Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1.

Patera AC, Drewry AM, Chang K, Beiter ER, Osborne D, Hotchkiss RS (2016) Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1. Journal of leukocyte biology, ():.

 PubMed


Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia.

Shindo Y, Fuchs AG, Davis CG, Eitas T, Unsinger J, Burnham CD, Green JM, Morre M, Bochicchio GV, Hotchkiss RS (2016) Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia. Journal of leukocyte biology, ():.

 PubMed


Is this critically ill patient immunocompromised?

Pène F, Pickkers P, Hotchkiss RS (2016) Is this critically ill patient immunocompromised? Intensive care medicine, 42(6):1051-4.

 PubMed


Erratum to: Is this critically ill patient immunocompromised?

Pène F, Pickkers P, Hotchkiss RS (2016) Erratum to: Is this critically ill patient immunocompromised? Intensive care medicine, 42(6):1106.

 PubMed


Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications.

Fuller BM, Ferguson I, Mohr NM, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH (2016) Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications. BMJ open, 6(4):e010991.

 PubMed


Understanding why clinicians should care about danger-associated molecular patterns.

Asehnoune K, Hotchkiss RS, Monneret G (2016) Understanding why clinicians should care about danger-associated molecular patterns. Intensive care medicine, 42(4):611-4.

 PubMed


The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315(8):801-10.

 PubMed


T cells from patients with Candida sepsis display a suppressive immunophenotype.

Spec A, Shindo Y, Burnham CA, Wilson S, Ablordeppey EA, Beiter ER, Chang K, Drewry AM, Hotchkiss RS (2016) T cells from patients with Candida sepsis display a suppressive immunophenotype. Critical care (London, England), 20():15.

 PubMed


Imaging Apoptosis in Sepsis--A Technology We Would Die for!

Hotchkiss RS, Crouser E (2015) Imaging Apoptosis in Sepsis--A Technology We Would Die for! Critical care medicine, 43(11):2506-8.

 PubMed


The authors reply.

Drewry AM, Fuller BM, Skrupky LP, Hotchkiss RS (2015) The authors reply. Critical care medicine, 43(11):e529-30.

 PubMed


The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia.

Drewry AM, Fuller BM, Skrupky LP, Hotchkiss RS (2015) The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia. Critical care medicine, 43(6):1165-9.

 PubMed


Sepsis: Revising definitions of sepsis.

Drewry AM, Hotchkiss RS (2015) Sepsis: Revising definitions of sepsis. Nature reviews. Nephrology, 11(6):326-8.

 PubMed


Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression.

Shindo Y, Unsinger J, Burnham CA, Green JM, Hotchkiss RS (2015) Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression. Shock (Augusta, Ga.), 43(4):334-43.

 PubMed


Immunology. Getting sepsis therapy right.

Hotchkiss RS, Sherwood ER (2015) Immunology. Getting sepsis therapy right. Science (New York, N.Y.), 347(6227):1201-2.

 PubMed


Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes.

Julian MW, Strange HR, Ballinger MN, Hotchkiss RS, Papenfuss TL, Crouser ED (2015) Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes. PloS one, 10(7):e0132921.

 PubMed


Persistent lymphopenia after diagnosis of sepsis predicts mortality.

Drewry AM, Samra N, Skrupky LP, Fuller BM, Compton SM, Hotchkiss RS (2014) Persistent lymphopenia after diagnosis of sepsis predicts mortality. Shock (Augusta, Ga.), 42(5):383-91.

 PubMed


Reducing the burden of acute respiratory distress syndrome: the case for early intervention and the potential role of the emergency department.

Fuller BM, Mohr NM, Hotchkiss RS, Kollef MH (2014) Reducing the burden of acute respiratory distress syndrome: the case for early intervention and the potential role of the emergency department. Shock (Augusta, Ga.), 41(5):378-87.

 PubMed


Reactivation of multiple viruses in patients with sepsis.

Walton AH, Muenzer JT, Rasche D, Boomer JS, Sato B, Brownstein BH, Pachot A, Brooks TL, Deych E, Shannon WD, Green JM, Storch GA, Hotchkiss RS (2014) Reactivation of multiple viruses in patients with sepsis. PloS one, 9(2):e98819.

 PubMed


Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.

Hotchkiss RS, Monneret G, Payen D (2013) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nature reviews. Immunology, 13(12):862-74.

 PubMed


Sepsis-induced disseminated intravascular coagulation, symmetrical peripheral gangrene, and amputations.

Hotchkiss RS, Levy JH, Levi M (2013) Sepsis-induced disseminated intravascular coagulation, symmetrical peripheral gangrene, and amputations. Critical care medicine, 41(10):e290-1.

 PubMed


TLR3 agonist improves survival to secondary pneumonia in a double injury model.

Davis CG, Chang K, Osborne D, Walton AH, Ghosh S, Dunne WM, Hotchkiss RS, Muenzer JT (2013) TLR3 agonist improves survival to secondary pneumonia in a double injury model. The Journal of surgical research, 182(2):270-6.

 PubMed


Mechanisms of cardiac and renal dysfunction in patients dying of sepsis.

Takasu O, Gaut JP, Watanabe E, To K, Fagley RE, Sato B, Jarman S, Efimov IR, Janks DL, Srivastava A, Bhayani SB, Drewry A, Swanson PE, Hotchkiss RS (2013) Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. American journal of respiratory and critical care medicine, 187(5):509-17.

 PubMed


Inhibition of intestinal epithelial apoptosis improves survival in a murine model of radiation combined injury.

Jung E, Perrone EE, Brahmamdan P, McDonough JS, Leathersich AM, Dominguez JA, Clark AT, Fox AC, Dunne WM, Hotchkiss RS (2013) Inhibition of intestinal epithelial apoptosis improves survival in a murine model of radiation combined injury. PloS one, 8(10):e77203.

 PubMed


Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis.

Unsinger J, Burnham CA, McDonough J, Morre M, Prakash PS, Caldwell CC, Dunne WM Jr, Hotchkiss RS (2012) Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. The Journal of infectious diseases, 206(4):606-16.

 PubMed


Pulmonary contusion is associated with toll-like receptor 4 upregulation and decreased susceptibility to pseudomonas pneumonia in a mouse model.

Southard R., Ghosh S., Hilliard J., Davis C., Mazuski C., Walton A., Hotchkiss R. (2012) Pulmonary contusion is associated with toll-like receptor 4 upregulation and decreased susceptibility to pseudomonas pneumonia in a mouse model. Shock (Augusta, Ga.), 37(6):629-33.

 PubMed


Sigma-2 ligands induce tumour cell death by multiple signalling pathways.

Zeng C., Rothfuss J., Zhang J., Chu W., Vangveravong S., Tu Z., Pan F., Chang K.C., Hotchkiss R., Mach R.H. (2012) Sigma-2 ligands induce tumour cell death by multiple signalling pathways. British journal of cancer, 106(4):693-701.

 PubMed


Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling.

Spitzer D., Simon Jr. P.O., Kashiwagi H., Xu J., Zeng C., Vangveravong S., Zhou D., Chang K., McDunn J.E., Hornick J.R., Goedegebuure P., Hotchkiss R.S., Mach R.H., Hawkins W.G. (2012) Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling. Cancer research, 72(1):201-9.

 PubMed


Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody.

Chen D.L., Zhou D., Chu W., Herrbrich P., Engle J.T., Griffin E., Jones L.A., Rothfuss J.M., Geraci M., Hotchkiss R.S., Mach R.H. (2012) Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody. Nuclear medicine and biology, 39(1):137-44.

 PubMed


Cecal ligation and puncture followed by methicillin-resistant Staphylococcus aureus pneumonia increases mortality in mice and blunts production of local and systemic cytokines.

Jung E., Perrone E.E., Liang Z., Breed E.R., Dominguez J.A., Clark A.T., Fox A.C., Dunne W.M., Burd E.M., Farris A.B., Hotchkiss R.S., Coopersmith C.M. (2012) Cecal ligation and puncture followed by methicillin-resistant Staphylococcus aureus pneumonia increases mortality in mice and blunts production of local and systemic cytokines. Shock (Augusta, Ga.), 37(1):85-94.

 PubMed


Immunosuppression in patients who die of sepsis and multiple organ failure.

Boomer J.S., To K., Chang K.C., Takasu O., Osborne D.F., Walton A.H., Bricker T.L., Jarman II S.D., Kreisel D., Krupnick A.S., Srivastava A., Swanson P.E., Green J.M., Hotchkiss R.S. (2011) Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA : the journal of the American Medical Association, 306(23):2594-605.

 PubMed


A genomic storm in critically injured humans.

Xiao W., Mindrinos M.N., Seok J., Cuschieri J., Cuenca A.G., Gao H., Hayden D.L., Hennessy L., Moore E.E., Minei J.P., Bankey P.E., Johnson J.L., Sperry J., Nathens A.B., Billiar T.R., West M.A., Brownstein B.H., Mason P.H., Baker H.V., Finnerty C.C., Jeschke M.G., Lopez M.C., Klein M.B., Gamelli R.L., Gibran N.S., Arnoldo B., Xu W., Zhang Y., Calvano S.E., Mcdonald-Smith G.P., Schoenfeld D.A., Storey J.D., Cobb J.P., Warren H.S., Moldawer L.L., Herndon D.N., Lowry S.F., Maier R.V., Davis R.W., Tompkins R.G., Xiao W., Mindrinos M., Seok J., Cuschieri J., Tompkins R., Davis R., Maier R., Moldawer L., Hennessy L., Moore E., Minei J., Bankey P., Johnson J., Sperry J., Nathens A., Billiar T., West M., Brownstein B., Herndon D., Baker H., Finnerty C., Jeschke M., Lopez M., Klein M., Gamelli R., Gibran N., Arnoldo B., McDonald-Smith G., Schoenfeld D., Cobb J., Warren S., Cuenca A., Lowry S., Calvano S., Hayden D., Mason P., Gao H., Storey J., Altstein L., Balis U.G.J., Camp D.G., De Asit K., Harbrecht B.G., Honari S.E., McKinley B.A., Miller-Graziano C.L., Moore F.A., O'Keefe G.E., Rahme L.G., Remick D.G., Shapiro M.B., Smith R.D., Tibshirani R., Toner M., Wispelwey B., Wong W.H. (2011) A genomic storm in critically injured humans. The Journal of experimental medicine, 208(13):2581-90.

 PubMed


Advances in the management of sepsis and the understanding of key immunologic defects.

Skrupky L.P., Kerby P.W., Hotchkiss R.S. (2011) Advances in the management of sepsis and the understanding of key immunologic defects. Anesthesiology, 115(6):1349-62.

 PubMed


Change in temperature profile may precede fever and be an early indicator of sepsis: a case report.

Mohr N.M., Hotchkiss R.S., Micek S.T., Durrani S., Fuller B.M. (2011) Change in temperature profile may precede fever and be an early indicator of sepsis: a case report. Shock (Augusta, Ga.), 36(3):318-20; discussion 320-1.

 PubMed


Dose-dependent effect of anti-CTLA-4 on survival in sepsis.

Inoue S., Bo L., Bian J., Unsinger J., Chang K., Hotchkiss R.S. (2011) Dose-dependent effect of anti-CTLA-4 on survival in sepsis. Shock (Augusta, Ga.), 36(1):38-44.

 PubMed


Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.

Kasten K.R., Prakash P.S., Unsinger J., Goetzman H.S., England L.G., Cave C.M., Seitz A.P., Mazuski C.N., Zhou T.T., Morre M., Hotchkiss R.S., Hildeman D.A., Caldwell C.C. (2010) Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infection and immunity, 78(11):4714-22.

 PubMed


Clinical microfluidics for neutrophil genomics and proteomics.

Kotz K.T., Xiao W., Miller-Graziano C., Qian W.-J., Russom A., Warner E.A., Moldawer L.L., De A., Bankey P.E., Petritis B.O., Camp II D.G., Rosenbach A.E., Goverman J., Fagan S.P., Brownstein B.H., Irimia D., Xu W., Wilhelmy J., Mindrinos M.N., Smith R.D., Davis R.W., Tompkins R.G., Toner M. (2010) Clinical microfluidics for neutrophil genomics and proteomics. Nature medicine, 16(9):1042-7.

 PubMed


Immunotherapy for sepsis--a new approach against an ancient foe.

Hotchkiss R.S., Opal S. (2010) Immunotherapy for sepsis--a new approach against an ancient foe. The New England journal of medicine, 363(1):87-9.

 PubMed


A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing.

Spitzer D., McDunn J.E., Plambeck-Suess S., Goedegebuure P.S., Hotchkiss R.S., Hawkins W.G. (2010) A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing. Molecular cancer therapeutics, 9(7):2142-51.

 PubMed


IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.

Unsinger J., McGlynn M., Kasten K.R., Hoekzema A.S., Watanabe E., Muenzer J.T., McDonough J.S., Tschoep J., Ferguson T.A., McDunn J.E., Morre M., Hildeman D.A., Caldwell C.C., Hotchkiss R.S. (2010) IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950), 184(7):3768-79.

 PubMed


Characterization and modulation of the immunosuppressive phase of sepsis.

Muenzer J.T., Davis C.G., Chang K., Schmidt R.E., Dunne W.M., Coopersmith C.M., Hotchkiss R.S. (2010) Characterization and modulation of the immunosuppressive phase of sepsis. Infection and immunity, 78(4):1582-92.

 PubMed


Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis.

Fox A.C., Robertson C.M., Belt B., Clark A.T., Chang K.C., Leathersich A.M., Dominguez J.A., Perrone E.E., Dunne W.M., Hotchkiss R.S., Buchman T.G., Linehan D.C., Coopersmith C.M. (2010) Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis. Critical care medicine, 38(3):886-93.

 PubMed


Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis.

Scatizzi J.C., Hutcheson J., Pope R.M., Firestein G.S., Koch A.E., Mavers M., Smason A., Agrawal H., Haines III G.K., Chandel N.S., Hotchkiss R.S., Perlman H. (2010) Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis and rheumatism, 62(2):441-51.

 PubMed


Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis.

Bradfute S.B., Swanson P.E., Smith M.A., Watanabe E., McDunn J.E., Hotchkiss R.S., Bavari S. (2010) Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis. Journal of immunology (Baltimore, Md. : 1950), 184(1):327-35.

 PubMed


Cell death.

Hotchkiss R.S., Strasser A., McDunn J.E., Swanson P.E. (2009) Cell death. The New England journal of medicine, 361(16):1570-83.

 PubMed


Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury.

Cobb J.P., Moore E.E., Hayden D.L., Minei J.P., Cuschieri J., Yang J., Li Q., Lin N., Brownstein B.H., Hennessy L., Mason P.H., Schierding W.S., Dixon D.J., Tompkins R.G., Warren H.S., Schoenfeld D.A., Maier R.V. (2009) Validation of the riboleukogram to detect ventilator-associated pneumonia after severe injury. Annals of surgery, 250(4):531-9.

 PubMed


Analysis of the relationship between longitudinal gene expressions and ordered categorical event data.

Rajicic N., Finkelstein D.M., Schoenfeld D.A., Baker H.V., Balis U., Bankey P., Billiar T.R., Brownstein B.H., Calvano S.E., Camp II D.G., Casella G., Chaudry I.H., Cobb J.P., Cuschieri J., Davis R.W., De A.K., Finnerty C.C., Freeman B., Gamelli R.L., Gibran N.S., Harbrecht B.G., Hayden D.L., Hennessy L., Herndon D.N., Horton J.W., Jeschke M.G., Johnson J., Klein M.B., Lederer J.A., Lowry S.F., Maier R.V., Mannick J.A., Mason P.H., McDonald-Smith G.P., Miller-Graziano C.L., Mindrinos M.N., Minei J.P., Moldawer L.L., Moore E.E., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Shapiro M.B., Silver G.M., Smith R.D., Storey J., Tibshirani R., Tompkins R.G., Toner M., Warren H.S., West M.A., Xiao W. (2009) Analysis of the relationship between longitudinal gene expressions and ordered categorical event data. Statistics in medicine, 28(22):2817-32.

 PubMed


Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma.

Simon Jr. P.O., McDunn J.E., Kashiwagi H., Chang K., Goedegebuure P.S., Hotchkiss R.S., Hawkins W.G. (2009) Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma. International journal of cancer. Journal international du cancer, 125(4):942-51.

 PubMed


Inflammation and the host response to injury, a Large-Scale Collaborative Project: patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients.

Evans H.L., Cuschieri J., Moore E.E., Shapiro M.B., Nathens A.B., Johnson J.L., Harbrecht B.G., Minei J.P., Bankey P.E., Maier R.V., West M.A., Baker H.V., Billiar T.R., Brownstein B.H., Calvano S.E., Chaudry I.H., Cobb J.P., Cooper C., Davis R.W., Fay A., Feezor R.J., Gamelli R.L., Gibran N.S., Hayden D., Herndon D.N., Hunt J.L., Laudanski K., Lederer J.A., Lowry S.F., Mannick J.A., Miller-Graziano C.L., Mindrinos M., Moldawer L.L., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D., Sheridan R.L., Silver G.M., Smith R.D., Stephanopoulos G., Tompkins R.G., Toner M., Warren H.S., Wolf S.E., Xiao W., Yarmush M., Young V.R. (2009) Inflammation and the host response to injury, a Large-Scale Collaborative Project: patient-oriented research core standard operating procedures for clinical care IX. Definitions for complications of clinical care of critically injured patients. The Journal of trauma, 67(2):384-8.

 PubMed


Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.

Unsinger J., McDonough J.S., Shultz L.D., Ferguson T.A., Hotchkiss R.S. (2009) Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. Journal of leukocyte biology, 86(2):219-27.

 PubMed


Targeted delivery of siRNA to cell death proteins in sepsis.

Brahmamdam P., Watanabe E., Unsinger J., Chang K.C., Schierding W., Hoekzema A.S., Zhou T.T., McDonough J.S., Holemon H., Heidel J.D., Coopersmith C.M., McDunn J.E., Hotchkiss R.S. (2009) Targeted delivery of siRNA to cell death proteins in sepsis. Shock (Augusta, Ga.), 32(2):131-9.

 PubMed


A genomic score prognostic of outcome in trauma patients.

Warren H.S., Elson C.M., Hayden D.L., Schoenfeld D.A., Cobb J.P., Maier R.V., Moldawer L.L., Moore E.E., Harbrecht B.G., Pelak K., Cuschieri J., Herndon D.N., Jeschke M.G., Finnerty C.C., Brownstein B.H., Hennessy L., Mason P.H., Tompkins R.G. (2009) A genomic score prognostic of outcome in trauma patients. Molecular medicine (Cambridge, Mass.), 15(7-8):220-7.

 PubMed


An anti-apoptotic peptide improves survival in lethal total body irradiation.

McDunn J.E., Muenzer J.T., Dunne B., Zhou A., Yuan K., Hoekzema A., Hilliard C., Chang K.C., Davis C.G., McDonough J., Hunt C., Grigsby P., Piwnica-Worms D., Hotchkiss R.S. (2009) An anti-apoptotic peptide improves survival in lethal total body irradiation. Biochemical and biophysical research communications, 382(4):657-62.

 PubMed


The sepsis seesaw: tilting toward immunosuppression.

Hotchkiss R.S., Coopersmith C.M., McDunn J.E., Ferguson T.A. (2009) The sepsis seesaw: tilting toward immunosuppression. Nature medicine, 15(5):496-7.

 PubMed


Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study.

Watanabe E., Muenzer J.T., Hawkins W.G., Davis C.G., Dixon D.J., McDunn J.E., Brackett D.J., Lerner M.R., Swanson P.E., Hotchkiss R.S. (2009) Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Laboratory investigation; a journal of technical methods and pathology, 89(5):549-61.

 PubMed


Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages.

Peck-Palmer O.M., Unsinger J., Chang K.C., McDonough J.S., Perlman H., McDunn J.E., Hotchkiss R.S. (2009) Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages. Shock (Augusta, Ga.), 31(4):359-66.

 PubMed


Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury.

Unsinger J., Kazama H., McDonough J.S., Hotchkiss R.S., Ferguson T.A. (2009) Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury. Journal of leukocyte biology, 85(3):382-90.

 PubMed


Leukocyte phenotyping to stratify septic shock patients.

McDunn J.E., Hotchkiss R.S. (2009) Leukocyte phenotyping to stratify septic shock patients. Critical care (London, England), 13(2):127.

 PubMed


Costimulatory blockade-mediated lung allograft acceptance is abrogated by overexpression of Bcl-2 in the recipient.

Okazaki M., Sugimoto S., Lai J., Kornfeld C.G., Hotchkiss R.S., Richardson S.B., Li W., Kreisel F.H., Huang H.J., Patterson G.A., Krupnick A.S., Gelman A.E., Kreisel D. (2009) Costimulatory blockade-mediated lung allograft acceptance is abrogated by overexpression of Bcl-2 in the recipient. Transplantation proceedings, 41(1):385-7.

 PubMed


Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance.

Robertson C.M., Perrone E.E., McConnell K.W., Dunne W.M., Boody B., Brahmbhatt T., Diacovo M.J., Van Rooijen N., Hogue L.A., Cannon C.L., Buchman T.G., Hotchkiss R.S., Coopersmith C.M. (2008) Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance. The Journal of surgical research, 150(2):278-85.

 PubMed


Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients.

Russom A., Sethu P., Irimia D., Mindrinos M.N., Calvano S.E., Garcia I., Finnerty C., Tannahill C., Abouhamze A., Wilhelmy J., Lopez M.C., Baker H.V., Herndon D.N., Lowry S.F., Maier R.V., Davis R.W., Moldawer L.L., Tompkins R.G., Toner M., Bankey P.E., Billiar T.R., Brownstein B.H., Camp II D.G., Casella G., Chaudry I.H., Choudhry M., Cobb J.P., De A., Elson C., Freeman B., Gamelli R.L., Gibran N.S., Hayden D.L., Harbrecht B.G., Horton J.W., Hubbard W., Johnson J., Klein M.B., Lederer J.A., Logvinenko T., Mannick J.A., Mason P.H., McDonald-Smith G.P., McKinley B.A., Miller-Graziano C., Minei J.P., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick D.G., Schoenfeld D.A., Shapiro M.B., Schwacha M., Silver G.M., Smith R.D., Storey J., Warren H.S., West M.A., Xiao W. (2008) Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. Clinical chemistry, 54(5):891-900.

 PubMed


Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.

Peck-Palmer O.M., Unsinger J., Chang K.C., Davis C.G., McDunn J.E., Hotchkiss R.S. (2008) Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival. Journal of leukocyte biology, 83(4):1009-18.

 PubMed


Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis.

Rajan S., Vyas D., Clark A.T., Woolsey C.A., Clark J.A., Hotchkiss R.S., Buchman T.G., Coopersmith C.M. (2008) Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis. Shock (Augusta, Ga.), 29(4):483-9.

 PubMed


Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice.

Lederer J.A., Brownstein B.H., Lopez M.C., MacMillan S., Delisle A.J., MacConmara M.P., Choudhry M.A., Xiao W., Lekousi S., Cobb J.P., Baker H.V., Mannick J.A., Chaudry I.H., Balis U., Bankey P., Billiar T.R., Calvano S.E., Camp II D.G., Cuschieri J., Davis R.W., De A.K., Elson C., Finnerty C.C., Freeman B., Gamelli R.L., Gibran N.S., Harbrecht B.G., Hayden D.L., Hennessy L., Herndon D.N., Horton J.W., Jeschke M.G., Johnson J., Klein M.B., Lowry S.F., Maier R.V., Mason P.H., McDonald-Smith G.P., Miller-Graziano C.L., Mindrinos M.N., Minei J.P., Moldawer L.L., Moore E.E., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D.A., Shapiro M.B., Silver G.M., Smith R.D., Storey J., Tibshirani R., Tompkins R.G., Toner M., Warren H.S., West M.A. (2008) Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice. Physiological genomics, 32(3):299-310.

 PubMed


Lymphocyte phenotyping to distinguish septic from nonseptic critical illness.

Schwulst S.J., Muenzer J.T., Chang K.C., Brahmbhatt T.S., Coopersmith C.M., Hotchkiss R.S. (2008) Lymphocyte phenotyping to distinguish septic from nonseptic critical illness. Journal of the American College of Surgeons, 206(2):335-42.

 PubMed


Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis.

McDunn J.E., Muenzer J.T., Rachdi L., Chang K.C., Davis C.G., Dunne W.M., Piwnica-Worms D., Bernal-Mizrachi E., Hotchkiss R.S. (2008) Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22(2):561-8.

 PubMed


V. Guidelines for sedation and analgesia during mechanical ventilation general overview.

Shapiro M.B., West M.A., Nathens A.B., Harbrecht B.G., Moore F.A., Bankey P.E., Freeman B., Johnson J.L., McKinley B.A., Minei J.P., Moore E.E., Maier R.V., Arnoldo B.D., Baker H.V., Billiar T.R., Brownstein B.H., Calvano S.E., Camp II D.G., Campbell-Finnerty C., Casell G., Chaudry I.H., Cobb J.P., Davis R.W., De A.K., Elson C., Gamelli R.L., Gibran N.S., Hayden D.L., Hennessy L., Herndon D.N., Horton J.W., Jeschke M.G., Klein M.B., Lederer J.A., Lowry S.F., Mannick J.A., Mason P.H., McDonald-Smith G.P., Miller-Graziano C.L., Mindrinos M.N., Moldawer L.L., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D.A., Silver G.M., Smith R.D., Storey J., Tompkins R.G., Toner M., Warren H.S., Xiao W. (2007) V. Guidelines for sedation and analgesia during mechanical ventilation general overview. The Journal of trauma, 63(4):945-50.

 PubMed


Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.

Chu W., Rothfuss J., D'Avignon A., Zeng C., Zhou D., Hotchkiss R.S., Mach R.H. (2007) Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. Journal of medicinal chemistry, 50(15):3751-5.

 PubMed


Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy.

Zeng C., Vangveravong S., Xu J., Chang K.C., Hotchkiss R.S., Wheeler K.T., Shen D., Zhuang Z.-P., Kung H.F., Mach R.H. (2007) Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer research, 67(14):6708-16.

 PubMed


TAT-Bim induces extensive apoptosis in cancer cells.

Kashiwagi H., McDunn J.E., Goedegebuure P.S., Gaffney M.C., Chang K., Trinkaus K., Piwnica-Worms D., Hotchkiss R.S., Hawkins W.G. (2007) TAT-Bim induces extensive apoptosis in cancer cells. Annals of surgical oncology, 14(5):1763-71.

 PubMed


Anti-apoptotic peptides protect against radiation-induced cell death.

McConnell K.W., Muenzer J.T., Chang K.C., Davis C.G., McDunn J.E., Coopersmith C.M., Hilliard C.A., Hotchkiss R.S., Grigsby P.W., Hunt C.R. (2007) Anti-apoptotic peptides protect against radiation-induced cell death. Biochemical and biophysical research communications, 355(2):501-7.

 PubMed


Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo.

Wagner T.H., Drewry A.M., MacMillan S., Dunne W.M., Chang K.C., Karl I.E., Hotchkiss R.S., Cobb J.P. (2007) Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo. American journal of physiology. Regulatory, integrative and comparative physiology, 292(4):R1751-9.

 PubMed


Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis.

Chang K.C., Unsinger J., Davis C.G., Schwulst S.J., Muenzer J.T., Strasser A., Hotchkiss R.S. (2007) Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 21(3):708-19.

 PubMed


Adoptive transfer of dying cells causes bystander-induced apoptosis.

Schwulst S.J., Davis C.G., Coopersmith C.M., Hotchkiss R.S. (2007) Adoptive transfer of dying cells causes bystander-induced apoptosis. Biochemical and biophysical research communications, 353(3):780-5.

 PubMed


Prevention of immune cell apoptosis as potential therapeutic strategy for severe infections.

Parrino J., Hotchkiss R.S., Bray M. (2007) Prevention of immune cell apoptosis as potential therapeutic strategy for severe infections. Emerging infectious diseases, 13(2):191-8.

 PubMed


Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis.

Muenzer J.T., Davis C.G., Dunne B.S., Unsinger J., Dunne W.M., Hotchkiss R.S. (2006) Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis. Shock (Augusta, Ga.), 26(6):565-70.

 PubMed


The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis.

Unsinger J., Herndon J.M., Davis C.G., Muenzer J.T., Hotchkiss R.S., Ferguson T.A. (2006) The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis. Journal of immunology (Baltimore, Md. : 1950), 177(11):7968-73.

 PubMed


Molecular diagnostics in sepsis: from bedside to bench.

Chung T.P., Laramie J.M., Meyer D.J., Downey T., Tam L.H.Y., Ding H., Buchman T.G., Karl I., Stormo G.D., Hotchkiss R.S., Cobb J.P. (2006) Molecular diagnostics in sepsis: from bedside to bench. Journal of the American College of Surgeons, 203(5):585-598.

 PubMed


Apoptosis and caspases regulate death and inflammation in sepsis.

Hotchkiss R.S., Nicholson D.W. (2006) Apoptosis and caspases regulate death and inflammation in sepsis. Nature reviews. Immunology, 6(11):813-22.

 PubMed


Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways.

Laudanski K., Miller-Graziano C., Xiao W., Mindrinos M.N., Richards D.R., De A., Moldawer L.L., Maier R.V., Bankey P., Baker H.V., Brownstein B.H., Cobb J.P., Galvano S.E., Davis R.W., Tompkins R.G., Billiar T.R., Camp II D., Campbell-Finnerty C., Casella G., Chaudry I.H., Choudhry M., Elson C., Freeman B., Gamelli R.L., Gibran N.S., Harbrecht B.G., Hayden D.L., Herndon D.N., Horton J.W., Hubbard W., Hunt J.L., Johnson J., Klein M.B., Lederer J.A., Logvinenko T., Lowry S.F., Mannick J.A., Mason P.H., McDonald-Smith G.P., McKinley B.A., Minei J.P., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D.A., Shapiro M.B., Schwacha M., Silver G.M., Smith R.D., Storey J., Toner M., Warren H.S., West M.A. (2006) Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proceedings of the National Academy of Sciences of the United States of America, 103(42):15564-9.

 PubMed


High dynamic range characterization of the trauma patient plasma proteome.

Liu T., Qiant W.-J., Gritsenko M.A., Xiao W., Moldawer L.L., Kaushal A., Monroe M.E., Varnum S.M., Moore R.J., Purvine S.O., Maier R.V., Davis R.W., Tompkins R.G., Camp II D.G., Smith R.D., Baker H.V., Bankey P.E., Billiar T.R., Brownstein B.H., Calvano S.E., Campbell-Finnerty C., Casella G., Chaudry I.H., Choudhry M., Cobb J.P., De A., Elson C., Freeman B., Gamelli R.L., Gibran N.S., Harbrecht B.G., Hayden D.L., Herndon D.N., Horton J.W., Hubbard W., Hunt J.L., Johnson J.L., Klein M.B., Lederer J.A., Logvinenko T., Lowry S.F., Mannick J.A., Mason P.H., McDonald-Smith G.P., McKinley B., Miller-Graziano C.L., Mindrinos M., Minei J.P., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick D.G., Schoenfeld D., Shapiro M.B., Schwacha M., Silver G.M., Storey J., Toner M., Shaw Warren H., West M.A. (2006) High dynamic range characterization of the trauma patient plasma proteome. Molecular & cellular proteomics : MCP, 5(10):1899-913.

 PubMed


The number of genes changing expression after chronic exposure to code division multiple access or frequency DMA radiofrequency radiation does not exceed the false-positive rate.

Whitehead T.D., Moros E.G., Brownstein B.H., Roti Roti J.L. (2006) The number of genes changing expression after chronic exposure to code division multiple access or frequency DMA radiofrequency radiation does not exceed the false-positive rate. Proteomics, 6(17):4739-44.

 PubMed


Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis.

McDunn J.E., Turnbull I.R., Polpitiya A.D., Tong A., MacMillan S.K., Osborne D.F., Hotchkiss R.S., Colonna M., Cobb J.P. (2006) Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis. Journal of the American College of Surgeons, 203(3):365-75.

 PubMed


Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis.

Schreiber T., Swanson P.E., Chang K.C., Davis C.C., Dunne W.M., Karl I.E., Reinhart K., Hotchkiss R.S. (2006) Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis. Shock (Augusta, Ga.), 26(3):271-6.

 PubMed


Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis.

Sethu P., Moldawer L.L., Mindrinos M.N., Scumpia P.O., Tannahill C.L., Wilhelmy J., Efron P.A., Brownstein B.H., Tompkins R.G., Toner M. (2006) Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis. Analytical chemistry, 78(15):5453-61.

 PubMed


Inflammation and the host response to injury: an overview of the multicenter study of the genomic and proteomic response to burn injury.

Klein M.B., Silver G., Gamelli R.L., Gibran N.S., Herndon D.N., Hunt J.L., Tompkins R.G., Baker H.V., Bankey P., Billiar T.R., Brownstein B.H., Calvano S.E., Camp II D.G., Campbell-Finnerty C., Casella G., Chaudry I.H., Cobb J.P., Davis R.W., De A.K., Elson C., Freeman B., Harbrecht B.G., Hayden D.L., Horton J.W., Johnson J., Lederer J.A., Logvinenko T., Lowry S.F., Maier R.V., Mannick J.A., Mason P.H., McDonald-Smith G.P., McKinley B.A., Miller-Graziano C.L., Mindrinos M.N., Minei J.P., Moldawer L.L., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D.A., Shapiro M.B., Silver G.M., Smith R.D., Storey J., Toner M., Warren H.S., West M.A., Xiao W. (2006) Inflammation and the host response to injury: an overview of the multicenter study of the genomic and proteomic response to burn injury. Journal of burn care & research : official publication of the American Burn Association, 27(4):448-51.

 PubMed


Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis.

Schwulst S.J., Grayson M.H., DiPasco P.J., Davis C.G., Brahmbhatt T.S., Ferguson T.A., Hotchkiss R.S. (2006) Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950), 177(1):557-65.

 PubMed


Gene expression does not change significantly in C3H 10T(1/2) cells after exposure to 847.74 CDMA or 835.62 FDMA radiofrequency radiation.

Whitehead T.D., Moros E.G., Brownstein B.H., Roti Roti J.L. (2006) Gene expression does not change significantly in C3H 10T(1/2) cells after exposure to 847.74 CDMA or 835.62 FDMA radiofrequency radiation. Radiation research, 165(6):626-35.

 PubMed


TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo.

Hotchkiss R.S., McConnell K.W., Bullok K., Davis C.G., Chang K.C., Schwulst S.J., Dunne J.C., Dietz G.P.H., Bahr M., McDunn J.E., Karl I.E., Wagner T.H., Cobb J.P., Coopersmith C.M., Piwnica-Worms D. (2006) TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. Journal of immunology (Baltimore, Md. : 1950), 176(9):5471-7.

 PubMed


Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury.

Brownstein B.H., Logvinenko T., Lederer J.A., Cobb J.P., Hubbard W.J., Chaudry I.H., Remick D.G., Baker H.V., Xiao W., Mannick J.A. (2006) Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury. Physiological genomics, 24(3):298-309.

 PubMed


Prevention of lymphocyte apoptosis--a potential treatment of sepsis?

Hotchkiss R.S., Coopersmith C.M., Karl I.E. (2005) Prevention of lymphocyte apoptosis--a potential treatment of sepsis? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 41 Suppl 7():S465-9.

 PubMed


A network-based analysis of systemic inflammation in humans.

Calvano S.E., Xiao W., Richards D.R., Felciano R.M., Baker H.V., Cho R.J., Chen R.O., Brownstein B.H., Cobb J.P., Tschoeke S.K., Miller-Graziano C., Moldawer L.L., Mindrinos M.N., Davis R.W., Tompkins R.G., Lowry S.F. (2005) A network-based analysis of systemic inflammation in humans. Nature, 437(7061):1032-7.

 PubMed


Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury.

Husain K.D., Stromberg P.E., Woolsey C.A., Turnbull I.R., Dunne W.M., Javadi P., Buchman T.G., Karl I.E., Hotchkiss R.S., Coopersmith C.M. (2005) Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury. Critical care medicine, 33(10):2350-7.

 PubMed


Expression of the proto-oncogene Fos after exposure to radiofrequency radiation relevant to wireless communications.

Whitehead T.D., Brownstein B.H., Parry J.J., Thompson D., Cha B.A., Moros E.G., Rogers B.E., Roti Roti J.L. (2005) Expression of the proto-oncogene Fos after exposure to radiofrequency radiation relevant to wireless communications. Radiation research, 164(4 Pt 1):420-30.

 PubMed


Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels.

Vyas D., Javadi P., DiPasco P.J., Buchman T.G., Hotchkiss R.S., Coopersmith C.M. (2005) Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels. American journal of physiology. Regulatory, integrative and comparative physiology, 289(4):R1048-53.

 PubMed


Iron dysregulation combined with aging prevents sepsis-induced apoptosis.

Javadi P., Buchman T.G., Stromberg P.E., Turnbull I.R., Vyas D., Hotchkiss R.S., Karl I.E., Coopersmith C.M. (2005) Iron dysregulation combined with aging prevents sepsis-induced apoptosis. The Journal of surgical research, 128(1):37-44.

 PubMed


Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach.

Qian W.-J., Monroe M.E., Liu T., Jacobs J.M., Anderson G.A., Shen Y., Moore R.J., Anderson D.J., Zhang R., Calvano S.E., Lowry S.F., Xiao W., Moldawer L.L., Davis R.W., Tompkins R.G., Camp II D.G., Smith R.D., Baker H.V., Bankey P., Billiar T.R., Brownstein B.H., Chaudry I.H., Cobb J.P., Fay A., Feezor R.J., Freeman B., Gamelli R.L., Gibran N.S., Harbrecht B.G., Hayden D., Herndon D.N., Horton J.W., Hunt J.L., Johnson J.L., Laudanski K., Lederer J.A., Logvinenko T., Maier R.V., Mannick J.A., McKinley B., Miller-Graziano C.L., Minei J.P., Mindrinos M., Moore E.E., Moore F.A., Nathens A.B., O'Keefe G.E., Rahme L.G., Remick Jr. D.G., Schoenfeld D., Shapiro M.B., Sheridan R.L., Silver G.M., Somers S., Toner M., Warren H.S., West M.A., Wolf S.E., Yarmush M., Young V.R. (2005) Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach. Molecular & cellular proteomics : MCP, 4(5):700-9.

 PubMed


Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways.

Hotchkiss R.S., Osmon S.B., Chang K.C., Wagner T.H., Coopersmith C.M., Karl I.E. (2005) Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. Journal of immunology (Baltimore, Md. : 1950), 174(8):5110-8.

 PubMed


Application of genome-wide expression analysis to human health and disease.

Cobb J.P., Mindrinos M.N., Miller-Graziano C., Calvano S.E., Baker H.V., Xiao W., Laudanski K., Brownstein B.H., Elson C.M., Hayden D.L., Herndon D.N., Lowry S.F., Maier R.V., Schoenfeld D.A., Moldawer L.L., Davis R.W., Tompkins R.G. (2005) Application of genome-wide expression analysis to human health and disease. Proceedings of the National Academy of Sciences of the United States of America, 102(13):4801-6.

 PubMed


Whole blood and leukocyte RNA isolation for gene expression analyses.

Feezor R.J., Baker H.V., Mindrinos M., Hayden D., Tannahill C.L., Brownstein B.H., Fay A., MacMillan S., Laramie J., Xiao W., Moldawer L.L., Cobb J.P., Laudanski K., Miller-Graziano C.L., Maier R.V., Schoenfeld D., Davis R.W., Tompkins R.G. (2005) Whole blood and leukocyte RNA isolation for gene expression analyses. Physiological genomics, 19(3):247-54.

 PubMed


Age disproportionately increases sepsis-induced apoptosis in the spleen and gut epithelium.

Turnbull I.R., Buchman T.G., Javadi P., Woolsey C.A., Hotchkiss R.S., Karl I.E., Coopersmith C.M. (2004) Age disproportionately increases sepsis-induced apoptosis in the spleen and gut epithelium. Shock (Augusta, Ga.), 22(4):364-8.

 PubMed