DBR Publications


Reversal of hypocalcemia and decreased afterload in sepsis. Effect on myocardial systolic and diastolic function.

Kovacs A., Courtois M.R., Barzilai B., Karl I.E., Ludbrook P.A., Hotchkiss R.S. (1998) Reversal of hypocalcemia and decreased afterload in sepsis. Effect on myocardial systolic and diastolic function. American journal of respiratory and critical care medicine, 158(6):1990-8.

Hotchkiss Lab  PubMed


A quantitative genetic approach towards volatile anesthetic mechanisms in C. elegans.

Van Swinderen B., Galifianakis A., Crowder C.M. (1998) A quantitative genetic approach towards volatile anesthetic mechanisms in C. elegans. Toxicology letters, 100-101():309-17.

 PubMed


Novel arterial pathology in mice and humans hemizygous for elastin.

Li D.Y., Faury G., Taylor D.G., Davis E.C., Boyle W.A., Mecham R.P., Stenzel P., Boak B., Keating M.T. (1998) Novel arterial pathology in mice and humans hemizygous for elastin. The Journal of clinical investigation, 102(10):1783-7.

Boyle Lab  PubMed


G-protein beta-subunit specificity in the fast membrane-delimited inhibition of Ca2+ channels.

Garcia D.E., Li B., Garcia-Ferreiro R.E., Hernandez-Ochoa E.O., Yan K., Gautam N., Catterall W.A., Mackie K., Hille B. (1998) G-protein beta-subunit specificity in the fast membrane-delimited inhibition of Ca2+ channels. The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(22):9163-70.

Gautam Lab  PubMed


[Compound A: toxicology and clinical relevance].

Kharasch E.D. (1998) [Compound A: toxicology and clinical relevance]. Der Anaesthesist, 47 Suppl 1():S7-10.

Kharasch Lab  PubMed


Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity.

Todorovic S.M., Prakriya M., Nakashima Y.M., Nilsson K.R., Han M., Zorumski C.F., Covery D.F., Lingle C.J. (1998) Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity. Molecular pharmacology, 54(5):918-27.

Lingle Lab  PubMed


Does ketamine-mediated N-methyl-D-aspartate receptor antagonism cause schizophrenia-like oculomotor abnormalities?

Radant A.D., Bowdle T.A., Cowley D.S., Kharasch E.D., Roy-Byrne P.P. (1998) Does ketamine-mediated N-methyl-D-aspartate receptor antagonism cause schizophrenia-like oculomotor abnormalities? Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 19(5):434-44.

Kharasch Lab  PubMed


Structure and mapping of the G protein gamma3 subunit gene and a divergently transcribed novel gene, gng3lg.

Downes G.B., Copeland N.G., Jenkins N.A., Gautam N. (1998) Structure and mapping of the G protein gamma3 subunit gene and a divergently transcribed novel gene, gng3lg. Genomics, 53(2):220-30.

Gautam Lab  PubMed


Mechanistic aspects of carbon monoxide formation from volatile anesthetics.

Baxter P.J., Garton K., Kharasch E.D. (1998) Mechanistic aspects of carbon monoxide formation from volatile anesthetics. Anesthesiology, 89(4):929-41.

Kharasch Lab  PubMed


Integrated YAC/STS physical and genetic map of 22.5 Mb of human Xq24-q26 at 56-kb inter-STS resolution.

Nagaraja R., MacMillan S., Jones C., Masisi M., Pengue G., Porta G., Miao S., Casamassimi A., D'Urso M., Brownstein B., Schlessinger D. (1998) Integrated YAC/STS physical and genetic map of 22.5 Mb of human Xq24-q26 at 56-kb inter-STS resolution. Genomics, 52(3):247-66.

Hotchkiss Lab  PubMed


Nitric oxide inhibits stress-induced endothelial cell apoptosis.

DeMeester S.L., Qiu Y., Buchman T.G., Hotchkiss R.S., Dunnigan K., Karl I.E., Cobb J.P. (1998) Nitric oxide inhibits stress-induced endothelial cell apoptosis. Critical care medicine, 26(9):1500-9.

Hotchkiss Lab  PubMed


The anesthetic steroid (+)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile blocks N-, Q-, and R-type, but not L- and P-type, high voltage-activated Ca2+ current in hippocampal and dorsal root ganglion neurons of the rat.

Nakashima Y.M., Todorovic S.M., Covey D.F., Lingle C.J. (1998) The anesthetic steroid (+)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile blocks N-, Q-, and R-type, but not L- and P-type, high voltage-activated Ca2+ current in hippocampal and dorsal root ganglion neurons of the rat. Molecular pharmacology, 54(3):559-68.

Lingle Lab  PubMed


Postanesthesia care unit length of stay: quantifying and assessing dependent factors.

Waddle J.P., Evers A.S., Piccirillo J.F. (1998) Postanesthesia care unit length of stay: quantifying and assessing dependent factors. Anesthesia and analgesia, 87(3):628-33.

Evers Lab  PubMed


Properties of Ba2+ currents arising from human alpha1E and alpha1Ebeta3 constructs expressed in HEK293 cells: physiology, pharmacology, and comparison to native T-type Ba2+ currents.

Nakashima Y.M., Todorovic S.M., Pereverzev A., Hescheler J., Schneider T., Lingle C.J. (1998) Properties of Ba2+ currents arising from human alpha1E and alpha1Ebeta3 constructs expressed in HEK293 cells: physiology, pharmacology, and comparison to native T-type Ba2+ currents. Neuropharmacology, 37(8):957-72.

Lingle Lab  PubMed


Stress-induced fractal rearrangement of the endothelial cell cytoskeleton causes apoptosis.

DeMeester S.L., Cobb J.P., Hotchkiss R.S., Osborne D.F., Karl I.E., Tinsley K.W., Buchman T.G., Soybel D.I. (1998) Stress-induced fractal rearrangement of the endothelial cell cytoskeleton causes apoptosis. Surgery, 124(2):362-71.

Hotchkiss Lab  PubMed


Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism.

Auerbach A., Akk G. (1998) Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism. The Journal of general physiology, 112(2):181-97.

Akk Lab  PubMed


YAC/STS map of 15Mb of Xp21.3-p11.3, at 100kb resolution, with refined comparisons of genetic distances and DMD structure.

Nagaraja R., Jermak C., Trusgnich M., Yoon J., MacMillan S., McCauley B., Brownstein B., Schlessinger D. (1998) YAC/STS map of 15Mb of Xp21.3-p11.3, at 100kb resolution, with refined comparisons of genetic distances and DMD structure. Gene, 215(2):259-67.

Hotchkiss Lab  PubMed


Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptors.

Contractor A., Gereau IV R.W., Green T., Heinemann S.F. (1998) Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptors. Proceedings of the National Academy of Sciences of the United States of America, 95(15):8969-74.

Gereau Lab  PubMed


The G-protein betagamma complex.

Gautam N., Downes G.B., Yan K., Kisselev O. (1998) The G-protein betagamma complex. Cellular signalling, 10(7):447-55.

Gautam Lab  PubMed


Single-dose disulfiram does not inhibit CYP2A6 activity.

Kharasch E.D., Hankins D.C., Baxter P.J., Thummel K.E. (1998) Single-dose disulfiram does not inhibit CYP2A6 activity. Clinical pharmacology and therapeutics, 64(1):39-45.

Kharasch Lab  PubMed


Pyrrolidine dithiocarbamate activates the heat shock response and thereby induces apoptosis in primed endothelial cells.

DeMeester S.L., Buchman T.G., Qiu Y., Dunnigan K., Hotchkiss R.S., Karl I.E., Cobb J.P. (1998) Pyrrolidine dithiocarbamate activates the heat shock response and thereby induces apoptosis in primed endothelial cells. Shock (Augusta, Ga.), 10(1):1-6.

Hotchkiss Lab  PubMed


Endotracheal administration of flumazenil.

Weiner A.L., McKay C.A. Jr., Shepherd G., Palmer R.B., Kharasch E.D. (1998) Endotracheal administration of flumazenil. The American journal of emergency medicine, 16(4):436-7.

Kharasch Lab  PubMed


Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats.

Kharasch E.D., Hoffman G.M., Thorning D., Hankins D.C., Kilty C.G. (1998) Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats. Anesthesiology, 88(6):1624-33.

Kharasch Lab  PubMed


Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms.

Spracklin D.K., Kharasch E.D. (1998) Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms. Drug metabolism and disposition: the biological fate of chemicals, 26(6):605-7.

Kharasch Lab  PubMed


Rapsyn clusters neuronal acetylcholine receptors but is inessential for formation of an interneuronal cholinergic synapse.

Feng G., Steinbach J.H., Sanes J.R. (1998) Rapsyn clusters neuronal acetylcholine receptors but is inessential for formation of an interneuronal cholinergic synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(11):4166-76.

Steinbach Lab  PubMed


Light-activated rhodopsin induces structural binding motif in G protein alpha subunit.

Kisselev O.G., Kao J., Ponder J.W., Fann Y.C., Gautam N., Marshall G.R. (1998) Light-activated rhodopsin induces structural binding motif in G protein alpha subunit. Proceedings of the National Academy of Sciences of the United States of America, 95(8):4270-5.

Gautam Lab  PubMed


Structure and chromosomal localization of mouse G protein subunit gamma 4 gene.

Kalyanaraman S., Copeland N.G., Gilbert D.G., Jenkins N.A., Gautam N. (1998) Structure and chromosomal localization of mouse G protein subunit gamma 4 gene. Genomics, 49(1):147-51.

Gautam Lab  PubMed


Primary afferent tachykinins are required to experience moderate to intense pain.

Cao Y.Q., Mantyh P.W., Carlson E.J., Gillespie A.-M., Epstein C.J., Basbaum A.I. (1998) Primary afferent tachykinins are required to experience moderate to intense pain. Nature, 392(6674):390-4.

Cao Lab  PubMed


Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers.

Ebert T.J., Frink Jr. E.J., Kharasch E.D. (1998) Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers. Anesthesiology, 88(3):601-10.

Kharasch Lab  PubMed


Endotracheal flumazenil: a new route of administration for benzodiazepine antagonism.

Palmer R.B., Mautz D.S., Cox K., Kharasch E.D. (1998) Endotracheal flumazenil: a new route of administration for benzodiazepine antagonism. The American journal of emergency medicine, 16(2):170-2.

Kharasch Lab  PubMed


Pentoxifylline and modulation of the inflammatory response.

Hotchkiss R.S., Karl I.E. (1998) Pentoxifylline and modulation of the inflammatory response. Critical care medicine, 26(3):427-8.

Hotchkiss Lab  PubMed


Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats.

Lochhead K.M., Kharasch E.D., Zager R.A. (1998) Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats. Journal of the American Society of Nephrology : JASN, 9(2):305-9.

Kharasch Lab  PubMed


Mapping anesthesia genes: why and how?

Crowder C.M. (1998) Mapping anesthesia genes: why and how? Anesthesiology, 88(2):293-6.

 PubMed


Acute tolerance and reversal of the motor control effects of midazolam.

Coldwell S.E., Kaufman E., Milgrom P., Kharasch E.D., Chen P., Mautz D., Ramsay D.S. (1998) Acute tolerance and reversal of the motor control effects of midazolam. Pharmacology, biochemistry, and behavior, 59(2):537-45.

Kharasch Lab  PubMed


The channel opening rate of adult- and fetal-type mouse muscle nicotinic receptors activated by acetylcholine.

Maconochie D.J., Steinbach J.H. (1998) The channel opening rate of adult- and fetal-type mouse muscle nicotinic receptors activated by acetylcholine. The Journal of physiology, 506 ( Pt 1)():53-72.

Steinbach Lab  PubMed


Role of protein kinase C phosphorylation in rapid desensitization of metabotropic glutamate receptor 5.

Gereau IV R.W., Heinemann S.F. (1998) Role of protein kinase C phosphorylation in rapid desensitization of metabotropic glutamate receptor 5. Neuron, 20(1):143-51.

Gereau Lab  PubMed


Inactivating BK channels in rat chromaffin cells may arise from heteromultimeric assembly of distinct inactivation-competent and noninactivating subunits.

Ding J.P., Li Z.W., Lingle C.J. (1998) Inactivating BK channels in rat chromaffin cells may arise from heteromultimeric assembly of distinct inactivation-competent and noninactivating subunits. Biophysical journal, 74(1):268-89.

Lingle Lab  PubMed


Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations.

Bowdle T.A., Radant A.D., Cowley D.S., Kharasch E.D., Strassman R.J., Roy-Byrne P.P. (1998) Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations. Anesthesiology, 88(1):82-8.

Kharasch Lab  PubMed


Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes.

Minami K., Gereau IV R.W., Minami M., Heinemann S.F., Harris R.A. (1998) Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes. Molecular pharmacology, 53(1):148-56.

Gereau Lab  PubMed


Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents.

Todorovic S.M., Lingle C.J. (1998) Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents. Journal of neurophysiology, 79(1):240-52.

Lingle Lab  PubMed