Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.

Kharasch E.D., Walker A., Hoffer C., Sheffels P. (2004) Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis. Clinical pharmacology and therapeutics, 76(5):452-66.

 PubMed


In vitro metabolism of cyclosporine A by human kidney CYP3A5.

Dai Y., Iwanaga K., Lin Y.S., Hebert M.F., Davis C.L., Huang W., Kharasch E.D., Thummel K.E. (2004) In vitro metabolism of cyclosporine A by human kidney CYP3A5. Biochemical pharmacology, 68(9):1889-902.

 PubMed


Stereoselective determination of methadone and the primary metabolite EDDP in human plasma by automated on-line extraction and liquid chromatography mass spectrometry.

Whittington D., Sheffels P., Kharasch E.D. (2004) Stereoselective determination of methadone and the primary metabolite EDDP in human plasma by automated on-line extraction and liquid chromatography mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 809(2):313-21.

 PubMed


Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.

Sheffels P., Schroeder J.L., Altuntas T.G., Liggitt H.D., Kharasch E.D. (2004) Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats. Chemical research in toxicology, 17(9):1177-89.

 PubMed


Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone.

Kharasch E.D., Hoffer C., Whittington D., Sheffels P. (2004) Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone. Clinical pharmacology and therapeutics, 76(3):250-69.

 PubMed


Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate.

Kharasch E.D., Hoffer C., Whittington D. (2004) Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate. Anesthesiology, 101(3):738-43.

 PubMed


Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate.

Kharasch E.D., Whittington D., Hoffer C. (2004) Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate. Anesthesiology, 101(3):729-37.

 PubMed


Bioavailabilities of rectal and oral methadone in healthy subjects.

Dale O., Sheffels P., Kharasch E.D. (2004) Bioavailabilities of rectal and oral methadone in healthy subjects. British journal of clinical pharmacology, 58(2):156-62.

 PubMed


The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone.

Kharasch E.D., Hoffer C., Whittington D. (2004) The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone. British journal of clinical pharmacology, 57(5):600-10.

 PubMed


Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).

Altuntas T.G., Park S.B., Kharasch E.D. (2004) Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A). Chemical research in toxicology, 17(3):435-45.

 PubMed


Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl.

Kharasch E.D., Hoffer C., Altuntas T.G., Whittington D. (2004) Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl. Journal of clinical pharmacology, 44(3):224-33.

 PubMed


Perioperative COX-2 inhibitors: knowledge and challenges.

Kharasch E.D. (2004) Perioperative COX-2 inhibitors: knowledge and challenges. Anesthesia and analgesia, 98(1):1-3.

 PubMed