Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis.

Unsinger J, Burnham CA, McDonough J, Morre M, Prakash PS, Caldwell CC, Dunne WM Jr, Hotchkiss RS (2012) Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. The Journal of infectious diseases, 206(4):606-16.

 PubMed


Pulmonary contusion is associated with toll-like receptor 4 upregulation and decreased susceptibility to pseudomonas pneumonia in a mouse model.

Southard R., Ghosh S., Hilliard J., Davis C., Mazuski C., Walton A., Hotchkiss R. (2012) Pulmonary contusion is associated with toll-like receptor 4 upregulation and decreased susceptibility to pseudomonas pneumonia in a mouse model. Shock (Augusta, Ga.), 37(6):629-33.

 PubMed


Sigma-2 ligands induce tumour cell death by multiple signalling pathways.

Zeng C., Rothfuss J., Zhang J., Chu W., Vangveravong S., Tu Z., Pan F., Chang K.C., Hotchkiss R., Mach R.H. (2012) Sigma-2 ligands induce tumour cell death by multiple signalling pathways. British journal of cancer, 106(4):693-701.

 PubMed


Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling.

Spitzer D., Simon Jr. P.O., Kashiwagi H., Xu J., Zeng C., Vangveravong S., Zhou D., Chang K., McDunn J.E., Hornick J.R., Goedegebuure P., Hotchkiss R.S., Mach R.H., Hawkins W.G. (2012) Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling. Cancer research, 72(1):201-9.

 PubMed


Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody.

Chen D.L., Zhou D., Chu W., Herrbrich P., Engle J.T., Griffin E., Jones L.A., Rothfuss J.M., Geraci M., Hotchkiss R.S., Mach R.H. (2012) Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody. Nuclear medicine and biology, 39(1):137-44.

 PubMed


Cecal ligation and puncture followed by methicillin-resistant Staphylococcus aureus pneumonia increases mortality in mice and blunts production of local and systemic cytokines.

Jung E., Perrone E.E., Liang Z., Breed E.R., Dominguez J.A., Clark A.T., Fox A.C., Dunne W.M., Burd E.M., Farris A.B., Hotchkiss R.S., Coopersmith C.M. (2012) Cecal ligation and puncture followed by methicillin-resistant Staphylococcus aureus pneumonia increases mortality in mice and blunts production of local and systemic cytokines. Shock (Augusta, Ga.), 37(1):85-94.

 PubMed