Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis.

Muenzer J.T., Davis C.G., Dunne B.S., Unsinger J., Dunne W.M., Hotchkiss R.S. (2006) Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis. Shock (Augusta, Ga.), 26(6):565-70.

 PubMed


The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis.

Unsinger J., Herndon J.M., Davis C.G., Muenzer J.T., Hotchkiss R.S., Ferguson T.A. (2006) The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis. Journal of immunology (Baltimore, Md. : 1950), 177(11):7968-73.

 PubMed


Molecular diagnostics in sepsis: from bedside to bench.

Chung T.P., Laramie J.M., Meyer D.J., Downey T., Tam L.H.Y., Ding H., Buchman T.G., Karl I., Stormo G.D., Hotchkiss R.S., Cobb J.P. (2006) Molecular diagnostics in sepsis: from bedside to bench. Journal of the American College of Surgeons, 203(5):585-598.

 PubMed


Apoptosis and caspases regulate death and inflammation in sepsis.

Hotchkiss R.S., Nicholson D.W. (2006) Apoptosis and caspases regulate death and inflammation in sepsis. Nature reviews. Immunology, 6(11):813-22.

 PubMed


Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways.

Laudanski K., Miller-Graziano C., Xiao W., Mindrinos M.N., Richards D.R., De A., Moldawer L.L., Maier R.V., Bankey P., Baker H.V., Brownstein B.H., Cobb J.P., Galvano S.E., Davis R.W., Tompkins R.G., Billiar T.R., Camp II D., Campbell-Finnerty C., Casella G., Chaudry I.H., Choudhry M., Elson C., Freeman B., Gamelli R.L., Gibran N.S., Harbrecht B.G., Hayden D.L., Herndon D.N., Horton J.W., Hubbard W., Hunt J.L., Johnson J., Klein M.B., Lederer J.A., Logvinenko T., Lowry S.F., Mannick J.A., Mason P.H., McDonald-Smith G.P., McKinley B.A., Minei J.P., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D.A., Shapiro M.B., Schwacha M., Silver G.M., Smith R.D., Storey J., Toner M., Warren H.S., West M.A. (2006) Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proceedings of the National Academy of Sciences of the United States of America, 103(42):15564-9.

 PubMed


High dynamic range characterization of the trauma patient plasma proteome.

Liu T., Qiant W.-J., Gritsenko M.A., Xiao W., Moldawer L.L., Kaushal A., Monroe M.E., Varnum S.M., Moore R.J., Purvine S.O., Maier R.V., Davis R.W., Tompkins R.G., Camp II D.G., Smith R.D., Baker H.V., Bankey P.E., Billiar T.R., Brownstein B.H., Calvano S.E., Campbell-Finnerty C., Casella G., Chaudry I.H., Choudhry M., Cobb J.P., De A., Elson C., Freeman B., Gamelli R.L., Gibran N.S., Harbrecht B.G., Hayden D.L., Herndon D.N., Horton J.W., Hubbard W., Hunt J.L., Johnson J.L., Klein M.B., Lederer J.A., Logvinenko T., Lowry S.F., Mannick J.A., Mason P.H., McDonald-Smith G.P., McKinley B., Miller-Graziano C.L., Mindrinos M., Minei J.P., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick D.G., Schoenfeld D., Shapiro M.B., Schwacha M., Silver G.M., Storey J., Toner M., Shaw Warren H., West M.A. (2006) High dynamic range characterization of the trauma patient plasma proteome. Molecular & cellular proteomics : MCP, 5(10):1899-913.

 PubMed


The number of genes changing expression after chronic exposure to code division multiple access or frequency DMA radiofrequency radiation does not exceed the false-positive rate.

Whitehead T.D., Moros E.G., Brownstein B.H., Roti Roti J.L. (2006) The number of genes changing expression after chronic exposure to code division multiple access or frequency DMA radiofrequency radiation does not exceed the false-positive rate. Proteomics, 6(17):4739-44.

 PubMed


Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis.

McDunn J.E., Turnbull I.R., Polpitiya A.D., Tong A., MacMillan S.K., Osborne D.F., Hotchkiss R.S., Colonna M., Cobb J.P. (2006) Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis. Journal of the American College of Surgeons, 203(3):365-75.

 PubMed


Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis.

Schreiber T., Swanson P.E., Chang K.C., Davis C.C., Dunne W.M., Karl I.E., Reinhart K., Hotchkiss R.S. (2006) Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis. Shock (Augusta, Ga.), 26(3):271-6.

 PubMed


Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis.

Sethu P., Moldawer L.L., Mindrinos M.N., Scumpia P.O., Tannahill C.L., Wilhelmy J., Efron P.A., Brownstein B.H., Tompkins R.G., Toner M. (2006) Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis. Analytical chemistry, 78(15):5453-61.

 PubMed


Inflammation and the host response to injury: an overview of the multicenter study of the genomic and proteomic response to burn injury.

Klein M.B., Silver G., Gamelli R.L., Gibran N.S., Herndon D.N., Hunt J.L., Tompkins R.G., Baker H.V., Bankey P., Billiar T.R., Brownstein B.H., Calvano S.E., Camp II D.G., Campbell-Finnerty C., Casella G., Chaudry I.H., Cobb J.P., Davis R.W., De A.K., Elson C., Freeman B., Harbrecht B.G., Hayden D.L., Horton J.W., Johnson J., Lederer J.A., Logvinenko T., Lowry S.F., Maier R.V., Mannick J.A., Mason P.H., McDonald-Smith G.P., McKinley B.A., Miller-Graziano C.L., Mindrinos M.N., Minei J.P., Moldawer L.L., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D.A., Shapiro M.B., Silver G.M., Smith R.D., Storey J., Toner M., Warren H.S., West M.A., Xiao W. (2006) Inflammation and the host response to injury: an overview of the multicenter study of the genomic and proteomic response to burn injury. Journal of burn care & research : official publication of the American Burn Association, 27(4):448-51.

 PubMed


Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis.

Schwulst S.J., Grayson M.H., DiPasco P.J., Davis C.G., Brahmbhatt T.S., Ferguson T.A., Hotchkiss R.S. (2006) Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950), 177(1):557-65.

 PubMed


Gene expression does not change significantly in C3H 10T(1/2) cells after exposure to 847.74 CDMA or 835.62 FDMA radiofrequency radiation.

Whitehead T.D., Moros E.G., Brownstein B.H., Roti Roti J.L. (2006) Gene expression does not change significantly in C3H 10T(1/2) cells after exposure to 847.74 CDMA or 835.62 FDMA radiofrequency radiation. Radiation research, 165(6):626-35.

 PubMed


TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo.

Hotchkiss R.S., McConnell K.W., Bullok K., Davis C.G., Chang K.C., Schwulst S.J., Dunne J.C., Dietz G.P.H., Bahr M., McDunn J.E., Karl I.E., Wagner T.H., Cobb J.P., Coopersmith C.M., Piwnica-Worms D. (2006) TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. Journal of immunology (Baltimore, Md. : 1950), 176(9):5471-7.

 PubMed


Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury.

Brownstein B.H., Logvinenko T., Lederer J.A., Cobb J.P., Hubbard W.J., Chaudry I.H., Remick D.G., Baker H.V., Xiao W., Mannick J.A. (2006) Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury. Physiological genomics, 24(3):298-309.

 PubMed