DBR Publications


Comparative analyses of proteins from Haemophilus influenzae biofilm and planktonic populations using metabolic labeling and mass spectrometry.

Post DM, Held JM, Ketterer MR, Phillips NJ, Sahu A, Apicella MA, Gibson BW (2014) Comparative analyses of proteins from Haemophilus influenzae biofilm and planktonic populations using metabolic labeling and mass spectrometry. BMC microbiology, 14():329.

Held Lab  PubMed


The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors.

Li P, Bracamontes JR, Manion BD, Mennerick S, Steinbach JH, Evers AS, Akk G (2014) The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors. British journal of pharmacology, 171(23):5446-57.

Akk Lab Evers Lab  PubMed


γ-aminobutyric acid type A α4, β2, and δ subunits assemble to produce more than one functionally distinct receptor type.

Eaton MM, Bracamontes J, Shu HJ, Li P, Mennerick S, Steinbach JH, Akk G (2014) γ-aminobutyric acid type A α4, β2, and δ subunits assemble to produce more than one functionally distinct receptor type. Molecular pharmacology, 86(6):647-56.

Akk Lab  PubMed


Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling.

Zhao ZQ, Liu XY, Jeffry J, Karunarathne WK, Li JL, Munanairi A, Zhou XY, Li H, Sun YG, Wan L (2014) Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling. Neuron, 84(4):821-34.

Gautam Lab  PubMed


HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors.

Zammataro M, Sortino MA, Parenti C, Gereau RW 4th, Chiechio S (2014) HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors. Molecular pain, 10(1):68.

Gereau Lab  PubMed


Persistent lymphopenia after diagnosis of sepsis predicts mortality.

Drewry AM, Samra N, Skrupky LP, Fuller BM, Compton SM, Hotchkiss RS (2014) Persistent lymphopenia after diagnosis of sepsis predicts mortality. Shock (Augusta, Ga.), 42(5):383-91.

Hotchkiss Lab  PubMed


Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism.

Zhou Y, Lingle CJ (2014) Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism. The Journal of general physiology, 144(5):415-40.

Lingle Lab  PubMed


A technique to measure cold adaptation in freely behaving mice.

Brenner DS, Vogt SK, Gereau RW 4th (2014) A technique to measure cold adaptation in freely behaving mice. Journal of Neuroscience Methods, 236():86-91.

Gereau Lab  PubMed


A Pain Research Agenda for the 21st Century.

Gereau RW 4th, Sluka KA, Maixner W, Savage SR, Price TJ, Murinson BB, Sullivan MD, Fillingim RB (2014) A Pain Research Agenda for the 21st Century. The Journal of Pain, 15(12):1203-14.

Gereau Lab  PubMed


Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity.

Martinez-Espinosa PL, Yang C, Gonzalez-Perez V, Xia XM, Lingle CJ (2014) Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity. The Journal of general physiology, 144(4):275-95.

Lingle Lab  PubMed


TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.

Chen Y, Kanju P, Fang Q, Lee SH, Parekh PK, Lee W, Moore C, Brenner D, Gereau RW 4th, Wang F (2014) TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. Pain, 155(12):2662-72.

Gereau Lab  PubMed


Modulation of the human ρ1 GABAA receptor by inhibitory steroids.

Eaton MM, Lim YB, Covey DF, Akk G (2014) Modulation of the human ρ1 GABAA receptor by inhibitory steroids. Psychopharmacology, 231(17):3467-78.

Akk Lab  PubMed


11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.

Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS (2014) 11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors. Psychopharmacology, 231(17):3479-91.

Akk Lab Evers Lab  PubMed


A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo.

Brenner DS, Golden JP, Vogt SK, Dhaka A, Story GM, Gereau RW 4th (2014) A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo. Pain, 155(10):2124–2133.

Gereau Lab  PubMed


Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration.

O'Neill PR, Gautam N (2014) Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration. Molecular biology of the cell, 25(15):2305-14.

Gautam Lab  PubMed


Mutations in the main cytoplasmic loop of the GABA(A) receptor α4 and δ subunits have opposite effects on surface expression.

Bracamontes JR, Li P, Akk G, Steinbach JH (2014) Mutations in the main cytoplasmic loop of the GABA(A) receptor α4 and δ subunits have opposite effects on surface expression. Molecular pharmacology, 86(1):20-7.

Akk Lab  PubMed


A G-protein subunit translocation embedded network motif underlies GPCR regulation of calcium oscillations.

Giri L, Patel AK, Karunarathne WK, Kalyanaraman V, Venkatesh KV, Gautam N (2014) A G-protein subunit translocation embedded network motif underlies GPCR regulation of calcium oscillations. Biophysical journal, 107(1):242-54.

Gautam Lab  PubMed


Human sensory neurons: Membrane properties and sensitization by inflammatory mediators.

Davidson S, Copits BA, Zhang J, Page G, Ghetti A, Gereau RW 4th (2014) Human sensory neurons: Membrane properties and sensitization by inflammatory mediators. Pain, 155(9):1861-70.

Gereau Lab  PubMed


Surgical safety checklists in ontario, Canada.

Avidan MS, Evers AS (2014) Surgical safety checklists in ontario, Canada. The New England journal of medicine, 370(24):2350-1.

Evers Lab  PubMed


The overlap and distinction of self-reported symptoms between interstitial cystitis/bladder pain syndrome and overactive bladder: a questionnaire-based analysis.

Lai HH, Vetter J, Jain S, Gereau RW 4th, Andriole GL (2014) The overlap and distinction of self-reported symptoms between interstitial cystitis/bladder pain syndrome and overactive bladder: a questionnaire-based analysis. The Journal of Urology, 192(6):1679-86 .

Gereau Lab  PubMed


Non-migraine associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons.

Guo Z, Liu P, Ren F, Cao YQ (2014) Non-migraine associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons. Journal of neurophysiology, 112(3):568-79.

Cao Lab  PubMed


Reducing the burden of acute respiratory distress syndrome: the case for early intervention and the potential role of the emergency department.

Fuller BM, Mohr NM, Hotchkiss RS, Kollef MH (2014) Reducing the burden of acute respiratory distress syndrome: the case for early intervention and the potential role of the emergency department. Shock (Augusta, Ga.), 41(5):378-87.

Hotchkiss Lab  PubMed


Functional regulation of BK potassium channels by γ1 auxiliary subunits.

Gonzalez-Perez V, Xia XM, Lingle CJ (2014) Functional regulation of BK potassium channels by γ1 auxiliary subunits. Proceedings of the National Academy of Sciences of the United States of America, 111(13):4868-73.

Lingle Lab  PubMed


The Ca2+-activated K+ current of human sperm is mediated by Slo3.

Brenker C, Zhou Y, Müller A, Echeverry FA, Trötschel C, Poetsch A, Xia XM, Bönigk W, Lingle CJ, Kaupp UB (2014) The Ca2+-activated K+ current of human sperm is mediated by Slo3. eLife, 3():e01438.

Lingle Lab  PubMed


Over-Expression of TRESK K(+) Channels Reduces the Excitability of Trigeminal Ganglion Nociceptors.

Guo Z, Cao YQ (2014) Over-Expression of TRESK K(+) Channels Reduces the Excitability of Trigeminal Ganglion Nociceptors. PloS one, 9(1):e87029.

Cao Lab  PubMed


Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine.

Fakira AK, Portugal GS, Carusillo B, Melyan Z, Morón JA (2014) Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine. Biological psychiatry, 75(2):105-14.

Moron-Concepcion Lab  PubMed


Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.

Qian M, Krishnan K, Kudova E, Li P, Manion BD, Taylor A, Elias G, Akk G, Evers AS, Zorumski CF (2014) Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone. Journal of medicinal chemistry, 57(1):171-90.

Akk Lab Evers Lab  PubMed


Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference.

Portugal GS, Al-Hasani R, Fakira AK, Gonzalez-Romero JL, Melyan Z, McCall JG, Bruchas MR, Morón JA (2014) Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(2):527-38.

Moron-Concepcion Lab  PubMed


Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference.

Portugal GS, Al-Hasani R, Fakira AK, Gonzalez-Romero JL, Melyan Z, McCall JG, Bruchas MR, Morón JA (2014) Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(2):527-38.

 PubMed


Reactivation of multiple viruses in patients with sepsis.

Walton AH, Muenzer JT, Rasche D, Boomer JS, Sato B, Brownstein BH, Pachot A, Brooks TL, Deych E, Shannon WD, Green JM, Storch GA, Hotchkiss RS (2014) Reactivation of multiple viruses in patients with sepsis. PloS one, 9(2):e98819.

Hotchkiss Lab  PubMed


The structure of dynamic GPCR signaling networks.

O'Neill PR, Giri L, Karunarathne WK, Patel AK, Venkatesh KV, Gautam N (2014) The structure of dynamic GPCR signaling networks. Wiley interdisciplinary reviews. Systems biology and medicine, 6(1):115-23.

Gautam Lab  PubMed