Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics.

Shin G, Gomez AM, Al-Hasani R, Jeong YR, Kim J, Xie Z, Banks A, Lee SM, Han SY, Yoo CJ, Lee JL, Lee SH, Kurniawan J, Tureb J, Guo Z, Yoon J, Park SI, Bang SY, Nam Y, Walicki MC, Samineni VK, Mickle AD, Lee K, Heo SY, McCall JG, Pan T, Wang L, Feng X, Kim TI, Kim JK, Li Y, Huang Y, Gereau RW, Ha JS, Bruchas MR, Rogers JA (2017) Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics. Neuron, 93(3):509-521.

 PubMed


Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics.

Park SI, Shin G, McCall JG, Al-Hasani R, Norris A, Xia L, Brenner DS, Noh KN, Bang SY, Bhatti DL, Jang KI, Kang SK, Mickle AD, Dussor G, Price TJ, Gereau RW 4th, Bruchas MR, Rogers JA. (2016) Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics. Proceedings of the National Academy of Sciences of the United States of America, 113(50):E8169-E8177.

 PubMed


Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures.

Valtcheva MV, Copits BA, Davidson S, Sheahan TD, Pullen MY, McCall JG, Dikranian K, Gereau RW 4th (2016) Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures. Nature Protocols, 11(10):1877-88.

 PubMed


Group II mGluRs suppress hyperexcitability in mouse and human nociceptors.

Davidson S, Golden JP, Copits BA, Ray PR, Vogt SK, Valtcheva MV, Schmidt RE, Ghetti A, Price T, Gereau RW 4th (2016) Group II mGluRs suppress hyperexcitability in mouse and human nociceptors. Pain, 157(9):2081-8.

 PubMed


Spotlight on pain: optogenetic approaches for interrogating somatosensory circuits.

Copits BA, Pullen MY, Gereau RW 4th (2016) Spotlight on pain: optogenetic approaches for interrogating somatosensory circuits. Pain, 157(11):2424-2433..

 PubMed


Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics.

Park SI, Brenner DS, Shin G, Morgan CD, Copits BA, Chung HU, Pullen MY, Noh KN, Davidson S, Oh SJ, Yoon J, Jank KI, Samineni VK, Norman M, Grajales-Reyes JG, Vogt SK, Sundaram SS, Wilson KM, Ha JS, Xu R, Pan T, Kim TI, Huan Y, Montana MC, Golden JP, Bruchas MR, Gereau RW, Rogers JA (2015) Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics. Nature Biotechnology, 33(12):1280-1286.

 PubMed


Animal Models of Urologic Chronic Pelvic Pain Syndromes: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network.

Lai H, Gereau RW 4th, Luo Y, O'Donnell M, Rudick CN, Pontari M, Mullins C, Klumpp DJ. (2015) Animal Models of Urologic Chronic Pelvic Pain Syndromes: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network. Urology, 85(6):1454-65.

 PubMed


ERK2 Alone Drives Inflammatory Pain But Cooperates with ERK1 in Sensory Neuron Survival.

O'Brien DE, Alter BJ, Satomoto M, Morgan CD, Davidson S, Vogt SK, Norman ME, Gereau GB, Demaro JA 3rd, Landreth GE, Golden JG, Gereau RW 4th (2015) ERK2 Alone Drives Inflammatory Pain But Cooperates with ERK1 in Sensory Neuron Survival. The Journal of Neuroscience, 35(25):9491-507.

 PubMed


Spatiotemporal Control of Opioid Signaling and Behavior.

Siuda ER, Copits BA, Schmidt MJ, Baird MA, Al-Hasani R, Planer WJ, Funderburk SC, McCall JG, Gereau RW 4th, Bruchas MR (2015) Spatiotemporal Control of Opioid Signaling and Behavior. Neuron, 86(4):923-35.

 PubMed


A simple and inexpensive method for determining cold sensitivity and adaptation in mice.

Brenner DS, Golden JP, Vogt SK, Gereau RW 4th (2015) A simple and inexpensive method for determining cold sensitivity and adaptation in mice. Journal of visualized experiments : JoVE, (97):.

 PubMed


Enhanced non-peptidergic intraepidermal fiber density and an expanded subset of chloroquine-responsive trigeminal neurons in a mouse model of dry skin itch.

Valtcheva MV, Samineni VK, Golden JP, Gereau RW 4th, Davidson S (2015) Enhanced non-peptidergic intraepidermal fiber density and an expanded subset of chloroquine-responsive trigeminal neurons in a mouse model of dry skin itch. The Journal of Pain, 16(4):346-56.

 PubMed


Protein kinase Cdelta mediates histamine-evoked itch and responses in pruriceptors.

Valtcheva MV, Davidson S, Zhao C, Leitges M, Gereau RW 4th (2015) Protein kinase Cdelta mediates histamine-evoked itch and responses in pruriceptors. Molecular pain, 11(1):1.

 PubMed


Voluntary Exercise Training: Analysis of Mice in Uninjured, Inflammatory, and Nerve-Injured Pain States.

Sheahan TD, Copits BA, Golden JP, Gereau RW 4th (2015) Voluntary Exercise Training: Analysis of Mice in Uninjured, Inflammatory, and Nerve-Injured Pain States. PloS one, 10(7):e0133191.

 PubMed


HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors.

Zammataro M, Sortino MA, Parenti C, Gereau RW 4th, Chiechio S (2014) HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors. Molecular pain, 10(1):68.

 PubMed


A technique to measure cold adaptation in freely behaving mice.

Brenner DS, Vogt SK, Gereau RW 4th (2014) A technique to measure cold adaptation in freely behaving mice. Journal of Neuroscience Methods, 236():86-91.

 PubMed


A Pain Research Agenda for the 21st Century.

Gereau RW 4th, Sluka KA, Maixner W, Savage SR, Price TJ, Murinson BB, Sullivan MD, Fillingim RB (2014) A Pain Research Agenda for the 21st Century. The Journal of Pain, 15(12):1203-14.

 PubMed


TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.

Chen Y, Kanju P, Fang Q, Lee SH, Parekh PK, Lee W, Moore C, Brenner D, Gereau RW 4th, Wang F (2014) TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. Pain, 155(12):2662-72.

 PubMed


A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo.

Brenner DS, Golden JP, Vogt SK, Dhaka A, Story GM, Gereau RW 4th (2014) A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo. Pain, 155(10):2124–2133.

 PubMed


Human sensory neurons: Membrane properties and sensitization by inflammatory mediators.

Davidson S, Copits BA, Zhang J, Page G, Ghetti A, Gereau RW 4th (2014) Human sensory neurons: Membrane properties and sensitization by inflammatory mediators. Pain, 155(9):1861-70.

 PubMed


The overlap and distinction of self-reported symptoms between interstitial cystitis/bladder pain syndrome and overactive bladder: a questionnaire-based analysis.

Lai HH, Vetter J, Jain S, Gereau RW 4th, Andriole GL (2014) The overlap and distinction of self-reported symptoms between interstitial cystitis/bladder pain syndrome and overactive bladder: a questionnaire-based analysis. The Journal of Urology, 192(6):1679-86 .

 PubMed


Segmental Hyperalgesia to Mechanical Stimulus in Interstitial Cystitis/Bladder Pain Syndrome - Evidence of Central Sensitization.

Lai HH, Gardner V, Ness TJ, Gereau RW 4th (2014) Segmental Hyperalgesia to Mechanical Stimulus in Interstitial Cystitis/Bladder Pain Syndrome - Evidence of Central Sensitization. The Journal of Urology, 191(5):1294-9.

 PubMed


Reproducibility of the heat/capsaicin skin sensitization model in healthy volunteers.

Cavallone LF, Frey K, Montana MC, Joyal J, Regina KJ, Petersen KL, Gereau RW 4th (2013) Reproducibility of the heat/capsaicin skin sensitization model in healthy volunteers. Journal of Pain Research, 6():771-84.

 PubMed


Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons.

Golden JP, Demaro JA 3rd, Knoten A, Hoshi M, Pehek E, Johnson EM Jr, Gereau RW 4th, Jain S (2013) Dopamine-dependent compensation maintains motor behavior in mice with developmental ablation of dopaminergic neurons. The Journal of Neuroscience, 33(43):17095-107.

 PubMed


Assessment of Pain and Itch Behavior in a Mouse Model of Neurofibromatosis Type 1.

O'Brien DE, Brenner DS, Gutmann DH, Gereau RW 4th (2013) Assessment of Pain and Itch Behavior in a Mouse Model of Neurofibromatosis Type 1. The journal of Pain, 14(6):628-37.

 PubMed


Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion.

Chen Y, Williams SH, McNulty AL, Hong JH, Lee SH, Rothfusz NE, Parekh PK, Moore C, Gereau RW 4th, Taylor AB, Wang F, Guilak F, Liedtke W (2013) Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion. Pain, 154(8):1295-304.

 PubMed


Protamine Sulfate Induced Bladder Injury Protects from Distention Induced Bladder Pain.

Stemler KM, Crock LW, Lai HH, Mills JC, Gereau RW 4th, Mysorekar IU (2013) Protamine Sulfate Induced Bladder Injury Protects from Distention Induced Bladder Pain. The Journal of Urology, 189(1):343-51.

 PubMed


Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain.

Crock LW, Kolber BJ, Morgan CD, Sadler KE, Vogt SK, Bruchas MR, Gereau RW 4th (2012) Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(41):14217-26.

 PubMed


Understanding chronic inflammatory and neuropathic pain.

Hughes JP, Chessell I, Malamut R, Perkins M, Bačkonja M, Baron R, Farrar JT, Field MJ, Gereau RW, Gilron I (2012) Understanding chronic inflammatory and neuropathic pain. Annals of the New York Academy of Sciences, 1255():30-44.

 PubMed


Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception.

Crock LW, Stemler KM, Song DG, Abbosh P, Vogt SK, Qiu CS, Lai HH, Mysorekar IU, Gereau RW 4th (2012) Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception. Molecular pain, 8():20.

 PubMed


A novel behavioral assay for measuring cold sensation in mice.

Brenner DS, Golden JP, Gereau RW 4th (2012) A novel behavioral assay for measuring cold sensation in mice. PloS one, 7(6):e39765.

 PubMed


Isozyme-specific effects of protein kinase C in pain modulation.

Zhao C., Leitges M., Gereau R.W. (2011) Isozyme-specific effects of protein kinase C in pain modulation. Anesthesiology, 115(6):1261-70.

 PubMed


Metabotropic glutamate receptor 5 antagonism with fenobam: examination of analgesic tolerance and side effect profile in mice.

Montana M.C., Conrardy B.A., Cavallone L.F., Kolber B.J., Rao L.K., Greco S.C., Gereau R.W. (2011) Metabotropic glutamate receptor 5 antagonism with fenobam: examination of analgesic tolerance and side effect profile in mice. Anesthesiology, 115(6):1239-50.

 PubMed


Metabotropic glutamate receptors as targets for analgesia: antagonism, activation, and allosteric modulation.

Montana M.C., Gereau IV R.W. (2011) Metabotropic glutamate receptors as targets for analgesia: antagonism, activation, and allosteric modulation. Current pharmaceutical biotechnology, 12(10):1681-8.

 PubMed


Activation of spinal extracellular signal-regulated kinases (ERK) 1/2 is associated with the development of visceral hyperalgesia of the bladder.

Lai H.H., Qiu C.-S., Crock L.W., Morales M.E.P., Ness T.J., Gereau IV R.W. (2011) Activation of spinal extracellular signal-regulated kinases (ERK) 1/2 is associated with the development of visceral hyperalgesia of the bladder. Pain, 152(9):2117-24.

 PubMed


Headache outcomes following treatment of unruptured intracranial aneurysms: a prospective analysis.

Schwedt T.J., Gereau R.W., Frey K., Kharasch E.D. (2011) Headache outcomes following treatment of unruptured intracranial aneurysms: a prospective analysis. Cephalalgia : an international journal of headache, 31(10):1082-9.

 PubMed


Metabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K⁺ channels primarily in excitatory neurons of the spinal dorsal horn.

Hu H.-J., Gereau R.W. (2011) Metabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K⁺ channels primarily in excitatory neurons of the spinal dorsal horn. Journal of neurophysiology, 105(6):3010-21.

 PubMed


Antinociceptive effects of MSVIII-19, a functional antagonist of the GluK1 kainate receptor.

Qiu C.-S., Wyhe L.L.-V., Sasaki M., Sakai R., Swanson G.T., Gereau IV R.W. (2011) Antinociceptive effects of MSVIII-19, a functional antagonist of the GluK1 kainate receptor. Pain, 152(5):1052-60.

 PubMed


mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists.

Zammataro M., Chiechio S., Montana M.C., Traficante A., Copani A., Nicoletti F., Gereau IV R.W. (2011) mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists. Molecular pain, 7():6.

 PubMed


Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks.

Schwedt T.J., Krauss M.J., Frey K., Gereau IV R.W. (2011) Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks. Cephalalgia : an international journal of headache, 31(1):6-12.

 PubMed


Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.

Lennerz J.K., Hurov J.B., White L.S., Lewandowski K.T., Prior J.L., Planer G.J., Gereau IV R.W., Piwnica-Worms D., Schmidt R.E., Piwnica-Worms H. (2010) Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis. Molecular and cellular biology, 30(21):5043-56.

 PubMed


Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models.

Alter B.J., Zhao C., Karim F., Landreth G.E., Gereau IV R.W. (2010) Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(34):11537-47.

 PubMed


Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior.

Kolber B.J., Montana M.C., Carrasquillo Y., Xu J., Heinemann S.F., Muglia L.J., Gereau IV R.W. (2010) Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(24):8203-13.

 PubMed


Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase.

Thors L., Burston J.J., Alter B.J., McKinney M.K., Cravatt B.F., Ross R.A., Pertwee R.G., Gereau IV R.W., Wiley J.L., Fowler C.J. (2010) Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. British journal of pharmacology, 160(3):549-60.

 PubMed


RET signaling is required for survival and normal function of nonpeptidergic nociceptors.

Golden J.P., Hoshi M., Nassar M.A., Enomoto H., Wood J.N., Milbrandt J., Gereau IV R.W., Johnson Jr. E.M., Jain S. (2010) RET signaling is required for survival and normal function of nonpeptidergic nociceptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(11):3983-94.

 PubMed


The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.

Montana M.C., Cavallone L.F., Stubbert K.K., Stefanescu A.D., Kharasch E.D., Gereau IV R.W. (2009) The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine. The Journal of pharmacology and experimental therapeutics, 330(3):834-43.

 PubMed


The effects of tail biopsy for genotyping on behavioral responses to nociceptive stimuli.

Morales M.E.P., Gereau IV R.W. (2009) The effects of tail biopsy for genotyping on behavioral responses to nociceptive stimuli. PloS one, 4(7):e6457.

 PubMed


The c-kit signaling pathway is involved in the development of persistent pain.

Sun Y.-G., Gracias N.G., Drobish J.K., Vasko M.R., Gereau R.W., Chen Z.-F. (2009) The c-kit signaling pathway is involved in the development of persistent pain. Pain, 144(1-2):178-86.

 PubMed


Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain.

Chiechio S., Zammataro M., Morales M.E., Busceti C.L., Drago F., Gereau IV R.W., Copani A., Nicoletti F. (2009) Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain. Molecular pharmacology, 75(5):1014-20.

 PubMed


MAP kinase and pain.

Ji R.-R., Gereau IV R.W., Malcangio M., Strichartz G.R. (2009) MAP kinase and pain. Brain research reviews, 60(1):135-48.

 PubMed


Metabotropic receptors for glutamate and GABA in pain.

Goudet C., Magnaghi V., Landry M., Nagy F., Gereau IV R.W., Pin J.-P. (2009) Metabotropic receptors for glutamate and GABA in pain. Brain research reviews, 60(1):43-56.

 PubMed


Hemispheric lateralization of a molecular signal for pain modulation in the amygdala.

Carrasquillo Y., Gereau IV R.W. (2008) Hemispheric lateralization of a molecular signal for pain modulation in the amygdala. Molecular pain, 4():24.

 PubMed


Hotheaded: TRPV1 as mediator of hippocampal synaptic plasticity.

Alter B.J., Gereau IV R.W. (2008) Hotheaded: TRPV1 as mediator of hippocampal synaptic plasticity. Neuron, 57(5):629-31.

 PubMed


Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons.

Hu H.-J., Alter B.J., Carrasquillo Y., Qiu C.-S., Gereau IV R.W. (2007) Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(48):13181-91.

 PubMed


Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward.

Zhao Z.-Q., Gao Y.-J., Sun Y.-G., Zhao C.-S., Gereau IV R.W., Chen Z.-F. (2007) Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward. Proceedings of the National Academy of Sciences of the United States of America, 104(36):14519-24.

 PubMed


Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs.

Zhao Z.-Q., Chiechio S., Sun Y.-G., Zhang K.-H., Zhao C.-S., Scott M., Johnson R.L., Deneris E.S., Renner K.J., Gereau IV R.W., Chen Z.-F. (2007) Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(22):6045-53.

 PubMed


Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception.

Carrasquillo Y., Gereau IV R.W. (2007) Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(7):1543-51.

 PubMed


Acetyl-L-carnitine in neuropathic pain: experimental data.

Chiechio S., Copani A., Gereau 4th. R.W., Nicoletti F. (2007) Acetyl-L-carnitine in neuropathic pain: experimental data. CNS drugs, 21 Suppl 1():31-8; discussion 45-6.

 PubMed


Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity.

Zhao Z.-Q., Scott M., Chiechio S., Wang J.-S., Renner K.J., Gereau IV R.W., Johnson R.L., Deneris E.S., Chen Z.-F. (2006) Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(49):12781-8.

 PubMed


Numbing the senses: role of TRPA1 in mechanical and cold sensation.

Story G.M., Gereau IV R.W. (2006) Numbing the senses: role of TRPA1 in mechanical and cold sensation. Neuron, 50(2):177-80.

 PubMed


The kv4.2 potassium channel subunit is required for pain plasticity.

Hu H.-J., Carrasquillo Y., Karim F., Jung W.E., Nerbonne J.M., Schwarz T.L., Gereau IV R.W. (2006) The kv4.2 potassium channel subunit is required for pain plasticity. Neuron, 50(1):89-100.

 PubMed


Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK).

Karim F., Hu H.-J., Adwanikar H., Kaplan D., Gereau IV R.W. (2006) Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK). Molecular pain, 2():2.

 PubMed


Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha.

Jin X., Gereau IV R.W. (2006) Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(1):246-55.

 PubMed


Neurofibromatosis pain is in the membrane. Focus on "sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability".

Gereau IV R.W. (2005) Neurofibromatosis pain is in the membrane. Focus on "sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability". Journal of neurophysiology, 94(6):3659-60.

 PubMed


NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin.

Alagarsamy S., Saugstad J., Warren L., Mansuy I.M., Gereau IV R.W., Conn P.J. (2005) NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin. Neuropharmacology, 49 Suppl 1():135-45.

 PubMed


Posttranslational mechanisms of peripheral sensitization.

Bhave G., Gereau IV R.W. (2004) Posttranslational mechanisms of peripheral sensitization. Journal of neurobiology, 61(1):88-106.

 PubMed


Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation.

Adwanikar H., Karim F., Gereau IV R.W. (2004) Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation. Pain, 111(1-2):125-35.

 PubMed


Group II metabotropic glutamate receptors inhibit cAMP-dependent protein kinase-mediated enhancemednt of tetrodotoxin-resistant sodium currents in mouse dorsal root ganglion neurons.

Yang D., Gereau IV R.W. (2004) Group II metabotropic glutamate receptors inhibit cAMP-dependent protein kinase-mediated enhancemednt of tetrodotoxin-resistant sodium currents in mouse dorsal root ganglion neurons. Neuroscience letters, 357(3):159-62.

 PubMed


Peripheral group II metabotropic glutamate receptors mediate endogenous anti-allodynia in inflammation.

Yang D., Gereau IV R.W. (2003) Peripheral group II metabotropic glutamate receptors mediate endogenous anti-allodynia in inflammation. Pain, 106(3):411-7.

 PubMed


Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).

Bhave G., Hu H.-J., Glauner K.S., Zhu W., Wang H., Brasier D.J., Oxford G.S., Gereau IV R.W. (2003) Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proceedings of the National Academy of Sciences of the United States of America, 100(21):12480-5.

 PubMed


ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. I. Modulation of A-type K+ currents.

Hu H.-J., Glauner K.S., Gereau IV R.W. (2003) ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. I. Modulation of A-type K+ currents. Journal of neurophysiology, 90(3):1671-9.

 PubMed


ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. II. Modulation of neuronal excitability.

Hu H.-J., Gereau IV R.W. (2003) ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. II. Modulation of neuronal excitability. Journal of neurophysiology, 90(3):1680-8.

 PubMed


Growing pains: the cytoskeleton as a critical regulator of pain plasticity.

Bhave G., Gereau IV R.W. (2003) Growing pains: the cytoskeleton as a critical regulator of pain plasticity. Neuron, 39(4):577-9.

 PubMed


Membrane topology of a metabotropic glutamate receptor.

Bhave G., Nadin B.M., Brasier D.J., Glauner K.S., Shah R.D., Heinemann S.F., Karim F., Gereau IV R.W. (2003) Membrane topology of a metabotropic glutamate receptor. The Journal of biological chemistry, 278(32):30294-301.

 PubMed


Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5.

Neugebauer V., Li W., Bird G.C., Bhave G., Gereau IV R.W. (2003) Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(1):52-63.

 PubMed


Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia.

Hu H.-J., Bhave G., Gereau IV R.W. (2002) Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(17):7444-52.

 PubMed


cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation.

Bhave G., Zhu W., Wang H., Brasier D.J., Oxford G.S., Gereau IV R.W. (2002) cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron, 35(4):721-31.

 PubMed


Modulation of presynaptic calcium transients by metabotropic glutamate receptor activation: a differential role in acute depression of synaptic transmission and long-term depression.

Faas G.C., Adwanikar H., Gereau IV R.W., Saggau P. (2002) Modulation of presynaptic calcium transients by metabotropic glutamate receptor activation: a differential role in acute depression of synaptic transmission and long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(16):6885-90.

 PubMed


Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception.

Yang D., Gereau IV R.W. (2002) Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(15):6388-93.

 PubMed


Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics.

Varney M.A., Gereau 4th. R.W. (2002) Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics. Current drug targets. CNS and neurological disorders, 1(3):283-96.

 PubMed


Metabotropic glutamate receptors on peripheral sensory neuron terminals as targets for the development of novel analgesics.

Karim F., Bhave G., Gereau IV R.W. (2001) Metabotropic glutamate receptors on peripheral sensory neuron terminals as targets for the development of novel analgesics. Molecular psychiatry, 6(6):615-7.

 PubMed


Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice.

Karim F., Wang C.-C., Gereau IV R.W. (2001) Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(11):3771-9.

 PubMed


Peripheral group I metabotropic glutamate receptors modulate nociception in mice.

Bhave G., Karim F., Carlton S.M., Gereau Iv R.W. (2001) Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Nature neuroscience, 4(4):417-23.

 PubMed


Activation of N-methyl-D-aspartate receptors reverses desensitization of metabotropic glutamate receptor, mGluR5, in native and recombinant systems.

Alagarsamy S., Rouse S.T., Gereau IV R.W., Heinemann S.F., Smith Y., Conn P.J. (1999) Activation of N-methyl-D-aspartate receptors reverses desensitization of metabotropic glutamate receptor, mGluR5, in native and recombinant systems. Annals of the New York Academy of Sciences, 868():526-30.

 PubMed


Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems.

Alagarsamy S., Marino M.J., Rouse S.T., Gereau IV R.W., Heinemann S.F., Conn P.J. (1999) Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems. Nature neuroscience, 2(3):234-40.

 PubMed


Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptors.

Contractor A., Gereau IV R.W., Green T., Heinemann S.F. (1998) Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptors. Proceedings of the National Academy of Sciences of the United States of America, 95(15):8969-74.

 PubMed


Role of protein kinase C phosphorylation in rapid desensitization of metabotropic glutamate receptor 5.

Gereau IV R.W., Heinemann S.F. (1998) Role of protein kinase C phosphorylation in rapid desensitization of metabotropic glutamate receptor 5. Neuron, 20(1):143-51.

 PubMed


Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes.

Minami K., Gereau IV R.W., Minami M., Heinemann S.F., Harris R.A. (1998) Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes. Molecular pharmacology, 53(1):148-56.

 PubMed


Identification of amino acid residues that control functional behavior in GluR5 and GluR6 kainate receptors.

Swanson G.T., Gereau IV R.W., Green T., Heinemann S.F. (1997) Identification of amino acid residues that control functional behavior in GluR5 and GluR6 kainate receptors. Neuron, 19(4):913-26.

 PubMed


Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses.

Macek T.A., Winder D.G., Gereau IV R.W., Ladd C.O., Conn P.J. (1996) Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses. Journal of neurophysiology, 76(6):3798-806.

 PubMed


Novel glial-neuronal signalling by coactivation of metabotropic glutamate and beta-adrenergic receptors in rat hippocampus.

Winder D.G., Ritch P.S., Gereau IV R.W., Conn P.J. (1996) Novel glial-neuronal signalling by coactivation of metabotropic glutamate and beta-adrenergic receptors in rat hippocampus. The Journal of physiology, 494 ( Pt 3)():743-55.

 PubMed


Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1.

Gereau IV R.W., Conn P.J. (1995) Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1. The Journal of neuroscience : the official journal of the Society for Neuroscience, 15(10):6879-89.

 PubMed


Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability.

Gereau IV R.W., Conn P.J. (1995) Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability. Journal of neurophysiology, 74(1):122-9.

 PubMed


Pharmacological differentiation of the effects of co-activation of beta-adrenergic and metabotropic glutamate receptors in rat hippocampus.

Gereau IV R.W., Winder D.G., Conn P.J. (1995) Pharmacological differentiation of the effects of co-activation of beta-adrenergic and metabotropic glutamate receptors in rat hippocampus. Neuroscience letters, 186(2-3):119-22.

 PubMed


Presynaptic enhancement of excitatory synaptic transmission by beta-adrenergic receptor activation.

Gereau IV R.W., Conn P.J. (1994) Presynaptic enhancement of excitatory synaptic transmission by beta-adrenergic receptor activation. Journal of neurophysiology, 72(3):1438-42.

 PubMed


Potentiation of cAMP responses by metabotropic glutamate receptors depresses excitatory synaptic transmission by a kinase-independent mechanism.

Gereau IV R.W., Conn P.J. (1994) Potentiation of cAMP responses by metabotropic glutamate receptors depresses excitatory synaptic transmission by a kinase-independent mechanism. Neuron, 12(5):1121-9.

 PubMed


A cyclic AMP-dependent form of associative synaptic plasticity induced by coactivation of beta-adrenergic receptors and metabotropic glutamate receptors in rat hippocampus.

Gereau IV R.W., Conn P.J. (1994) A cyclic AMP-dependent form of associative synaptic plasticity induced by coactivation of beta-adrenergic receptors and metabotropic glutamate receptors in rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 14(5 Pt 2):3310-8.

 PubMed


Effect of progesterone on serotonin turnover in rats primed with estrogen implants into the ventromedial hypothalamus.

Gereau IV R.W., Kedzie K.A., Renner K.J. (1993) Effect of progesterone on serotonin turnover in rats primed with estrogen implants into the ventromedial hypothalamus. Brain research bulletin, 32(3):293-300.

 PubMed


Diffusible factor(s) from adult rat sciatic nerve increases cell number and neurite outgrowth of cultured embryonic ventral mesencephalic tyrosine hydroxylase-positive neurons.

Collier T.J., Sladek C.D., Gallagher M.J., Gereau IV R.W., Springer J.E. (1990) Diffusible factor(s) from adult rat sciatic nerve increases cell number and neurite outgrowth of cultured embryonic ventral mesencephalic tyrosine hydroxylase-positive neurons. Journal of neuroscience research, 27(3):394-9.

 PubMed