DBR Publications


Tyrosine phosphorylation of K(ir)3.1 in spinal cord is induced by acute inflammation, chronic neuropathic pain, and behavioral stress.

Ippolito D.L., Xu M., Bruchas M.R., Wickman K., Chavkin C. (2005) Tyrosine phosphorylation of K(ir)3.1 in spinal cord is induced by acute inflammation, chronic neuropathic pain, and behavioral stress. The Journal of biological chemistry, 280(50):41683-93.

Bruchas Lab  PubMed


Neurosteroid access to the GABAA receptor.

Akk G., Shu H.-J., Wang C., Steinbach J.H., Zorumski C.F., Covey D.F., Mennerick S. (2005) Neurosteroid access to the GABAA receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(50):11605-13.

Akk Lab Steinbach Lab  PubMed


Influence of sevoflurane on the metabolism and renal effects of compound A in rats.

Kharasch E.D., Schroeder J.L., Sheffels P., Liggitt H.D. (2005) Influence of sevoflurane on the metabolism and renal effects of compound A in rats. Anesthesiology, 103(6):1183-8.

Kharasch Lab  PubMed


Neurofibromatosis pain is in the membrane. Focus on "sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability".

Gereau IV R.W. (2005) Neurofibromatosis pain is in the membrane. Focus on "sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability". Journal of neurophysiology, 94(6):3659-60.

Gereau Lab  PubMed


Prevention of lymphocyte apoptosis--a potential treatment of sepsis?

Hotchkiss R.S., Coopersmith C.M., Karl I.E. (2005) Prevention of lymphocyte apoptosis--a potential treatment of sepsis? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 41 Suppl 7():S465-9.

Hotchkiss Lab  PubMed


Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam.

Chaobal H.N., Kharasch E.D. (2005) Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam. Clinical pharmacology and therapeutics, 78(5):529-39.

Kharasch Lab  PubMed


Marked synergism between vasopressin and angiotensin II in a human isolated artery.

Hidaka T., Tsuneyoshi I., Boyle III W.A., Onomoto M., Yonetani S., Hamasaki J., Katai R., Kanmura Y. (2005) Marked synergism between vasopressin and angiotensin II in a human isolated artery. Critical care medicine, 33(11):2613-20.

Boyle Lab  PubMed


A network-based analysis of systemic inflammation in humans.

Calvano S.E., Xiao W., Richards D.R., Felciano R.M., Baker H.V., Cho R.J., Chen R.O., Brownstein B.H., Cobb J.P., Tschoeke S.K., Miller-Graziano C., Moldawer L.L., Mindrinos M.N., Davis R.W., Tompkins R.G., Lowry S.F. (2005) A network-based analysis of systemic inflammation in humans. Nature, 437(7061):1032-7.

Hotchkiss Lab  PubMed


Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury.

Husain K.D., Stromberg P.E., Woolsey C.A., Turnbull I.R., Dunne W.M., Javadi P., Buchman T.G., Karl I.E., Hotchkiss R.S., Coopersmith C.M. (2005) Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury. Critical care medicine, 33(10):2350-7.

Hotchkiss Lab  PubMed


Volatile anesthetics bind rat synaptic snare proteins.

Nagele P., Mendel J.B., Placzek W.J., Scott B.A., D'Avignon D.A., Crowder C.M. (2005) Volatile anesthetics bind rat synaptic snare proteins. Anesthesiology, 103(4):768-78.

 PubMed


Expression of the proto-oncogene Fos after exposure to radiofrequency radiation relevant to wireless communications.

Whitehead T.D., Brownstein B.H., Parry J.J., Thompson D., Cha B.A., Moros E.G., Rogers B.E., Roti Roti J.L. (2005) Expression of the proto-oncogene Fos after exposure to radiofrequency radiation relevant to wireless communications. Radiation research, 164(4 Pt 1):420-30.

Hotchkiss Lab  PubMed


Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity.

Kharasch E.D., Walker A., Hoffer C., Sheffels P. (2005) Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity. Journal of clinical pharmacology, 45(10):1187-97.

Kharasch Lab  PubMed


Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels.

Vyas D., Javadi P., DiPasco P.J., Buchman T.G., Hotchkiss R.S., Coopersmith C.M. (2005) Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels. American journal of physiology. Regulatory, integrative and comparative physiology, 289(4):R1048-53.

Hotchkiss Lab  PubMed


Vitamin K3 (menadione)-induced oncosis associated with keratin 8 phosphorylation and histone H3 arylation.

Scott GK, Atsriku C, Kaminker P, Held J, Gibson B, Baldwin MA, Benz CC (2005) Vitamin K3 (menadione)-induced oncosis associated with keratin 8 phosphorylation and histone H3 arylation. Molecular pharmacology, 68(3):606-15.

Held Lab  PubMed


Xenon acts by inhibition of non-N-methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in Caenorhabditis elegans.

Nagele P., Metz L.B., Crowder M. (2005) Xenon acts by inhibition of non-N-methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in Caenorhabditis elegans. Anesthesiology, 103(3):508-13.

 PubMed


Decreased circulating elastin peptide levels in humans with sepsis.

Faury G., Wynnychenko T.M., Cand F., Leone M., Jacob M.-P., Verdetti J., Boyle W.A. (2005) Decreased circulating elastin peptide levels in humans with sepsis. Pathologie-biologie, 53(7):443-7.

Boyle Lab  PubMed


Iron dysregulation combined with aging prevents sepsis-induced apoptosis.

Javadi P., Buchman T.G., Stromberg P.E., Turnbull I.R., Vyas D., Hotchkiss R.S., Karl I.E., Coopersmith C.M. (2005) Iron dysregulation combined with aging prevents sepsis-induced apoptosis. The Journal of surgical research, 128(1):37-44.

Hotchkiss Lab  PubMed


Gating deficiency in a familial hemiplegic migraine type 1 mutant P/Q-type calcium channel.

Barrett C.P., Cao Y.-Q., Tsien R.W. (2005) Gating deficiency in a familial hemiplegic migraine type 1 mutant P/Q-type calcium channel. The Journal of biological chemistry, 280(25):24064-71.

Cao Lab  PubMed


CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition.

Kharasch E.D., Thummel K.E., Watkins P.B. (2005) CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition. Molecular interventions, 5(3):151-3.

Kharasch Lab  PubMed


Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach.

Qian W.-J., Monroe M.E., Liu T., Jacobs J.M., Anderson G.A., Shen Y., Moore R.J., Anderson D.J., Zhang R., Calvano S.E., Lowry S.F., Xiao W., Moldawer L.L., Davis R.W., Tompkins R.G., Camp II D.G., Smith R.D., Baker H.V., Bankey P., Billiar T.R., Brownstein B.H., Chaudry I.H., Cobb J.P., Fay A., Feezor R.J., Freeman B., Gamelli R.L., Gibran N.S., Harbrecht B.G., Hayden D., Herndon D.N., Horton J.W., Hunt J.L., Johnson J.L., Laudanski K., Lederer J.A., Logvinenko T., Maier R.V., Mannick J.A., McKinley B., Miller-Graziano C.L., Minei J.P., Mindrinos M., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D., Shapiro M.B., Sheridan R.L., Silver G.M., Somers S., Toner M., Warren H.S., West M.A., Wolf S.E., Yarmush M., Young V.R. (2005) Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach. Molecular & cellular proteomics : MCP, 4(5):700-9.

Hotchkiss Lab  PubMed


Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.

Zeng C.-M., Manion B.D., Benz A., Evers A.S., Zorumski C.F., Mennerick S., Covey D.F. (2005) Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. Journal of medicinal chemistry, 48(8):3051-9.

Evers Lab  PubMed


Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways.

Hotchkiss R.S., Osmon S.B., Chang K.C., Wagner T.H., Coopersmith C.M., Karl I.E. (2005) Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. Journal of immunology (Baltimore, Md. : 1950), 174(8):5110-8.

Hotchkiss Lab  PubMed


Activation of heteroliganded mouse muscle nicotinic receptors.

Akk G., Milescu L.S., Heckmann M. (2005) Activation of heteroliganded mouse muscle nicotinic receptors. The Journal of physiology, 564(Pt 2):359-76.

Akk Lab  PubMed


Maximum likelihood estimation of ion channel kinetics from macroscopic currents.

Milescu L.S., Akk G., Sachs F. (2005) Maximum likelihood estimation of ion channel kinetics from macroscopic currents. Biophysical journal, 88(4):2494-515.

Akk Lab  PubMed


Application of genome-wide expression analysis to human health and disease.

Cobb J.P., Mindrinos M.N., Miller-Graziano C., Calvano S.E., Baker H.V., Xiao W., Laudanski K., Brownstein B.H., Elson C.M., Hayden D.L., Herndon D.N., Lowry S.F., Maier R.V., Schoenfeld D.A., Moldawer L.L., Davis R.W., Tompkins R.G. (2005) Application of genome-wide expression analysis to human health and disease. Proceedings of the National Academy of Sciences of the United States of America, 102(13):4801-6.

Hotchkiss Lab  PubMed


Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin.

Moqrich A., Hwang S.W., Earley T.J., Petrus M.J., Murray A.N., Spencer K.S.R., Andahazy M., Story G.M., Patapoutian A. (2005) Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science (New York, N.Y.), 307(5714):1468-72.

 PubMed


Terlipressin: a new therapeutic for calcium-channel blockers overdose.

Leone M., Charvet A., Delmas A., Albanese J., Martin C., Boyle W.A. (2005) Terlipressin: a new therapeutic for calcium-channel blockers overdose. Journal of critical care, 20(1):114-5.

Boyle Lab  PubMed


Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites.

Zeng X.-H., Xia X.-M., Lingle C.J. (2005) Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites. The Journal of general physiology, 125(3):273-86.

Lingle Lab  PubMed


Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5.

Klees T.M., Sheffels P., Thummel K.E., Kharasch E.D. (2005) Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5. Anesthesiology, 102(3):550-6.

Kharasch Lab  PubMed


Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes.

Klees T.M., Sheffels P., Dale O., Kharasch E.D. (2005) Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. Drug metabolism and disposition: the biological fate of chemicals, 33(3):303-11.

Kharasch Lab  PubMed


Galantamine activates muscle-type nicotinic acetylcholine receptors without binding to the acetylcholine-binding site.

Akk G., Steinbach J.H. (2005) Galantamine activates muscle-type nicotinic acetylcholine receptors without binding to the acetylcholine-binding site. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(8):1992-2001.

Akk Lab Steinbach Lab  PubMed


Effects of familial hemiplegic migraine type 1 mutations on neuronal P/Q-type Ca2+ channel activity and inhibitory synaptic transmission.

Cao Y.-Q., Tsien R.W. (2005) Effects of familial hemiplegic migraine type 1 mutations on neuronal P/Q-type Ca2+ channel activity and inhibitory synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America, 102(7):2590-5.

Cao Lab  PubMed


Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans.

Dembo G., Park S.B., Kharasch E.D. (2005) Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans. Anesthesiology, 102(2):409-15.

Kharasch Lab  PubMed


NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin.

Alagarsamy S., Saugstad J., Warren L., Mansuy I.M., Gereau IV R.W., Conn P.J. (2005) NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin. Neuropharmacology, 49 Suppl 1():135-45.

Gereau Lab  PubMed


Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies.

Kharasch E.D., Whittington D., Hoffer C., Krudys K., Craig K., Vicini P., Sheffels P., Lalovic B. (2005) Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies. Clinical pharmacokinetics, 44(7):731-51.

Kharasch Lab  PubMed


Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination.

Kharasch E.D., Walker A., Hoffer C., Sheffels P. (2005) Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination. Journal of clinical pharmacology, 45(1):79-88.

Kharasch Lab  PubMed