Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival.

Husain K.D., Stromberg P.E., Javadi P., Buchman T.G., Karl I.E., Hotchkiss R.S., Coopersmith C.M. (2003) Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival. Shock (Augusta, Ga.), 20(5):437-43.

 PubMed


Induction of chondrocyte apoptosis following impact load.

Borrelli Jr. J., Tinsley K., Ricci W.M., Burns M., Karl I.E., Hotchkiss R. (2003) Induction of chondrocyte apoptosis following impact load. Journal of orthopaedic trauma, 17(9):635-41.

 PubMed


Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells.

Tinsley K.W., Grayson M.H., Swanson P.E., Drewry A.M., Chang K.C., Karl I.E., Hotchkiss R.S. (2003) Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. Journal of immunology (Baltimore, Md. : 1950), 171(2):909-14.

 PubMed


Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest.

Coopersmith C.M., Stromberg P.E., Davis C.G., Dunne W.M., Amiot II D.M., Karl I.E., Hotchkiss R.S., Buchman T.G. (2003) Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Critical care medicine, 31(6):1630-7.

 PubMed


Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node.

Grayson M.H., Hotchkiss R.S., Karl I.E., Holtzman M.J., Chaplin D.D. (2003) Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node. American journal of physiology. Heart and circulatory physiology, 284(6):H2213-26.

 PubMed


Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis.

Hotchkiss R.S., Chang K.C., Grayson M.H., Tinsley K.W., Dunne B.S., Davis C.G., Osborne D.F., Karl I.E. (2003) Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. Proceedings of the National Academy of Sciences of the United States of America, 100(11):6724-9.

 PubMed


Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia.

Coopersmith C.M., Amiot II D.M., Stromberg P.E., Dunne W.M., Davis C.G., Osborne D.F., Husain K.D., Turnbull I.R., Karl I.E., Hotchkiss R.S., Buchman T.G. (2003) Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia. Shock (Augusta, Ga.), 19(5):408-14.

 PubMed


Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture.

Turnbull I.R., Wlzorek J.J., Osborne D., Hotchkiss R.S., Coopersmith C.M., Buchman T.G. (2003) Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock (Augusta, Ga.), 19(4):310-3.

 PubMed


Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells.

Upadhya G.A., Topp S.A., Hotchkiss R.S., Anagli J., Strasberg S.M. (2003) Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells. Hepatology (Baltimore, Md.), 37(2):313-23.

 PubMed


The pathophysiology and treatment of sepsis.

Hotchkiss R.S., Karl I.E. (2003) The pathophysiology and treatment of sepsis. The New England journal of medicine, 348(2):138-50.

 PubMed


Role of apoptotic cell death in sepsis.

Hotchkiss R.S., Tinsley K.W., Karl I.E. (2003) Role of apoptotic cell death in sepsis. Scandinavian journal of infectious diseases, 35(9):585-92.

 PubMed