Perioperative pharmacokinetics of methadone in adolescents.

Sharma A., Tallchief D., Blood J., Kim T., London A., Kharasch E.D. (2011) Perioperative pharmacokinetics of methadone in adolescents. Anesthesiology, 115(6):1153-61.

 PubMed


Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active.

Brown S.M., Holtzman M., Kim T., Kharasch E.D. (2011) Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active. Anesthesiology, 115(6):1251-60.

 PubMed


Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir.

Kirby B.J., Collier A.C., Kharasch E.D., Dixit V., Desai P., Whittington D., Thummel K.E., Unadkat J.D. (2011) Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir. Drug metabolism and disposition: the biological fate of chemicals, 39(12):2329-37.

 PubMed


Nitrous oxide anesthesia and plasma homocysteine in adolescents.

Nagele P., Tallchief D., Blood J., Sharma A., Kharasch E.D. (2011) Nitrous oxide anesthesia and plasma homocysteine in adolescents. Anesthesia and analgesia, 113(4):843-8.

 PubMed


Pharmacokinetics and tissue penetration of cefoxitin in obesity: implications for risk of surgical site infection.

Toma O., Suntrup P., Stefanescu A., London A., Mutch M., Kharasch E. (2011) Pharmacokinetics and tissue penetration of cefoxitin in obesity: implications for risk of surgical site infection. Anesthesia and analgesia, 113(4):730-7.

 PubMed


The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.

Bloom J., Hinrichs A.L., Wang J.C., Von Weymarn L.B., Kharasch E.D., Bierut L.J., Goate A., Murphy S.E. (2011) The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans. Pharmacogenetics and genomics, 21(7):403-16.

 PubMed


Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.

Kharasch E.D., Francis A., London A., Frey K., Kim T., Blood J. (2011) Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction. Clinical pharmacology and therapeutics, 90(1):100-8.

 PubMed


Headache outcomes following treatment of unruptured intracranial aneurysms: a prospective analysis.

Schwedt T.J., Gereau R.W., Frey K., Kharasch E.D. (2011) Headache outcomes following treatment of unruptured intracranial aneurysms: a prospective analysis. Cephalalgia : an international journal of headache, 31(10):1082-9.

 PubMed


Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration.

Noppers I., Olofsen E., Niesters M., Aarts L., Mooren R., Dahan A., Kharasch E., Sarton E. (2011) Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration. Anesthesiology, 114(6):1435-45.

 PubMed


Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir.

Kirby B.J., Collier A.C., Kharasch E.D., Whittington D., Thummel K.E., Unadkat J.D. (2011) Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir. Drug metabolism and disposition: the biological fate of chemicals, 39(6):1070-8.

 PubMed


Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry.

Kim T., London A., Kharasch E.D. (2011) Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis, 55(3):487-93.

 PubMed


Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide.

Fan J., Brown S.M., Tu Z., Kharasch E.D. (2011) Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide. Bioconjugate chemistry, 22(4):752-8.

 PubMed


Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil.

Kharasch E.D., Vangveravong S., Buck N., London A., Kim T., Blood J., MacH R.H. (2011) Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. Clinical pharmacology and therapeutics, 89(4):562-70.

 PubMed


Sensitivity and specificity of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for the diagnosis of renal cell carcinoma.

Morrissey J.J., London A.N., Lambert M.C., Kharasch E.D. (2011) Sensitivity and specificity of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for the diagnosis of renal cell carcinoma. American journal of nephrology, 34(5):391-8.

 PubMed


Intraoperative methadone: rediscovery, reappraisal, and reinvigoration?

Kharasch E.D. (2011) Intraoperative methadone: rediscovery, reappraisal, and reinvigoration? Anesthesia and analgesia, 112(1):13-6.

 PubMed