Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics.

Kharasch E.D., Whittington D., Ensign D., Hoffer C., Bedynek P.S., Campbell S., Stubbert K., Crafford A., London A., Kim T. (2012) Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics. Clinical pharmacology and therapeutics, 91(4):673-84.

 PubMed


Getting oil and water to mix.

Kharasch E.D. (2012) Getting oil and water to mix. Anesthesiology, 116(3):504-6.

 PubMed


Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion.

Kirby B.J., Collier A.C., Kharasch E.D., Whittington D., Thummel K.E., Unadkat J.D. (2012) Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion. Drug metabolism and disposition: the biological fate of chemicals, 40(3):610-6.

 PubMed


Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A).

Kharasch E.D., Bedynek P.S., Hoffer C., Walker A., Whittington D. (2012) Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A). Anesthesiology, 116(2):432-47.

 PubMed


Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.

Crews K.R., Gaedigk A., Dunnenberger H.M., Klein T.E., Shen D.D., Callaghan J.T., Kharasch E.D., Skaar T.C. (2012) Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype. Clinical pharmacology and therapeutics, 91(2):321-6.

 PubMed