DBR Publications


Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.

Lyssand J.S., Whiting J.L., Lee K.-S., Kastl R., Wacker J.L., Bruchas M.R., Miyatake M., Langeberg L.K., Chavkin C., Scott J.D., Gardner R.G., Adams M.E., Hague C. (2010) Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome. Proceedings of the National Academy of Sciences of the United States of America, 107(50):21854-9.

Bruchas Lab  PubMed


Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.

Bandyopadhyaya A.K., Manion B.D., Benz A., Taylor A., Rath N.P., Evers A.S., Zorumski C.F., Mennerick S., Covey D.F. (2010) Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues. Bioorganic & medicinal chemistry letters, 20(22):6680-4.

Evers Lab  PubMed


Postoperative cognitive decline: the unsubstantiated phenotype.

Avidan M.S., Xiong C., Evers A.S. (2010) Postoperative cognitive decline: the unsubstantiated phenotype. Anesthesiology, 113(5):1246-8; author reply 1248-50.

Evers Lab  PubMed


Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.

Kasten K.R., Prakash P.S., Unsinger J., Goetzman H.S., England L.G., Cave C.M., Seitz A.P., Mazuski C.N., Zhou T.T., Morre M., Hotchkiss R.S., Hildeman D.A., Caldwell C.C. (2010) Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infection and immunity, 78(11):4714-22.

Hotchkiss Lab  PubMed


Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.

Lennerz J.K., Hurov J.B., White L.S., Lewandowski K.T., Prior J.L., Planer G.J., Gereau IV R.W., Piwnica-Worms D., Schmidt R.E., Piwnica-Worms H. (2010) Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis. Molecular and cellular biology, 30(21):5043-56.

Gereau Lab  PubMed


Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery.

Mao X.R., Crowder C.M. (2010) Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery. Molecular and cellular biology, 30(21):5033-42.

 PubMed


The antinociceptive effect of (-)-linalool in models of chronic inflammatory and neuropathic hypersensitivity in mice.

Batista P.A., De Paula Werner M.F., Oliveira E.C., Burgos L., Pereira P., Da Silva Brum L.F., Story G.M., Santos A.R.S. (2010) The antinociceptive effect of (-)-linalool in models of chronic inflammatory and neuropathic hypersensitivity in mice. The journal of pain : official journal of the American Pain Society, 11(11):1222-9.

 PubMed


Clinical microfluidics for neutrophil genomics and proteomics.

Kotz K.T., Xiao W., Miller-Graziano C., Qian W.-J., Russom A., Warner E.A., Moldawer L.L., De A., Bankey P.E., Petritis B.O., Camp II D.G., Rosenbach A.E., Goverman J., Fagan S.P., Brownstein B.H., Irimia D., Xu W., Wilhelmy J., Mindrinos M.N., Smith R.D., Davis R.W., Tompkins R.G., Toner M. (2010) Clinical microfluidics for neutrophil genomics and proteomics. Nature medicine, 16(9):1042-7.

Hotchkiss Lab  PubMed


Leadership in postgraduate medical education.

Leadership in postgraduate medical education. Anesthesiology, 113(3):754; author reply 754-5.

Evers Lab  PubMed


Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models.

Alter B.J., Zhao C., Karim F., Landreth G.E., Gereau IV R.W. (2010) Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(34):11537-47.

Gereau Lab  PubMed


Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse.

Billa SK, Xia Y, Morón JA (2010) Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse. The European journal of neuroscience, 32(4):625-31.

Moron-Concepcion Lab  PubMed


Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach.

Held JM, Danielson SR, Behring JB, Atsriku C, Britton DJ, Puckett RL, Schilling B, Campisi J, Benz CC, Gibson BW (2010) Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach. Molecular & cellular proteomics : MCP, 9(7):1400-10.

Held Lab  PubMed


Immunotherapy for sepsis--a new approach against an ancient foe.

Hotchkiss R.S., Opal S. (2010) Immunotherapy for sepsis--a new approach against an ancient foe. The New England journal of medicine, 363(1):87-9.

Hotchkiss Lab  PubMed


A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing.

Spitzer D., McDunn J.E., Plambeck-Suess S., Goedegebuure P.S., Hotchkiss R.S., Hawkins W.G. (2010) A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing. Molecular cancer therapeutics, 9(7):2142-51.

Hotchkiss Lab  PubMed


Regulation of Golgi structure and secretion by receptor-induced G protein βγ complex translocation.

Saini D.K., Karunarathne W.K.A., Angaswamy N., Saini D., Cho J.-H., Kalyanaraman V., Gautam N. (2010) Regulation of Golgi structure and secretion by receptor-induced G protein βγ complex translocation. Proceedings of the National Academy of Sciences of the United States of America, 107(25):11417-22.

Gautam Lab  PubMed


Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling.

Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling. Proceedings of the National Academy of Sciences of the United States of America, 107(25):11608-13.

Bruchas Lab  PubMed


Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior.

Kolber B.J., Montana M.C., Carrasquillo Y., Xu J., Heinemann S.F., Muglia L.J., Gereau IV R.W. (2010) Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(24):8203-13.

Gereau Lab  PubMed


Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase.

Thors L., Burston J.J., Alter B.J., McKinney M.K., Cravatt B.F., Ross R.A., Pertwee R.G., Gereau IV R.W., Wiley J.L., Fowler C.J. (2010) Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. British journal of pharmacology, 160(3):549-60.

Gereau Lab  PubMed


Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases.

Joy M.S., Frye R.F., Stubbert K., Brouwer K.R., Falk R.J., Kharasch E.D. (2010) Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases. Journal of clinical pharmacology, 50(6):714-20.

Kharasch Lab  PubMed


Kinase cascades and ligand-directed signaling at the kappa opioid receptor.

Bruchas M.R., Chavkin C. (2010) Kinase cascades and ligand-directed signaling at the kappa opioid receptor. Psychopharmacology, 210(2):137-47.

Bruchas Lab  PubMed


ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination.

Marx C, Held JM, Gibson BW, Benz CC (2010) ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination. Cancer research, 70(9):3709-17.

Held Lab  PubMed


Increased insertion of glutamate receptor 2-lacking alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors at hippocampal synapses upon repeated morphine administration.

Billa SK, Liu J, Bjorklund NL, Sinha N, Fu Y, Shinnick-Gallagher P, Morón JA (2010) Increased insertion of glutamate receptor 2-lacking alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors at hippocampal synapses upon repeated morphine administration. Molecular pharmacology, 77(5):874-83.

Moron-Concepcion Lab  PubMed


Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix.

Zhou Y., Tang Q.-Y., Xia O.-M., Lingle C.J. (2010) Glycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix. The Journal of general physiology, 135(5):481-94.

Lingle Lab  PubMed


Structurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions.

Chisari M., Shu H.-J., Taylor A., Steinbach J.H., Zorumski C.F., Mennerick S. (2010) Structurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions. British journal of pharmacology, 160(1):130-41.

Steinbach Lab  PubMed


Urinary biomarkers for the early diagnosis of kidney cancer.

Morrissey J.J., London A.N., Luo J., Kharasch E.D. (2010) Urinary biomarkers for the early diagnosis of kidney cancer. Mayo Clinic proceedings. Mayo Clinic, 85(5):413-21.

Kharasch Lab  PubMed


A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors.

Evers A.S., Chen Z.-W., Manion B.D., Han M., Jiang X., Darbandi-Tonkabon R., Kable T., Bracamontes J., Zorumski C.F., Mennerick S., Steinbach J.H., Covey D.F. (2010) A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors. The Journal of pharmacology and experimental therapeutics, 333(2):404-13.

Evers Lab Steinbach Lab  PubMed


Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain.

Brambrink A.M., Evers A.S., Avidan M.S., Farber N.B., Smith D.J., Zhang X., Dissen G.A., Creeley C.E., Olney J.W. (2010) Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain. Anesthesiology, 112(4):834-41.

Evers Lab  PubMed


IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.

Unsinger J., McGlynn M., Kasten K.R., Hoekzema A.S., Watanabe E., Muenzer J.T., McDonough J.S., Tschoep J., Ferguson T.A., McDunn J.E., Morre M., Hildeman D.A., Caldwell C.C., Hotchkiss R.S. (2010) IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950), 184(7):3768-79.

Hotchkiss Lab  PubMed


Characterization and modulation of the immunosuppressive phase of sepsis.

Muenzer J.T., Davis C.G., Chang K., Schmidt R.E., Dunne W.M., Coopersmith C.M., Hotchkiss R.S. (2010) Characterization and modulation of the immunosuppressive phase of sepsis. Infection and immunity, 78(4):1582-92.

Hotchkiss Lab  PubMed


Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids.

Li P., Khatri A., Bracamontes J., Weiss D.S., Steinbach J.H., Akk G. (2010) Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids. Molecular pharmacology, 77(4):539-46.

Akk Lab Steinbach Lab  PubMed


Different relationship of N- and P/Q-type Ca2+ channels to channel-interacting slots in controlling neurotransmission at cultured hippocampal synapses.

Cao Y.-Q., Tsien R.W. (2010) Different relationship of N- and P/Q-type Ca2+ channels to channel-interacting slots in controlling neurotransmission at cultured hippocampal synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(13):4536-46.

Cao Lab  PubMed


RET signaling is required for survival and normal function of nonpeptidergic nociceptors.

Golden J.P., Hoshi M., Nassar M.A., Enomoto H., Wood J.N., Milbrandt J., Gereau IV R.W., Johnson Jr. E.M., Jain S. (2010) RET signaling is required for survival and normal function of nonpeptidergic nociceptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(11):3983-94.

Gereau Lab  PubMed


Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis.

Fox A.C., Robertson C.M., Belt B., Clark A.T., Chang K.C., Leathersich A.M., Dominguez J.A., Perrone E.E., Dunne W.M., Hotchkiss R.S., Buchman T.G., Linehan D.C., Coopersmith C.M. (2010) Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis. Critical care medicine, 38(3):886-93.

Hotchkiss Lab  PubMed


Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy.

Clayton C.C., Bruchas M.R., Lee M.L., Chavkin C. (2010) Phosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy. Molecular pharmacology, 77(3):339-47.

Bruchas Lab  PubMed


Molecular pharmacology of the GABA(A) receptor.

Akk G Molecular pharmacology of the GABA(A) receptor. Current neuropharmacology, 8(1):1.

Akk Lab  PubMed


Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.

Akk G, Covey DF, Evers AS, Mennerick S, Zorumski CF, Steinbach JH Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids. Current neuropharmacology, 8(1):18-25.

Akk Lab Evers Lab  PubMed


The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors.

Bruchas M.R., Land B.B., Chavkin C. (2010) The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain research, 1314():44-55.

Bruchas Lab  PubMed


Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis.

Scatizzi J.C., Hutcheson J., Pope R.M., Firestein G.S., Koch A.E., Mavers M., Smason A., Agrawal H., Haines III G.K., Chandel N.S., Hotchkiss R.S., Perlman H. (2010) Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis and rheumatism, 62(2):441-51.

Hotchkiss Lab  PubMed


Live cell imaging for studying g protein-coupled receptor activation in single cells.

Saini D.K., Gautam N. (2010) Live cell imaging for studying g protein-coupled receptor activation in single cells. Methods in molecular biology (Clifton, N.J.), 617():191-207.

Gautam Lab  PubMed


Inhibition of muscle acetylcholine receptors by nondepolarizing drugs: humans are not unique.

Dilger J.P., Steinbach J.H. (2010) Inhibition of muscle acetylcholine receptors by nondepolarizing drugs: humans are not unique. Anesthesiology, 112(1):247-9; author reply 249-50.

Steinbach Lab  PubMed


Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis.

Bradfute S.B., Swanson P.E., Smith M.A., Watanabe E., McDunn J.E., Hotchkiss R.S., Bavari S. (2010) Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis. Journal of immunology (Baltimore, Md. : 1950), 184(1):327-35.

Hotchkiss Lab  PubMed


Corticosteroids and the original vasopressin and septic shock trial subgroups.

Southard R.E., Boyle W.A. (2010) Corticosteroids and the original vasopressin and septic shock trial subgroups. Critical care medicine, 38(1):338; authore reply 338-9.

Boyle Lab  PubMed


Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.

Tang Q.Y., Zhang Z., Xia X.M., Lingle C.J. (2010) Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine. Channels (Austin, Tex.), 4(1):22-41.

Lingle Lab  PubMed