DBR Publications


The G protein subunit gene families.

Downes G.B., Gautam N. (1999) The G protein subunit gene families. Genomics, 62(3):544-52.

Gautam Lab  PubMed


A G protein gamma subunit-specific peptide inhibits muscarinic receptor signaling.

Azpiazu I., Cruzblanca H., Li P., Linder M., Zhuo M., Gautam N. (1999) A G protein gamma subunit-specific peptide inhibits muscarinic receptor signaling. The Journal of biological chemistry, 274(50):35305-8.

Gautam Lab  PubMed


Prevention of lymphocyte cell death in sepsis improves survival in mice.

Hotchkiss R.S., Tinsley K.W., Swanson P.E., Chang K.C., Cobb J.P., Buchman T.G., Korsmeyer S.J., Karl I.E. (1999) Prevention of lymphocyte cell death in sepsis improves survival in mice. Proceedings of the National Academy of Sciences of the United States of America, 96(25):14541-6.

Hotchkiss Lab  PubMed


Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists.

Akk G., Auerbach A. (1999) Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists. British journal of pharmacology, 128(7):1467-76.

Akk Lab  PubMed


Relation between outer and luminal diameter in cannulated arteries.

Faury G., Maher G.M., Li D.Y., Keating M.T., Mecham R.P., Boyle W.A. (1999) Relation between outer and luminal diameter in cannulated arteries. The American journal of physiology, 277(5 Pt 2):H1745-53.

Boyle Lab  PubMed


Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison.

Kharasch E.D., Jubert C. (1999) Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison. Anesthesiology, 91(5):1267-78.

Kharasch Lab  PubMed


Putting the brakes on anesthetic breakdown.

Kharasch E.D. (1999) Putting the brakes on anesthetic breakdown. Anesthesiology, 91(5):1192-4.

Kharasch Lab  PubMed


Acute renal failure after cardiopulmonary bypass in related to decreased serum ferritin levels.

Davis C.L., Kausz A.T., Zager R.A., Kharasch E.D., Cochran R.P. (1999) Acute renal failure after cardiopulmonary bypass in related to decreased serum ferritin levels. Journal of the American Society of Nephrology : JASN, 10(11):2396-402.

Kharasch Lab  PubMed


Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene.

Liu H., Cao Y., Basbaum A.I., Mazarati A.M., Sankar R., Wasterlain C.G. (1999) Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene. Proceedings of the National Academy of Sciences of the United States of America, 96(21):12096-101.

Cao Lab  PubMed


Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats.

Kharasch E.D., Jubert C., Spracklin D.K., Hoffman G.M. (1999) Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats. Toxicology and applied pharmacology, 160(1):49-59.

Kharasch Lab  PubMed


Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans.

Emery M.G., Jubert C., Thummel K.E., Kharasch E.D. (1999) Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans. The Journal of pharmacology and experimental therapeutics, 291(1):213-9.

Kharasch Lab  PubMed


Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice.

Cobb J.P., Hotchkiss R.S., Swanson P.E., Chang K., Qiu Y., Laubach V.E., Karl I.E., Buchman T.G. (1999) Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice. Surgery, 126(2):438-42.

Hotchkiss Lab  PubMed


Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction.

Hotchkiss R.S., Swanson P.E., Freeman B.D., Tinsley K.W., Cobb J.P., Matuschak G.M., Buchman T.G., Karl I.E. (1999) Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Critical care medicine, 27(7):1230-51.

Hotchkiss Lab  PubMed


Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance.

Kharasch E.D., Jubert C., Senn T., Bowdle T.A., Thummel K.E. (1999) Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance. Journal of clinical pharmacology, 39(7):664-9.

Kharasch Lab  PubMed


Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells.

Xia X.-M., Ding J.P., Lingle C.J. (1999) Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(13):5255-64.

Lingle Lab  PubMed


Blockade of Ba2+ current through human alpha1E channels by two steroid analogs, (+)-ACN and (+)-ECN.

Nakashima Y.M., Pereverzev A., Schneider T., Covey D.F., Lingle C.J. (1999) Blockade of Ba2+ current through human alpha1E channels by two steroid analogs, (+)-ACN and (+)-ECN. Neuropharmacology, 38(6):843-55.

Lingle Lab  PubMed


Sepsis increases intracellular free calcium in brain.

Anderson S.A., Song S.-K., Ackerman J.J.H., Hotchkiss R.S. (1999) Sepsis increases intracellular free calcium in brain. Journal of neurochemistry, 72(6):2617-20.

Hotchkiss Lab  PubMed


Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1.

Kharasch E.D., Hankins D.C., Jubert C., Thummel K.E., Taraday J.K. (1999) Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1. Drug metabolism and disposition: the biological fate of chemicals, 27(6):717-23.

Kharasch Lab  PubMed


Comparison of renal function following anesthesia with low-flow sevoflurane and isoflurane.

Groudine S.B., Fragen R.J., Kharasch E.D., Eisenman T.S., Frink E.J., McConnell S. (1999) Comparison of renal function following anesthesia with low-flow sevoflurane and isoflurane. Journal of clinical anesthesia, 11(3):201-7.

Kharasch Lab  PubMed


BK channel activation by brief depolarizations requires Ca2+ influx through L- and Q-type Ca2+ channels in rat chromaffin cells.

Prakriya M., Lingle C.J. (1999) BK channel activation by brief depolarizations requires Ca2+ influx through L- and Q-type Ca2+ channels in rat chromaffin cells. Journal of neurophysiology, 81(5):2267-78.

Lingle Lab  PubMed


Activation of N-methyl-D-aspartate receptors reverses desensitization of metabotropic glutamate receptor, mGluR5, in native and recombinant systems.

Alagarsamy S., Rouse S.T., Gereau IV R.W., Heinemann S.F., Smith Y., Conn P.J. (1999) Activation of N-methyl-D-aspartate receptors reverses desensitization of metabotropic glutamate receptor, mGluR5, in native and recombinant systems. Annals of the New York Academy of Sciences, 868():526-30.

Gereau Lab  PubMed


Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis.

Hotchkiss R.S., Swanson P.E., Knudson C.M., Chang K.C., Cobb J.P., Osborne D.F., Zollner K.M., Buchman T.G., Korsmeyer S.J., Karl I.E. (1999) Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950), 162(7):4148-56.

Hotchkiss Lab  PubMed


Chromosomal mapping of five mouse G protein gamma subunits.

Downes G.B., Gilbert D.J., Copeland N.G., Gautam N., Jenkins N.A. (1999) Chromosomal mapping of five mouse G protein gamma subunits. Genomics, 57(1):173-6.

Gautam Lab  PubMed


KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation.

Bell B., Xing H., Yan K., Gautam N., Muslin A.J. (1999) KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation. The Journal of biological chemistry, 274(12):7982-6.

Gautam Lab  PubMed


A neomorphic syntaxin mutation blocks volatile-anesthetic action in Caenorhabditis elegans.

Van Swinderen B., Saifee O., Shebester L., Roberson R., Nonet M.L., Crowder C.M. (1999) A neomorphic syntaxin mutation blocks volatile-anesthetic action in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America, 96(5):2479-84.

 PubMed


Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems.

Alagarsamy S., Marino M.J., Rouse S.T., Gereau IV R.W., Heinemann S.F., Conn P.J. (1999) Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems. Nature neuroscience, 2(3):234-40.

Gereau Lab  PubMed


Renal cysteine conjugate beta-lyase and compound A nephrotoxicity: minimal evidence for an association.

Njoku D.B., Martin J.L., Pohl L.R., Kharasch E.D., Hankins D. (1999) Renal cysteine conjugate beta-lyase and compound A nephrotoxicity: minimal evidence for an association. Anesthesiology, 90(3):921-2.

Kharasch Lab  PubMed


Clinical isoflurane metabolism by cytochrome P450 2E1.

Kharasch E.D., Hankins D.C., Cox K. (1999) Clinical isoflurane metabolism by cytochrome P450 2E1. Anesthesiology, 90(3):766-71.

Kharasch Lab  PubMed


Menstrual cycle variability in midazolam pharmacokinetics.

Kharasch E.D., Mautz D., Senn T., Lentz G., Cox K. (1999) Menstrual cycle variability in midazolam pharmacokinetics. Journal of clinical pharmacology, 39(3):275-80.

Kharasch Lab  PubMed


RINm5f cells express inactivating BK channels whereas HIT cells express noninactivating BK channels.

Li Z.-W., Ding J.P., Kalyanaraman V., Lingle C.J. (1999) RINm5f cells express inactivating BK channels whereas HIT cells express noninactivating BK channels. Journal of neurophysiology, 81(2):611-24.

Lingle Lab  PubMed


Effect of Ca2+ agonists in the perfused liver: determination via laser scanning confocal microscopy.

Motoyama K., Karl I.E., Flye M.W., Osborne D.F., Hotchkiss R.S. (1999) Effect of Ca2+ agonists in the perfused liver: determination via laser scanning confocal microscopy. The American journal of physiology, 276(2 Pt 2):R575-85.

Hotchkiss Lab  PubMed


Double-edged swords: volatile anesthetics both enhance and inhibit ligand-gated ion channels.

Evers A.S., Steinbach J.H. (1999) Double-edged swords: volatile anesthetics both enhance and inhibit ligand-gated ion channels. Anesthesiology, 90(1):1-3.

Evers Lab Steinbach Lab  PubMed


Ligand binding and activation of rat nicotinic alpha4beta2 receptors stably expressed in HEK293 cells.

Sabey K., Paradiso K., Zhang J., Steinbach J.H. (1999) Ligand binding and activation of rat nicotinic alpha4beta2 receptors stably expressed in HEK293 cells. Molecular pharmacology, 55(1):58-66.

Steinbach Lab  PubMed


A mutational analysis of the acetylcholine receptor channel transmitter binding site.

Akk G., Zhou M., Auerbach A. (1999) A mutational analysis of the acetylcholine receptor channel transmitter binding site. Biophysical journal, 76(1 Pt 1):207-18.

Akk Lab  PubMed