Cell death.

Hotchkiss R.S., Strasser A., McDunn J.E., Swanson P.E. (2009) Cell death. The New England journal of medicine, 361(16):1570-83.

 PubMed


Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury.

Cobb J.P., Moore E.E., Hayden D.L., Minei J.P., Cuschieri J., Yang J., Li Q., Lin N., Brownstein B.H., Hennessy L., Mason P.H., Schierding W.S., Dixon D.J., Tompkins R.G., Warren H.S., Schoenfeld D.A., Maier R.V. (2009) Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury. Annals of surgery, 250(4):531-9.

 PubMed


Analysis of the relationship between longitudinal gene expressions and ordered categorical event data.

Rajicic N., Finkelstein D.M., Schoenfeld D.A., Baker H.V., Balis U., Bankey P., Billiar T.R., Brownstein B.H., Calvano S.E., Camp II D.G., Casella G., Chaudry I.H., Cobb J.P., Cuschieri J., Davis R.W., De A.K., Finnerty C.C., Freeman B., Gamelli R.L., Gibran N.S., Harbrecht B.G., Hayden D.L., Hennessy L., Herndon D.N., Horton J.W., Jeschke M.G., Johnson J., Klein M.B., Lederer J.A., Lowry S.F., Maier R.V., Mannick J.A., Mason P.H., McDonald-Smith G.P., Miller-Graziano C.L., Mindrinos M.N., Minei J.P., Moldawer L.L., Moore E.E., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Shapiro M.B., Silver G.M., Smith R.D., Storey J., Tibshirani R., Tompkins R.G., Toner M., Warren H.S., West M.A., Xiao W. (2009) Analysis of the relationship between longitudinal gene expressions and ordered categorical event data. Statistics in medicine, 28(22):2817-32.

 PubMed


Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma.

Simon Jr. P.O., McDunn J.E., Kashiwagi H., Chang K., Goedegebuure P.S., Hotchkiss R.S., Hawkins W.G. (2009) Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma. International journal of cancer. Journal international du cancer, 125(4):942-51.

 PubMed


Inflammation and the host response to injury, a Large-Scale Collaborative Project: patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients.

Evans H.L., Cuschieri J., Moore E.E., Shapiro M.B., Nathens A.B., Johnson J.L., Harbrecht B.G., Minei J.P., Bankey P.E., Maier R.V., West M.A., Baker H.V., Billiar T.R., Brownstein B.H., Calvano S.E., Chaudry I.H., Cobb J.P., Cooper C., Davis R.W., Fay A., Feezor R.J., Gamelli R.L., Gibran N.S., Hayden D., Herndon D.N., Hunt J.L., Laudanski K., Lederer J.A., Lowry S.F., Mannick J.A., Miller-Graziano C.L., Mindrinos M., Moldawer L.L., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D., Sheridan R.L., Silver G.M., Smith R.D., Stephanopoulos G., Tompkins R.G., Toner M., Warren H.S., Wolf S.E., Xiao W., Yarmush M., Young V.R. (2009) Inflammation and the host response to injury, a Large-Scale Collaborative Project: patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients. The Journal of trauma, 67(2):384-8.

 PubMed


Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.

Unsinger J., McDonough J.S., Shultz L.D., Ferguson T.A., Hotchkiss R.S. (2009) Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. Journal of leukocyte biology, 86(2):219-27.

 PubMed


Targeted delivery of siRNA to cell death proteins in sepsis.

Brahmamdam P., Watanabe E., Unsinger J., Chang K.C., Schierding W., Hoekzema A.S., Zhou T.T., McDonough J.S., Holemon H., Heidel J.D., Coopersmith C.M., McDunn J.E., Hotchkiss R.S. (2009) Targeted delivery of siRNA to cell death proteins in sepsis. Shock (Augusta, Ga.), 32(2):131-9.

 PubMed


A genomic score prognostic of outcome in trauma patients.

Warren H.S., Elson C.M., Hayden D.L., Schoenfeld D.A., Cobb J.P., Maier R.V., Moldawer L.L., Moore E.E., Harbrecht B.G., Pelak K., Cuschieri J., Herndon D.N., Jeschke M.G., Finnerty C.C., Brownstein B.H., Hennessy L., Mason P.H., Tompkins R.G. (2009) A genomic score prognostic of outcome in trauma patients. Molecular medicine (Cambridge, Mass.), 15(7-8):220-7.

 PubMed


An anti-apoptotic peptide improves survival in lethal total body irradiation.

McDunn J.E., Muenzer J.T., Dunne B., Zhou A., Yuan K., Hoekzema A., Hilliard C., Chang K.C., Davis C.G., McDonough J., Hunt C., Grigsby P., Piwnica-Worms D., Hotchkiss R.S. (2009) An anti-apoptotic peptide improves survival in lethal total body irradiation. Biochemical and biophysical research communications, 382(4):657-62.

 PubMed


The sepsis seesaw: tilting toward immunosuppression.

Hotchkiss R.S., Coopersmith C.M., McDunn J.E., Ferguson T.A. (2009) The sepsis seesaw: tilting toward immunosuppression. Nature medicine, 15(5):496-7.

 PubMed


Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study.

Watanabe E., Muenzer J.T., Hawkins W.G., Davis C.G., Dixon D.J., McDunn J.E., Brackett D.J., Lerner M.R., Swanson P.E., Hotchkiss R.S. (2009) Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Laboratory investigation; a journal of technical methods and pathology, 89(5):549-61.

 PubMed


Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages.

Peck-Palmer O.M., Unsinger J., Chang K.C., McDonough J.S., Perlman H., McDunn J.E., Hotchkiss R.S. (2009) Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages. Shock (Augusta, Ga.), 31(4):359-66.

 PubMed


Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury.

Unsinger J., Kazama H., McDonough J.S., Hotchkiss R.S., Ferguson T.A. (2009) Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury. Journal of leukocyte biology, 85(3):382-90.

 PubMed


Leukocyte phenotyping to stratify septic shock patients.

McDunn J.E., Hotchkiss R.S. (2009) Leukocyte phenotyping to stratify septic shock patients. Critical care (London, England), 13(2):127.

 PubMed


Costimulatory blockade-mediated lung allograft acceptance is abrogated by overexpression of Bcl-2 in the recipient.

Okazaki M., Sugimoto S., Lai J., Kornfeld C.G., Hotchkiss R.S., Richardson S.B., Li W., Kreisel F.H., Huang H.J., Patterson G.A., Krupnick A.S., Gelman A.E., Kreisel D. (2009) Costimulatory blockade-mediated lung allograft acceptance is abrogated by overexpression of Bcl-2 in the recipient. Transplantation proceedings, 41(1):385-7.

 PubMed