Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.

Kharasch E.D., Bedynek P.S., Walker A., Whittington D., Hoffer C. (2008) Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities. Clinical pharmacology and therapeutics, 84(4):506-12.

 PubMed


Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance.

Kharasch E.D., Bedynek P.S., Park S., Whittington D., Walker A., Hoffer C. (2008) Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance. Clinical pharmacology and therapeutics, 84(4):497-505.

 PubMed


Mutations in a molecule: the virtues of antagonism.

Kharasch E.D. (2008) Mutations in a molecule: the virtues of antagonism. Mayo Clinic proceedings. Mayo Clinic, 83(10):1083-6.

 PubMed


Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting.

Lerman J., Kharasch E.D., Eisenach J.C., Warner M.A., Jevtovic-Todorovic V., Patel P.M., Sun L.S. (2008) Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting. Anesthesiology, 109(3):365.

 PubMed


Adverse drug reactions with halogenated anesthetics.

Kharasch E.D. (2008) Adverse drug reactions with halogenated anesthetics. Clinical pharmacology and therapeutics, 84(1):158-62.

 PubMed


Molecular characterization of CYP2B6 substrates.

Ekins S., Iyer M., Krasowski M.D., Kharasch E.D. (2008) Molecular characterization of CYP2B6 substrates. Current drug metabolism, 9(5):363-73.

 PubMed


Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes.

Coles R., Kharasch E.D. (2008) Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes. Pharmaceutical research, 25(6):1405-11.

 PubMed


Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir.

Kharasch E.D., Mitchell D., Coles R., Blanco R. (2008) Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir. Antimicrobial agents and chemotherapy, 52(5):1663-9.

 PubMed


Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.

Kharasch E.D., Mitchell D., Coles R. (2008) Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity. Journal of clinical pharmacology, 48(4):464-74.

 PubMed


Role of CYP2B6 in stereoselective human methadone metabolism.

Totah R.A., Sheffels P., Roberts T., Whittington D., Thummel K., Kharasch E.D. (2008) Role of CYP2B6 in stereoselective human methadone metabolism. Anesthesiology, 108(3):363-74.

 PubMed


Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.

Templeton I.E., Thummel K.E., Kharasch E.D., Kunze K.L., Hoffer C., Nelson W.L., Isoherranen N. (2008) Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo. Clinical pharmacology and therapeutics, 83(1):77-85.

 PubMed