DBR Publications


Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays.

Cobb J.P., Laramie J.M., Stormo G.D., Morrissey J.J., Shannon W.D., Qiu Y., Karl I.E., Buchman T.G., Hotchkiss R.S. (2002) Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays. Critical care medicine, 30(12):2711-21.

Hotchkiss Lab  PubMed


Disposition of nasal, intravenous, and oral methadone in healthy volunteers.

Dale O., Hoffer C., Sheffels P., Kharasch E.D. (2002) Disposition of nasal, intravenous, and oral methadone in healthy volunteers. Clinical pharmacology and therapeutics, 72(5):536-45.

Kharasch Lab  PubMed


Contributions of the non-alpha subunit residues (loop D) to agonist binding and channel gating in the muscle nicotinic acetylcholine receptor.

Akk G. (2002) Contributions of the non-alpha subunit residues (loop D) to agonist binding and channel gating in the muscle nicotinic acetylcholine receptor. The Journal of physiology, 544(Pt 3):695-705.

Akk Lab  PubMed


Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency.

Conzen P.F., Kharasch E.D., Czerner S.F.A., Artru A.A., Reichle F.M., Michalowski P., Rooke G.A., Weiss B.M., Ebert T.J. (2002) Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency. Anesthesiology, 97(3):578-84.

Kharasch Lab  PubMed


Setting the stage for molecular dissection of the regulatory components of BK channels.

Lingle C.J. (2002) Setting the stage for molecular dissection of the regulatory components of BK channels. The Journal of general physiology, 120(3):261-5.

Lingle Lab  PubMed


The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam.

Ibrahim A., Karim A., Feldman J., Kharasch E. (2002) The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam. Anesthesia and analgesia, 95(3):667-73, table of contents.

Kharasch Lab  PubMed


Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia.

Hu H.-J., Bhave G., Gereau IV R.W. (2002) Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(17):7444-52.

Gereau Lab  PubMed


Calcium-independent phospholipase A(2)-derived arachidonic acid is essential for endothelium-dependent relaxation by acetylcholine.

Seegers H.C., Gross R.W., Boyle W.A. (2002) Calcium-independent phospholipase A(2)-derived arachidonic acid is essential for endothelium-dependent relaxation by acetylcholine. The Journal of pharmacology and experimental therapeutics, 302(3):918-23.

Boyle Lab  PubMed


Multiple regulatory sites in large-conductance calcium-activated potassium channels.

Xia X.-M., Zeng X., Lingle C.J. (2002) Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature, 418(6900):880-4.

Lingle Lab  PubMed


cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation.

Bhave G., Zhu W., Wang H., Brasier D.J., Oxford G.S., Gereau IV R.W. (2002) cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron, 35(4):721-31.

Gereau Lab  PubMed


Modulation of presynaptic calcium transients by metabotropic glutamate receptor activation: a differential role in acute depression of synaptic transmission and long-term depression.

Faas G.C., Adwanikar H., Gereau IV R.W., Saggau P. (2002) Modulation of presynaptic calcium transients by metabotropic glutamate receptor activation: a differential role in acute depression of synaptic transmission and long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(16):6885-90.

Gereau Lab  PubMed


Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception.

Yang D., Gereau IV R.W. (2002) Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(15):6388-93.

Gereau Lab  PubMed


Nasal administration of opioids for pain management in adults.

Dale O., Hjortkjaer R., Kharasch E.D. (2002) Nasal administration of opioids for pain management in adults. Acta anaesthesiologica Scandinavica, 46(7):759-70.

Kharasch Lab  PubMed


Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network.

Telgkamp P., Cao Y.Q., Basbaum A.I., Ramirez J.-M. (2002) Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network. Journal of neurophysiology, 88(1):206-13.

Cao Lab  PubMed


Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2.

Scott B.A., Avidan M.S., Crowder C.M. (2002) Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2. Science (New York, N.Y.), 296(5577):2388-91.

 PubMed


A heat-sensitive TRP channel expressed in keratinocytes.

Peier A.M., Reeve A.J., Andersson D.A., Moqrich A., Earley T.J., Hergarden A.C., Story G.M., Colley S., Hogenesch J.B., McIntyre P., Bevan S., Patapoutian A. (2002) A heat-sensitive TRP channel expressed in keratinocytes. Science (New York, N.Y.), 296(5575):2046-9.

 PubMed


Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics.

Varney M.A., Gereau 4th. R.W. (2002) Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics. Current drug targets. CNS and neurological disorders, 1(3):283-96.

Gereau Lab  PubMed


Dual alpha(2)-adrenergic agonist and alpha(1)-adrenergic antagonist actions of dexmedetomidine on human isolated endothelium-denuded gastroepiploic arteries.

Hamasaki J., Tsuneyoshi I., Katai R., Hidaka T., Boyle W.A., Kanmura Y. (2002) Dual alpha(2)-adrenergic agonist and alpha(1)-adrenergic antagonist actions of dexmedetomidine on human isolated endothelium-denuded gastroepiploic arteries. Anesthesia and analgesia, 94(6):1434-40, table of contents.

Boyle Lab  PubMed


Role of the G protein gamma subunit in beta gamma complex modulation of phospholipase Cbeta function.

Akgoz M., Azpiazu I., Kalyanaraman V., Gautam N. (2002) Role of the G protein gamma subunit in beta gamma complex modulation of phospholipase Cbeta function. The Journal of biological chemistry, 277(22):19573-8.

Gautam Lab  PubMed


Myeloperoxidase produces nitrating oxidants in vivo.

Gaut J.P., Byun J., Tran H.D., Lauber W.M., Carroll J.A., Hotchkiss R.S., Belaaouaj A., Heinecke J.W. (2002) Myeloperoxidase produces nitrating oxidants in vivo. The Journal of clinical investigation, 109(10):1311-9.

Hotchkiss Lab  PubMed


A Caenorhabditis elegans pheromone antagonizes volatile anesthetic action through a go-coupled pathway.

Van Swinderen B., Metz L.B., Shebester L.D., Michael Crowder C. (2002) A Caenorhabditis elegans pheromone antagonizes volatile anesthetic action through a go-coupled pathway. Genetics, 161(1):109-19.

 PubMed


Endothelial cell apoptosis in sepsis.

Hotchkiss R.S., Tinsley K.W., Swanson P.E., Karl I.E. (2002) Endothelial cell apoptosis in sepsis. Critical care medicine, 30(5 Suppl):S225-8.

Hotchkiss Lab  PubMed


3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists.

Wang M., He Y., Eisenman L.N., Fields C., Zeng C.-M., Mathews J., Benz A., Fu T., Zorumski E., Steinbach J.H., Covey D.F., Zorumski C.F., Mennerick S. (2002) 3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(9):3366-75.

Steinbach Lab  PubMed


Steady-state and closed-state inactivation properties of inactivating BK channels.

Ding J.P., Lingle C.J. (2002) Steady-state and closed-state inactivation properties of inactivating BK channels. Biophysical journal, 82(5):2448-65.

Lingle Lab  PubMed


Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis.

Coopersmith C.M., Stromberg P.E., Michael Dunne W., Davis C.G., Amiot II D.M., Buchman T.G., Karl I.E., Hotchkiss R.S. (2002) Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA : the journal of the American Medical Association, 287(13):1716-21.

Hotchkiss Lab  PubMed


A TRP channel that senses cold stimuli and menthol.

Peier A.M., Moqrich A., Hergarden A.C., Reeve A.J., Andersson D.A., Story G.M., Earley T.J., Dragoni I., McIntyre P., Bevan S., Patapoutian A. (2002) A TRP channel that senses cold stimuli and menthol. Cell, 108(5):705-15.

 PubMed


Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels.

Wang Y.-W., Ding J.P., Xia X.-M., Lingle C.J. (2002) Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(5):1550-61.

Lingle Lab  PubMed


Depletion of dendritic cells, but not macrophages, in patients with sepsis.

Hotchkiss R.S., Tinsley K.W., Swanson P.E., Grayson M.H., Osborne D.F., Wagner T.H., Cobb J.P., Coopersmith C., Karl I.E. (2002) Depletion of dendritic cells, but not macrophages, in patients with sepsis. Journal of immunology (Baltimore, Md. : 1950), 168(5):2493-500.

Hotchkiss Lab  PubMed


Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism.

Altuntas T.G., Kharasch E.D. (2002) Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism. Drug metabolism and disposition: the biological fate of chemicals, 30(2):148-54.

Kharasch Lab  PubMed


Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit.

Coopersmith C.M., Rebmann T.L., Zack J.E., Ward M.R., Corcoran R.M., Schallom M.E., Sona C.S., Buchman T.G., Boyle W.A., Polish L.B., Fraser V.J. (2002) Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit. Critical care medicine, 30(1):59-64.

Boyle Lab  PubMed


Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice.

Coopersmith C.M., Chang K.C., Swanson P.E., Tinsley K.W., Stromberg P.E., Buchman T.G., Karl I.E., Hotchkiss R.S. (2002) Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Critical care medicine, 30(1):195-201.

Hotchkiss Lab  PubMed


Determining G protein heterotrimer formation.

Hou Y., Chang V., Gautam N. (2001) Determining G protein heterotrimer formation. Methods in enzymology, 344():505-12.

Gautam Lab  PubMed


Preparation and application of G protein gamma subunit-derived peptides incorporating a photoactive isoprenoid.

Kale T.A., Turek T.C., Chang V., Gautam N., Distefano M.D. (2001) Preparation and application of G protein gamma subunit-derived peptides incorporating a photoactive isoprenoid. Methods in enzymology, 344():245-58.

Gautam Lab  PubMed


Role of G protein beta gamma complex in receptor-G protein interaction.

Azpiazu I., Gautam N. (2001) Role of G protein beta gamma complex in receptor-G protein interaction. Methods in enzymology, 344():112-25.

Gautam Lab  PubMed


Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo.

Kharasch E.D., Powers K.M., Artru A.A. (2002) Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo. Anesthesiology, 96(1):173-82.

Kharasch Lab  PubMed


Effects of parecoxib, a parenteral COX-2-specific inhibitor, on the pharmacokinetics and pharmacodynamics of propofol.

Ibrahim A., Park S., Feldman J., Karim A., Kharasch E.D. (2002) Effects of parecoxib, a parenteral COX-2-specific inhibitor, on the pharmacokinetics and pharmacodynamics of propofol. Anesthesiology, 96(1):88-95.

Kharasch Lab  PubMed