DBR Publications


Vascular actions of 'caged' phenylephrine analogs depend on the structure and site of attachment of the 2-nitrobenzyl group.

Boyle W.A., Muralidharan S., Maher G.M., Nerbonne J.M. (1997) Vascular actions of 'caged' phenylephrine analogs depend on the structure and site of attachment of the 2-nitrobenzyl group. Journal of photochemistry and photobiology. B, Biology, 41(3):233-44.

Boyle Lab  PubMed


Optimal rehydration of desiccated CO2 absorbents.

Woehlck H., Kharasch E.D. (1997) Optimal rehydration of desiccated CO2 absorbents. Anesthesiology, 87(6):1590-1.

Kharasch Lab  PubMed


Heat shock induces IkappaB-alpha and prevents stress-induced endothelial cell apoptosis.

DeMeester S.L., Buchman T.G., Qiu Y., Jacob A.K., Dunnigan K., Hotchkiss R.S., Karl I., Cobb J.P. (1997) Heat shock induces IkappaB-alpha and prevents stress-induced endothelial cell apoptosis. Archives of surgery (Chicago, Ill. : 1960), 132(12):1283-7; discussion 1287-8.

Hotchkiss Lab  PubMed


Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors.

Kem W.R., Mahnir V.M., Papke R.L., Lingle C.J. (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. The Journal of pharmacology and experimental therapeutics, 283(3):979-92.

Lingle Lab  PubMed


Deficient development and maintenance of postsynaptic specializations in mutant mice lacking an 'adult' acetylcholine receptor subunit.

Missias A.C., Mudd J., Cunningham J.M., Steinbach J.H., Merlie J.P., Sanes J.R. (1997) Deficient development and maintenance of postsynaptic specializations in mutant mice lacking an 'adult' acetylcholine receptor subunit. Development (Cambridge, England), 124(24):5075-86.

 PubMed


Cost-effective reduction of neuromuscular-blocking drug expenditures.

Freund P.R., Bowdle T.A., Posner K.L., Kharasch E.D., Burkhart V.D. (1997) Cost-effective reduction of neuromuscular-blocking drug expenditures. Anesthesiology, 87(5):1044-9.

Kharasch Lab  PubMed


Myocardial ischemia and adverse cardiac outcomes in cardiac patients undergoing noncardiac surgery with sevoflurane and isoflurane. Sevoflurane Ischemia Study Group.

Ebert T.J., Kharasch E.D., Alec Rooke G., Shroff A., Muzi M., Howard S., Eisenkraft J., Gold M., Marty J., Wong D., Thapar P., Harris A., Coriat P., Hantler C., Prys-Roberts C., Chelly J. (1997) Myocardial ischemia and adverse cardiac outcomes in cardiac patients undergoing noncardiac surgery with sevoflurane and isoflurane. Sevoflurane Ischemia Study Group. Anesthesia and analgesia, 85(5):993-9.

Kharasch Lab  PubMed


Identification of amino acid residues that control functional behavior in GluR5 and GluR6 kainate receptors.

Swanson G.T., Gereau IV R.W., Green T., Heinemann S.F. (1997) Identification of amino acid residues that control functional behavior in GluR5 and GluR6 kainate receptors. Neuron, 19(4):913-26.

Gereau Lab  PubMed


Calcium antagonists inhibit oxidative burst and nitrite formation in lipopolysaccharide-stimulated rat peritoneal macrophages.

Hotchkiss R.S., Bowling W.M., Karl I.E., Osborne D.F., Wayne Flye M. (1997) Calcium antagonists inhibit oxidative burst and nitrite formation in lipopolysaccharide-stimulated rat peritoneal macrophages. Shock (Augusta, Ga.), 8(3):170-8.

Hotchkiss Lab  PubMed


Is guanosine-5'-triphosphate involved in calcium-activation of contractile proteins in vascular smooth muscle?

Akata T., Boyle III W.A. (1997) Is guanosine-5'-triphosphate involved in calcium-activation of contractile proteins in vascular smooth muscle? Japanese journal of pharmacology, 75(1):1-12.

Boyle Lab  PubMed


Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions.

Labroo R.B., Paine M.F., Thummel K.E., Kharasch E.D. (1997) Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions. Drug metabolism and disposition: the biological fate of chemicals, 25(9):1072-80.

Kharasch Lab  PubMed


G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.

Giambarella U, Yamatsuji T, Okamoto T, Matsui T, Ikezu T, Murayama Y, Levine MA, Katz A, Gautam N, Nishimoto I (1997) G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. The EMBO journal, 16(16):4897-907.

 PubMed


Endothelial cell apoptosis is accelerated by inorganic iron and heat via an oxygen radical dependent mechanism.

Jacob A.K., Hotchkiss R.S., DeMeester S.L., Hiramatsu M., Karl I.E., Swanson P.E., Cobb J.P., Buchman T.G. (1997) Endothelial cell apoptosis is accelerated by inorganic iron and heat via an oxygen radical dependent mechanism. Surgery, 122(2):243-53; discussion 254.

Hotchkiss Lab  PubMed


Keep the blood red...the right way.

Kharasch E.D. (1997) Keep the blood red...the right way. Anesthesiology, 87(2):202-3.

Kharasch Lab  PubMed


Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice.

Hotchkiss R.S., Swanson P.E., Cobb J.P., Jacobson A., Buchman T.G., Karl I.E. (1997) Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Critical care medicine, 25(8):1298-307.

Hotchkiss Lab  PubMed


The cytosolic inactivation domains of BKi channels in rat chromaffin cells do not behave like simple, open-channel blockers.

Solaro C.R., Ding J.P., Li Z.W., Lingle C.J. (1997) The cytosolic inactivation domains of BKi channels in rat chromaffin cells do not behave like simple, open-channel blockers. Biophysical journal, 73(2):819-30.

Lingle Lab  PubMed


Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans.

Van Swinderen B., Shook D.R., Ebert R.H., Cherkasova V.A., Johnson T.E., Reis R.J., Crowder C.M. (1997) Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America, 94(15):8232-7.

 PubMed


Transition to post-operative epidural or patient-controlled intravenous analgesia following total intravenous anaesthesia with remifentanil and propofol for abdominal surgery.

Bowdle T.A., Ready L.B., Kharasch E.D., Nichols W.W., Cox K. (1997) Transition to post-operative epidural or patient-controlled intravenous analgesia following total intravenous anaesthesia with remifentanil and propofol for abdominal surgery. European journal of anaesthesiology, 14(4):374-9.

Kharasch Lab  PubMed


Convection versus conduction cooling for induction of mild hypothermia during neurovascular procedures in adults.

Theard M.A., Tempelhoff R., Crowder C.M., Cheng M.A., Todorov A., Dacey Jr. R.G. (1997) Convection versus conduction cooling for induction of mild hypothermia during neurovascular procedures in adults. Journal of neurosurgical anesthesiology, 9(3):250-5.

 PubMed


The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions.

Kharasch E.D., Russell M., Mautz D., Thummel K.E., Kunze K.L., Andrew Bowdle T., Cox K. (1997) The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions. Anesthesiology, 87(1):36-50.

Kharasch Lab  PubMed


Assessment of cytochrome P450 3A4 activity during the menstrual cycle using alfentanil as a noninvasive probe.

Kharasch E.D., Russell M., Garton K., Lentz G., Andrew Bowdle T., Cox K. (1997) Assessment of cytochrome P450 3A4 activity during the menstrual cycle using alfentanil as a noninvasive probe. Anesthesiology, 87(1):26-35.

Kharasch Lab  PubMed


Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity.

Kharasch E.D., Frink Jr. E.J., Zager R., Bowdle T.A., Artru A., Nogami W.M. (1997) Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity. Anesthesiology, 86(6):1238-53.

Kharasch Lab  PubMed


Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury.

Lochhead K.M., Kharasch E.D., Zager R.A. (1997) Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury. The American journal of pathology, 150(6):2209-21.

Kharasch Lab  PubMed


Pharmacokinetics of oral triazolam in children.

Karl H.W., Milgrom P., Domoto P., Kharasch E.D., Coldwell S.E., Weinstein P., Leroux B., Awamura K., Mautz D. (1997) Pharmacokinetics of oral triazolam in children. Journal of clinical psychopharmacology, 17(3):169-72.

Kharasch Lab  PubMed


Determination of the halothane metabolites trifluoroacetic acid and bromide in plasma and urine by ion chromatography.

Hankins D.C., Kharasch E.D. (1997) Determination of the halothane metabolites trifluoroacetic acid and bromide in plasma and urine by ion chromatography. Journal of chromatography. B, Biomedical sciences and applications, 692(2):413-8.

Kharasch Lab  PubMed


A cysteine-rich domain defined by a novel exon in a slo variant in rat adrenal chromaffin cells and PC12 cells.

Saito M., Nelson C., Salkoff L., Lingle C.J. (1997) A cysteine-rich domain defined by a novel exon in a slo variant in rat adrenal chromaffin cells and PC12 cells. The Journal of biological chemistry, 272(18):11710-7.

Lingle Lab  PubMed


Inhibition of ion transport in septic rat heart: 133Cs+ as an NMR active K+ analog.

Schornack P.A., Song S.-K., Hotchkiss R., Ackerman J.J.H. (1997) Inhibition of ion transport in septic rat heart: 133Cs+ as an NMR active K+ analog. The American journal of physiology, 272(5 Pt 1):C1635-41.

Hotchkiss Lab  PubMed


Quantification of ion transport in perfused rat heart: 133Cs+ as an NMR active K+ analog.

Schornack P.A., Song S.-K., Ling C.S., Hotchkiss R., Ackerman J.J.H. (1997) Quantification of ion transport in perfused rat heart: 133Cs+ as an NMR active K+ analog. The American journal of physiology, 272(5 Pt 1):C1618-34.

Hotchkiss Lab  PubMed


Rehydration of desiccated Baralyme prevents carbon monoxide formation from desflurane in an anesthesia machine.

Baxter P.J., Kharasch E.D. (1997) Rehydration of desiccated Baralyme prevents carbon monoxide formation from desflurane in an anesthesia machine. Anesthesiology, 86(5):1061-5.

Kharasch Lab  PubMed


Ca2+, a regulator of the inflammatory response--the good, the bad, and the possibilities.

Hotchkiss R.S., Karl I.E. (1997) Ca2+, a regulator of the inflammatory response--the good, the bad, and the possibilities. Shock (Augusta, Ga.), 7(4):308-10.

Hotchkiss Lab  PubMed


Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway.

Hiramatsu M., Hotchkiss R.S., Karl I.E., Buchman T.G. (1997) Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway. Shock (Augusta, Ga.), 7(4):247-53.

Hotchkiss Lab  PubMed


Supersensitive sites in the central nervous system. Anesthetics block brain nicotinic receptors.

Evers A.S., Steinbach J.H. (1997) Supersensitive sites in the central nervous system. Anesthetics block brain nicotinic receptors. Anesthesiology, 86(4):760-2.

Evers Lab  PubMed


Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro.

Spracklin D.K., Hankins D.C., Fisher J.M., Thummel K.E., Kharasch E.D. (1997) Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro. The Journal of pharmacology and experimental therapeutics, 281(1):400-11.

Kharasch Lab  PubMed


X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content.

Nagaraja R., MacMillan S., Kere J., Jones C., Griffin S., Schmatz M., Terrell J., Shomaker M., Jermak C., Hott C., Masisi M., Mumm S., Srivastava A., Pilia G., Featherstone T., Mazzarella R., Kesterson S., McCauley B., Railey B., Burough F., Nowotny V., D'Urso M., States D., Brownstein B., Schlessinger D. (1997) X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content. Genome research, 7(3):210-22.

Hotchkiss Lab  PubMed


Structural determinants for interaction with three different effectors on the G protein beta subunit.

Yan R., Gautam N. (1997) Structural determinants for interaction with three different effectors on the G protein beta subunit. The Journal of biological chemistry, 272(4):2056-9.

Gautam Lab  PubMed


Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor.

Ueno S., Bracamontes J., Zorumski C., Weiss D.S., Steinbach J.H. (1997) Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(2):625-34.

 PubMed


Pharmacovigilance and safety aspects of sevoflurane.

Kharasch E.D. (1997) Pharmacovigilance and safety aspects of sevoflurane. Acta anaesthesiologica Scandinavica. Supplementum, 111():146-8.

Kharasch Lab  PubMed


Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats.

Kharasch E.D., Thorning D., Garton K., Hankins D.C., Kilty C.G. (1997) Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats. Anesthesiology, 86(1):160-71.

Kharasch Lab  PubMed