Disposition of nasal, intravenous, and oral methadone in healthy volunteers.

Dale O., Hoffer C., Sheffels P., Kharasch E.D. (2002) Disposition of nasal, intravenous, and oral methadone in healthy volunteers. Clinical pharmacology and therapeutics, 72(5):536-45.

 PubMed


Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency.

Conzen P.F., Kharasch E.D., Czerner S.F.A., Artru A.A., Reichle F.M., Michalowski P., Rooke G.A., Weiss B.M., Ebert T.J. (2002) Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency. Anesthesiology, 97(3):578-84.

 PubMed


The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam.

Ibrahim A., Karim A., Feldman J., Kharasch E. (2002) The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam. Anesthesia and analgesia, 95(3):667-73, table of contents.

 PubMed


Nasal administration of opioids for pain management in adults.

Dale O., Hjortkjaer R., Kharasch E.D. (2002) Nasal administration of opioids for pain management in adults. Acta anaesthesiologica Scandinavica, 46(7):759-70.

 PubMed


Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism.

Altuntas T.G., Kharasch E.D. (2002) Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism. Drug metabolism and disposition: the biological fate of chemicals, 30(2):148-54.

 PubMed


Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo.

Kharasch E.D., Powers K.M., Artru A.A. (2002) Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo. Anesthesiology, 96(1):173-82.

 PubMed


Effects of parecoxib, a parenteral COX-2-specific inhibitor, on the pharmacokinetics and pharmacodynamics of propofol.

Ibrahim A., Park S., Feldman J., Karim A., Kharasch E.D. (2002) Effects of parecoxib, a parenteral COX-2-specific inhibitor, on the pharmacokinetics and pharmacodynamics of propofol. Anesthesiology, 96(1):88-95.

 PubMed