Pharmacokinetic interactions between buprenorphine and antiretroviral medications.

Bruce R.D., McCance-Katz E., Kharasch E.D., Moody D.E., Morse G.D. (2006) Pharmacokinetic interactions between buprenorphine and antiretroviral medications. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 43 Suppl 4():S216-23.

 PubMed


Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities.

Kirby B., Kharasch E.D., Thummel K.T., Narang V.S., Hoffer C.J., Unadkat J.D. (2006) Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities. Journal of clinical pharmacology, 46(11):1313-9.

 PubMed


New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites.

Kharasch E.D., Schroeder J.L., Liggitt H.D., Ensign D., Whittington D. (2006) New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites. Anesthesiology, 105(4):737-45.

 PubMed


New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway.

Kharasch E.D., Schroeder J.L., Liggitt H.D., Park S.B., Whittington D., Sheffels P. (2006) New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway. Anesthesiology, 105(4):726-36.

 PubMed


Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites.

Lalovic B., Kharasch E., Hoffer C., Risler L., Liu-Chen L.-Y., Shen D.D. (2006) Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clinical pharmacology and therapeutics, 79(5):461-79.

 PubMed


Stereochemical aspects of itraconazole metabolism in vitro and in vivo.

Kunze K.L., Nelson W.L., Kharasch E.D., Thummel K.E., Isoherranen N. (2006) Stereochemical aspects of itraconazole metabolism in vitro and in vivo. Drug metabolism and disposition: the biological fate of chemicals, 34(4):583-90.

 PubMed


Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats.

Kharasch E.D., Schroeder J.L., Bammler T., Beyer R., Srinouanprachanh S. (2006) Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats. Toxicological sciences : an official journal of the Society of Toxicology, 90(2):419-31.

 PubMed


Pharmacokinetics and clinical effects of multidose sublingual triazolam in healthy volunteers.

Jackson D.L., Milgrom P., Heacox G.A., Kharasch E.D. (2006) Pharmacokinetics and clinical effects of multidose sublingual triazolam in healthy volunteers. Journal of clinical psychopharmacology, 26(1):4-8.

 PubMed