Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation.

Li P., Shu H.-J., Wang C., Mennerick S., Zorumski C.F., Covey D.F., Steinbach J.H., Akk G. (2007) Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation. The Journal of physiology, 584(Pt 3):789-800.

 PubMed


Mechanisms of neurosteroid interactions with GABA(A) receptors.

Akk G., Covey D.F., Evers A.S., Steinbach J.H., Zorumski C.F., Mennerick S. (2007) Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacology & therapeutics, 116(1):35-57.

 PubMed


Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor.

Li P., Bracamontes J., Katona B.W., Covey D.F., Steinbach J.H., Akk G. (2007) Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Molecular pharmacology, 71(6):1582-90.

 PubMed


Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.

Eisenman L.N., Shu H.-J., Akk G., Wang C., Manion B.D., Kress G.J., Evers A.S., Steinbach J.H., Covey D.F., Zorumski C.F., Mennerick S. (2007) Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. Nature neuroscience, 10(4):523-30.

 PubMed


Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor.

Akk G., Li P., Manion B.D., Evers A.S., Steinbach J.H. (2007) Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor. Molecular pharmacology, 71(2):461-72.

 PubMed