DBR Publications


An evolutionarily conserved presynaptic protein is required for isoflurane sensitivity in Caenorhabditis elegans.

Metz L.B., Dasgupta N., Liu C., Hunt S.J., Crowder C.M. (2007) An evolutionarily conserved presynaptic protein is required for isoflurane sensitivity in Caenorhabditis elegans. Anesthesiology, 107(6):971-82.

 PubMed


Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons.

Hu H.-J., Alter B.J., Carrasquillo Y., Qiu C.-S., Gereau IV R.W. (2007) Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(48):13181-91.

Gereau Lab  PubMed


Hypoxic preconditioning requires the apoptosis protein CED-4 in C. elegans.

Dasgupta N., Patel A.M., Scott B.A., Crowder C.M. (2007) Hypoxic preconditioning requires the apoptosis protein CED-4 in C. elegans. Current biology : CB, 17(22):1954-9.

 PubMed


Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles.

Zhang Q., Cao Y.-Q., Tsien R.W. (2007) Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles. Proceedings of the National Academy of Sciences of the United States of America, 104(45):17843-8.

Cao Lab  PubMed


Performance of residents and anesthesiologists in a simulation-based skill assessment.

Murray D.J., Boulet J.R., Avidan M., Kras J.F., Henrichs B., Woodhouse J., Evers A.S. (2007) Performance of residents and anesthesiologists in a simulation-based skill assessment. Anesthesiology, 107(5):705-13.

Evers Lab  PubMed


Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation.

Li P., Shu H.-J., Wang C., Mennerick S., Zorumski C.F., Covey D.F., Steinbach J.H., Akk G. (2007) Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation. The Journal of physiology, 584(Pt 3):789-800.

Akk Lab Steinbach Lab  PubMed


Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria.

Bruchas M.R., Land B.B., Aita M., Xu M., Barot S.K., Li S., Chavkin C. (2007) Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(43):11614-23.

Bruchas Lab  PubMed


Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase.

Bruchas M.R., Yang T., Schreiber S., DeFino M., Kwan S.C., Li S., Chavkin C. (2007) Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase. The Journal of biological chemistry, 282(41):29803-11.

Bruchas Lab  PubMed


V. Guidelines for sedation and analgesia during mechanical ventilation general overview.

Shapiro M.B., West M.A., Nathens A.B., Harbrecht B.G., Moore F.A., Bankey P.E., Freeman B., Johnson J.L., McKinley B.A., Minei J.P., Moore E.E., Maier R.V., Arnoldo B.D., Baker H.V., Billiar T.R., Brownstein B.H., Calvano S.E., Camp II D.G., Campbell-Finnerty C., Casell G., Chaudry I.H., Cobb J.P., Davis R.W., De A.K., Elson C., Gamelli R.L., Gibran N.S., Hayden D.L., Hennessy L., Herndon D.N., Horton J.W., Jeschke M.G., Klein M.B., Lederer J.A., Lowry S.F., Mannick J.A., Mason P.H., McDonald-Smith G.P., Miller-Graziano C.L., Mindrinos M.N., Moldawer L.L., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D.A., Silver G.M., Smith R.D., Storey J., Tompkins R.G., Toner M., Warren H.S., Xiao W. (2007) V. Guidelines for sedation and analgesia during mechanical ventilation general overview. The Journal of trauma, 63(4):945-50.

Hotchkiss Lab  PubMed


Neuroactive steroids and human recombinant rho1 GABAC receptors.

Li W., Jin X., Covey D.F., Steinbach J.H. (2007) Neuroactive steroids and human recombinant rho1 GABAC receptors. The Journal of pharmacology and experimental therapeutics, 323(1):236-47.

Steinbach Lab  PubMed


Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam.

Kharasch E.D., Walker A., Isoherranen N., Hoffer C., Sheffels P., Thummel K., Whittington D., Ensign D. (2007) Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. Clinical pharmacology and therapeutics, 82(4):410-26.

Kharasch Lab  PubMed


Mechanisms of neurosteroid interactions with GABA(A) receptors.

Akk G., Covey D.F., Evers A.S., Steinbach J.H., Zorumski C.F., Mennerick S. (2007) Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacology & therapeutics, 116(1):35-57.

Akk Lab Evers Lab Steinbach Lab  PubMed


Stereoselective analysis of bupropion and hydroxybupropion in human plasma and urine by LC/MS/MS.

Coles R., Kharasch E.D. (2007) Stereoselective analysis of bupropion and hydroxybupropion in human plasma and urine by LC/MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 857(1):67-75.

Kharasch Lab  PubMed


Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward.

Zhao Z.-Q., Gao Y.-J., Sun Y.-G., Zhao C.-S., Gereau IV R.W., Chen Z.-F. (2007) Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward. Proceedings of the National Academy of Sciences of the United States of America, 104(36):14519-24.

Gereau Lab  PubMed


A family of G protein βγ subunits translocate reversibly from the plasma membrane to endomembranes on receptor activation.

Saini D.K., Kalyanaraman V., Chisari M., Gautam N. (2007) A family of G protein βγ subunits translocate reversibly from the plasma membrane to endomembranes on receptor activation. The Journal of biological chemistry, 282(33):24099-108.

Gautam Lab  PubMed


Shuttling of G protein subunits between the plasma membrane and intracellular membranes.

Chisari M., Saini D.K., Kalyanaraman V., Gautam N. (2007) Shuttling of G protein subunits between the plasma membrane and intracellular membranes. The Journal of biological chemistry, 282(33):24092-8.

Gautam Lab  PubMed


Effect of chlorhexidine/silver sulfadiazine-impregnated central venous catheters in an intensive care unit with a low blood stream infection rate after implementation of an educational program: a before-after trial.

Schuerer D.J.E., Zack J.E., Thomas J., Borecki I.B., Sona C.S., Schallom M.E., Venker M., Nemeth J.L., Ward M.R., Verjan L., Warren D.K., Fraser V.J., Mazuski J.E., Boyle W.A., Buchman T.G., Coopersmith C.M. (2007) Effect of chlorhexidine/silver sulfadiazine-impregnated central venous catheters in an intensive care unit with a low blood stream infection rate after implementation of an educational program: a before-after trial. Surgical infections, 8(4):445-54.

Boyle Lab  PubMed


Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.

Bordet T., Buisson B., Michaud M., Drouot C., Galea P., Delaage P., Akentieva N.P., Evers A.S., Covey D.F., Ostuni M.A., Lacapere J.-J., Massaad C., Schumacher M., Steidl E.-M., Maux D., Delaage M., Henderson C.E., Pruss R.M. (2007) Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. The Journal of pharmacology and experimental therapeutics, 322(2):709-20.

Evers Lab  PubMed


Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.

Chu W., Rothfuss J., D'Avignon A., Zeng C., Zhou D., Hotchkiss R.S., Mach R.H. (2007) Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. Journal of medicinal chemistry, 50(15):3751-5.

Hotchkiss Lab  PubMed


Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy.

Zeng C., Vangveravong S., Xu J., Chang K.C., Hotchkiss R.S., Wheeler K.T., Shen D., Zhuang Z.-P., Kung H.F., Mach R.H. (2007) Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer research, 67(14):6708-16.

Hotchkiss Lab  PubMed


The absence of endogenous beta-endorphin selectively blocks phosphorylation and desensitization of mu opioid receptors following partial sciatic nerve ligation.

Petraschka M., Li S., Gilbert T.L., Westenbroek R.E., Bruchas M.R., Schreiber S., Lowe J., Low M.J., Pintar J.E., Chavkin C. (2007) The absence of endogenous beta-endorphin selectively blocks phosphorylation and desensitization of mu opioid receptors following partial sciatic nerve ligation. Neuroscience, 146(4):1795-807.

Bruchas Lab  PubMed


Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor.

Li P., Bracamontes J., Katona B.W., Covey D.F., Steinbach J.H., Akk G. (2007) Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Molecular pharmacology, 71(6):1582-90.

Akk Lab Steinbach Lab  PubMed


Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs.

Zhao Z.-Q., Chiechio S., Sun Y.-G., Zhang K.-H., Zhao C.-S., Scott M., Johnson R.L., Deneris E.S., Renner K.J., Gereau IV R.W., Chen Z.-F. (2007) Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(22):6045-53.

Gereau Lab  PubMed


A slip 'twixt the cup and the lip: a new way to impair function of transmitter-gated channels.

Steinbach J.H. (2007) A slip 'twixt the cup and the lip: a new way to impair function of transmitter-gated channels. The Journal of physiology, 581(Pt 1):3.

Steinbach Lab  PubMed


TAT-Bim induces extensive apoptosis in cancer cells.

Kashiwagi H., McDunn J.E., Goedegebuure P.S., Gaffney M.C., Chang K., Trinkaus K., Piwnica-Worms D., Hotchkiss R.S., Hawkins W.G. (2007) TAT-Bim induces extensive apoptosis in cancer cells. Annals of surgical oncology, 14(5):1763-71.

Hotchkiss Lab  PubMed


BK channels with beta3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism.

Zeng X.-H., Benzinger G.R., Xia X.-M., Lingle C.J. (2007) BK channels with beta3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(17):4707-15.

Lingle Lab  PubMed


Anti-apoptotic peptides protect against radiation-induced cell death.

McConnell K.W., Muenzer J.T., Chang K.C., Davis C.G., McDunn J.E., Coopersmith C.M., Hilliard C.A., Hotchkiss R.S., Grigsby P.W., Hunt C.R. (2007) Anti-apoptotic peptides protect against radiation-induced cell death. Biochemical and biophysical research communications, 355(2):501-7.

Hotchkiss Lab  PubMed


Every breath you take, we'll be watching you.

Kharasch E.D., Shelden R.D., Shelden M.B. (2007) Every breath you take, we'll be watching you. Anesthesiology, 106(4):652-4.

Kharasch Lab  PubMed


Can we get there if we don't know where we're going?

Evers A.S., Miller R.D. (2007) Can we get there if we don't know where we're going? Anesthesiology, 106(4):651-2.

Evers Lab  PubMed


Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.

Eisenman L.N., Shu H.-J., Akk G., Wang C., Manion B.D., Kress G.J., Evers A.S., Steinbach J.H., Covey D.F., Zorumski C.F., Mennerick S. (2007) Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. Nature neuroscience, 10(4):523-30.

Akk Lab Evers Lab Steinbach Lab  PubMed


Enantiomeric metabolic interactions and stereoselective human methadone metabolism.

Totah R.A., Allen K.E., Sheffels P., Whittington D., Kharasch E.D. (2007) Enantiomeric metabolic interactions and stereoselective human methadone metabolism. The Journal of pharmacology and experimental therapeutics, 321(1):389-99.

Kharasch Lab  PubMed


Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo.

Wagner T.H., Drewry A.M., MacMillan S., Dunne W.M., Chang K.C., Karl I.E., Hotchkiss R.S., Cobb J.P. (2007) Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo. American journal of physiology. Regulatory, integrative and comparative physiology, 292(4):R1751-9.

Hotchkiss Lab  PubMed


Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase.

Xu M., Bruchas M.R., Ippolito D.L., Gendron L., Chavkin C. (2007) Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(10):2570-81.

Bruchas Lab  PubMed


Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis.

Chang K.C., Unsinger J., Davis C.G., Schwulst S.J., Muenzer J.T., Strasser A., Hotchkiss R.S. (2007) Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 21(3):708-19.

Hotchkiss Lab  PubMed


Adoptive transfer of dying cells causes bystander-induced apoptosis.

Schwulst S.J., Davis C.G., Coopersmith C.M., Hotchkiss R.S. (2007) Adoptive transfer of dying cells causes bystander-induced apoptosis. Biochemical and biophysical research communications, 353(3):780-5.

Hotchkiss Lab  PubMed


Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception.

Carrasquillo Y., Gereau IV R.W. (2007) Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(7):1543-51.

Gereau Lab  PubMed


Prevention of immune cell apoptosis as potential therapeutic strategy for severe infections.

Parrino J., Hotchkiss R.S., Bray M. (2007) Prevention of immune cell apoptosis as potential therapeutic strategy for severe infections. Emerging infectious diseases, 13(2):191-8.

Hotchkiss Lab  PubMed


Gating rings formed by RCK domains: keys to gate opening.

Lingle C.J. (2007) Gating rings formed by RCK domains: keys to gate opening. The Journal of general physiology, 129(2):101-7.

Lingle Lab  PubMed


Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor.

Akk G., Li P., Manion B.D., Evers A.S., Steinbach J.H. (2007) Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor. Molecular pharmacology, 71(2):461-72.

Akk Lab Evers Lab Steinbach Lab  PubMed


Acetyl-L-carnitine in neuropathic pain: experimental data.

Chiechio S., Copani A., Gereau 4th. R.W., Nicoletti F. (2007) Acetyl-L-carnitine in neuropathic pain: experimental data. CNS drugs, 21 Suppl 1():31-8; discussion 45-6.

Gereau Lab  PubMed


Variation in cortical bone histology within the human femur and its impact on estimating age at death.

Chan A.H.W., Crowder C.M., Rogers T.L. (2007) Variation in cortical bone histology within the human femur and its impact on estimating age at death. American journal of physical anthropology, 132(1):80-8.

 PubMed