DBR Publications


G-protein signaling leverages subunit-dependent membrane affinity to differentially control βγ translocation to intracellular membranes.

O'Neill PR, Karunarathne WK, Kalyanaraman V, Silvius JR, Gautam N (2012) G-protein signaling leverages subunit-dependent membrane affinity to differentially control βγ translocation to intracellular membranes. Proceedings of the National Academy of Sciences of the United States of America, 109(51):E3568-77.

Gautam Lab  PubMed


Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling.

Zhang NR, Planer W, Siuda ER, Zhao HC, Stickler L, Chang SD, Baird MA, Cao YQ, Bruchas MR (2012) Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling. The Journal of biological chemistry, 287(50):42019-30.

Cao Lab Bruchas Lab  PubMed


Protamine Sulfate Induced Bladder Injury Protects from Distention Induced Bladder Pain.

Stemler KM, Crock LW, Lai HH, Mills JC, Gereau RW 4th, Mysorekar IU (2013) Protamine Sulfate Induced Bladder Injury Protects from Distention Induced Bladder Pain. The Journal of Urology, 189(1):343-51.

Gereau Lab  PubMed


A neurosteroid potentiation site can be moved among GABAA receptor subunits.

Bracamontes JR, Li P, Akk G, Steinbach JH (2012) A neurosteroid potentiation site can be moved among GABAA receptor subunits. The Journal of physiology, 590(Pt 22):5739-47.

Akk Lab  PubMed


Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors.

Tammimäki A, Herder P, Li P, Esch C, Laughlin JR, Akk G, Stitzel JA. (2012) Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors. Neuropharmacology, 63(6):1002-11.

Akk Lab  PubMed


Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain.

Crock LW, Kolber BJ, Morgan CD, Sadler KE, Vogt SK, Bruchas MR, Gereau RW 4th (2012) Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(41):14217-26.

Gereau Lab Bruchas Lab  PubMed


Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura.

Huang D, Li SY, Dhaka A, Story GM, Cao YQ (2012) Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura. Molecular pain, 8(1):66.

Cao Lab  PubMed


Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor.

Chen ZW, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, Sieghart W, Fuchs K, Evers AS (2012) Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. Molecular pharmacology, 82(3):408-19.

Akk Lab Evers Lab Steinbach Lab  PubMed


Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis.

Unsinger J, Burnham CA, McDonough J, Morre M, Prakash PS, Caldwell CC, Dunne WM Jr, Hotchkiss RS (2012) Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. The Journal of infectious diseases, 206(4):606-16.

Hotchkiss Lab  PubMed


Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305.

Held JM, Britton DJ, Scott GK, Lee EL, Schilling B, Baldwin MA, Gibson BW, Benz CC (2012) Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305. Molecular cancer research : MCR, 10(8):1120-32.

Held Lab  PubMed


Agonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor.

Eaton MM, Lim YB, Bracamontes J, Steinbach JH, Akk G (2012) Agonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor. Molecular pharmacology, 82(2):255-63.

Akk Lab  PubMed


Barium ions selectively activate BK channels via the Ca2+-bowl site.

Zhou Y, Zeng XH, Lingle CJ (2012) Barium ions selectively activate BK channels via the Ca2+-bowl site. Proceedings of the National Academy of Sciences of the United States of America, 109(28):11413-8.

Lingle Lab  PubMed


Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.

Zhang N, Li B, Al-Ramahi I, Cong X, Held JM, Kim E, Botas J, Gibson BW, Ellerby LM (2012) Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity. The Journal of biological chemistry, 287(25):21204-13.

Held Lab  PubMed


Pulmonary contusion is associated with toll-like receptor 4 upregulation and decreased susceptibility to pseudomonas pneumonia in a mouse model.

Southard R., Ghosh S., Hilliard J., Davis C., Mazuski C., Walton A., Hotchkiss R. (2012) Pulmonary contusion is associated with toll-like receptor 4 upregulation and decreased susceptibility to pseudomonas pneumonia in a mouse model. Shock (Augusta, Ga.), 37(6):629-33.

Hotchkiss Lab  PubMed


All G protein βγ complexes are capable of translocation on receptor activation.

Ajith Karunarathne W.K., O'Neill P.R., Martinez-Espinosa P.L., Kalyanaraman V., Gautam N. (2012) All G protein βγ complexes are capable of translocation on receptor activation. Biochemical and biophysical research communications, 421(3):605-11.

Gautam Lab  PubMed


Stereospecific binding of a disordered peptide segment mediates BK channel inactivation.

Gonzalez-Perez V., Zeng X.-H., Henzler-Wildman K., Lingle C.J. (2012) Stereospecific binding of a disordered peptide segment mediates BK channel inactivation. Nature, 485(7396):133-6.

Lingle Lab  PubMed


Understanding chronic inflammatory and neuropathic pain.

Hughes JP, Chessell I, Malamut R, Perkins M, Bačkonja M, Baron R, Farrar JT, Field MJ, Gereau RW, Gilron I (2012) Understanding chronic inflammatory and neuropathic pain. Annals of the New York Academy of Sciences, 1255():30-44.

Gereau Lab  PubMed


Lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers.

Drake PM, Schilling B, Niles RK, Prakobphol A, Li B, Jung K, Cho W, Braten M, Inerowicz HD, Williams K (2012) Lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers. Journal of proteome research, 11(4):2508-20.

Held Lab  PubMed


Regulatory control or oxidative damage? Proteomic approaches to interrogate the role of cysteine oxidation status in biological processes.

Held JM, Gibson BW (2012) Regulatory control or oxidative damage? Proteomic approaches to interrogate the role of cysteine oxidation status in biological processes. Molecular & cellular proteomics : MCP, 11(4):R111.013037.

Held Lab  PubMed


Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics.

Kharasch E.D., Whittington D., Ensign D., Hoffer C., Bedynek P.S., Campbell S., Stubbert K., Crafford A., London A., Kim T. (2012) Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics. Clinical pharmacology and therapeutics, 91(4):673-84.

Kharasch Lab  PubMed


Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.

Shu H.-J., Bracamontes J., Taylor A., Wu K., Eaton M.M., Akk G., Manion B., Evers A.S., Krishnan K., Covey D.F., Zorumski C.F., Steinbach J.H., Mennerick S. (2012) Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes. British journal of pharmacology, 165(7):2228-43.

Akk Lab Evers Lab Steinbach Lab  PubMed


Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception.

Crock LW, Stemler KM, Song DG, Abbosh P, Vogt SK, Qiu CS, Lai HH, Mysorekar IU, Gereau RW 4th (2012) Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception. Molecular pain, 8():20.

Gereau Lab  PubMed


Infrared microspectroscopy using prism-based spectrographs and focal plane array detection

Lanzarotta A, Marcott C, Story GM, Dowrey AE, Sommer AJ (2012) Infrared microspectroscopy using prism-based spectrographs and focal plane array detection Applied Spectroscopy, 66(3):304-11.

 PubMed


Perspective: Hospital support for anesthesiology departments: aligning incentives and improving productivity.

Hill L.L., Evers A.S. (2012) Perspective: Hospital support for anesthesiology departments: aligning incentives and improving productivity. Academic medicine : journal of the Association of American Medical Colleges, 87(3):348-55.

Evers Lab  PubMed


Getting oil and water to mix.

Kharasch E.D. (2012) Getting oil and water to mix. Anesthesiology, 116(3):504-6.

Kharasch Lab  PubMed


Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion.

Kirby B.J., Collier A.C., Kharasch E.D., Whittington D., Thummel K.E., Unadkat J.D. (2012) Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion. Drug metabolism and disposition: the biological fate of chemicals, 40(3):610-6.

Kharasch Lab  PubMed


Effects of familial hemiplegic migraine type 1 mutation T666M on voltage-gated calcium channel activities in trigeminal ganglion neurons.

Tao J., Liu P., Xiao Z., Zhao H., Gerber B.R., Cao Y.-Q. (2012) Effects of familial hemiplegic migraine type 1 mutation T666M on voltage-gated calcium channel activities in trigeminal ganglion neurons. Journal of neurophysiology, 107(6):1666-80.

Cao Lab  PubMed


Sigma-2 ligands induce tumour cell death by multiple signalling pathways.

Zeng C., Rothfuss J., Zhang J., Chu W., Vangveravong S., Tu Z., Pan F., Chang K.C., Hotchkiss R., Mach R.H. (2012) Sigma-2 ligands induce tumour cell death by multiple signalling pathways. British journal of cancer, 106(4):693-701.

Hotchkiss Lab  PubMed


Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors.

Krishnan K., Manion B.D., Taylor A., Bracamontes J., Steinbach J.H., Reichert D.E., Evers A.S., Zorumski C.F., Mennerick S., Covey D.F. (2012) Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors. Journal of medicinal chemistry, 55(3):1334-45.

Evers Lab Steinbach Lab  PubMed


A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis.

Chen Z.-W., Chen L.-H., Akentieva N., Lichti C.F., Darbandi R., Hastings R., Covey D.F., Reichert D.E., Townsend R.R., Evers A.S. (2012) A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis. Electrophoresis, 33(4):666-74.

Evers Lab  PubMed


Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A).

Kharasch E.D., Bedynek P.S., Hoffer C., Walker A., Whittington D. (2012) Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A). Anesthesiology, 116(2):432-47.

Kharasch Lab  PubMed


Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain.

Brambrink A.M., Evers A.S., Avidan M.S., Farber N.B., Smith D.J., Martin L.D., Dissen G.A., Creeley C.E., Olney J.W. (2012) Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain. Anesthesiology, 116(2):372-84.

Evers Lab  PubMed


Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.

Crews K.R., Gaedigk A., Dunnenberger H.M., Klein T.E., Shen D.D., Callaghan J.T., Kharasch E.D., Skaar T.C. (2012) Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clinical pharmacology and therapeutics, 91(2):321-6.

Kharasch Lab  PubMed


Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence.

Haller G, Druley T, Vallania FL, Mitra RD, Li P, Akk G, Steinbach JH, Breslau N, Johnson E, Hatsukami D, Stitzel J, Bierut LJ, Goate AM Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Human molecular genetics, 21(3):647-55.

Akk Lab  PubMed


Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference.

Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(4):1488-95.

Bruchas Lab  PubMed


A novel behavioral assay for measuring cold sensation in mice.

Brenner DS, Golden JP, Gereau RW 4th (2012) A novel behavioral assay for measuring cold sensation in mice. PloS one, 7(6):e39765.

Gereau Lab  PubMed


Deep amino acid sequencing of native brain GABAA receptors using high-resolution mass spectrometry.

Chen Z.W., Fuchs K., Sieghart W., Townsend R.R., Evers A.S. (2012) Deep amino acid sequencing of native brain GABAA receptors using high-resolution mass spectrometry. Molecular & cellular proteomics : MCP, 11(1):M111.011445.

Evers Lab  PubMed


Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling.

Spitzer D., Simon Jr. P.O., Kashiwagi H., Xu J., Zeng C., Vangveravong S., Zhou D., Chang K., McDunn J.E., Hornick J.R., Goedegebuure P., Hotchkiss R.S., Mach R.H., Hawkins W.G. (2012) Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling. Cancer research, 72(1):201-9.

Hotchkiss Lab  PubMed


Real time analysis of protein location and function: a Golgi-specific PKD sensor.

Gautam N. (2012) Real time analysis of protein location and function: a Golgi-specific PKD sensor. Biotechnology journal, 7(1):17-8.

Gautam Lab  PubMed


Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody.

Chen D.L., Zhou D., Chu W., Herrbrich P., Engle J.T., Griffin E., Jones L.A., Rothfuss J.M., Geraci M., Hotchkiss R.S., Mach R.H. (2012) Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody. Nuclear medicine and biology, 39(1):137-44.

Hotchkiss Lab  PubMed


Cecal ligation and puncture followed by methicillin-resistant Staphylococcus aureus pneumonia increases mortality in mice and blunts production of local and systemic cytokines.

Jung E., Perrone E.E., Liang Z., Breed E.R., Dominguez J.A., Clark A.T., Fox A.C., Dunne W.M., Burd E.M., Farris A.B., Hotchkiss R.S., Coopersmith C.M. (2012) Cecal ligation and puncture followed by methicillin-resistant Staphylococcus aureus pneumonia increases mortality in mice and blunts production of local and systemic cytokines. Shock (Augusta, Ga.), 37(1):85-94.

Hotchkiss Lab  PubMed