Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1.

Patera AC, Drewry AM, Chang K, Beiter ER, Osborne D, Hotchkiss RS (2016) Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1. Journal of leukocyte biology, ():.

 PubMed


Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia.

Shindo Y, Fuchs AG, Davis CG, Eitas T, Unsinger J, Burnham CD, Green JM, Morre M, Bochicchio GV, Hotchkiss RS (2016) Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia. Journal of leukocyte biology, ():.

 PubMed


Is this critically ill patient immunocompromised?

Pène F, Pickkers P, Hotchkiss RS (2016) Is this critically ill patient immunocompromised? Intensive care medicine, 42(6):1051-4.

 PubMed


Erratum to: Is this critically ill patient immunocompromised?

Pène F, Pickkers P, Hotchkiss RS (2016) Erratum to: Is this critically ill patient immunocompromised? Intensive care medicine, 42(6):1106.

 PubMed


Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications.

Fuller BM, Ferguson I, Mohr NM, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH (2016) Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications. BMJ open, 6(4):e010991.

 PubMed


Understanding why clinicians should care about danger-associated molecular patterns.

Asehnoune K, Hotchkiss RS, Monneret G (2016) Understanding why clinicians should care about danger-associated molecular patterns. Intensive care medicine, 42(4):611-4.

 PubMed


The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315(8):801-10.

 PubMed


T cells from patients with Candida sepsis display a suppressive immunophenotype.

Spec A, Shindo Y, Burnham CA, Wilson S, Ablordeppey EA, Beiter ER, Chang K, Drewry AM, Hotchkiss RS (2016) T cells from patients with Candida sepsis display a suppressive immunophenotype. Critical care (London, England), 20():15.

 PubMed