DBR Publications


Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics.

Noh KN, Park SI, Qazi R, Zou Z, Mickle AD, Grajales-Reyes JG, Jang KI, Gereau RW 4th, Xiao J, Rogers JA  (2017) Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics. Small (Weinheim an der Bergstrasse, Germany), ():.

Gereau Lab  PubMed


Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain.

Samineni VK, Mickle AD, Yoon J, Grajales-Reyes JG, Pullen MY, Crawford KE, Noh KN, Gereau GB, Vogt SK, Lai HH  (2017) Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain. Scientific reports, 7(1):15865.

Gereau Lab  PubMed


Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch.

Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS.  (2017) Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. Cell, 171(1):217-228.

Gereau Lab  PubMed


Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain.

Sheahan TD, Siuda ER, Bruchas MR, Shepherd AJ, Mohapatra DP, Gereau RW 4th, Golden JP  (2017) Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain. Neurobiology of pain (Elsevier), 2():1-12.

Gereau Lab  PubMed


The dynamic interaction between pain and opioid misuse.

Wilson-Poe AR, Moron JA,  (2017) The dynamic interaction between pain and opioid misuse. British journal of pharmacology, ():.

Moron-Concepcion Lab  PubMed


Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics.

Samineni VK, Yoon J, Crawford KE, Jeong YR, McKenzie KC, Shin G, Xie Z, Sundaram SS, Li Y, Yang MY, Kim J, Wu D, Xue Y, Feng X, Huang Y, Mickle AD, Banks A, Ha JS, Golden JP, Rogers JA, Gereau RW 4th  (2017) Fully implantable, battery-free wireless optoelectronic devices for spinal optogenetics. Pain, 158(11):2108-2116.

Gereau Lab  PubMed


Anti-VEGF treatment decreases bladder pain in cyclophosphamide cystitis - a MAPP Research Network Animal Model Study.

Lai HH, Shen B, Vijairania P, Xiaowei Z, Vogt SK, Gereau RW 4th  (2017) Anti-VEGF treatment decreases bladder pain in cyclophosphamide cystitis - a MAPP Research Network Animal Model Study. BJU international, ():.

Gereau Lab  PubMed


Reply to comment on: Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.

Horst J, Kharasch ED, {Authors/Author/Name#4}  (2017) Reply to comment on: Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease. Pediatric blood & cancer, 64(5):.

Kharasch Lab  PubMed


A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome.

Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC  (2017) A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome. Critical care medicine, 45(4):645-652.

Hotchkiss Lab  PubMed


Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study.

Lai HH, Jemielita T, Sutcliffe S, Bradley CS, Naliboff B, Williams DA, Gereau RW 4th, Kreder K, Clemens JQ, Rodriguez LV  (2017) Characterization of Whole Body Pain in Urological Chronic Pelvic Pain Syndrome at Baseline: A MAPP Research Network Study. The Journal of urology, ():.

Gereau Lab  PubMed


Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray.

Samineni VK, Grajales-Reyes JG, Copits BA, O'Brien DE, Trigg SL, Gomez AM, Bruchas MR, Gereau RW 4th  (2017) Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray. eNeuro, 4(2):.

Gereau Lab  PubMed


Single Molecule Force Spectroscopy to Compare Natural versus Artificial Antibody-Antigen Interaction.

Wang C, Hu R, Morrissey JJ, Kharasch ED, Singamaneni S  (2017) Single Molecule Force Spectroscopy to Compare Natural versus Artificial Antibody-Antigen Interaction. Small (Weinheim an der Bergstrasse, Germany), ():.

Kharasch Lab  PubMed


Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain.

Teitelbaum AM, Murphy SE, Akk G, Baker TB, Germann A, von Weymarn LB, Bierut LJ, Goate A, Kharasch ED, Bloom AJ  (2017) Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. The pharmacogenomics journal, ():.

Akk Lab Kharasch Lab  PubMed


The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic α4β2 Receptors.

Jin X, McCollum MM, Germann AL, Akk G, Steinbach JH (2017) The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic α4β2 Receptors. Molecular pharmacology, 91(2):100-109.

Akk Lab  PubMed


Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics.

Shin G, Gomez AM, Al-Hasani R, Jeong YR, Kim J, Xie Z, Banks A, Lee SM, Han SY, Yoo CJ, Lee JL, Lee SH, Kurniawan J, Tureb J, Guo Z, Yoon J, Park SI, Bang SY, Nam Y, Walicki MC, Samineni VK, Mickle AD, Lee K, Heo SY, McCall JG, Pan T, Wang L, Feng X, Kim TI, Kim JK, Li Y, Huang Y, Gereau RW, Ha JS, Bruchas MR, Rogers JA (2017) Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics. Neuron, 93(3):509-521.

Gereau Lab Bruchas Lab  PubMed


Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics.

Park SI, Shin G, McCall JG, Al-Hasani R, Norris A, Xia L, Brenner DS, Noh KN, Bang SY, Bhatti DL, Jang KI, Kang SK, Mickle AD, Dussor G, Price TJ, Gereau RW 4th, Bruchas MR, Rogers JA. (2016) Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics. Proceedings of the National Academy of Sciences of the United States of America, 113(50):E8169-E8177.

Gereau Lab Bruchas Lab  PubMed


A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System.

Massaly N, Morón JA, Al-Hasani R (2016) A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System. Frontiers in neuroscience, 10():480.

Moron-Concepcion Lab  PubMed


Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities

Cabanero D, Irie T, Celorrio M, Trousdale C, Owens DM, Virley D, Albrecht PH, Caterina MJ, Rice FL, Moron JA (2016) Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities PAIN Reports, ():.

Moron-Concepcion Lab  PubMed


Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1.

Patera AC, Drewry AM, Chang K, Beiter ER, Osborne D, Hotchkiss RS (2016) Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1. Journal of leukocyte biology, ():.

Hotchkiss Lab  PubMed


Stress-Induced Reinstatement of Nicotine Preference Requires Dynorphin/Kappa Opioid Activity in the Basolateral Amygdala.

Nygard SK, Hourguettes NJ, Sobczak GG, Carlezon WA, Bruchas MR (2016) Stress-Induced Reinstatement of Nicotine Preference Requires Dynorphin/Kappa Opioid Activity in the Basolateral Amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(38):9937-48.

Bruchas Lab  PubMed


PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity.

Luan J, Liu KK, Tadepalli S, Jiang Q, Morrissey JJ, Kharasch ED, Singamaneni S (2016) PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity. ACS applied materials & interfaces, 8(36):23509-16.

Kharasch Lab  PubMed


Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia.

Shindo Y, Fuchs AG, Davis CG, Eitas T, Unsinger J, Burnham CD, Green JM, Morre M, Bochicchio GV, Hotchkiss RS (2016) Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia. Journal of leukocyte biology, ():.

Hotchkiss Lab  PubMed


Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures.

Valtcheva MV, Copits BA, Davidson S, Sheahan TD, Pullen MY, McCall JG, Dikranian K, Gereau RW 4th (2016) Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures. Nature Protocols, 11(10):1877-88.

Gereau Lab  PubMed


Synthesis and Characteristics of FePt Nanoparticle Films Under In Situ-Applied Magnetic Field.

Qian X, Gao MY, Li AD, Zhou XY, Liu XJ, Cao YQ, Li C, Wu D (2016) Synthesis and Characteristics of FePt Nanoparticle Films Under In Situ-Applied Magnetic Field. Nanoscale research letters, 11(1):325.

Cao Lab  PubMed


Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.

Horst J, Frei-Jones M, Deych E, Shannon W, Kharasch ED (2016) Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease. Pediatric blood & cancer, ():.

Kharasch Lab  PubMed


Silk-Encapsulated Plasmonic Biochips with Enhanced Thermal Stability.

Wang C, Luan J, Tadepalli S, Liu KK, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S (2016) Silk-Encapsulated Plasmonic Biochips with Enhanced Thermal Stability. ACS applied materials & interfaces, ():.

Kharasch Lab  PubMed


CASE 8-2016 Percutaneous Fetal Cardiac Intervention for Severe Aortic Stenosis and Evolving Hypoplastic Left-Heart Syndrome.

Ferschl MB, Moon-Grady AJ, Rollins MD, Gilliss B, Schulman SR, Tulzer G, Stohl S, Ginosar Y (2016) CASE 8-2016 Percutaneous Fetal Cardiac Intervention for Severe Aortic Stenosis and Evolving Hypoplastic Left-Heart Syndrome. Journal of cardiothoracic and vascular anesthesia, 30(4):1118-28.

Ginosar Lab  PubMed


In Reply.

Avidan MS, Evers AS (2016) In Reply. Anesthesiology, 125(2):428-9.

Evers Lab  PubMed


Development, validation and application of a comprehensive stereoselective LC/MS-MS assay for bupropion and oxidative, reductive, and glucuronide metabolites in human urine.

Teitelbaum AM, Flaker AM, Kharasch ED (2016) Development, validation and application of a comprehensive stereoselective LC/MS-MS assay for bupropion and oxidative, reductive, and glucuronide metabolites in human urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1027():239-53.

Kharasch Lab  PubMed


Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol.

Germann AL, Shin DJ, Manion BD, Edge CJ, Smith EH, Franks NP, Evers AS, Akk G (2016) Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol. British journal of pharmacology, 173(21):3110-3120.

Akk Lab Evers Lab  PubMed


Chemogenetic and Optogenetic Activation of Gαs Signaling in the Basolateral Amygdala Induces Acute and Social Anxiety-Like States.

Siuda ER, Al-Hasani R, McCall JG, Bhatti DL, Bruchas MR (2016) Chemogenetic and Optogenetic Activation of Gαs Signaling in the Basolateral Amygdala Induces Acute and Social Anxiety-Like States. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology, 41(8):2011-23.

Bruchas Lab  PubMed


Changes: Thank You, Dr. Eisenach.

Kharasch ED, Tedeschi V, Kendall G (2016) Changes: Thank You, Dr. Eisenach. Anesthesiology, 125(1):1-3.

Kharasch Lab  PubMed


Changes: Handing Off and the Future of ANESTHESIOLOGY.

Kharasch ED (2016) Changes: Handing Off and the Future of ANESTHESIOLOGY. Anesthesiology, 125(1):4-6.

Kharasch Lab  PubMed


Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans.

Reis Rodrigues P, Kaul TK, Ho JH, Lucanic M, Burkewitz K, Mair WB, Held JM, Bohn LM, Gill MS (2016) Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans. G3 (Bethesda, Md.), 6(6):1695-705.

Held Lab  PubMed


Architectural Representation of Valence in the Limbic System.

Namburi P, Al-Hasani R, Calhoon GG, Bruchas MR, Tye KM (2016) Architectural Representation of Valence in the Limbic System. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41(7):1697-715.

Bruchas Lab  PubMed


Is this critically ill patient immunocompromised?

Pène F, Pickkers P, Hotchkiss RS (2016) Is this critically ill patient immunocompromised? Intensive care medicine, 42(6):1051-4.

Hotchkiss Lab  PubMed


Erratum to: Is this critically ill patient immunocompromised?

Pène F, Pickkers P, Hotchkiss RS (2016) Erratum to: Is this critically ill patient immunocompromised? Intensive care medicine, 42(6):1106.

Hotchkiss Lab  PubMed


Group II mGluRs suppress hyperexcitability in mouse and human nociceptors.

Davidson S, Golden JP, Copits BA, Ray PR, Vogt SK, Valtcheva MV, Schmidt RE, Ghetti A, Price T, Gereau RW 4th (2016) Group II mGluRs suppress hyperexcitability in mouse and human nociceptors. Pain, 157(9):2081-8.

Gereau Lab  PubMed


Spotlight on pain: optogenetic approaches for interrogating somatosensory circuits.

Copits BA, Pullen MY, Gereau RW 4th (2016) Spotlight on pain: optogenetic approaches for interrogating somatosensory circuits. Pain, 157(11):2424-2433..

Gereau Lab  PubMed


Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons.

Fakira AK, Massaly N, Cohensedgh O, Berman A, Morón JA (2016) Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, ():.

Moron-Concepcion Lab  PubMed


The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1.

Shutov LP, Warwick CA, Shi X, Gnanasekaran A, Shepherd AJ, Mohapatra DP, Woodruff TM, Clark JD, Usachev YM (2016) The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(18):5055-70.

Mohapatra Lab  PubMed


A Novel Proliposomal Ropivacaine Oil: Pharmacokinetic-Pharmacodynamic Studies After Subcutaneous Administration in Pigs.

Davidson EM, Haroutounian S, Kagan L, Naveh M, Aharon A, Ginosar Y (2016) A Novel Proliposomal Ropivacaine Oil: Pharmacokinetic-Pharmacodynamic Studies After Subcutaneous Administration in Pigs. Anesthesia and analgesia, 122(5):1663-72.

Ginosar Lab  PubMed


Proliposomal Ropivacaine Oil: Pharmacokinetic and Pharmacodynamic Data After Subcutaneous Administration in Volunteers.

Ginosar Y, Haroutounian S, Kagan L, Naveh M, Aharon A, Davidson EM (2016) Proliposomal Ropivacaine Oil: Pharmacokinetic and Pharmacodynamic Data After Subcutaneous Administration in Volunteers. Anesthesia and analgesia, 122(5):1673-80.

Ginosar Lab  PubMed


Gestational sleep apnea: have we been caught napping?

Karan S, Ginosar Y (2016) Gestational sleep apnea: have we been caught napping? International journal of obstetric anesthesia, 26():1-3.

Ginosar Lab  PubMed


The GAS trial.

Orser BA, Evers AS, Suresh S, Hertz S (2016) The GAS trial. Lancet (London, England), 387(10028):1613-4.

Evers Lab  PubMed


Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications.

Fuller BM, Ferguson I, Mohr NM, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH (2016) Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications. BMJ open, 6(4):e010991.

Hotchkiss Lab  PubMed


Characterization of a mouse model of headache.

Huang D, Ren L, Qiu CS, Liu P, Peterson J, Yanagawa Y, Cao YQ (2016) Characterization of a mouse model of headache. Pain, ():.

Cao Lab  PubMed


New Technologies for Elucidating Opioid Receptor Function.

Bruchas MR, Roth BL (2016) New Technologies for Elucidating Opioid Receptor Function. Trends in pharmacological sciences, 37(4):279-89.

Bruchas Lab  PubMed


Understanding why clinicians should care about danger-associated molecular patterns.

Asehnoune K, Hotchkiss RS, Monneret G (2016) Understanding why clinicians should care about danger-associated molecular patterns. Intensive care medicine, 42(4):611-4.

Hotchkiss Lab  PubMed


Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury.

Welch TP, Wallendorf MJ, Kharasch ED, Leonard JR, Doctor A, Pineda JA (2016) Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury. Critical care medicine, 44(4):809-18.

Kharasch Lab  PubMed


Perioperative Opioids and Public Health.

Kharasch ED, Brunt LM (2016) Perioperative Opioids and Public Health. Anesthesiology, 124(4):960-5.

Kharasch Lab  PubMed


Development and validation of a high-throughput stereoselective LC-MS/MS assay for bupropion, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion in human plasma.

Teitelbaum AM, Flaker AM, Kharasch ED (2016) Development and validation of a high-throughput stereoselective LC-MS/MS assay for bupropion, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1017-1018():101-13.

Kharasch Lab  PubMed


Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit.

Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ (2016) Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Cell reports, 14(12):2774-83.

Bruchas Lab  PubMed


Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration.

O'Neill PR, Kalyanaraman V, Gautam N (2016) Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration. Molecular biology of the cell, ():E15-12-0832. [Epub ahead of print].

Gautam Lab  PubMed


The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315(8):801-10.

Hotchkiss Lab  PubMed


The Effect of Medicinal Cannabis on Pain and Quality of Life Outcomes in Chronic Pain: A Prospective Open-label Study.

Haroutounian S, Ratz Y, Ginosar Y, Furmanov K, Saifi F, Meidan R, Davidson E (2016) The Effect of Medicinal Cannabis on Pain and Quality of Life Outcomes in Chronic Pain: A Prospective Open-label Study. The Clinical journal of pain, ():.

Ginosar Lab  PubMed


Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.

Eaton MM, Germann AL, Arora R, Cao LQ, Gao X, Shin DJ, Wu A, Chiara DC, Cohen JB, Steinbach JH (2016) Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol. Current neuropharmacology, 14(7):772-780.

Akk Lab Evers Lab  PubMed


Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.

Gupte RP, Kadunganattil S, Shepherd AJ, Merrill R, Planer W, Bruchas MR, Strack S, Mohapatra DP (2016) Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide. Neuropharmacology, 101():291-308.

Bruchas Lab Mohapatra Lab  PubMed


The Fallacy of Persistent Postoperative Cognitive Decline.

Avidan MS, Evers AS (2016) The Fallacy of Persistent Postoperative Cognitive Decline. Anesthesiology, 124(2):255-8.

Evers Lab  PubMed


T cells from patients with Candida sepsis display a suppressive immunophenotype.

Spec A, Shindo Y, Burnham CA, Wilson S, Ablordeppey EA, Beiter ER, Chang K, Drewry AM, Hotchkiss RS (2016) T cells from patients with Candida sepsis display a suppressive immunophenotype. Critical care (London, England), 20():15.

Hotchkiss Lab  PubMed


Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABAA Receptors.

Chakrabarti S, Qian M, Krishnan K, Covey DF, Mennerick S, Akk G (2016) Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABAA Receptors. Molecular pharmacology, 89(4):399-406.

Akk Lab  PubMed


Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J. (2016) Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Science signaling, 9(410):ra5.

Moron-Concepcion Lab  PubMed


Surgeon-Performed Hemodynamic Transesophageal Echocardiography in the Burn Intensive Care Unit.

Held JM, Litt J, Kennedy JD, McGrane S, Gunter OL, Rae L, Kahn SA (2016) Surgeon-Performed Hemodynamic Transesophageal Echocardiography in the Burn Intensive Care Unit. Journal of burn care & research : official publication of the American Burn Association, 37(1):e63-8.

Held Lab  PubMed


Wherefore Gabapentinoids?: Was There Rush Too Soon to Judgment?

Kharasch ED, Eisenach JC (2016) Wherefore Gabapentinoids?: Was There Rush Too Soon to Judgment? Anesthesiology, 124(1):10-2.

Kharasch Lab  PubMed


Introduced Amino Terminal Epitopes Can Reduce Surface Expression of Neuronal Nicotinic Receptors.

Bracamontes JR, Akk G, Steinbach JH (2016) Introduced Amino Terminal Epitopes Can Reduce Surface Expression of Neuronal Nicotinic Receptors. PloS one, 11(3):e0151071.

Akk Lab  PubMed


Effect of HAART on Brain Organization and Function in HIV-Negative Subjects.

Brier MR, Wu Q, Tanenbaum AB, Westerhaus ET, Kharasch ED, Ances BM (2015) Effect of HAART on Brain Organization and Function in HIV-Negative Subjects. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 10(4):517-21.

Kharasch Lab  PubMed


Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.

Martinez-Espinosa PL, Wu J, Yang C, Gonzalez-Perez V, Zhou H, Liang H, Xia XM, Lingle CJ (2015) Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. eLife, 4():.

Lingle Lab  PubMed


Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices.

Tadepalli S, Kuang Z, Jiang Q, Liu KK, Fisher MA, Morrissey JJ, Kharasch ED, Slocik JM, Naik RR, Singamaneni S (2015) Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices. Scientific reports, 5():16206.

Kharasch Lab  PubMed


Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics.

Park SI, Brenner DS, Shin G, Morgan CD, Copits BA, Chung HU, Pullen MY, Noh KN, Davidson S, Oh SJ, Yoon J, Jank KI, Samineni VK, Norman M, Grajales-Reyes JG, Vogt SK, Sundaram SS, Wilson KM, Ha JS, Xu R, Pan T, Kim TI, Huan Y, Montana MC, Golden JP, Bruchas MR, Gereau RW, Rogers JA (2015) Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics. Nature Biotechnology, 33(12):1280-1286.

Gereau Lab Bruchas Lab  PubMed


Imaging Apoptosis in Sepsis--A Technology We Would Die for!

Hotchkiss RS, Crouser E (2015) Imaging Apoptosis in Sepsis--A Technology We Would Die for! Critical care medicine, 43(11):2506-8.

Hotchkiss Lab  PubMed


The authors reply.

Drewry AM, Fuller BM, Skrupky LP, Hotchkiss RS (2015) The authors reply. Critical care medicine, 43(11):e529-30.

Hotchkiss Lab  PubMed


Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism.

Kharasch ED, Regina KJ, Blood J, Friedel C (2015) Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism. Anesthesiology, 123(5):1142-53.

Kharasch Lab  PubMed


Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows.

Schilling B, MacLean B, Held JM, Sahu AK, Rardin MJ, Sorensen DJ, Peters T, Wolfe AJ, Hunter CL, MacCoss MJ (2015) Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows. Analytical chemistry, 87(20):10222-9.

Held Lab  PubMed


Ultraminiaturized photovoltaic and radio frequency powered optoelectronic systems for wireless optogenetics.

Park SI, Shin G, Banks A, McCall JG, Siuda ER, Schmidt MJ, Chung HU, Noh KN, Mun JG, Rhodes J (2015) Ultraminiaturized photovoltaic and radio frequency powered optoelectronic systems for wireless optogenetics. Journal of neural engineering, 12(5):056002.

Bruchas Lab  PubMed


Optodynamic simulation of β-adrenergic receptor signalling.

Siuda ER, McCall JG, Al-Hasani R, Shin G, Il Park S, Schmidt MJ, Anderson SL, Planer WJ, Rogers JA, Bruchas MR (2015) Optodynamic simulation of β-adrenergic receptor signalling. Nature communications, 6():8480.

Bruchas Lab  PubMed


Optimizing optogenetic constructs for control over signaling and cell behaviours.

O'Neill PR, Gautam N (2015) Optimizing optogenetic constructs for control over signaling and cell behaviours. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 14(9):1578-85.

Gautam Lab  PubMed


Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating.

Gonzalez-Perez V, Xia XM, Lingle CJ (2015) Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating. Nature communications, 6():8341.

Lingle Lab  PubMed


Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.

Eaton MM, Cao LQ, Chen Z, Franks NP, Evers AS, Akk G (2015) Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors. Molecular pharmacology, 88(4):736-45.

Akk Lab Evers Lab  PubMed


Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward.

Al-Hasani R, McCall JG, Shin G, Gomez AM, Schmitz GP, Bernardi JM, Pyo CO, Park SI, Marcinkiewcz CM, Crowley NA (2015) Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward. Neuron, 87(5):1063-77.

Bruchas Lab  PubMed


Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors.

Hipólito L, Wilson-Poe A, Campos-Jurado Y, Zhong E, Gonzalez-Romero J, Virag L, Whittington R, Comer SD, Carlton SM, Walker BM (2015) Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area μ Opioid Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(35):12217-31.

Moron-Concepcion Lab  PubMed


Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking.

Mickle AD, Shepherd AJ, Loo L, Mohapatra DP (2015) Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking. Pain, 156(9):1620-36.

Mohapatra Lab  PubMed


Effectiveness of Minocycline and Rifampin vs Chlorhexidine and Silver Sulfadiazine-Impregnated Central Venous Catheters in Preventing Central Line-Associated Bloodstream Infection in a High-Volume Academic Intensive Care Unit: A Before and after Trial.

Bonne S, Mazuski JE, Sona C, Schallom M, Boyle W, Buchman TG, Bochicchio GV, Coopersmith CM, Schuerer DJ (2015) Effectiveness of Minocycline and Rifampin vs Chlorhexidine and Silver Sulfadiazine-Impregnated Central Venous Catheters in Preventing Central Line-Associated Bloodstream Infection in a High-Volume Academic Intensive Care Unit: A Before and after Trial. Journal of the American College of Surgeons, 221(3):739-47.

Boyle Lab  PubMed


Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor.

Chang SD, Mascarella SW, Spangler SM, Gurevich VV, Navarro HA, Carroll FI, Bruchas MR (2015) Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor. Molecular pharmacology, 88(3):502-11.

Bruchas Lab  PubMed


CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety.

McCall JG, Al-Hasani R, Siuda ER, Hong DY, Norris AJ, Ford CP, Bruchas MR (2015) CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety. Neuron, 87(3):605-20.

Bruchas Lab  PubMed


Evidence of CNIH3 involvement in opioid dependence.

Nelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH.,Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, Gordon S, Henders AK, Hesselbrock V, Kapoor M, Lynskey MT, Madden PA, Moron JA, Rice JP, Saccone NL, Schwab SG, Shand FL, Todorov AA, Wallace L, Wang T, Wray NR, Zhou X, Degenhardt L, Martin NG, Hariri AR, Kranzler HR, Gelernter J, Bierut LJ, Clark DJ, Montgomery GW. (2015) Evidence of CNIH3 involvement in opioid dependence. Molecular psychiatry, ():.

Moron-Concepcion Lab  PubMed


Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics.

Jeong JW, McCall JG, Shin G, Zhang Y, Al-Hasani R, Kim M, Li S, Sim JY, Jang KI, Shi Y (2015) Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics. Cell, 162(3):662-74.

Bruchas Lab  PubMed


Animal Models of Urologic Chronic Pelvic Pain Syndromes: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network.

Lai H, Gereau RW 4th, Luo Y, O'Donnell M, Rudick CN, Pontari M, Mullins C, Klumpp DJ. (2015) Animal Models of Urologic Chronic Pelvic Pain Syndromes: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network. Urology, 85(6):1454-65.

Gereau Lab  PubMed


Bio-Enabled Gold Superstructures with Built-In and Accessible Electromagnetic Hotspots.

Tian L, Fei M, Tadepalli S, Morrissey JJ, Kharasch ED, Singamaneni S (2015) Bio-Enabled Gold Superstructures with Built-In and Accessible Electromagnetic Hotspots. Advanced healthcare materials, 4(10):1502-9, 1423.

Kharasch Lab  PubMed


Differences in Methadone Metabolism by CYP2B6 Variants.

Gadel S, Friedel C, Kharasch ED (2015) Differences in Methadone Metabolism by CYP2B6 Variants. Drug metabolism and disposition: the biological fate of chemicals, 43(7):994-1001.

Kharasch Lab  PubMed


Function and postnatal changes of dural afferent fibers expressing TRPM8 channels.

Ren L, Dhaka A, Cao YQ (2015) Function and postnatal changes of dural afferent fibers expressing TRPM8 channels. Molecular pain, 11(1):37.

Cao Lab  PubMed


ERK2 Alone Drives Inflammatory Pain But Cooperates with ERK1 in Sensory Neuron Survival.

O'Brien DE, Alter BJ, Satomoto M, Morgan CD, Davidson S, Vogt SK, Norman ME, Gereau GB, Demaro JA 3rd, Landreth GE, Golden JG, Gereau RW 4th (2015) ERK2 Alone Drives Inflammatory Pain But Cooperates with ERK1 in Sensory Neuron Survival. The Journal of Neuroscience, 35(25):9491-507.

Gereau Lab  PubMed


The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia.

Drewry AM, Fuller BM, Skrupky LP, Hotchkiss RS (2015) The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia. Critical care medicine, 43(6):1165-9.

Hotchkiss Lab  PubMed


Sepsis: Revising definitions of sepsis.

Drewry AM, Hotchkiss RS (2015) Sepsis: Revising definitions of sepsis. Nature reviews. Nephrology, 11(6):326-8.

Hotchkiss Lab  PubMed


The hematological effects of nitrous oxide anesthesia in pediatric patients.

Duma A, Cartmill C, Blood J, Sharma A, Kharasch ED, Nagele P (2015) The hematological effects of nitrous oxide anesthesia in pediatric patients. Anesthesia and analgesia, 120(6):1325-30.

Kharasch Lab  PubMed


Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.

Gallo EF, Salling MC, Feng B, Morón JA, Harrison NL, Javitch JA, Kellendonk C (2015) Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(7):1609-18.

Moron-Concepcion Lab  PubMed


Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.

Gallo EF, Salling MC, Feng B, Morón JA, Harrison NL, Javitch JA, Kellendonk C (2015) Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(7):1609-18.

 PubMed


Influence of HIV antiretrovirals on methadone N-demethylation and transport.

Campbell SD, Gadel S, Friedel C, Crafford A, Regina KJ, Kharasch ED (2015) Influence of HIV antiretrovirals on methadone N-demethylation and transport. Biochemical pharmacology, 95(2):115-25.

Kharasch Lab  PubMed


Opioid Half-lives and Hemlines: The Long and Short of Fashion.

Kharasch ED, {Authors/Author/Name#2} (2015) Opioid Half-lives and Hemlines: The Long and Short of Fashion. Anesthesiology, 122(5):969-70.

Kharasch Lab  PubMed


Steroid Anesthesia Revisited: Again.

Kharasch ED, Hollmann MW (2015) Steroid Anesthesia Revisited: Again. Anesthesia and analgesia, 120(5):983-4.

Kharasch Lab  PubMed


Evaluation of Urine Aquaporin-1 and Perilipin-2 Concentrations as Biomarkers to Screen for Renal Cell Carcinoma: A Prospective Cohort Study.

Morrissey JJ, Mellnick VM, Luo J, Siegel MJ, Figenshau RS, Bhayani S, Kharasch ED (2015) Evaluation of Urine Aquaporin-1 and Perilipin-2 Concentrations as Biomarkers to Screen for Renal Cell Carcinoma: A Prospective Cohort Study. JAMA oncology, 1(2):204-12.

Kharasch Lab  PubMed