inexpensive method for determining cold sensitivity and adaptation in mice. Journal of visualized experiments : JoVE, (97):.

Gereau Lab  PubMed


Immunology. Getting sepsis therapy right.

Hotchkiss RS, Sherwood ER (2015) Immunology. Getting sepsis therapy right. Science (New York, N.Y.), 347(6227):1201-2.

Hotchkiss Lab  PubMed


Anesthetic neurotoxicity--clinical implications of animal models.

Rappaport BA, Suresh S, Hertz S, Evers AS, Orser BA (2015) Anesthetic neurotoxicity--clinical implications of animal models. The New England journal of medicine, 372(9):796-7.

Evers Lab  PubMed


SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility.

Zeng XH, Yang C, Xia XM, Liu M, Lingle CJ (2015) SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility. Proceedings of the National Academy of Sciences of the United States of America, 112(8):2599-604.

Lingle Lab  PubMed


NAVigating a transition from single action potential firing to bursting in chromaffin cells.

Lingle CJ, {Authors/Author/Name#2} (2015) NAVigating a transition from single action potential firing to bursting in chromaffin cells. The Journal of physiology, 593(4):761-2.

Lingle Lab  PubMed


Enhanced non-peptidergic intraepidermal fiber density and an expanded subset of chloroquine-responsive trigeminal neurons in a mouse model of dry skin itch.

Valtcheva MV, Samineni VK, Golden JP, Gereau RW 4th, Davidson S (2015) Enhanced non-peptidergic intraepidermal fiber density and an expanded subset of chloroquine-responsive trigeminal neurons in a mouse model of dry skin itch. The Journal of Pain, 16(4):346-56.

Gereau Lab  PubMed


Protein kinase Cdelta mediates histamine-evoked itch and responses in pruriceptors.

Valtcheva MV, Davidson S, Zhao C, Leitges M, Gereau RW 4th (2015) Protein kinase Cdelta mediates histamine-evoked itch and responses in pruriceptors. Molecular pain, 11(1):1.

Gereau Lab  PubMed


Sensory TRP channels: the key transducers of nociception and pain.

Mickle AD, Shepherd AJ, Mohapatra DP (2015) Sensory TRP channels: the key transducers of nociception and pain. Progress in molecular biology and translational science, 131():73-118.

Mohapatra Lab  PubMed


Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes.

Julian MW, Strange HR, Ballinger MN, Hotchkiss RS, Papenfuss TL, Crouser ED (2015) Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes. PloS one, 10(7):e0132921.

Hotchkiss Lab  PubMed


Urine aquaporin 1 and perilipin 2 differentiate renal carcinomas from other imaged renal masses and bladder and prostate cancer.

Morrissey JJ, Mobley J, Figenshau RS, Vetter J, Bhayani S, Kharasch ED (2015) Urine aquaporin 1 and perilipin 2 differentiate renal carcinomas from other imaged renal masses and bladder and prostate cancer. Mayo Clinic proceedings, 90(1):35-42.

Kharasch Lab  PubMed


Voluntary Exercise Training: Analysis of Mice in Uninjured, Inflammatory, and Nerve-Injured Pain States.

Sheahan TD, Copits BA, Golden JP, Gereau RW 4th (2015) Voluntary Exercise Training: Analysis of Mice in Uninjured, Inflammatory, and Nerve-Injured Pain States. PloS one, 10(7):e0133191.

Gereau Lab  PubMed


Subcellular optogenetics - controlling signaling and single-cell behavior.

Karunarathne WK, O'Neill PR, Gautam N (2015) Subcellular optogenetics - controlling signaling and single-cell behavior. Journal of cell science, 128(1):15-25.

Gautam Lab  PubMed