DBR Publications


Modulation of GABA(A) receptor channel gating by pentobarbital.

Steinbach J.H., Akk G. (2001) Modulation of GABA(A) receptor channel gating by pentobarbital. The Journal of physiology, 537(Pt 3):715-33.

Akk Lab  PubMed


A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans.

Phimmasone S., Kharasch E.D. (2001) A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans. Clinical pharmacology and therapeutics, 70(6):505-17.

Kharasch Lab  PubMed


The effect of prone positioning on intraocular pressure in anesthetized patients.

Cheng M.A., Todorov A., Tempelhoff R., McHugh T., Crowder C.M., Lauryssen C. (2001) The effect of prone positioning on intraocular pressure in anesthetized patients. Anesthesiology, 95(6):1351-5.

 PubMed


Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro.

Altuntas T.G., Kharasch E.D. (2001) Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro. Toxicology and applied pharmacology, 177(2):85-93.

Kharasch Lab  PubMed


In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration.

Lin Y.S., Lockwood G.F., Graham M.A., Brian W.R., Loi C.-M., Dobrinska M.R., Shen D.D., Watkins P.B., Wilkinson G.R., Kharasch E.D., Thummel K.E. (2001) In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration. Pharmacogenetics, 11(9):781-91.

Kharasch Lab  PubMed


Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function.

Kharasch E.D., Frink Jr. E.J., Artru A., Michalowski P., Rooke G.A., Nogami W. (2001) Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function. Anesthesia and analgesia, 93(6):1511-20, table of contents.

Kharasch Lab  PubMed


Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.

Thummel K.E., Brimer C., Yasuda K., Thottassery J., Senn T., Lin Y., Ishizuka H., Kharasch E., Schuetz J., Schuetz E. (2001) Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. Molecular pharmacology, 60(6):1399-406.

Kharasch Lab  PubMed


Role of apoptosis in Pseudomonas aeruginosa pneumonia.

Hotchkiss R.S., Dunne W.M., Swanson P.E., Davis C.G., Tinsley K.W., Chang K.C., Buchman T.G., Karl I.E. (2001) Role of apoptosis in Pseudomonas aeruginosa pneumonia. Science (New York, N.Y.), 294(5548):1783.

Hotchkiss Lab  PubMed


Enantiospecificity of cholesterol function in vivo.

Enantiospecificity of cholesterol function in vivo. The Journal of biological chemistry, 276(48):44369-72.

 PubMed


G protein gamma subunit interaction with a receptor regulates receptor-stimulated nucleotide exchange.

Azpiazu I., Gautam N. (2001) G protein gamma subunit interaction with a receptor regulates receptor-stimulated nucleotide exchange. The Journal of biological chemistry, 276(45):41742-7.

Gautam Lab  PubMed


Role of the gamma subunit prenyl moiety in G protein beta gamma complex interaction with phospholipase Cbeta.

Fogg VC, Azpiazu I, Linder ME, Smrcka A, Scarlata S, Gautam N (2001) Role of the gamma subunit prenyl moiety in G protein beta gamma complex interaction with phospholipase Cbeta. The Journal of biological chemistry, 276(45):41797-802.

Gautam Lab  PubMed


Impaired response to chemical irritation of the urinary tract in mice with disruption of the preprotachykinin gene.

Kiss S., Yoshiyama M., Cao Y.Q., Basbaum A.I., De Groat W.C., Lecci A., Maggi C.A., Birder L.A. (2001) Impaired response to chemical irritation of the urinary tract in mice with disruption of the preprotachykinin gene. Neuroscience letters, 313(1-2):57-60.

Cao Lab  PubMed


Recent developments in structure-activity relationships for steroid modulators of GABA(A) receptors.

Covey D.F., Evers A.S., Mennerick S., Zorumski C.F., Purdy R.H. (2001) Recent developments in structure-activity relationships for steroid modulators of GABA(A) receptors. Brain research. Brain research reviews, 37(1-3):91-7.

Evers Lab  PubMed


Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2.

Yao C., Kunze K.L., Kharasch E.D., Wang Y., Trager W.F., Ragueneau I., Levy R.H. (2001) Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2. Clinical pharmacology and therapeutics, 70(5):415-24.

Kharasch Lab  PubMed


Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation site.

Zhang X., Solaro C.R., Lingle C.J. (2001) Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation site. The Journal of general physiology, 118(5):607-36.

Lingle Lab  PubMed


Bispectral index monitoring during sedation with sevoflurane, midazolam, and propofol.

Ibrahim A.E., Taraday J.K., Kharasch E.D. (2001) Bispectral index monitoring during sedation with sevoflurane, midazolam, and propofol. Anesthesiology, 95(5):1151-9.

Kharasch Lab  PubMed


NADPH oxidase of neutrophils elevates o,o'-dityrosine cross-links in proteins and urine during inflammation.

Bhattacharjee S., Pennathur S., Byun J., Crowley J., Mueller D., Gischler J., Hotchkiss R.S., Heinecke J.W. (2001) NADPH oxidase of neutrophils elevates o,o'-dityrosine cross-links in proteins and urine during inflammation. Archives of biochemistry and biophysics, 395(1):69-77.

Hotchkiss Lab  PubMed


Metabotropic glutamate receptors on peripheral sensory neuron terminals as targets for the development of novel analgesics.

Karim F., Bhave G., Gereau IV R.W. (2001) Metabotropic glutamate receptors on peripheral sensory neuron terminals as targets for the development of novel analgesics. Molecular psychiatry, 6(6):615-7.

Gereau Lab  PubMed


Kinetic and pharmacological properties of GABA(A) receptors in single thalamic neurons and GABA(A) subunit expression.

Browne S.H., Kang J., Akk G., Chiang L.W., Schulman H., Huguenard J.R., Prince D.A. (2001) Kinetic and pharmacological properties of GABA(A) receptors in single thalamic neurons and GABA(A) subunit expression. Journal of neurophysiology, 86(5):2312-22.

Akk Lab  PubMed


Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis.

Gaut J.P., Yeh G.C., Tran H.D., Byun J., Henderson J.P., Richter G.M., Brennan M.-L., Lusis A.J., Belaaouaj A., Hotchkiss R.S., Heinecke J.W. (2001) Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis. Proceedings of the National Academy of Sciences of the United States of America, 98(21):11961-6.

Hotchkiss Lab  PubMed


Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development.

Hurle B., Lane K., Kenney J., Tarantino L.M., Bucan M., Brownstein B.H., Ornitz D.M. (2001) Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development. Genomics, 77(3):189-99.

Hotchkiss Lab  PubMed


Effects on gamma-aminobutyric acid (GABA)(A) receptors of a neuroactive steroid that negatively modulates glutamate neurotransmission and augments GABA neurotransmission.

Mennerick S., Zeng C.-M., Benz A., Shen W., Izumi Y., Evers A.S., Covey D.F., Zorumski C.F. (2001) Effects on gamma-aminobutyric acid (GABA)(A) receptors of a neuroactive steroid that negatively modulates glutamate neurotransmission and augments GABA neurotransmission. Molecular pharmacology, 60(4):732-41.

Evers Lab  PubMed


Confocal fluorescent intravital microscopy of the murine spleen.

Grayson M.H., Chaplin D.D., Karl I.E., Hotchkiss R.S. (2001) Confocal fluorescent intravital microscopy of the murine spleen. Journal of immunological methods, 256(1-2):55-63.

Hotchkiss Lab  PubMed


Aromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the alphaY93 and alphaW149 residues.

Akk G. (2001) Aromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the alphaY93 and alphaW149 residues. The Journal of physiology, 535(Pt 3):729-40.

Akk Lab  PubMed


The C terminus of the human nicotinic alpha4beta2 receptor forms a binding site required for potentiation by an estrogenic steroid.

Paradiso K., Zhang J., Steinbach J.H. (2001) The C terminus of the human nicotinic alpha4beta2 receptor forms a binding site required for potentiation by an estrogenic steroid. The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(17):6561-8.

 PubMed


Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.

Oda Y., Kharasch E.D. (2001) Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. The Journal of pharmacology and experimental therapeutics, 298(3):1021-32.

Kharasch Lab  PubMed


The effects of clonidine premedication and scalp infiltration of lidocaine on hemodynamic responses to laryngoscopy and skull pin head-holder insertion during skull base procedures.

The effects of clonidine premedication and scalp infiltration of lidocaine on hemodynamic responses to laryngoscopy and skull pin head-holder insertion during skull base procedures. Skull base : official journal of North American Skull Base Society ... [et al.], 11(3):169-76.

 PubMed


Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6).

Minoda Y., Kharasch E.D. (2001) Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6). Anesthesiology, 95(2):509-14.

Kharasch Lab  PubMed


G Protein beta subunit types differentially interact with a muscarinic receptor but not adenylyl cyclase type II or phospholipase C-beta 2/3.

Hou Y, Chang V, Capper AB, Taussig R, Gautam N (2001) G Protein beta subunit types differentially interact with a muscarinic receptor but not adenylyl cyclase type II or phospholipase C-beta 2/3. The Journal of biological chemistry, 276(23):19982-8.

Gautam Lab  PubMed


Goalpha regulates volatile anesthetic action in Caenorhabditis elegans.

Van Swinderen B., Metz L.B., Shebester L.D., Mendel J.E., Sternberg P.W., Crowder C.M. (2001) Goalpha regulates volatile anesthetic action in Caenorhabditis elegans. Genetics, 158(2):643-55.

 PubMed


Pharmacokinetics and clinical effects of sublingual triazolam in pediatric dental patients.

Tweedy C.M., Milgrom P., Kharasch E.D., Kaakko T., Spieker M., Coldwell S.E. (2001) Pharmacokinetics and clinical effects of sublingual triazolam in pediatric dental patients. Journal of clinical psychopharmacology, 21(3):268-72.

Kharasch Lab  PubMed


Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini.

Zeng X.-H., Ding J.-P., Xia X.-M., Lingle C.J. (2001) Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini. The Journal of general physiology, 117(6):607-28.

Lingle Lab  PubMed


Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade.

Lingle C.J., Zeng X.-H., Ding J.-P., Xia X.-M. (2001) Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade. The Journal of general physiology, 117(6):583-606.

Lingle Lab  PubMed


Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans.

Hotchkiss R.S., Tinsley K.W., Swanson P.E., Schmieg Jr. R.E., Hui J.J., Chang K.C., Osborne D.F., Freeman B.D., Cobb J.P., Buchman T.G., Karl I.E. (2001) Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. Journal of immunology (Baltimore, Md. : 1950), 166(11):6952-63.

Hotchkiss Lab  PubMed


Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice.

Karim F., Wang C.-C., Gereau IV R.W. (2001) Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(11):3771-9.

Gereau Lab  PubMed


Overview of strategies for screening YAC libraries and analyzing YAC clones.

Chaplin D.D., Brownstein B.H. (2001) Overview of strategies for screening YAC libraries and analyzing YAC clones. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.], Chapter 6():Unit6.9.

Hotchkiss Lab  PubMed


Analysis of isolated YAC clones.

Chaplin D.D., Brownstein B.H. (2001) Analysis of isolated YAC clones. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.], Chapter 6():Unit6.10.

Hotchkiss Lab  PubMed


A prospective, randomized study comparing percutaneous with surgical tracheostomy in critically ill patients.

Freeman B.D., Isabella K., Perren Cobb J., Boyle III W.A., Schmieg Jr R.E., Kolleff M.H., Lin N., Saak T., Thompson E.C., Buchman T.G. (2001) A prospective, randomized study comparing percutaneous with surgical tracheostomy in critically ill patients. Critical care medicine, 29(5):926-30.

Boyle Lab  PubMed


Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit.

Akk G., Bracamontes J., Steinbach J.H. (2001) Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit. The Journal of physiology, 532(Pt 3):673-84.

Akk Lab  PubMed


The Fas death pathway as a mechanism of multiple organ dysfunction syndrome: not so fast.

Hotchkiss R.S., Karl I.E. (2001) The Fas death pathway as a mechanism of multiple organ dysfunction syndrome: not so fast. Critical care medicine, 29(4):901-2.

Hotchkiss Lab  PubMed


Peripheral group I metabotropic glutamate receptors modulate nociception in mice.

Bhave G., Karim F., Carlton S.M., Gereau Iv R.W. (2001) Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nature neuroscience, 4(4):417-23.

Gereau Lab  PubMed


Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites.

Oda Y., Kharasch E.D. (2001) Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites. The Journal of pharmacology and experimental therapeutics, 297(1):410-22.

Kharasch Lab  PubMed


Cytokine blockade in sepsis--Are two better than one?

Hotchkiss R.S., Karl I.E. (2001) Cytokine blockade in sepsis--Are two better than one? Critical care medicine, 29(3):671-2.

Hotchkiss Lab  PubMed


Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock.

Tsuneyoshi I., Yamada H., Kakihana Y., Nakamura M., Nakano Y., Boyle W.A. (2001) Hemodynamic and metabolic effects of low-dose vasopressin infusions in vasodilatory septic shock. Critical care medicine, 29(3):487-93.

Boyle Lab  PubMed


Injury in the era of genomics.

Cobb J.P., Brownstein B.H., Watson M.A., Shannon W.D., Laramie J.M., Qiu Y., Stormo G.D., Morrissey J.J., Buchman T.G., Karl I.E., Hotchkiss R.S. (2001) Injury in the era of genomics. Shock (Augusta, Ga.), 15(3):165-70.

Hotchkiss Lab  PubMed


Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons.

Sun Q.-Q., Akk G., Huguenard J.R., Prince D.A. (2001) Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons. The Journal of physiology, 531(Pt 1):81-94.

Akk Lab  PubMed


Hyperbaric hyperoxia suppresses growth of Staphylococcus aureus, including methicillin-resistant strains.

Hyperbaric hyperoxia suppresses growth of Staphylococcus aureus, including methicillin-resistant strains. Journal of anesthesia, 15(1):29-32.

Boyle Lab  PubMed


Speed of recovery and side-effect profile of sevoflurane sedation compared with midazolam.

Ibrahim A.E., Ghoneim M.M., Kharasch E.D., Epstein R.H., Groudine S.B., Ebert T.J., Binstock W.B., Philip B.K. (2001) Speed of recovery and side-effect profile of sevoflurane sedation compared with midazolam. Anesthesiology, 94(1):87-94.

Kharasch Lab  PubMed


Co-ordinated programme of gene expression during asexual intraerythrocytic development of the human malaria parasite Plasmodium falciparum revealed by microarray analysis.

Mamoun C.B., Gluzman I.Y., Hott C., MacMillan S.K., Amarakone A.S., Anderson D.L., Carlton J.M.-R., Dame J.B., Chakrabarti D., Martin R.K., Brownstein B.H., Goldberg D.E. (2001) Co-ordinated programme of gene expression during asexual intraerythrocytic development of the human malaria parasite Plasmodium falciparum revealed by microarray analysis. Molecular microbiology, 39(1):26-36.

Hotchkiss Lab  PubMed