A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans.

Phimmasone S., Kharasch E.D. (2001) A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans. Clinical pharmacology and therapeutics, 70(6):505-17.

 PubMed


Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro.

Altuntas T.G., Kharasch E.D. (2001) Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro. Toxicology and applied pharmacology, 177(2):85-93.

 PubMed


In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration.

Lin Y.S., Lockwood G.F., Graham M.A., Brian W.R., Loi C.-M., Dobrinska M.R., Shen D.D., Watkins P.B., Wilkinson G.R., Kharasch E.D., Thummel K.E. (2001) In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration. Pharmacogenetics, 11(9):781-91.

 PubMed


Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function.

Kharasch E.D., Frink Jr. E.J., Artru A., Michalowski P., Rooke G.A., Nogami W. (2001) Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function. Anesthesia and analgesia, 93(6):1511-20, table of contents.

 PubMed


Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.

Thummel K.E., Brimer C., Yasuda K., Thottassery J., Senn T., Lin Y., Ishizuka H., Kharasch E., Schuetz J., Schuetz E. (2001) Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. Molecular pharmacology, 60(6):1399-406.

 PubMed


Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2.

Yao C., Kunze K.L., Kharasch E.D., Wang Y., Trager W.F., Ragueneau I., Levy R.H. (2001) Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2. Clinical pharmacology and therapeutics, 70(5):415-24.

 PubMed


Bispectral index monitoring during sedation with sevoflurane, midazolam, and propofol.

Ibrahim A.E., Taraday J.K., Kharasch E.D. (2001) Bispectral index monitoring during sedation with sevoflurane, midazolam, and propofol. Anesthesiology, 95(5):1151-9.

 PubMed


Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.

Oda Y., Kharasch E.D. (2001) Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. The Journal of pharmacology and experimental therapeutics, 298(3):1021-32.

 PubMed


Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6).

Minoda Y., Kharasch E.D. (2001) Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6). Anesthesiology, 95(2):509-14.

 PubMed


Pharmacokinetics and clinical effects of sublingual triazolam in pediatric dental patients.

Tweedy C.M., Milgrom P., Kharasch E.D., Kaakko T., Spieker M., Coldwell S.E. (2001) Pharmacokinetics and clinical effects of sublingual triazolam in pediatric dental patients. Journal of clinical psychopharmacology, 21(3):268-72.

 PubMed


Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites.

Oda Y., Kharasch E.D. (2001) Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites. The Journal of pharmacology and experimental therapeutics, 297(1):410-22.

 PubMed


Speed of recovery and side-effect profile of sevoflurane sedation compared with midazolam.

Ibrahim A.E., Ghoneim M.M., Kharasch E.D., Epstein R.H., Groudine S.B., Ebert T.J., Binstock W.B., Philip B.K. (2001) Speed of recovery and side-effect profile of sevoflurane sedation compared with midazolam. Anesthesiology, 94(1):87-94.

 PubMed