DBR Publications


Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1.

Garton K.J., Yuen P., Meinwald J., Thummel K.E., Kharasch E.D. (1995) Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1. Drug metabolism and disposition: the biological fate of chemicals, 23(12):1426-30.

Kharasch Lab  PubMed


Biotransformation of sevoflurane.

Kharasch E.D. (1995) Biotransformation of sevoflurane. Anesthesia and analgesia, 81(6 Suppl):S27-38.

Kharasch Lab  PubMed


Designing safer chemicals: predicting the rates of metabolism of halogenated alkanes.

Yin H., Anders M.W., Korzekwa K.R., Higgins L., Thummel K.E., Kharasch E.D., Jones J.P. (1995) Designing safer chemicals: predicting the rates of metabolism of halogenated alkanes. Proceedings of the National Academy of Sciences of the United States of America, 92(24):11076-80.

Kharasch Lab  PubMed


A brain-specific G protein gamma subunit.

Kalyanaraman S., Kalyanaraman V., Gautam N. (1995) A brain-specific G protein gamma subunit. Biochemical and biophysical research communications, 216(1):126-32.

Gautam Lab  PubMed


Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo.

Mitra A.K., Thummel K.E., Kalhorn T.F., Kharasch E.D., Unadkat J.D., Slattery J.T. (1995) Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo. Clinical pharmacology and therapeutics, 58(5):556-66.

Kharasch Lab  PubMed


Sepsis-induced acute lung injury is attenuated by selectin blockade following the onset of sepsis.

Ridings P.C., Bloomfield G.L., Holloway S., Windsor A.C.J., Jutila M.A., Fowler III A.A., Sugerman H.J., Barie P.S., Hotchkiss R.S. (1995) Sepsis-induced acute lung injury is attenuated by selectin blockade following the onset of sepsis. Archives of surgery (Chicago, Ill. : 1960), 130(11):1199-208.

Hotchkiss Lab  PubMed


Efficient interaction with a receptor requires a specific type of prenyl group on the G protein gamma subunit.

Kisselev O., Ermolaeva M., Gautam N. (1995) Efficient interaction with a receptor requires a specific type of prenyl group on the G protein gamma subunit. The Journal of biological chemistry, 270(43):25356-8.

Gautam Lab  PubMed


Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1.

Gereau IV R.W., Conn P.J. (1995) Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1. The Journal of neuroscience : the official journal of the Society for Neuroscience, 15(10):6879-89.

Gereau Lab  PubMed


Receptor-G protein coupling is established by a potential conformational switch in the beta gamma complex.

Kisselev O., Pronin A., Ermolaeva M., Gautam N. (1995) Receptor-G protein coupling is established by a potential conformational switch in the beta gamma complex. Proceedings of the National Academy of Sciences of the United States of America, 92(20):9102-6.

Gautam Lab  PubMed


Neonatal rat cerebellar granule and Purkinje neurons in culture express different GABAA receptors.

Zempel J.M., Steinbach J.H. (1995) Neonatal rat cerebellar granule and Purkinje neurons in culture express different GABAA receptors. The European journal of neuroscience, 7(9):1895-905.

 PubMed


A human calcium-activated potassium channel gene expressed in vascular smooth muscle.

McCobb D.P., Fowler N.L., Featherstone T., Lingle C.J., Saito M., Krause J.E., Salkoff L. (1995) A human calcium-activated potassium channel gene expressed in vascular smooth muscle. The American journal of physiology, 269(3 Pt 2):H767-77.

Lingle Lab  PubMed


Inactivating and noninactivating Ca(2+)- and voltage-dependent K+ current in rat adrenal chromaffin cells.

Solaro C.R., Prakriya M., Ding J.P., Lingle C.J. (1995) Inactivating and noninactivating Ca(2+)- and voltage-dependent K+ current in rat adrenal chromaffin cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 15(9):6110-23.

Lingle Lab  PubMed


Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating.

Chen J., Zhang Y., Akk G., Sine S., Auerbach A. (1995) Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating. Biophysical journal, 69(3):849-59.

Akk Lab  PubMed


Determination of intracellular calcium in vivo via fluorine-19 nuclear magnetic resonance spectroscopy.

Song S.-K., Hotchkiss R.S., Neil J., Morris Jr. P.E., Hsu C.Y., Ackerman J.J.H. (1995) Determination of intracellular calcium in vivo via fluorine-19 nuclear magnetic resonance spectroscopy. The American journal of physiology, 269(2 Pt 1):C318-22.

Hotchkiss Lab  PubMed


Sevoflurane, fluoride ion, and renal toxicity.

Tinker J.H., Baker M.T., Brown Jr. B.R., Kharasch E.D., Hankins D., Thummel K. (1995) Sevoflurane, fluoride ion, and renal toxicity. Anesthesiology, 83(1):232-5.

Kharasch Lab  PubMed


Successful pharmacologic treatment of massive atenolol overdose: sequential hemodynamics and plasma atenolol concentrations.

DeLima L.G.R., Kharasch E.D., Butler S. (1995) Successful pharmacologic treatment of massive atenolol overdose: sequential hemodynamics and plasma atenolol concentrations. Anesthesiology, 83(1):204-7.

Kharasch Lab  PubMed


Block by acetylcholine of mouse muscle nicotinic receptors, stably expressed in fibroblasts.

Maconochie D.J., Steinbach J.H. (1995) Block by acetylcholine of mouse muscle nicotinic receptors, stably expressed in fibroblasts. The Journal of general physiology, 106(1):113-47.

 PubMed


Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability.

Gereau IV R.W., Conn P.J. (1995) Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability. Journal of neurophysiology, 74(1):122-9.

Gereau Lab  PubMed


Clinical sevoflurane metabolism and disposition. II. The role of cytochrome P450 2E1 in fluoride and hexafluoroisopropanol formation.

Kharasch E.D., Armstrong A.S., Gunn K., Artru A., Cox K., Karol M.D. (1995) Clinical sevoflurane metabolism and disposition. II. The role of cytochrome P450 2E1 in fluoride and hexafluoroisopropanol formation. Anesthesiology, 82(6):1379-88.

Kharasch Lab  PubMed


Clinical sevoflurane metabolism and disposition. I. Sevoflurane and metabolite pharmacokinetics.

Kharasch E.D., Karol M.D., Lanni C., Sawchuk R. (1995) Clinical sevoflurane metabolism and disposition. I. Sevoflurane and metabolite pharmacokinetics. Anesthesiology, 82(6):1369-78.

Kharasch Lab  PubMed


The suppression of Ca(2+)- and voltage-dependent outward K+ current during mAChR activation in rat adrenal chromaffin cells.

Herrington J., Solaro C.R., Neely A., Lingle C.J. (1995) The suppression of Ca(2+)- and voltage-dependent outward K+ current during mAChR activation in rat adrenal chromaffin cells. The Journal of physiology, 485 ( Pt 2)():297-318.

Lingle Lab  PubMed


Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase.

Jin L., Baillie T.A., Davis M.R., Kharasch E.D. (1995) Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase. Biochemical and biophysical research communications, 210(2):498-506.

Kharasch Lab  PubMed


Calcium antagonists decrease plasma and tissue concentrations of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-1 alpha in a mouse model of endotoxin.

Hotchkiss R.S., Osborne D.F., Lappas G.D., Karl I.E. (1995) Calcium antagonists decrease plasma and tissue concentrations of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-1 alpha in a mouse model of endotoxin. Shock (Augusta, Ga.), 3(5):337-42.

Hotchkiss Lab  PubMed


Selection of stably transfected cells expressing a high level of fetal muscle nicotinic receptors.

Chen Q., Fletcher G.H., Steinbach J.H. (1995) Selection of stably transfected cells expressing a high level of fetal muscle nicotinic receptors. Journal of neuroscience research, 40(5):606-12.

 PubMed


Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism.

Labroo R.B., Thummel K.E., Kunze K.L., Podoll T., Trager W.F., Kharasch E.D. (1995) Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism. Drug metabolism and disposition: the biological fate of chemicals, 23(4):490-6.

Kharasch Lab  PubMed


Volatile anesthetic actions on contractile proteins in membrane-permeabilized small mesenteric arteries.

Akata T., Boyle III W.A. (1995) Volatile anesthetic actions on contractile proteins in membrane-permeabilized small mesenteric arteries. Anesthesiology, 82(3):700-12.

Boyle Lab  PubMed


Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity.

Kharasch E.D., Hankins D.C., Thummel K.E. (1995) Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. Anesthesiology, 82(3):689-99.

Kharasch Lab  PubMed


Pharmacological differentiation of the effects of co-activation of beta-adrenergic and metabotropic glutamate receptors in rat hippocampus.

Gereau IV R.W., Winder D.G., Conn P.J. (1995) Pharmacological differentiation of the effects of co-activation of beta-adrenergic and metabotropic glutamate receptors in rat hippocampus. Neuroscience letters, 186(2-3):119-22.

Gereau Lab  PubMed


The conductance of the muscle nicotinic receptor channel changes rapidly upon gating.

Maconochie D.J., Fletcher G.H., Steinbach J.H. (1995) The conductance of the muscle nicotinic receptor channel changes rapidly upon gating. Biophysical journal, 68(2):483-90.

 PubMed


Brachytherapy-related complications for medically inoperable stage I endometrial carcinoma.

Chao C.K.S. (1995) Brachytherapy-related complications for medically inoperable stage I endometrial carcinoma. International journal of radiation oncology, biology, physics, 31(1):37-42.

Boyle Lab  PubMed


Description of a 700-kb yeast artificial chromosome contig containing the BCL1 translocation breakpoint region at 11q13.

Szepetowski P., Perucca-Lostanlen D., Grosgeorge J., LePaslier D., Brownstein B.H., Carle G.F., Gaudray P. (1995) Description of a 700-kb yeast artificial chromosome contig containing the BCL1 translocation breakpoint region at 11q13. Cytogenetics and cell genetics, 69(1-2):101-7.

Hotchkiss Lab  PubMed


Endothelium-independent vasoconstricting and vasodilating actions of halothane on rat mesenteric resistance blood vessels.

Boyle III W.A., Maher G.M. (1995) Endothelium-independent vasoconstricting and vasodilating actions of halothane on rat mesenteric resistance blood vessels. Anesthesiology, 82(1):221-35.

Boyle Lab  PubMed


Effects of volatile anesthetics on acetylcholine-induced relaxation in the rabbit mesenteric resistance artery.

Akata T., Nakashima M., Kodama K., Boyle III W.A., Takahashi S. (1995) Effects of volatile anesthetics on acetylcholine-induced relaxation in the rabbit mesenteric resistance artery. Anesthesiology, 82(1):188-204.

Boyle Lab  PubMed


Antagonist and partial agonist actions of d-tubocurarine at mammalian muscle acetylcholine receptors.

Steinbach J.H., Chen Q. (1995) Antagonist and partial agonist actions of d-tubocurarine at mammalian muscle acetylcholine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 15(1 Pt 1):230-40.

 PubMed