DBR Publications


Pharmacokinetic interactions between buprenorphine and antiretroviral medications.

Bruce R.D., McCance-Katz E., Kharasch E.D., Moody D.E., Morse G.D. (2006) Pharmacokinetic interactions between buprenorphine and antiretroviral medications. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 43 Suppl 4():S216-23.

Kharasch Lab  PubMed


Voltage-gated calcium channels and pain.

Cao Y.-Q. (2006) Voltage-gated calcium channels and pain. Pain, 126(1-3):5-9.

Cao Lab  PubMed


Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity.

Zhao Z.-Q., Scott M., Chiechio S., Wang J.-S., Renner K.J., Gereau IV R.W., Johnson R.L., Deneris E.S., Chen Z.-F. (2006) Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(49):12781-8.

Gereau Lab  PubMed


Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis.

Muenzer J.T., Davis C.G., Dunne B.S., Unsinger J., Dunne W.M., Hotchkiss R.S. (2006) Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis. Shock (Augusta, Ga.), 26(6):565-70.

Hotchkiss Lab  PubMed


The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis.

Unsinger J., Herndon J.M., Davis C.G., Muenzer J.T., Hotchkiss R.S., Ferguson T.A. (2006) The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis. Journal of immunology (Baltimore, Md. : 1950), 177(11):7968-73.

Hotchkiss Lab  PubMed


Role of the agonist binding site in up-regulation of neuronal nicotinic alpha4beta2 receptors.

Kishi M., Steinbach J.H. (2006) Role of the agonist binding site in up-regulation of neuronal nicotinic alpha4beta2 receptors. Molecular pharmacology, 70(6):2037-44.

 PubMed


A limited access compartment between the pore domain and cytosolic domain of the BK channel.

Zhang Z., Zhou Y., Ding J.-P., Xia X.-M., Lingle C.J. (2006) A limited access compartment between the pore domain and cytosolic domain of the BK channel. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(46):11833-43.

Lingle Lab  PubMed


Empirical considerations regarding the use of ensemble-variance analysis of macroscopic currents.

Lingle C.J. (2006) Empirical considerations regarding the use of ensemble-variance analysis of macroscopic currents. Journal of neuroscience methods, 158(1):121-32.

Lingle Lab  PubMed


Molecular diagnostics in sepsis: from bedside to bench.

Chung T.P., Laramie J.M., Meyer D.J., Downey T., Tam L.H.Y., Ding H., Buchman T.G., Karl I., Stormo G.D., Hotchkiss R.S., Cobb J.P. (2006) Molecular diagnostics in sepsis: from bedside to bench. Journal of the American College of Surgeons, 203(5):585-598.

Hotchkiss Lab  PubMed


Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities.

Kirby B., Kharasch E.D., Thummel K.T., Narang V.S., Hoffer C.J., Unadkat J.D. (2006) Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities. Journal of clinical pharmacology, 46(11):1313-9.

Kharasch Lab  PubMed


Apoptosis and caspases regulate death and inflammation in sepsis.

Hotchkiss R.S., Nicholson D.W. (2006) Apoptosis and caspases regulate death and inflammation in sepsis. Nature reviews. Immunology, 6(11):813-22.

Hotchkiss Lab  PubMed


Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses.

Li S., Lee M.L., Bruchas M.R., Chan G.C., Storm D.R., Chavkin C. (2006) Calmodulin-stimulated adenylyl cyclase gene deletion affects morphine responses. Molecular pharmacology, 70(5):1742-9.

Bruchas Lab  PubMed


Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways.

Laudanski K., Miller-Graziano C., Xiao W., Mindrinos M.N., Richards D.R., De A., Moldawer L.L., Maier R.V., Bankey P., Baker H.V., Brownstein B.H., Cobb J.P., Galvano S.E., Davis R.W., Tompkins R.G., Billiar T.R., Camp II D., Campbell-Finnerty C., Casella G., Chaudry I.H., Choudhry M., Elson C., Freeman B., Gamelli R.L., Gibran N.S., Harbrecht B.G., Hayden D.L., Herndon D.N., Horton J.W., Hubbard W., Hunt J.L., Johnson J., Klein M.B., Lederer J.A., Logvinenko T., Lowry S.F., Mannick J.A., Mason P.H., McDonald-Smith G.P., McKinley B.A., Minei J.P., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D.A., Shapiro M.B., Schwacha M., Silver G.M., Smith R.D., Storey J., Toner M., Warren H.S., West M.A. (2006) Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proceedings of the National Academy of Sciences of the United States of America, 103(42):15564-9.

Hotchkiss Lab  PubMed


New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites.

Kharasch E.D., Schroeder J.L., Liggitt H.D., Ensign D., Whittington D. (2006) New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites. Anesthesiology, 105(4):737-45.

Kharasch Lab  PubMed


New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway.

Kharasch E.D., Schroeder J.L., Liggitt H.D., Park S.B., Whittington D., Sheffels P. (2006) New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway. Anesthesiology, 105(4):726-36.

Kharasch Lab  PubMed


High dynamic range characterization of the trauma patient plasma proteome.

Liu T., Qiant W.-J., Gritsenko M.A., Xiao W., Moldawer L.L., Kaushal A., Monroe M.E., Varnum S.M., Moore R.J., Purvine S.O., Maier R.V., Davis R.W., Tompkins R.G., Camp II D.G., Smith R.D., Baker H.V., Bankey P.E., Billiar T.R., Brownstein B.H., Calvano S.E., Campbell-Finnerty C., Casella G., Chaudry I.H., Choudhry M., Cobb J.P., De A., Elson C., Freeman B., Gamelli R.L., Gibran N.S., Harbrecht B.G., Hayden D.L., Herndon D.N., Horton J.W., Hubbard W., Hunt J.L., Johnson J.L., Klein M.B., Lederer J.A., Logvinenko T., Lowry S.F., Mannick J.A., Mason P.H., McDonald-Smith G.P., McKinley B., Miller-Graziano C.L., Mindrinos M., Minei J.P., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick D.G., Schoenfeld D., Shapiro M.B., Schwacha M., Silver G.M., Storey J., Toner M., Shaw Warren H., West M.A. (2006) High dynamic range characterization of the trauma patient plasma proteome. Molecular & cellular proteomics : MCP, 5(10):1899-913.

Hotchkiss Lab  PubMed


G protein betagamma complex translocation from plasma membrane to Golgi complex is influenced by receptor gamma subunit interaction.

Akgoz M., Kalyanaraman V., Gautam N. (2006) G protein betagamma complex translocation from plasma membrane to Golgi complex is influenced by receptor gamma subunit interaction. Cellular signalling, 18(10):1758-68.

Gautam Lab  PubMed


Slo3 K+ channels: voltage and pH dependence of macroscopic currents.

Zhang X., Zeng X., Lingle C.J. (2006) Slo3 K+ channels: voltage and pH dependence of macroscopic currents. The Journal of general physiology, 128(3):317-36.

Lingle Lab  PubMed


pH-regulated Slo3 K+ channels: properties of unitary currents.

Zhang X., Zeng X., Xia X.-M., Lingle C.J. (2006) pH-regulated Slo3 K+ channels: properties of unitary currents. The Journal of general physiology, 128(3):301-15.

Lingle Lab  PubMed


The number of genes changing expression after chronic exposure to code division multiple access or frequency DMA radiofrequency radiation does not exceed the false-positive rate.

Whitehead T.D., Moros E.G., Brownstein B.H., Roti Roti J.L. (2006) The number of genes changing expression after chronic exposure to code division multiple access or frequency DMA radiofrequency radiation does not exceed the false-positive rate. Proteomics, 6(17):4739-44.

Hotchkiss Lab  PubMed


Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis.

McDunn J.E., Turnbull I.R., Polpitiya A.D., Tong A., MacMillan S.K., Osborne D.F., Hotchkiss R.S., Colonna M., Cobb J.P. (2006) Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis. Journal of the American College of Surgeons, 203(3):365-75.

Hotchkiss Lab  PubMed


Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis.

Schreiber T., Swanson P.E., Chang K.C., Davis C.C., Dunne W.M., Karl I.E., Reinhart K., Hotchkiss R.S. (2006) Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis. Shock (Augusta, Ga.), 26(3):271-6.

Hotchkiss Lab  PubMed


DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid.

Held JM, White MP, Fisher AL, Gibson BW, Lithgow GJ, Gill MS (2006) DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid. Aging cell, 5(4):283-91.

Held Lab  PubMed


Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis.

Sethu P., Moldawer L.L., Mindrinos M.N., Scumpia P.O., Tannahill C.L., Wilhelmy J., Efron P.A., Brownstein B.H., Tompkins R.G., Toner M. (2006) Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis. Analytical chemistry, 78(15):5453-61.

Hotchkiss Lab  PubMed


More than cool: promiscuous relationships of menthol and other sensory compounds.

Macpherson L.J., Hwang S.W., Miyamoto T., Dubin A.E., Patapoutian A., Story G.M. (2006) More than cool: promiscuous relationships of menthol and other sensory compounds. Molecular and cellular neurosciences, 32(4):335-43.

 PubMed


G protein betagamma11 complex translocation is induced by Gi, Gq and Gs coupling receptors and is regulated by the alpha subunit type.

Azpiazu I., Akgoz M., Kalyanaraman V., Gautam N. (2006) G protein betagamma11 complex translocation is induced by Gi, Gq and Gs coupling receptors and is regulated by the alpha subunit type. Cellular signalling, 18(8):1190-200.

Gautam Lab  PubMed


Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.

Scaglione J.B., Manion B.D., Benz A., Taylor A., DeKoster G.T., Rath N.P., Evers A.S., Zorumski C.F., Mennerick S., Covey D.F. (2006) Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. Journal of medicinal chemistry, 49(15):4595-605.

Evers Lab  PubMed


Inflammation and the host response to injury: an overview of the multicenter study of the genomic and proteomic response to burn injury.

Klein M.B., Silver G., Gamelli R.L., Gibran N.S., Herndon D.N., Hunt J.L., Tompkins R.G., Baker H.V., Bankey P., Billiar T.R., Brownstein B.H., Calvano S.E., Camp II D.G., Campbell-Finnerty C., Casella G., Chaudry I.H., Cobb J.P., Davis R.W., De A.K., Elson C., Freeman B., Harbrecht B.G., Hayden D.L., Horton J.W., Johnson J., Lederer J.A., Logvinenko T., Lowry S.F., Maier R.V., Mannick J.A., Mason P.H., McDonald-Smith G.P., McKinley B.A., Miller-Graziano C.L., Mindrinos M.N., Minei J.P., Moldawer L.L., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D.A., Shapiro M.B., Silver G.M., Smith R.D., Storey J., Toner M., Warren H.S., West M.A., Xiao W. (2006) Inflammation and the host response to injury: an overview of the multicenter study of the genomic and proteomic response to burn injury. Journal of burn care & research : official publication of the American Burn Association, 27(4):448-51.

Hotchkiss Lab  PubMed


Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis.

Schwulst S.J., Grayson M.H., DiPasco P.J., Davis C.G., Brahmbhatt T.S., Ferguson T.A., Hotchkiss R.S. (2006) Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950), 177(1):557-65.

Hotchkiss Lab  PubMed


Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes.

Bruchas M.R., Macey T.A., Lowe J.D., Chavkin C. (2006) Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. The Journal of biological chemistry, 281(26):18081-9.

Bruchas Lab  PubMed


Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo.

Scherrer G., Tryoen-Toth P., Filliol D., Matifas A., Laustriat D., Cao Y.Q., Basbaum A.I., Dierich A., Vonesh J.-L., Gaveriaux-Ruff C., Kieffer B.L. (2006) Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proceedings of the National Academy of Sciences of the United States of America, 103(25):9691-6.

Cao Lab  PubMed


Gene expression does not change significantly in C3H 10T(1/2) cells after exposure to 847.74 CDMA or 835.62 FDMA radiofrequency radiation.

Whitehead T.D., Moros E.G., Brownstein B.H., Roti Roti J.L. (2006) Gene expression does not change significantly in C3H 10T(1/2) cells after exposure to 847.74 CDMA or 835.62 FDMA radiofrequency radiation. Radiation research, 165(6):626-35.

Hotchkiss Lab  PubMed


A new safety event reporting system improves physician reporting in the surgical intensive care unit.

Schuerer D.J.E., Nast P.A., Harris C.B., Krauss M.J., Jones R.M., Boyle W.A., Buchman T.G., Coopersmith C.M., Dunagan W.C., Fraser V.J. (2006) A new safety event reporting system improves physician reporting in the surgical intensive care unit. Journal of the American College of Surgeons, 202(6):881-7.

Boyle Lab  PubMed


Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors.

Li P., Covey D.F., Steinbach J.H., Akk G. (2006) Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors. Molecular pharmacology, 69(6):2015-26.

Akk Lab  PubMed


Enantiomers of neuroactive steroids support a specific interaction with the GABA-C receptor as the mechanism of steroid action.

Li W., Covey D.F., Alakoskela J.-M., Kinnunen P.K.J., Steinbach J.H. (2006) Enantiomers of neuroactive steroids support a specific interaction with the GABA-C receptor as the mechanism of steroid action. Molecular pharmacology, 69(6):1779-82.

 PubMed


Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites.

Lalovic B., Kharasch E., Hoffer C., Risler L., Liu-Chen L.-Y., Shen D.D. (2006) Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clinical pharmacology and therapeutics, 79(5):461-79.

Kharasch Lab  PubMed


TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo.

Hotchkiss R.S., McConnell K.W., Bullok K., Davis C.G., Chang K.C., Schwulst S.J., Dunne J.C., Dietz G.P.H., Bahr M., McDunn J.E., Karl I.E., Wagner T.H., Cobb J.P., Coopersmith C.M., Piwnica-Worms D. (2006) TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. Journal of immunology (Baltimore, Md. : 1950), 176(9):5471-7.

Hotchkiss Lab  PubMed


Numbing the senses: role of TRPA1 in mechanical and cold sensation.

Story G.M., Gereau IV R.W. (2006) Numbing the senses: role of TRPA1 in mechanical and cold sensation. Neuron, 50(2):177-80.

Gereau Lab  PubMed


The kv4.2 potassium channel subunit is required for pain plasticity.

Hu H.-J., Carrasquillo Y., Karim F., Jung W.E., Nerbonne J.M., Schwarz T.L., Gereau IV R.W. (2006) The kv4.2 potassium channel subunit is required for pain plasticity. Neuron, 50(1):89-100.

Gereau Lab  PubMed


Decreased vasopressin responsiveness in vasodilatory septic shock-like conditions.

Leone M., Boyle W.A. (2006) Decreased vasopressin responsiveness in vasodilatory septic shock-like conditions. Critical care medicine, 34(4):1126-30.

Boyle Lab  PubMed


Stereochemical aspects of itraconazole metabolism in vitro and in vivo.

Kunze K.L., Nelson W.L., Kharasch E.D., Thummel K.E., Isoherranen N. (2006) Stereochemical aspects of itraconazole metabolism in vitro and in vivo. Drug metabolism and disposition: the biological fate of chemicals, 34(4):583-90.

Kharasch Lab  PubMed


Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats.

Kharasch E.D., Schroeder J.L., Bammler T., Beyer R., Srinouanprachanh S. (2006) Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats. Toxicological sciences : an official journal of the Society of Toxicology, 90(2):419-31.

Kharasch Lab  PubMed


The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors.

McCann C.M., Bracamontes J., Steinbach J.H., Sanes J.R. (2006) The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors. Proceedings of the National Academy of Sciences of the United States of America, 103(13):5149-54.

 PubMed


A G protein gamma subunit peptide stabilizes a novel muscarinic receptor state.

Azpiazu I., Gautam N. (2006) A G protein gamma subunit peptide stabilizes a novel muscarinic receptor state. Biochemical and biophysical research communications, 341(4):904-10.

Gautam Lab  PubMed


Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury.

Brownstein B.H., Logvinenko T., Lederer J.A., Cobb J.P., Hubbard W.J., Chaudry I.H., Remick D.G., Baker H.V., Xiao W., Mannick J.A. (2006) Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury. Physiological genomics, 24(3):298-309.

Hotchkiss Lab  PubMed


Intrapatient reproducibility of the BISxp monitor.

Intrapatient reproducibility of the BISxp monitor. Anesthesiology, 104(2):242-8.

Evers Lab  PubMed


Direct observation of a preinactivated, open state in BK channels with beta2 subunits.

Benzinger G.R., Xia X.-M., Lingle C.J. (2006) Direct observation of a preinactivated, open state in BK channels with beta2 subunits. The Journal of general physiology, 127(2):119-31.

Lingle Lab  PubMed


Pharmacokinetics and clinical effects of multidose sublingual triazolam in healthy volunteers.

Jackson D.L., Milgrom P., Heacox G.A., Kharasch E.D. (2006) Pharmacokinetics and clinical effects of multidose sublingual triazolam in healthy volunteers. Journal of clinical psychopharmacology, 26(1):4-8.

Kharasch Lab  PubMed


Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK).

Karim F., Hu H.-J., Adwanikar H., Kaplan D., Gereau IV R.W. (2006) Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK). Molecular pain, 2():2.

Gereau Lab  PubMed


Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha.

Jin X., Gereau IV R.W. (2006) Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(1):246-55.

Gereau Lab  PubMed


Efficacy and safety of an insulin infusion protocol in a surgical ICU.

Taylor B.E., Schallom M.E., Sona C.S., Buchman T.G., Boyle W.A., Mazuski J.E., Schuerer D.E., Thomas J.M., Kaiser C., Huey W.Y., Ward M.R., Zack J.E., Coopersmith C.M. (2006) Efficacy and safety of an insulin infusion protocol in a surgical ICU. Journal of the American College of Surgeons, 202(1):1-9.

Boyle Lab  PubMed