DBR Publications


Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses.

Macek T.A., Winder D.G., Gereau IV R.W., Ladd C.O., Conn P.J. (1996) Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses. Journal of neurophysiology, 76(6):3798-806.

Gereau Lab  PubMed


Enantioselectivity of steroid-induced gamma-aminobutyric acidA receptor modulation and anesthesia.

Wittmer L.L., Hu Y., Kalkbrenner M., Evers A.S., Zorumski C.F., Covey D.F. (1996) Enantioselectivity of steroid-induced gamma-aminobutyric acidA receptor modulation and anesthesia. Molecular pharmacology, 50(6):1581-6.

Evers Lab  PubMed


Bombesin and thrombin affect discrete pools of intracellular calcium through different G-proteins.

Wang J.-L., Kalyanaraman S., De Vivo M., Gautam N. (1996) Bombesin and thrombin affect discrete pools of intracellular calcium through different G-proteins. The Biochemical journal, 320 ( Pt 1)():87-91.

Gautam Lab  PubMed


Behavioral effects of volatile anesthetics in Caenorhabditis elegans.

Crowder C.M., Shebester L.D., Schedl T. (1996) Behavioral effects of volatile anesthetics in Caenorhabditis elegans. Anesthesiology, 85(4):901-12.

 PubMed


Endogenous subunits can cause ambiguities in the pharmacology of exogenous gamma-aminobutyric acidA receptors expressed in human embryonic kidney 293 cells.

Ueno S., Zorumski C., Bracamontes J., Steinbach J.H. (1996) Endogenous subunits can cause ambiguities in the pharmacology of exogenous gamma-aminobutyric acidA receptors expressed in human embryonic kidney 293 cells. Molecular pharmacology, 50(4):931-8.

 PubMed


Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors.

Akk G., Sine S., Auerbach A. (1996) Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors. The Journal of physiology, 496 ( Pt 1)():185-96.

Akk Lab  PubMed


Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4.

Spracklin D.K., Thummel K.E., Kharasch E.D. (1996) Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4. Drug metabolism and disposition: the biological fate of chemicals, 24(9):976-83.

Kharasch Lab  PubMed


Novel glial-neuronal signalling by coactivation of metabotropic glutamate and beta-adrenergic receptors in rat hippocampus.

Winder D.G., Ritch P.S., Gereau IV R.W., Conn P.J. (1996) Novel glial-neuronal signalling by coactivation of metabotropic glutamate and beta-adrenergic receptors in rat hippocampus. The Journal of physiology, 494 ( Pt 3)():743-55.

Gereau Lab  PubMed


Gastroesophageal perforation after intraoperative transesophageal echocardiography.

Kharasch E.D., Sivarajan M. (1996) Gastroesophageal perforation after intraoperative transesophageal echocardiography. Anesthesiology, 85(2):426-8.

Kharasch Lab  PubMed


A domain on the G protein beta subunit interacts with both adenylyl cyclase 2 and the muscarinic atrial potassium channel.

Yan K., Gautam N. (1996) A domain on the G protein beta subunit interacts with both adenylyl cyclase 2 and the muscarinic atrial potassium channel. The Journal of biological chemistry, 271(30):17597-600.

Gautam Lab  PubMed


[Ca2+]i elevations detected by BK channels during Ca2+ influx and muscarine-mediated release of Ca2+ from intracellular stores in rat chromaffin cells.

Prakriya M., Solaro C.R., Lingle C.J. (1996) [Ca2+]i elevations detected by BK channels during Ca2+ influx and muscarine-mediated release of Ca2+ from intracellular stores in rat chromaffin cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 16(14):4344-59.

Lingle Lab  PubMed


Mechanisms of cell injury and death.

Cobb J.P., Hotchkiss R.S., Karl I.E., Buchman T.G. (1996) Mechanisms of cell injury and death. British journal of anaesthesia, 77(1):3-10.

Hotchkiss Lab  PubMed


Jugular bulb temperature: comparison with brain surface and core temperatures in neurosurgical patients during mild hypothermia.

Crowder C.M., Tempelhoff R., Theard M.A., Cheng M.A., Todorov A., Dacey Jr. R.G. (1996) Jugular bulb temperature: comparison with brain surface and core temperatures in neurosurgical patients during mild hypothermia. Journal of neurosurgery, 85(1):98-103.

 PubMed


Voltage dependence of mouse acetylcholine receptor gating: different charge movements in di-, mono- and unliganded receptors.

Auerbach A., Sigurdson W., Chen J., Akk G. (1996) Voltage dependence of mouse acetylcholine receptor gating: different charge movements in di-, mono- and unliganded receptors. The Journal of physiology, 494 ( Pt 1)():155-70.

Akk Lab  PubMed


Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase.

Spracklin D.K., Kharasch E.D. (1996) Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase. Chemical research in toxicology, 9(4):696-702.

Kharasch Lab  PubMed


P450-dependent and nonenzymatic human liver microsomal defluorination of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product.

Kharasch E.D., Hankins D.C. (1996) P450-dependent and nonenzymatic human liver microsomal defluorination of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product. Drug metabolism and disposition: the biological fate of chemicals, 24(6):649-54.

Kharasch Lab  PubMed


The hemodynamic and renal effects of sevoflurane and isoflurane in patients with coronary artery disease and chronic hypertension. Sevoflurane Ischemia Study Group.

Alec Rooke G., Ebert T., Muzi M., Kharasch E.D., Howard S., Eisenkraft J., Gold M., Marty J., Wong D., Thapar P., Harris A., Coriat P., Hantler C., Prys-Roberts C., Chelly J. (1996) The hemodynamic and renal effects of sevoflurane and isoflurane in patients with coronary artery disease and chronic hypertension. Sevoflurane Ischemia Study Group. Anesthesia and analgesia, 82(6):1159-65.

Kharasch Lab  PubMed


Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors.

Akk G., Auerbach A. (1996) Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors. Biophysical journal, 70(6):2652-8.

Akk Lab  PubMed


Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis.

Kharasch E.D., Hankins D., Mautz D., Thummel K.E. (1996) Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis. Lancet, 347(9012):1367-71.

Kharasch Lab  PubMed


Ability of nondepolarizing neuromuscular blocking drugs to act as partial agonists at fetal and adult mouse muscle nicotinic receptors.

Fletcher G.H., Steinbach J.H. (1996) Ability of nondepolarizing neuromuscular blocking drugs to act as partial agonists at fetal and adult mouse muscle nicotinic receptors. Molecular pharmacology, 49(5):938-47.

 PubMed


Differences in the expression of GABA(A) receptors between functionally innervated and non-innervated granule neurons in neonatal rat cerebellar cultures.

Ueno S., Zempel J.M., Steinbach J.H. (1996) Differences in the expression of GABA(A) receptors between functionally innervated and non-innervated granule neurons in neonatal rat cerebellar cultures. Brain research, 714(1-2):49-56.

 PubMed


Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families.

Yan K., Kalyanaraman V., Gautam N. (1996) Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. The Journal of biological chemistry, 271(12):7141-6.

Gautam Lab  PubMed


Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.

Jin L., Davis M.R., Kharasch E.D., Doss G.A., Baillie T.A. (1996) Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane. Chemical research in toxicology, 9(2):555-61.

Kharasch Lab  PubMed


Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers.

Mitra A.K., Thummel K.E., Kalhorn T.F., Kharasch E.D., Unadkat J.D., Slattery J.T. (1996) Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers. Clinical pharmacology and therapeutics, 59(3):332-40.

Kharasch Lab  PubMed


Calcium: a regulator of the inflammatory response in endotoxemia and sepsis.

Hotchkiss R.S., Karl I.E. (1996) Calcium: a regulator of the inflammatory response in endotoxemia and sepsis. New horizons (Baltimore, Md.), 4(1):58-71.

Hotchkiss Lab  PubMed


Calcium-activated potassium channels in adrenal chromaffin cells.

Lingle C.J., Solaro C.R., Prakriya M., Ding J.P. (1996) Calcium-activated potassium channels in adrenal chromaffin cells. Ion channels, 4():261-301.

Lingle Lab  PubMed


Metabolism and toxicity of the new anesthetic agents.

Kharasch E.D. (1996) Metabolism and toxicity of the new anesthetic agents. Acta anaesthesiologica Belgica, 47(1):7-14.

Kharasch Lab  PubMed