DBR Publications


Hyperthermia protects mice against the lethal effects of endotoxin.

Hotchkiss R., Nunnally I., Lindquist S., Taulien J., Perdrizet G., Karl I. (1993) Hyperthermia protects mice against the lethal effects of endotoxin. The American journal of physiology, 265(6 Pt 2):R1447-57.

Hotchkiss Lab  PubMed


Specific interaction with rhodopsin is dependent on the gamma subunit type in a G protein.

Kisselev O., Gautam N. (1993) Specific interaction with rhodopsin is dependent on the gamma subunit type in a G protein. The Journal of biological chemistry, 268(33):24519-22.

Gautam Lab  PubMed


Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.

Kharasch E.D., Thummel K.E. (1993) Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology, 79(4):795-807.

Kharasch Lab  PubMed


Proper processing of a G protein gamma subunit depends on complex formation with a beta subunit.

Pronin A.N., Gautam N. (1993) Proper processing of a G protein gamma subunit depends on complex formation with a beta subunit. FEBS letters, 328(1-2):89-93.

Gautam Lab  PubMed


Effect of sepsis on brain energy metabolism in normoxic and hypoxic rats.

Hotchkiss R.S., Rust R.S., Song S.-K., Ackerman J.J.H. (1993) Effect of sepsis on brain energy metabolism in normoxic and hypoxic rats. Circulatory shock, 40(4):303-10.

Hotchkiss Lab  PubMed


Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin kappa locus.

Davies N.P., Rosewell I.R., Richardson J.C., Cook G.P., Neuberger M.S., Brownstein B.H., Norris M.L., Bruggemann M. (1993) Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin kappa locus. Bio/technology (Nature Publishing Company), 11(8):911-4.

Hotchkiss Lab  PubMed


Volatile anesthetics compete for common binding sites on bovine serum albumin: a 19F-NMR study.

Dubois B.W., Cherian S.F., Evers A.S. (1993) Volatile anesthetics compete for common binding sites on bovine serum albumin: a 19F-NMR study. Proceedings of the National Academy of Sciences of the United States of America, 90(14):6478-82.

Evers Lab  PubMed


Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1.

Kharasch E.D., Thummel K.E., Mhyre J., Lillibridge J.H. (1993) Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1. Clinical pharmacology and therapeutics, 53(6):643-50.

Kharasch Lab  PubMed


"Caged" phenylephrine: development and application to probe the mechanism of alpha-receptor-mediated vasoconstriction.

Muralidharan S., Maher G.M., Boyle W.A., Nerbonne J.M. (1993) "Caged" phenylephrine: development and application to probe the mechanism of alpha-receptor-mediated vasoconstriction. Proceedings of the National Academy of Sciences of the United States of America, 90(11):5199-203.

Boyle Lab  PubMed


Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?

Kharasch E.D., Thummel K.E. (1993) Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance? Anesthesia and analgesia, 76(5):1033-9.

Kharasch Lab  PubMed


Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis?

Song S.-K., Karl I.E., Ackerman J.J.H., Hotchkiss R.S. (1993) Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis? Proceedings of the National Academy of Sciences of the United States of America, 90(9):3933-7.

Hotchkiss Lab  PubMed


Activation of nicotinic acetylcholine receptors on cultured Drosophila and other insect neurones.

Albert J.L., Lingle C.J. (1993) Activation of nicotinic acetylcholine receptors on cultured Drosophila and other insect neurones. The Journal of physiology, 463():605-30.

Lingle Lab  PubMed


Modulation of acetylcholine-elicited currents in clonal rat phaeochromocytoma (PC12) cells by internal polyphosphates.

Ifune C.K., Steinbach J.H. (1993) Modulation of acetylcholine-elicited currents in clonal rat phaeochromocytoma (PC12) cells by internal polyphosphates. The Journal of physiology, 463():431-47.

Steinbach Lab  PubMed


Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1.

Thummel K.E., Kharasch E.D., Podoll T., Kunze K. (1993) Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1. Drug metabolism and disposition: the biological fate of chemicals, 21(2):350-7.

Kharasch Lab  PubMed


Direct observation of a fluorinated anticonvulsant in brain tissue using 19F-NMR techniques.

Canney D.J., Covey D.F., Evers A.S. (1993) Direct observation of a fluorinated anticonvulsant in brain tissue using 19F-NMR techniques. Biochemical pharmacology, 45(4):949-59.

Evers Lab  PubMed


Effect of progesterone on serotonin turnover in rats primed with estrogen implants into the ventromedial hypothalamus.

Gereau IV R.W., Kedzie K.A., Renner K.J. (1993) Effect of progesterone on serotonin turnover in rats primed with estrogen implants into the ventromedial hypothalamus. Brain research bulletin, 32(3):293-300.

Gereau Lab  PubMed