DBR Publications


Selective role of G protein gamma subunits in receptor interaction.

Hou Y., Azpiazu I., Smrcka A., Gautam N. (2000) Selective role of G protein gamma subunits in receptor interaction. The Journal of biological chemistry, 275(50):38961-4.

Gautam Lab  PubMed


Complications associated with intermittent pneumatic compression devices.

Anand A., Siddiqui A.U., Buchman T.G., Hotchkiss R.S. (2000) Complications associated with intermittent pneumatic compression devices. Anesthesiology, 93(6):1556-7.

Hotchkiss Lab  PubMed


Molecular biology of multiple organ dysfunction syndrome: injury, adaptation, and apoptosis.

Cobb J.P., Buchman T.G., Karl I.E., Hotchkiss R.S. (2000) Molecular biology of multiple organ dysfunction syndrome: injury, adaptation, and apoptosis. Surgical infections, 1(3):207-13; discussion 214-5.

Hotchkiss Lab  PubMed


Injection of iron compounds followed by induction of the stress response causes tissue injury and apoptosis.

Jacob A.K., Hotchkiss R.S., Swanson P.E., Tinsley K.W., Karl I.E., Buchman T.G. (2000) Injection of iron compounds followed by induction of the stress response causes tissue injury and apoptosis. Shock (Augusta, Ga.), 14(4):460-4.

Hotchkiss Lab  PubMed


iNOS gene expression modulates microvascular responsiveness in endotoxin-challenged mice.

Boyle 3rd. W.A., Parvathaneni L.S., Bourlier V., Sauter C., Laubach V.E., Cobb J.P. (2000) iNOS gene expression modulates microvascular responsiveness in endotoxin-challenged mice. Circulation research, 87(7):E18-24.

Boyle Lab  PubMed


Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision.

Akk G., Steinbach J.H. (2000) Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision. The Journal of physiology, 527 Pt 3():405-17.

Akk Lab Steinbach Lab  PubMed


Monitoring of peripheral nerves and muscle function in patients with multiple organ dysfunction syndrome.

Latronico N., Hotchkiss R.S., Swanson P.E., Freeman B.D., Tinsley K.W., Cobb J.P., Buchman T.G., Karl I.E. (2000) Monitoring of peripheral nerves and muscle function in patients with multiple organ dysfunction syndrome. Critical care medicine, 28(9):3375.

Hotchkiss Lab  PubMed


Rapid onset of intestinal epithelial and lymphocyte apoptotic cell death in patients with trauma and shock.

Hotchkiss R.S., Schmieg Jr. R.E., Swanson P.E., Freeman B.D., Tinsley K.W., Cobb J.P., Karl I.E., Buchman T.G. (2000) Rapid onset of intestinal epithelial and lymphocyte apoptotic cell death in patients with trauma and shock. Critical care medicine, 28(9):3207-17.

Hotchkiss Lab  PubMed


Rapid onset of hepatocyte apoptosis in a patient with trauma.

Schmieg Jr. R.E., Tinsley K.W., Swanson P.E., Karl I.E., Aft R., Buchman T.G., Hotchkiss R.S. (2000) Rapid onset of hepatocyte apoptosis in a patient with trauma. The Journal of trauma, 49(3):542-6.

Hotchkiss Lab  PubMed


Activation of BK channels in rat chromaffin cells requires summation of Ca(2+) influx from multiple Ca(2+) channels.

Prakriya M., Lingle C.J. (2000) Activation of BK channels in rat chromaffin cells requires summation of Ca(2+) influx from multiple Ca(2+) channels. Journal of neurophysiology, 84(3):1123-35.

Lingle Lab  PubMed


How to force conformity on transmitter-gated channels.

Steinbach J.H. (2000) How to force conformity on transmitter-gated channels. The Journal of general physiology, 116(3):445-8.

Steinbach Lab  PubMed


Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.

Covey D.F., Han M., Sampath Kumar A., De la Cruz M.A.M., Meadows E.S., Hu Y., Tonnies A., Nathan D., Coleman M., Benz A., Evers A.S., Zorumski C.F., Mennerick S. (2000) Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. Journal of medicinal chemistry, 43(17):3201-4.

Evers Lab  PubMed


Steroid inhibition of rat neuronal nicotinic alpha4beta2 receptors expressed in HEK 293 cells.

Paradiso K., Sabey K., Evers A.S., Zorumski C.F., Covey D.F., Steinbach J.H. (2000) Steroid inhibition of rat neuronal nicotinic alpha4beta2 receptors expressed in HEK 293 cells. Molecular pharmacology, 58(2):341-51.

Evers Lab Steinbach Lab  PubMed


Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit.

Xia X.-M., Ding J.-P., Zeng X.-H., Duan K.-L., Lingle C.J. (2000) Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(13):4890-903.

Lingle Lab  PubMed


Anticonvulsants but not general anesthetics have differential blocking effects on different T-type current variants.

Todorovic S.M., Perez-Reyes E., Lingle C.J. (2000) Anticonvulsants but not general anesthetics have differential blocking effects on different T-type current variants. Molecular pharmacology, 58(1):98-108.

Lingle Lab  PubMed


Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region.

Steinbach J.H., Bracamontes J., Yu L., Zhang P., Covey D.F. (2000) Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region. Molecular pharmacology, 58(1):11-7.

Steinbach Lab  PubMed


Role of CuZn superoxide dismutase in regulating lymphocyte apoptosis during sepsis.

Freeman B.D., Reaume A.G., Swanson P.E., Epstein C.J., Carlson E.J., Buchman T.G., Karl I.E., Hotchkiss R.S. (2000) Role of CuZn superoxide dismutase in regulating lymphocyte apoptosis during sepsis. Critical care medicine, 28(6):1701-8.

Hotchkiss Lab  PubMed


Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia.

Covey D.F., Nathan D., Kalkbrenner M., Nilsson K.R., Hu Y., Zorumski C.F., Evers A.S. (2000) Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia. The Journal of pharmacology and experimental therapeutics, 293(3):1009-16.

Evers Lab  PubMed


Structural domains of the human GABAA receptor 3 subunit involved in the actions of pentobarbital.

Serafini R., Bracamontes J., Steinbach J.H. (2000) Structural domains of the human GABAA receptor 3 subunit involved in the actions of pentobarbital. The Journal of physiology, 524 Pt 3():649-76.

Steinbach Lab  PubMed


Activation and block of recombinant GABA(A) receptors by pentobarbitone: a single-channel study.

Akk G., Steinbach J.H. (2000) Activation and block of recombinant GABA(A) receptors by pentobarbitone: a single-channel study. British journal of pharmacology, 130(2):249-58.

Akk Lab Steinbach Lab  PubMed


p53-dependent and -independent pathways of apoptotic cell death in sepsis.

Hotchkiss R.S., Tinsley K.W., Hui J.-J., Chang K.C., Swanson P.E., Drewry A.M., Buchman T.G., Karl I.E. (2000) p53-dependent and -independent pathways of apoptotic cell death in sepsis. Journal of immunology (Baltimore, Md. : 1950), 164(7):3675-80.

Hotchkiss Lab  PubMed


Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation.

Manyike P.T., Kharasch E.D., Kalhorn T.F., Slattery J.T. (2000) Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. Clinical pharmacology and therapeutics, 67(3):275-82.

Kharasch Lab  PubMed


Pulmonary embolism as a consequence of applying sequential compression device on legs in a patient asymptomatic of deep vein thrombosis.

Siddiqui A.U., Buchman T.G., Hotchkiss R.S. (2000) Pulmonary embolism as a consequence of applying sequential compression device on legs in a patient asymptomatic of deep vein thrombosis. Anesthesiology, 92(3):880-2.

Hotchkiss Lab  PubMed


Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4.

Kharasch E.D., Hankins D.C., Fenstamaker K., Cox K. (2000) Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4. European journal of clinical pharmacology, 55(11-12):853-9.

Kharasch Lab  PubMed


Endotracheal lidocaine administration via an esophageal combitube.

Palmer R.B., Mautz D.S., Cox K., Kharasch E.D. (2000) Endotracheal lidocaine administration via an esophageal combitube. The Journal of emergency medicine, 18(2):153-7.

Kharasch Lab  PubMed


Caspases -2, -3, -6, and -9, but not caspase-1, are activated in sepsis-induced thymocyte apoptosis.

Tinsley K.W., Cheng S.L., Buchman T.G., Chang K.C., Hui J.J., Swanson P.E., Karl I.E., Hotchkiss R.S. (2000) Caspases -2, -3, -6, and -9, but not caspase-1, are activated in sepsis-induced thymocyte apoptosis. Shock (Augusta, Ga.), 13(1):1-7.

Hotchkiss Lab  PubMed


Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity.

Kharasch E.D., Hankins D.C., Taraday J.K. (2000) Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity. Drug metabolism and disposition: the biological fate of chemicals, 28(1):28-33.

Kharasch Lab  PubMed