DBR Publications


Nicotine is highly effective at producing desensitization of rat alpha4beta2 neuronal nicotinic receptors.

Paradiso K.G., Steinbach J.H. (2003) Nicotine is highly effective at producing desensitization of rat alpha4beta2 neuronal nicotinic receptors. The Journal of physiology, 553(Pt 3):857-71.

Steinbach Lab  PubMed


Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.

Jiang X., Manion B.D., Benz A., Rath N.P., Evers A.S., Zorumski C.F., Mennerick S., Covey D.F. (2003) Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. Journal of medicinal chemistry, 46(25):5334-48.

Evers Lab  PubMed


Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine.

Kharasch E.D., Hoffer C., Whittington D., Sheffels P. (2003) Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine. Clinical pharmacology and therapeutics, 74(6):543-54.

Kharasch Lab  PubMed


Peripheral group II metabotropic glutamate receptors mediate endogenous anti-allodynia in inflammation.

Yang D., Gereau IV R.W. (2003) Peripheral group II metabotropic glutamate receptors mediate endogenous anti-allodynia in inflammation. Pain, 106(3):411-7.

Gereau Lab  PubMed


Initial pharmacokinetic, safety and efficacy evaluation of nasal morphine gluconate for breakthrough pain in cancer patients.

Fitzgibbon D., Morgan D., Dockter D., Barry C., Kharasch E.D. (2003) Initial pharmacokinetic, safety and efficacy evaluation of nasal morphine gluconate for breakthrough pain in cancer patients. Pain, 106(3):309-15.

Kharasch Lab  PubMed


Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.

Altuntas T.G., Zager R.A., Kharasch E.D. (2003) Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line. Toxicology and applied pharmacology, 193(1):55-65.

Kharasch Lab  PubMed


Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency.

Faury G., Pezet M., Knutsen R.H., Boyle W.A., Heximer S.P., McLean S.E., Minkes R.K., Blumer K.J., Kovacs A., Kelly D.P., Li D.Y., Starcher B., Mecham R.P. (2003) Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. The Journal of clinical investigation, 112(9):1419-28.

Boyle Lab  PubMed


Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival.

Husain K.D., Stromberg P.E., Javadi P., Buchman T.G., Karl I.E., Hotchkiss R.S., Coopersmith C.M. (2003) Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival. Shock (Augusta, Ga.), 20(5):437-43.

Hotchkiss Lab  PubMed


Determination of morphine and morphine glucuronides in human plasma by 96-well plate solid-phase extraction and liquid chromatography-electrospray ionization mass spectrometry.

Whittington D., Kharasch E.D. (2003) Determination of morphine and morphine glucuronides in human plasma by 96-well plate solid-phase extraction and liquid chromatography-electrospray ionization mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 796(1):95-103.

Kharasch Lab  PubMed


Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).

Bhave G., Hu H.-J., Glauner K.S., Zhu W., Wang H., Brasier D.J., Oxford G.S., Gereau IV R.W. (2003) Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proceedings of the National Academy of Sciences of the United States of America, 100(21):12480-5.

Gereau Lab  PubMed


Induction of chondrocyte apoptosis following impact load.

Borrelli Jr. J., Tinsley K., Ricci W.M., Burns M., Karl I.E., Hotchkiss R. (2003) Induction of chondrocyte apoptosis following impact load. Journal of orthopaedic trauma, 17(9):635-41.

Hotchkiss Lab  PubMed


Mervyn Maze, M.B., Ch.B., F.R.C.P.: recipient of the 2003 Excellence in Research Award.

Evers A.S. (2003) Mervyn Maze, M.B., Ch.B., F.R.C.P.: recipient of the 2003 Excellence in Research Award. Anesthesiology, 99(4):777-8.

Evers Lab  PubMed


Safety of low-flow sevoflurane anesthesia in patients with chronically impaired renal function is not proven.

Saidman L.J., Eger E.I., Kharasch E.D., Conzen P., Michalowski P., Weiss B.M., Rooke G.A., Artru A., Ebert T., Czerner S.F.A., Reichle F.M. (2003) Safety of low-flow sevoflurane anesthesia in patients with chronically impaired renal function is not proven. Anesthesiology, 99(3):752; author reply 752-4.

Kharasch Lab  PubMed


Ca2+- and myosin phosphorylation-independent relaxation by halothane in K+-depolarized rat mesenteric arteries.

Tsuneyoshi I., Zhang D., Boyle III W.A. (2003) Ca2+- and myosin phosphorylation-independent relaxation by halothane in K+-depolarized rat mesenteric arteries. Anesthesiology, 99(3):656-65.

Boyle Lab  PubMed


ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. I. Modulation of A-type K+ currents.

Hu H.-J., Glauner K.S., Gereau IV R.W. (2003) ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. I. Modulation of A-type K+ currents. Journal of neurophysiology, 90(3):1671-9.

Gereau Lab  PubMed


ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. II. Modulation of neuronal excitability.

Hu H.-J., Gereau IV R.W. (2003) ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. II. Modulation of neuronal excitability. Journal of neurophysiology, 90(3):1680-8.

Gereau Lab  PubMed


Activation and block of mouse muscle-type nicotinic receptors by tetraethylammonium.

Akk G., Steinbach J.H. (2003) Activation and block of mouse muscle-type nicotinic receptors by tetraethylammonium. The Journal of physiology, 551(Pt 1):155-68.

Akk Lab Steinbach Lab  PubMed


Growing pains: the cytoskeleton as a critical regulator of pain plasticity.

Bhave G., Gereau IV R.W. (2003) Growing pains: the cytoskeleton as a critical regulator of pain plasticity. Neuron, 39(4):577-9.

Gereau Lab  PubMed


Membrane topology of a metabotropic glutamate receptor.

Bhave G., Nadin B.M., Brasier D.J., Glauner K.S., Shah R.D., Heinemann S.F., Karim F., Gereau IV R.W. (2003) Membrane topology of a metabotropic glutamate receptor. The Journal of biological chemistry, 278(32):30294-301.

Gereau Lab  PubMed


CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.

Emery M.G., Fisher J.M., Chien J.Y., Kharasch E.D., Dellinger E.P., Kowdley K.V., Thummel K.E. (2003) CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.), 38(2):428-35.

Kharasch Lab  PubMed


Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells.

Tinsley K.W., Grayson M.H., Swanson P.E., Drewry A.M., Chang K.C., Karl I.E., Hotchkiss R.S. (2003) Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. Journal of immunology (Baltimore, Md. : 1950), 171(2):909-14.

Hotchkiss Lab  PubMed


ThermoTRP channels and beyond: mechanisms of temperature sensation.

Patapoutian A., Peier A.M., Story G.M., Viswanath V. (2003) ThermoTRP channels and beyond: mechanisms of temperature sensation. Nature reviews. Neuroscience, 4(7):529-39.

 PubMed


Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats.

Spracklin D.K., Emery M.E., Thummel K.E., Kharasch E.D. (2003) Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats. Acta anaesthesiologica Scandinavica, 47(6):765-70.

Kharasch Lab  PubMed


Opposite thermosensor in fruitfly and mouse.

Viswanath V., Story G.M., Peier A.M., Petrus M.J., Lee V.M., Hwang S.W., Patapoutian A., Tim J. (2003) Opposite thermosensor in fruitfly and mouse. Nature, 423(6942):822-3.

 PubMed


Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest.

Coopersmith C.M., Stromberg P.E., Davis C.G., Dunne W.M., Amiot II D.M., Karl I.E., Hotchkiss R.S., Buchman T.G. (2003) Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Critical care medicine, 31(6):1630-7.

Hotchkiss Lab  PubMed


Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemia.

McIlroy D.R., Kharasch E.D. (2003) Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemia. Anesthesia and analgesia, 96(6):1572-7, table of contents.

Kharasch Lab  PubMed


Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels.

Zeng X.-H., Xia X.-M., Lingle C.J. (2003) Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels. Nature structural biology, 10(6):448-54.

Lingle Lab  PubMed


Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node.

Grayson M.H., Hotchkiss R.S., Karl I.E., Holtzman M.J., Chaplin D.D. (2003) Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node. American journal of physiology. Heart and circulatory physiology, 284(6):H2213-26.

Hotchkiss Lab  PubMed


Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis.

Hotchkiss R.S., Chang K.C., Grayson M.H., Tinsley K.W., Dunne B.S., Davis C.G., Osborne D.F., Karl I.E. (2003) Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. Proceedings of the National Academy of Sciences of the United States of America, 100(11):6724-9.

Hotchkiss Lab  PubMed


Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia.

Coopersmith C.M., Amiot II D.M., Stromberg P.E., Dunne W.M., Davis C.G., Osborne D.F., Husain K.D., Turnbull I.R., Karl I.E., Hotchkiss R.S., Buchman T.G. (2003) Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia. Shock (Augusta, Ga.), 19(5):408-14.

Hotchkiss Lab  PubMed


Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19.

Yao C., Kunze K.L., Trager W.F., Kharasch E.D., Levy R.H. (2003) Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19. Drug metabolism and disposition: the biological fate of chemicals, 31(5):565-71.

Kharasch Lab  PubMed


Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury.

Bhatia M., Slavin J., Cao Y., Basbaum A.I., Neoptolemos J.P. (2003) Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury. American journal of physiology. Gastrointestinal and liver physiology, 284(5):G830-6.

Cao Lab  PubMed


Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain.

Darbandi-Tonkabon R., Hastings W.R., Zeng C.-M., Akk G., Manion B.D., Bracamontes J.R., Steinbach J.H., Mennerick S.J., Covey D.F., Evers A.S. (2003) Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. The Journal of biological chemistry, 278(15):13196-206.

Akk Lab Evers Lab Steinbach Lab  PubMed


Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture.

Turnbull I.R., Wlzorek J.J., Osborne D., Hotchkiss R.S., Coopersmith C.M., Buchman T.G. (2003) Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock (Augusta, Ga.), 19(4):310-3.

Hotchkiss Lab  PubMed


A conformational switch regulates receptor-G protein interaction.

Gautam N. (2003) A conformational switch regulates receptor-G protein interaction. Structure (London, England : 1993), 11(4):359-60.

Gautam Lab  PubMed


Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.

Ibrahim A.E., Feldman J., Karim A., Kharasch E.D. (2003) Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil. Anesthesiology, 98(4):853-61.

Kharasch Lab  PubMed


ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.

Story G.M., Peier A.M., Reeve A.J., Eid S.R., Mosbacher J., Hricik T.R., Earley T.J., Hergarden A.C., Andersson D.A., Hwang S.W., McIntyre P., Jegla T., Bevan S., Patapoutian A. (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell, 112(6):819-29.

 PubMed


The sodium-activated potassium channel is encoded by a member of the Slo gene family.

Yuan A., Santi C.M., Wei A., Wang Z.-W., Pollak K., Nonet M., Kaczmarek L., Crowder C.M., Salkoff L. (2003) The sodium-activated potassium channel is encoded by a member of the Slo gene family. Neuron, 37(5):765-73.

 PubMed


Gender differences in drug effects: implications for anesthesiologists.

Pleym H., Spigset O., Kharasch E.D., Dale O. (2003) Gender differences in drug effects: implications for anesthesiologists. Acta anaesthesiologica Scandinavica, 47(3):241-59.

Kharasch Lab  PubMed


Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity.

Kharasch E.D., Hoffer C., Walker A., Sheffels P. (2003) Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity. Clinical pharmacology and therapeutics, 73(3):199-208.

Kharasch Lab  PubMed


Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues.

Xia X.-M., Ding J.P., Lingle C.J. (2003) Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues. The Journal of general physiology, 121(2):125-48.

Lingle Lab  PubMed


Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function.

Akk G., Steinbach J.H. (2003) Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function. The Journal of physiology, 546(Pt 3):641-6.

Akk Lab Steinbach Lab  PubMed


Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells.

Upadhya G.A., Topp S.A., Hotchkiss R.S., Anagli J., Strasberg S.M. (2003) Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells. Hepatology (Baltimore, Md.), 37(2):313-23.

Hotchkiss Lab  PubMed


The pathophysiology and treatment of sepsis.

Hotchkiss R.S., Karl I.E. (2003) The pathophysiology and treatment of sepsis. The New England journal of medicine, 348(2):138-50.

Hotchkiss Lab  PubMed


Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates.

Zhang J., Steinbach J.H. (2003) Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates. Brain research, 959(1):98-102.

Steinbach Lab  PubMed


Role of apoptotic cell death in sepsis.

Hotchkiss R.S., Tinsley K.W., Karl I.E. (2003) Role of apoptotic cell death in sepsis. Scandinavian journal of infectious diseases, 35(9):585-92.

Hotchkiss Lab  PubMed


Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5.

Neugebauer V., Li W., Bird G.C., Bhave G., Gereau IV R.W. (2003) Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(1):52-63.

Gereau Lab  PubMed