DBR Publications


Receptor-mediated reversible translocation of the G protein betagamma complex from the plasma membrane to the Golgi complex.

Akgoz M., Kalyanaraman V., Gautam N. (2004) Receptor-mediated reversible translocation of the G protein betagamma complex from the plasma membrane to the Golgi complex. The Journal of biological chemistry, 279(49):51541-4.

Gautam Lab  PubMed


Lipophilic regulator of a developmental switch in Caenorhabditis elegans.

Gill MS, Held JM, Fisher AL, Gibson BW, Lithgow GJ (2004) Lipophilic regulator of a developmental switch in Caenorhabditis elegans. Aging cell, 3(6):413-21.

Held Lab  PubMed


Whole blood and leukocyte RNA isolation for gene expression analyses.

Feezor R.J., Baker H.V., Mindrinos M., Hayden D., Tannahill C.L., Brownstein B.H., Fay A., MacMillan S., Laramie J., Xiao W., Moldawer L.L., Cobb J.P., Laudanski K., Miller-Graziano C.L., Maier R.V., Schoenfeld D., Davis R.W., Tompkins R.G. (2005) Whole blood and leukocyte RNA isolation for gene expression analyses. Physiological genomics, 19(3):247-54.

Hotchkiss Lab  PubMed


Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.

Kharasch E.D., Walker A., Hoffer C., Sheffels P. (2004) Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis. Clinical pharmacology and therapeutics, 76(5):452-66.

Kharasch Lab  PubMed


In vitro metabolism of cyclosporine A by human kidney CYP3A5.

Dai Y., Iwanaga K., Lin Y.S., Hebert M.F., Davis C.L., Huang W., Kharasch E.D., Thummel K.E. (2004) In vitro metabolism of cyclosporine A by human kidney CYP3A5. Biochemical pharmacology, 68(9):1889-902.

Kharasch Lab  PubMed


Stereoselective determination of methadone and the primary metabolite EDDP in human plasma by automated on-line extraction and liquid chromatography mass spectrometry.

Whittington D., Sheffels P., Kharasch E.D. (2004) Stereoselective determination of methadone and the primary metabolite EDDP in human plasma by automated on-line extraction and liquid chromatography mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 809(2):313-21.

Kharasch Lab  PubMed


Resistance to volatile anesthetics by mutations enhancing excitatory neurotransmitter release in Caenorhabditis elegans.

Hawasli A.H., Saifee O., Liu C., Nonet M.L., Crowder C.M. (2004) Resistance to volatile anesthetics by mutations enhancing excitatory neurotransmitter release in Caenorhabditis elegans. Genetics, 168(2):831-43.

 PubMed


Age disproportionately increases sepsis-induced apoptosis in the spleen and gut epithelium.

Turnbull I.R., Buchman T.G., Javadi P., Woolsey C.A., Hotchkiss R.S., Karl I.E., Coopersmith C.M. (2004) Age disproportionately increases sepsis-induced apoptosis in the spleen and gut epithelium. Shock (Augusta, Ga.), 22(4):364-8.

Hotchkiss Lab  PubMed


Ethanol targets: a BK channel cocktail in C. elegans.

Crowder C.M. (2004) Ethanol targets: a BK channel cocktail in C. elegans. Trends in neurosciences, 27(10):579-82.

 PubMed


Posttranslational mechanisms of peripheral sensitization.

Bhave G., Gereau IV R.W. (2004) Posttranslational mechanisms of peripheral sensitization. Journal of neurobiology, 61(1):88-106.

Gereau Lab  PubMed


Submandibular gland acinar cells express multiple alpha1-adrenoceptor subtypes.

Bockman C.S., Bruchas M.R., Zeng W., O'Connell K.A., Abel P.W., Scofield M.A., Dowd F.J. (2004) Submandibular gland acinar cells express multiple alpha1-adrenoceptor subtypes. The Journal of pharmacology and experimental therapeutics, 311(1):364-72.

Bruchas Lab  PubMed


Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.

Sheffels P., Schroeder J.L., Altuntas T.G., Liggitt H.D., Kharasch E.D. (2004) Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats. Chemical research in toxicology, 17(9):1177-89.

Kharasch Lab  PubMed


Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone.

Kharasch E.D., Hoffer C., Whittington D., Sheffels P. (2004) Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone. Clinical pharmacology and therapeutics, 76(3):250-69.

Kharasch Lab  PubMed


Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate.

Kharasch E.D., Hoffer C., Whittington D. (2004) Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate. Anesthesiology, 101(3):738-43.

Kharasch Lab  PubMed


Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate.

Kharasch E.D., Whittington D., Hoffer C. (2004) Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate. Anesthesiology, 101(3):729-37.

Kharasch Lab  PubMed


Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation.

Adwanikar H., Karim F., Gereau IV R.W. (2004) Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation. Pain, 111(1-2):125-35.

Gereau Lab  PubMed


Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis.

Efron P.A., Martins A., Minnich D., Tinsley K., Ungaro R., Bahjat F.R., Hotchkiss R., Clare-Salzler M., Moldawer L.L. (2004) Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. Journal of immunology (Baltimore, Md. : 1950), 173(5):3035-43.

Hotchkiss Lab  PubMed


Sequence makes a difference: paradoxical effects of stress in vivo.

Wizorek J.J., Coopersmith C.M., Laramie J.M., Tong A., Stromberg P.E., Hotchkiss R.S., Buchman T.G., Cobb J.P. (2004) Sequence makes a difference: paradoxical effects of stress in vivo. Shock (Augusta, Ga.), 22(3):229-33.

Hotchkiss Lab  PubMed


Bioavailabilities of rectal and oral methadone in healthy subjects.

Dale O., Sheffels P., Kharasch E.D. (2004) Bioavailabilities of rectal and oral methadone in healthy subjects. British journal of clinical pharmacology, 58(2):156-62.

Kharasch Lab  PubMed


Neuroactive steroids have multiple actions to potentiate GABAA receptors.

Akk G., Bracamontes J.R., Covey D.F., Evers A., Dao T., Steinbach J.H. (2004) Neuroactive steroids have multiple actions to potentiate GABAA receptors. The Journal of physiology, 558(Pt 1):59-74.

Akk Lab  PubMed


Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major.

Akopyants N.S., Matlib R.S., Bukanova E.N., Smeds M.R., Brownstein B.H., Stormo G.D., Beverley S.M. (2004) Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major. Molecular and biochemical parasitology, 136(1):71-86.

Hotchkiss Lab  PubMed


A fluorescence resonance energy transfer-based sensor indicates that receptor access to a G protein is unrestricted in a living mammalian cell.

Azpiazu I., Gautam N. (2004) A fluorescence resonance energy transfer-based sensor indicates that receptor access to a G protein is unrestricted in a living mammalian cell. The Journal of biological chemistry, 279(26):27709-18.

Gautam Lab  PubMed


Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains.

Xia X.-M., Zhang X., Lingle C.J. (2004) Ligand-dependent activation of Slo family channels is defined by interchangeable cytosolic domains. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(24):5585-91.

Lingle Lab  PubMed


Akt decreases lymphocyte apoptosis and improves survival in sepsis.

Bommhardt U., Chang K.C., Swanson P.E., Wagner T.H., Tinsley K.W., Karl I.E., Hotchkiss R.S. (2004) Akt decreases lymphocyte apoptosis and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950), 172(12):7583-91.

Hotchkiss Lab  PubMed


Nitrous oxide (N(2)O) requires the N-methyl-D-aspartate receptor for its action in Caenorhabditis elegans.

Nagele P., Metz L.B., Crowder C.M. (2004) Nitrous oxide (N(2)O) requires the N-methyl-D-aspartate receptor for its action in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America, 101(23):8791-6.

 PubMed


15th Annual Spring Brain Conference, March 10-13, 2004, summary report.

Anstrom K., Bergles D., Bradley K., Cao Y., Cestnick L., Lee S., Piedras-Renteria E., Savoie K., Smith S.M., Woolsey T.A. (2004) 15th Annual Spring Brain Conference, March 10-13, 2004, summary report. Somatosensory & motor research, 21(2):137-43.

Cao Lab  PubMed


Increased lymphoid tissue apoptosis in baboons with bacteremic shock.

Efron P.A., Tinsley K., Minnich D.J., Monterroso V., Wagner J., Lainee P., Lorre K., Swanson P.E., Hotchkiss R., Moldawer L.L. (2004) Increased lymphoid tissue apoptosis in baboons with bacteremic shock. Shock (Augusta, Ga.), 21(6):566-71.

Hotchkiss Lab  PubMed


Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.

Saleh M., Vaillancourt J.P., Graham R.K., Huyck M., Srinivasula S.M., Alnemri E.S., Steinberg M.H., Holan V., Baldwin C.T., Hotchkiss R.S., Buchman T.G., Zehnbauer B.A., Hayden M.R., Farrer L.A., Roy S., Nicholson D.W. (2004) Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature, 429(6987):75-9.

Hotchkiss Lab  PubMed


High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis.

Javadi P., Buchman T.G., Stromberg P.E., Husain K.D., Dunne W.M., Woolsey C.A., Turnbull I.R., Hotchkiss R.S., Karl I.E., Coopersmith C.M. (2004) High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis. Critical care medicine, 32(5):1178-85.

Hotchkiss Lab  PubMed


Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors.

Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. Molecular pharmacology, 65(5):1191-7.

Evers Lab  PubMed


The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone.

Kharasch E.D., Hoffer C., Whittington D. (2004) The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone. British journal of clinical pharmacology, 57(5):600-10.

Kharasch Lab  PubMed


Characterization of wide dynamic range neurons in the deep dorsal horn of the spinal cord in preprotachykinin-a null mice in vivo.

Martin W.J., Cao Y., Basbaum A.I. (2004) Characterization of wide dynamic range neurons in the deep dorsal horn of the spinal cord in preprotachykinin-a null mice in vivo. Journal of neurophysiology, 91(5):1945-54.

Cao Lab  PubMed


Activation of GABA(A) receptors containing the alpha4 subunit by GABA and pentobarbital.

Akk G., Bracamontes J., Steinbach J.H. (2004) Activation of GABA(A) receptors containing the alpha4 subunit by GABA and pentobarbital. The Journal of physiology, 556(Pt 2):387-99.

Akk Lab  PubMed


Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.

Bandell M., Story G.M., Hwang S.W., Viswanath V., Eid S.R., Petrus M.J., Earley T.J., Patapoutian A. (2004) Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron, 41(6):849-57.

 PubMed


Group II metabotropic glutamate receptors inhibit cAMP-dependent protein kinase-mediated enhancemednt of tetrodotoxin-resistant sodium currents in mouse dorsal root ganglion neurons.

Yang D., Gereau IV R.W. (2004) Group II metabotropic glutamate receptors inhibit cAMP-dependent protein kinase-mediated enhancemednt of tetrodotoxin-resistant sodium currents in mouse dorsal root ganglion neurons. Neuroscience letters, 357(3):159-62.

Gereau Lab  PubMed


Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway.

Piedras-Renteria E.S., Pyle J.L., Diehn M., Glickfeld L.L., Harata N.C., Cao Y., Kavalali E.T., Brown P.O., Tsien R.W. (2004) Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway. Proceedings of the National Academy of Sciences of the United States of America, 101(10):3609-14.

Cao Lab  PubMed


Isoflurane inhibits transmitter release and the presynaptic action potential.

Wu X.-S., Sun J.-Y., Evers A.S., Crowder M., Wu L.-G. (2004) Isoflurane inhibits transmitter release and the presynaptic action potential. Anesthesiology, 100(3):663-70.

Evers Lab  PubMed


Endothelial cell apoptosis in sepsis: a case of habeas corpus?

Hotchkiss R.S., Karl I.E. (2004) Endothelial cell apoptosis in sepsis: a case of habeas corpus? Critical care medicine, 32(3):901-2.

Hotchkiss Lab  PubMed


Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).

Altuntas T.G., Park S.B., Kharasch E.D. (2004) Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A). Chemical research in toxicology, 17(3):435-45.

Kharasch Lab  PubMed


Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl.

Kharasch E.D., Hoffer C., Altuntas T.G., Whittington D. (2004) Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl. Journal of clinical pharmacology, 44(3):224-33.

Kharasch Lab  PubMed


The impact of bedside behavior on catheter-related bacteremia in the intensive care unit.

Coopersmith C.M., Zack J.E., Ward M.R., Sona C.S., Schallom M.E., Everett S.J., Huey W.Y., Garrison T.M., McDonald J., Buchman T.G., Boyle W.A., Fraser V.J., Polish L.B. (2004) The impact of bedside behavior on catheter-related bacteremia in the intensive care unit. Archives of surgery (Chicago, Ill. : 1960), 139(2):131-6.

Boyle Lab  PubMed


Treatment of hypophosphatemia using a protocol based on patient weight and serum phosphorus level in a surgical intensive care unit.

Taylor B.E., Huey W.Y., Buchman T.G., Boyle W.A., Coopersmith C.M. (2004) Treatment of hypophosphatemia using a protocol based on patient weight and serum phosphorus level in a surgical intensive care unit. Journal of the American College of Surgeons, 198(2):198-204.

Boyle Lab  PubMed


Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels.

Turnbull I.R., Javadi P., Buchman T.G., Hotchkiss R.S., Karl I.E., Coopersmith C.M. (2004) Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels. Shock (Augusta, Ga.), 21(2):121-5.

Hotchkiss Lab  PubMed


Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia.

Darbandi-Tonkabon R., Manion B.D., Hastings W.R., Craigen W.J., Akk G., Bracamontes J.R., He Y., Sheiko T.V., Steinbach J.H., Mennerick S.J., Covey D.F., Evers A.S. (2004) Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. The Journal of pharmacology and experimental therapeutics, 308(2):502-11.

Akk Lab Evers Lab  PubMed


Typing single-nucleotide polymorphisms in Toxoplasma gondii by allele-specific primer extension and microarray detection.

Su C., Hott C., Brownstein B.H., Sibley L.D. (2004) Typing single-nucleotide polymorphisms in Toxoplasma gondii by allele-specific primer extension and microarray detection. Methods in molecular biology (Clifton, N.J.), 270():249-62.

Hotchkiss Lab  PubMed


Perioperative COX-2 inhibitors: knowledge and challenges.

Kharasch E.D. (2004) Perioperative COX-2 inhibitors: knowledge and challenges. Anesthesia and analgesia, 98(1):1-3.

Kharasch Lab  PubMed