DBR Publications


Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance.

Robertson C.M., Perrone E.E., McConnell K.W., Dunne W.M., Boody B., Brahmbhatt T., Diacovo M.J., Van Rooijen N., Hogue L.A., Cannon C.L., Buchman T.G., Hotchkiss R.S., Coopersmith C.M. (2008) Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance. The Journal of surgical research, 150(2):278-85.

Hotchkiss Lab  PubMed


Autophagy protects against hypoxic injury in C. elegans.

Samokhvalov V., Scott B.A., Crowder C.M. (2008) Autophagy protects against hypoxic injury in C. elegans. Autophagy, 4(8):1034-41.

 PubMed


The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat alpha1beta2gamma2L GABA(A) receptor.

Li P., Akk G. (2008) The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat alpha1beta2gamma2L GABA(A) receptor. British journal of pharmacology, 155(5):783-94.

Akk Lab  PubMed


Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.

Kharasch E.D., Bedynek P.S., Walker A., Whittington D., Hoffer C. (2008) Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities. Clinical pharmacology and therapeutics, 84(4):506-12.

Kharasch Lab  PubMed


Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance.

Kharasch E.D., Bedynek P.S., Park S., Whittington D., Walker A., Hoffer C. (2008) Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance. Clinical pharmacology and therapeutics, 84(4):497-505.

Kharasch Lab  PubMed


Mutations in a molecule: the virtues of antagonism.

Kharasch E.D. (2008) Mutations in a molecule: the virtues of antagonism. Mayo Clinic proceedings. Mayo Clinic, 83(10):1083-6.

Kharasch Lab  PubMed


Multiple modes for conferring surface expression of homomeric beta1 GABAA receptors.

Bracamontes J.R., Steinbach J.H. (2008) Multiple modes for conferring surface expression of homomeric beta1 GABAA receptors. The Journal of biological chemistry, 283(38):26128-36.

 PubMed


Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2.

Bruchas M.R., Xu M., Chavkin C. (2008) Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2. Neuroreport, 19(14):1417-22.

Bruchas Lab  PubMed


Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting.

Lerman J., Kharasch E.D., Eisenach J.C., Warner M.A., Jevtovic-Todorovic V., Patel P.M., Sun L.S. (2008) Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting. Anesthesiology, 109(3):365.

Kharasch Lab  PubMed


Does natural selection explain the universal response of metazoans to volatile anesthetics?

Crowder C.M. (2008) Does natural selection explain the universal response of metazoans to volatile anesthetics? Anesthesia and analgesia, 107(3):862-3.

 PubMed


Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.

Akk G., Li P., Bracamontes J., Reichert D.E., Covey D.F., Steinbach J.H. (2008) Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Molecular pharmacology, 74(3):614-27.

Akk Lab  PubMed


Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies.

Militante J., Ma B.-W., Akk G., Steinbach J.H. (2008) Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies. Molecular pharmacology, 74(3):764-76.

Akk Lab  PubMed


Pharmacology: Unready for action.

Steinbach J.H. (2008) Pharmacology: Unready for action. Nature, 454(7205):704-5.

 PubMed


Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1.

Cruz-Orengo L., Dhaka A., Heuermann R.J., Young T.J., Montana M.C., Cavanaugh E.J., Kim D., Story G.M. (2008) Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. Molecular pain, 4():30.

 PubMed


Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain.

Cattano D., Williamson P., Fukui K., Avidan M., Evers A.S., Olney J.W., Young C. (2008) Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 55(7):429-36.

Evers Lab  PubMed


Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits.

Zeng X., Xia X.-M., Lingle C.J. (2008) Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits. The Journal of general physiology, 132(1):115-29.

Lingle Lab  PubMed


Adverse drug reactions with halogenated anesthetics.

Kharasch E.D. (2008) Adverse drug reactions with halogenated anesthetics. Clinical pharmacology and therapeutics, 84(1):158-62.

Kharasch Lab  PubMed


Hemispheric lateralization of a molecular signal for pain modulation in the amygdala.

Carrasquillo Y., Gereau IV R.W. (2008) Hemispheric lateralization of a molecular signal for pain modulation in the amygdala. Molecular pain, 4():24.

Gereau Lab  PubMed


Vasopressin in septic shock.

Landry D.W., Oliver J.A. (2008) Vasopressin in septic shock. The New England journal of medicine, 358(25):2736; author reply 2737-8.

Boyle Lab  PubMed


Molecular characterization of CYP2B6 substrates.

Ekins S., Iyer M., Krasowski M.D., Kharasch E.D. (2008) Molecular characterization of CYP2B6 substrates. Current drug metabolism, 9(5):363-73.

Kharasch Lab  PubMed


Tracheostomy protocol: experience with development and potential utility.

Tracheostomy protocol: experience with development and potential utility. Critical care medicine, 36(6):1742-8.

Boyle Lab  PubMed


Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes.

Coles R., Kharasch E.D. (2008) Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes. Pharmaceutical research, 25(6):1405-11.

Kharasch Lab  PubMed


A novel serine phosphorylation site detected in the N-terminal domain of estrogen receptor isolated from human breast cancer cells.

Britton DJ, Scott GK, Schilling B, Atsriku C, Held JM, Gibson BW, Benz CC, Baldwin MA (2008) A novel serine phosphorylation site detected in the N-terminal domain of estrogen receptor isolated from human breast cancer cells. Journal of the American Society for Mass Spectrometry, 19(5):729-40.

Held Lab  PubMed


Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients.

Russom A., Sethu P., Irimia D., Mindrinos M.N., Calvano S.E., Garcia I., Finnerty C., Tannahill C., Abouhamze A., Wilhelmy J., Lopez M.C., Baker H.V., Herndon D.N., Lowry S.F., Maier R.V., Davis R.W., Moldawer L.L., Tompkins R.G., Toner M., Bankey P.E., Billiar T.R., Brownstein B.H., Camp II D.G., Casella G., Chaudry I.H., Choudhry M., Cobb J.P., De A., Elson C., Freeman B., Gamelli R.L., Gibran N.S., Hayden D.L., Harbrecht B.G., Horton J.W., Hubbard W., Johnson J., Klein M.B., Lederer J.A., Logvinenko T., Mannick J.A., Mason P.H., McDonald-Smith G.P., McKinley B.A., Miller-Graziano C., Minei J.P., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick D.G., Schoenfeld D.A., Shapiro M.B., Schwacha M., Silver G.M., Smith R.D., Storey J., Warren H.S., West M.A., Xiao W. (2008) Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. Clinical chemistry, 54(5):891-900.

Hotchkiss Lab  PubMed


Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir.

Kharasch E.D., Mitchell D., Coles R., Blanco R. (2008) Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir. Antimicrobial agents and chemotherapy, 52(5):1663-9.

Kharasch Lab  PubMed


Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.

Kharasch E.D., Mitchell D., Coles R. (2008) Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity. Journal of clinical pharmacology, 48(4):464-74.

Kharasch Lab  PubMed


Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.

Peck-Palmer O.M., Unsinger J., Chang K.C., Davis C.G., McDunn J.E., Hotchkiss R.S. (2008) Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival. Journal of leukocyte biology, 83(4):1009-18.

Hotchkiss Lab  PubMed


Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis.

Rajan S., Vyas D., Clark A.T., Woolsey C.A., Clark J.A., Hotchkiss R.S., Buchman T.G., Coopersmith C.M. (2008) Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis. Shock (Augusta, Ga.), 29(4):483-9.

Hotchkiss Lab  PubMed


Hotheaded: TRPV1 as mediator of hippocampal synaptic plasticity.

Alter B.J., Gereau IV R.W. (2008) Hotheaded: TRPV1 as mediator of hippocampal synaptic plasticity. Neuron, 57(5):629-31.

Gereau Lab  PubMed


Anesthesia awareness and the bispectral index.

Avidan M.S., Zhang L., Burnside B.A., Finkel K.J., Searleman A.C., Selvidge J.A., Saager L., Turner M.S., Rao S., Bottros M., Hantler C., Jacobsohn E., Evers A.S. (2008) Anesthesia awareness and the bispectral index. The New England journal of medicine, 358(11):1097-108.

Evers Lab  PubMed


Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopentaphenanthrenes and cyclopentaanthracenes.

Scaglione J.B., Jastrzebska I., Krishnan K., Li P., Akk G., Manion B.D., Benz A., Taylor A., Rath N.P., Evers A.S., Zorumski C.F., Mennerick S., Covey D.F. (2008) Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopentaphenanthrenes and cyclopentaanthracenes. Journal of medicinal chemistry, 51(5):1309-18.

Akk Lab  PubMed


Volatile anesthetic preconditioning present in the invertebrate Caenorhabditis elegans.

Jia B., Crowder C.M. (2008) Volatile anesthetic preconditioning present in the invertebrate Caenorhabditis elegans. Anesthesiology, 108(3):426-33.

 PubMed


Role of CYP2B6 in stereoselective human methadone metabolism.

Totah R.A., Sheffels P., Roberts T., Whittington D., Thummel K., Kharasch E.D. (2008) Role of CYP2B6 in stereoselective human methadone metabolism. Anesthesiology, 108(3):363-74.

Kharasch Lab  PubMed


Can variation in risk of nest predation explain altitudinal migration in tropical birds?

Boyle W.A. (2008) Can variation in risk of nest predation explain altitudinal migration in tropical birds? Oecologia, 155(2):397-403.

Boyle Lab  PubMed


Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice.

Lederer J.A., Brownstein B.H., Lopez M.C., MacMillan S., Delisle A.J., MacConmara M.P., Choudhry M.A., Xiao W., Lekousi S., Cobb J.P., Baker H.V., Mannick J.A., Chaudry I.H., Balis U., Bankey P., Billiar T.R., Calvano S.E., Camp II D.G., Cuschieri J., Davis R.W., De A.K., Elson C., Finnerty C.C., Freeman B., Gamelli R.L., Gibran N.S., Harbrecht B.G., Hayden D.L., Hennessy L., Herndon D.N., Horton J.W., Jeschke M.G., Johnson J., Klein M.B., Lowry S.F., Maier R.V., Mason P.H., McDonald-Smith G.P., Miller-Graziano C.L., Mindrinos M.N., Minei J.P., Moldawer L.L., Moore E.E., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D.A., Shapiro M.B., Silver G.M., Smith R.D., Storey J., Tibshirani R., Tompkins R.G., Toner M., Warren H.S., West M.A. (2008) Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice. Physiological genomics, 32(3):299-310.

Hotchkiss Lab  PubMed


Lymphocyte phenotyping to distinguish septic from nonseptic critical illness.

Schwulst S.J., Muenzer J.T., Chang K.C., Brahmbhatt T.S., Coopersmith C.M., Hotchkiss R.S. (2008) Lymphocyte phenotyping to distinguish septic from nonseptic critical illness. Journal of the American College of Surgeons, 206(2):335-42.

Hotchkiss Lab  PubMed


Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate.

Li P., Reichert D.E., Rodriguez A.D., Manion B.D., Evers A.S., Eterovic V.A., Steinbach J.H., Akk G. (2008) Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate. British journal of pharmacology, 153(3):598-608.

Akk Lab Evers Lab  PubMed


Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis.

McDunn J.E., Muenzer J.T., Rachdi L., Chang K.C., Davis C.G., Dunne W.M., Piwnica-Worms D., Bernal-Mizrachi E., Hotchkiss R.S. (2008) Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22(2):561-8.

Hotchkiss Lab  PubMed


Characterization of the alpha1-adrenoceptor subtype activating extracellular signal-regulated kinase in submandibular gland acinar cells.

Bruchas M.R., Toews M.L., Bockman C.S., Abel P.W. (2008) Characterization of the alpha1-adrenoceptor subtype activating extracellular signal-regulated kinase in submandibular gland acinar cells. European journal of pharmacology, 578(2-3):349-58.

Bruchas Lab  PubMed


The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.

Land B.B., Bruchas M.R., Lemos J.C., Xu M., Melief E.J., Chavkin C. (2008) The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(2):407-14.

Bruchas Lab  PubMed


Actions of anesthetics on excitatory transmitter-gated channels.

Akk G., Mennerick S., Steinbach J.H. (2008) Actions of anesthetics on excitatory transmitter-gated channels. Handbook of experimental pharmacology, (182):53-84.

Akk Lab  PubMed


Mg2+-dependent regulation of BK channels: importance of electrostatics.

Lingle C.J. (2008) Mg2+-dependent regulation of BK channels: importance of electrostatics. The Journal of general physiology, 131(1):5-11.

Lingle Lab  PubMed


Mode of cembranoid action on embryonic muscle acetylcholine receptor.

Ulrich H., Akk G., Nery A.A., Trujillo C.A., Rodriguez A.D., Eterovic V.A. (2008) Mode of cembranoid action on embryonic muscle acetylcholine receptor. Journal of neuroscience research, 86(1):93-107.

Akk Lab  PubMed


Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.

Templeton I.E., Thummel K.E., Kharasch E.D., Kunze K.L., Hoffer C., Nelson W.L., Isoherranen N. (2008) Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo. Clinical pharmacology and therapeutics, 83(1):77-85.

Kharasch Lab  PubMed


Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens.

Katona B.W., Krishnan K., Cai Z.Y., Manion B.D., Benz A., Taylor A., Evers A.S., Zorumski C.F., Mennerick S., Covey D.F. (2008) Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens. European journal of medicinal chemistry, 43(1):107-13.

Evers Lab  PubMed