DBR Publications


Immunosuppression in patients who die of sepsis and multiple organ failure.

Boomer J.S., To K., Chang K.C., Takasu O., Osborne D.F., Walton A.H., Bricker T.L., Jarman II S.D., Kreisel D., Krupnick A.S., Srivastava A., Swanson P.E., Green J.M., Hotchkiss R.S. (2011) Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA : the journal of the American Medical Association, 306(23):2594-605.

Hotchkiss Lab  PubMed


A genomic storm in critically injured humans.

Xiao W., Mindrinos M.N., Seok J., Cuschieri J., Cuenca A.G., Gao H., Hayden D.L., Hennessy L., Moore E.E., Minei J.P., Bankey P.E., Johnson J.L., Sperry J., Nathens A.B., Billiar T.R., West M.A., Brownstein B.H., Mason P.H., Baker H.V., Finnerty C.C., Jeschke M.G., Lopez M.C., Klein M.B., Gamelli R.L., Gibran N.S., Arnoldo B., Xu W., Zhang Y., Calvano S.E., Mcdonald-Smith G.P., Schoenfeld D.A., Storey J.D., Cobb J.P., Warren H.S., Moldawer L.L., Herndon D.N., Lowry S.F., Maier R.V., Davis R.W., Tompkins R.G., Xiao W., Mindrinos M., Seok J., Cuschieri J., Tompkins R., Davis R., Maier R., Moldawer L., Hennessy L., Moore E., Minei J., Bankey P., Johnson J., Sperry J., Nathens A., Billiar T., West M., Brownstein B., Herndon D., Baker H., Finnerty C., Jeschke M., Lopez M., Klein M., Gamelli R., Gibran N., Arnoldo B., McDonald-Smith G., Schoenfeld D., Cobb J., Warren S., Cuenca A., Lowry S., Calvano S., Hayden D., Mason P., Gao H., Storey J., Altstein L., Balis U.G.J., Camp D.G., De Asit K., Harbrecht B.G., Honari S.E., McKinley B.A., Miller-Graziano C.L., Moore F.A., O'Keefe G.E., Rahme L.G., Remick D.G., Shapiro M.B., Smith R.D., Tibshirani R., Toner M., Wispelwey B., Wong W.H. (2011) A genomic storm in critically injured humans. The Journal of experimental medicine, 208(13):2581-90.

Hotchkiss Lab  PubMed


Isozyme-specific effects of protein kinase C in pain modulation.

Zhao C., Leitges M., Gereau R.W. (2011) Isozyme-specific effects of protein kinase C in pain modulation. Anesthesiology, 115(6):1261-70.

Gereau Lab  PubMed


Relationship between bispectral index values and volatile anesthetic concentrations during the maintenance phase of anesthesia in the B-Unaware trial.

Whitlock E.L., Villafranca A.J., Lin N., Palanca B.J., Jacobsohn E., Finkel K.J., Zhang L., Burnside B.A., Kaiser H.A., Evers A.S., Avidan M.S. (2011) Relationship between bispectral index values and volatile anesthetic concentrations during the maintenance phase of anesthesia in the B-Unaware trial. Anesthesiology, 115(6):1209-18.

Evers Lab  PubMed


Perioperative pharmacokinetics of methadone in adolescents.

Sharma A., Tallchief D., Blood J., Kim T., London A., Kharasch E.D. (2011) Perioperative pharmacokinetics of methadone in adolescents. Anesthesiology, 115(6):1153-61.

Kharasch Lab  PubMed


Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active.

Brown S.M., Holtzman M., Kim T., Kharasch E.D. (2011) Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active. Anesthesiology, 115(6):1251-60.

Kharasch Lab  PubMed


Metabotropic glutamate receptor 5 antagonism with fenobam: examination of analgesic tolerance and side effect profile in mice.

Montana M.C., Conrardy B.A., Cavallone L.F., Kolber B.J., Rao L.K., Greco S.C., Gereau R.W. (2011) Metabotropic glutamate receptor 5 antagonism with fenobam: examination of analgesic tolerance and side effect profile in mice. Anesthesiology, 115(6):1239-50.

Gereau Lab  PubMed


A gain-of-function mutation in adenylate cyclase confers isoflurane resistance in Caenorhabditis elegans.

Saifee O., Metz L.B., Nonet M.L., Crowder C.M. (2011) A gain-of-function mutation in adenylate cyclase confers isoflurane resistance in Caenorhabditis elegans. Anesthesiology, 115(6):1162-71.

 PubMed


Memories and dreams: building an academic department at Washington University in St. Louis.

Evers A.S., Owens W.D. (2011) Memories and dreams: building an academic department at Washington University in St. Louis. Anesthesiology, 115(6):1147-8.

Evers Lab  PubMed


Advances in the management of sepsis and the understanding of key immunologic defects.

Skrupky L.P., Kerby P.W., Hotchkiss R.S. (2011) Advances in the management of sepsis and the understanding of key immunologic defects. Anesthesiology, 115(6):1349-62.

Hotchkiss Lab  PubMed


Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir.

Kirby B.J., Collier A.C., Kharasch E.D., Dixit V., Desai P., Whittington D., Thummel K.E., Unadkat J.D. (2011) Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir. Drug metabolism and disposition: the biological fate of chemicals, 39(12):2329-37.

Kharasch Lab  PubMed


Molecular mechanisms of opioid receptor-dependent signaling and behavior.

Al-Hasani R., Bruchas M.R. (2011) Molecular mechanisms of opioid receptor-dependent signaling and behavior. Anesthesiology, 115(6):1363-81.

Bruchas Lab  PubMed


Structural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptor.

Akk G., Steinbach J.H. (2011) Structural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptor. Anesthesiology, 115(6):1338-48.

Akk Lab  PubMed


Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation.

Steinbach J.H., Akk G. (2011) Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation. Anesthesiology, 115(6):1328-37.

Akk Lab  PubMed


LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel.

Yang C., Zeng X.-H., Zhou Y., Xia X.-M., Lingle C.J. (2011) LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel. Proceedings of the National Academy of Sciences of the United States of America, 108(48):19419-24.

Lingle Lab  PubMed


Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine.

Xia Y, Portugal GS, Fakira AK, Melyan Z, Neve R, Lee HT, Russo SJ, Liu J, Morón JA (2011) Hippocampal GluA1-containing AMPA receptors mediate context-dependent sensitization to morphine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(45):16279-91.

Moron-Concepcion Lab  PubMed


Functional characterization of the α5(Asn398) variant associated with risk for nicotine dependence in the α3β4α5 nicotinic receptor.

Li P., McCollum M., Bracamontes J., Steinbach J.H., Akk G. (2011) Functional characterization of the α5(Asn398) variant associated with risk for nicotine dependence in the α3β4α5 nicotinic receptor. Molecular pharmacology, 80(5):818-27.

Akk Lab  PubMed


Confident identification of 3-nitrotyrosine modifications in mass spectral data across multiple mass spectrometry platforms.

Li B, Held JM, Schilling B, Danielson SR, Gibson BW (2011) Confident identification of 3-nitrotyrosine modifications in mass spectral data across multiple mass spectrometry platforms. Journal of proteomics, 74(11):2510-21.

Held Lab  PubMed


Mass spectrometric identification of novel lysine acetylation sites in huntingtin.

Cong X, Held JM, DeGiacomo F, Bonner A, Chen JM, Schilling B, Czerwieniec GA, Gibson BW, Ellerby LM (2011) Mass spectrometric identification of novel lysine acetylation sites in huntingtin. Molecular & cellular proteomics : MCP, 10(10):M111.009829.

Held Lab  PubMed


Congratulations from the IARS!

Congratulations from the IARS! Anesthesiology, 115(4):679-80.

Evers Lab  PubMed


Nitrous oxide anesthesia and plasma homocysteine in adolescents.

Nagele P., Tallchief D., Blood J., Sharma A., Kharasch E.D. (2011) Nitrous oxide anesthesia and plasma homocysteine in adolescents. Anesthesia and analgesia, 113(4):843-8.

Kharasch Lab  PubMed


Pharmacokinetics and tissue penetration of cefoxitin in obesity: implications for risk of surgical site infection.

Toma O., Suntrup P., Stefanescu A., London A., Mutch M., Kharasch E. (2011) Pharmacokinetics and tissue penetration of cefoxitin in obesity: implications for risk of surgical site infection. Anesthesia and analgesia, 113(4):730-7.

Kharasch Lab  PubMed


Metabotropic glutamate receptors as targets for analgesia: antagonism, activation, and allosteric modulation.

Montana M.C., Gereau IV R.W. (2011) Metabotropic glutamate receptors as targets for analgesia: antagonism, activation, and allosteric modulation. Current pharmaceutical biotechnology, 12(10):1681-8.

Gereau Lab  PubMed


Change in temperature profile may precede fever and be an early indicator of sepsis: a case report.

Mohr N.M., Hotchkiss R.S., Micek S.T., Durrani S., Fuller B.M. (2011) Change in temperature profile may precede fever and be an early indicator of sepsis: a case report. Shock (Augusta, Ga.), 36(3):318-20; discussion 320-1.

Hotchkiss Lab  PubMed


Activation of spinal extracellular signal-regulated kinases (ERK) 1/2 is associated with the development of visceral hyperalgesia of the bladder.

Lai H.H., Qiu C.-S., Crock L.W., Morales M.E.P., Ness T.J., Gereau IV R.W. (2011) Activation of spinal extracellular signal-regulated kinases (ERK) 1/2 is associated with the development of visceral hyperalgesia of the bladder. Pain, 152(9):2117-24.

Gereau Lab  PubMed


Prevention of intraoperative awareness in a high-risk surgical population.

Avidan M.S., Jacobsohn E., Glick D., Burnside B.A., Zhang L., Villafranca A., Karl L., Kamal S., Torres B., O'Connor M., Evers A.S., Gradwohl S., Lin N., Palanca B.J., Mashour G.A. (2011) Prevention of intraoperative awareness in a high-risk surgical population. The New England journal of medicine, 365(7):591-600.

Evers Lab  PubMed


Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction.

Bruchas M., Schindler A., Shankar H., Messinger D., Miyatake M., Land B., Lemos J., Hagan C.E., Neumaier J., Quintana A., Palmiter R., Chavkin C. (2011) Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron, 71(3):498-511.

Bruchas Lab  PubMed


Activation and modulation of human α4β2 nicotinic acetylcholine receptors by the neonicotinoids clothianidin and imidacloprid.

Li P., Ann J., Akk G. (2011) Activation and modulation of human α4β2 nicotinic acetylcholine receptors by the neonicotinoids clothianidin and imidacloprid. Journal of neuroscience research, 89(8):1295-301.

Akk Lab  PubMed


Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.

Zhou Y., Xia X.-M., Lingle C.J. (2011) Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region. Proceedings of the National Academy of Sciences of the United States of America, 108(29):12161-6.

Lingle Lab  PubMed


The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.

Bloom J., Hinrichs A.L., Wang J.C., Von Weymarn L.B., Kharasch E.D., Bierut L.J., Goate A., Murphy S.E. (2011) The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans. Pharmacogenetics and genomics, 21(7):403-16.

Kharasch Lab  PubMed


Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.

Kharasch E.D., Francis A., London A., Frey K., Kim T., Blood J. (2011) Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction. Clinical pharmacology and therapeutics, 90(1):100-8.

Kharasch Lab  PubMed


Common polymorphisms in FMO1 are associated with nicotine dependence.

Hinrichs A.L., Murphy S.E., Wang J.C., Saccone S., Saccone N., Steinbach J.H., Goate A., Stevens V.L., Bierut L.J. (2011) Common polymorphisms in FMO1 are associated with nicotine dependence. Pharmacogenetics and genomics, 21(7):397-402.

 PubMed


Headache outcomes following treatment of unruptured intracranial aneurysms: a prospective analysis.

Schwedt T.J., Gereau R.W., Frey K., Kharasch E.D. (2011) Headache outcomes following treatment of unruptured intracranial aneurysms: a prospective analysis. Cephalalgia : an international journal of headache, 31(10):1082-9.

Gereau Lab Kharasch Lab  PubMed


Dose-dependent effect of anti-CTLA-4 on survival in sepsis.

Inoue S., Bo L., Bian J., Unsinger J., Chang K., Hotchkiss R.S. (2011) Dose-dependent effect of anti-CTLA-4 on survival in sepsis. Shock (Augusta, Ga.), 36(1):38-44.

Hotchkiss Lab  PubMed


Occupation of either site for the neurosteroid allopregnanolone potentiates the opening of the GABAA receptor induced from either transmitter binding site.

Bracamontes J., McCollum M., Esch C., Li P., Ann J., Steinbach J.H., Akk G. (2011) Occupation of either site for the neurosteroid allopregnanolone potentiates the opening of the GABAA receptor induced from either transmitter binding site. Molecular pharmacology, 80(1):79-86.

Akk Lab  PubMed


Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity.

Stastna E., Krishnan K., Manion B.D., Taylor A., Rath N.P., Chen Z.-W., Evers A.S., Zorumski C.F., Mennerick S., Covey D.F. (2011) Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity. Journal of medicinal chemistry, 54(11):3926-34.

Evers Lab  PubMed


Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration.

Noppers I., Olofsen E., Niesters M., Aarts L., Mooren R., Dahan A., Kharasch E., Sarton E. (2011) Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration. Anesthesiology, 114(6):1435-45.

Kharasch Lab  PubMed


Metabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K⁺ channels primarily in excitatory neurons of the spinal dorsal horn.

Hu H.-J., Gereau R.W. (2011) Metabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K⁺ channels primarily in excitatory neurons of the spinal dorsal horn. Journal of neurophysiology, 105(6):3010-21.

Gereau Lab  PubMed


Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir.

Kirby B.J., Collier A.C., Kharasch E.D., Whittington D., Thummel K.E., Unadkat J.D. (2011) Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir. Drug metabolism and disposition: the biological fate of chemicals, 39(6):1070-8.

Kharasch Lab  PubMed


Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry.

Kim T., London A., Kharasch E.D. (2011) Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis, 55(3):487-93.

Kharasch Lab  PubMed


N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans.

Lucanic M, Held JM, Vantipalli MC, Klang IM, Graham JB, Gibson BW, Lithgow GJ, Gill MS (2011) N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. Nature, 473(7346):226-9.

Held Lab  PubMed


Antinociceptive effects of MSVIII-19, a functional antagonist of the GluK1 kainate receptor.

Qiu C.-S., Wyhe L.L.-V., Sasaki M., Sakai R., Swanson G.T., Gereau IV R.W. (2011) Antinociceptive effects of MSVIII-19, a functional antagonist of the GluK1 kainate receptor. Pain, 152(5):1052-60.

Gereau Lab  PubMed


Alteration of Golgi structure in senescent cells and its regulation by a G protein γ subunit.

Cho J.-H., Saini D.K., Karunarathne W.K.A., Kalyanaraman V., Gautam N. (2011) Alteration of Golgi structure in senescent cells and its regulation by a G protein γ subunit. Cellular signalling, 23(5):785-93.

Gautam Lab  PubMed


Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide.

Fan J., Brown S.M., Tu Z., Kharasch E.D. (2011) Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide. Bioconjugate chemistry, 22(4):752-8.

Kharasch Lab  PubMed


Liu Y, Jiang Y, Si Y, Kim JY, Chen ZF, Rao Y (2011)  Nature, 472(7341):95-9.

 PubMed


Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa.

Zeng X.-H., Yang C., Kim S.T., Lingle C.J., Xia X.-M. (2011) Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa. Proceedings of the National Academy of Sciences of the United States of America, 108(14):5879-84.

Lingle Lab  PubMed


Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil.

Kharasch E.D., Vangveravong S., Buck N., London A., Kim T., Blood J., MacH R.H. (2011) Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. Clinical pharmacology and therapeutics, 89(4):562-70.

Kharasch Lab  PubMed


Diagnostic utility of plasma procalcitonin for nosocomial pneumonia in the intensive care unit setting.

Dallas J., Brown S.M., Hock K., Scott M.G., Skrupky L.P., Boyle W.A., Kollef M.H. (2011) Diagnostic utility of plasma procalcitonin for nosocomial pneumonia in the intensive care unit setting. Respiratory care, 56(4):412-9.

Boyle Lab  PubMed


A portable site: a binding element for 17β-estradiol can be placed on any subunit of a nicotinic α4β2 receptor.

Jin X., Steinbach J.H. (2011) A portable site: a binding element for 17β-estradiol can be placed on any subunit of a nicotinic α4β2 receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(13):5045-54.

 PubMed


Quantitative mapping of reversible mitochondrial Complex I cysteine oxidation in a Parkinson disease mouse model.

Danielson SR, Held JM, Oo M, Riley R, Gibson BW, Andersen JK (2011) Quantitative mapping of reversible mitochondrial Complex I cysteine oxidation in a Parkinson disease mouse model. The Journal of biological chemistry, 286(9):7601-8.

Held Lab  PubMed


Flapping loops: roles for hinges in a ligand-binding domain of the nicotinic receptor.

Steinbach J.H. (2011) Flapping loops: roles for hinges in a ligand-binding domain of the nicotinic receptor. Molecular pharmacology, 79(3):337-9.

 PubMed


Ventilator-associated tracheobronchitis in a mixed surgical and medical ICU population.

Dallas J., Skrupky L., Abebe N., Boyle III W.A., Kollef M.H. (2011) Ventilator-associated tracheobronchitis in a mixed surgical and medical ICU population. Chest, 139(3):513-8.

Boyle Lab  PubMed


Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence.

Culverhouse R.C., Saccone N.L., Stitzel J.A., Wang J.C., Steinbach J.H., Goate A.M., Schwantes-An T.-H., Grucza R.A., Stevens V.L., Bierut L.J. (2011) Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. Human genetics, 129(2):177-88.

 PubMed


Pharmacology of structural changes at the GABA(A) receptor transmitter binding site.

Akk G., Li P., Bracamontes J., Wang M., Steinbach J.H. (2011) Pharmacology of structural changes at the GABA(A) receptor transmitter binding site. British journal of pharmacology, 162(4):840-50.

Akk Lab  PubMed


mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists.

Zammataro M., Chiechio S., Montana M.C., Traficante A., Copani A., Nicoletti F., Gereau IV R.W. (2011) mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists. Molecular pain, 7():6.

Gereau Lab  PubMed


Sensitivity and specificity of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for the diagnosis of renal cell carcinoma.

Morrissey J.J., London A.N., Lambert M.C., Kharasch E.D. (2011) Sensitivity and specificity of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for the diagnosis of renal cell carcinoma. American journal of nephrology, 34(5):391-8.

Kharasch Lab  PubMed


Review of clinical evidence for persistent cognitive decline or incident dementia attributable to surgery or general anesthesia.

Avidan M.S., Evers A.S. (2011) Review of clinical evidence for persistent cognitive decline or incident dementia attributable to surgery or general anesthesia. Journal of Alzheimer's disease : JAD, 24(2):201-16.

Evers Lab  PubMed


Intraoperative methadone: rediscovery, reappraisal, and reinvigoration?

Kharasch E.D. (2011) Intraoperative methadone: rediscovery, reappraisal, and reinvigoration? Anesthesia and analgesia, 112(1):13-6.

Kharasch Lab  PubMed


Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks.

Schwedt T.J., Krauss M.J., Frey K., Gereau IV R.W. (2011) Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks. Cephalalgia : an international journal of headache, 31(1):6-12.

Gereau Lab  PubMed