The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat alpha1beta2gamma2L GABA(A) receptor.

Li P., Akk G. (2008) The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat alpha1beta2gamma2L GABA(A) receptor. British journal of pharmacology, 155(5):783-94.

 PubMed


Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.

Akk G., Li P., Bracamontes J., Reichert D.E., Covey D.F., Steinbach J.H. (2008) Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Molecular pharmacology, 74(3):614-27.

 PubMed


Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies.

Militante J., Ma B.-W., Akk G., Steinbach J.H. (2008) Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies. Molecular pharmacology, 74(3):764-76.

 PubMed


Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopentaphenanthrenes and cyclopentaanthracenes.

Scaglione J.B., Jastrzebska I., Krishnan K., Li P., Akk G., Manion B.D., Benz A., Taylor A., Rath N.P., Evers A.S., Zorumski C.F., Mennerick S., Covey D.F. (2008) Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopentaphenanthrenes and cyclopentaanthracenes. Journal of medicinal chemistry, 51(5):1309-18.

 PubMed


Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate.

Li P., Reichert D.E., Rodriguez A.D., Manion B.D., Evers A.S., Eterovic V.A., Steinbach J.H., Akk G. (2008) Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate. British journal of pharmacology, 153(3):598-608.

 PubMed


Actions of anesthetics on excitatory transmitter-gated channels.

Akk G., Mennerick S., Steinbach J.H. (2008) Actions of anesthetics on excitatory transmitter-gated channels. Handbook of experimental pharmacology, (182):53-84.

 PubMed


Mode of cembranoid action on embryonic muscle acetylcholine receptor.

Ulrich H., Akk G., Nery A.A., Trujillo C.A., Rodriguez A.D., Eterovic V.A. (2008) Mode of cembranoid action on embryonic muscle acetylcholine receptor. Journal of neuroscience research, 86(1):93-107.

 PubMed