Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain.

Teitelbaum AM, Murphy SE, Akk G, Baker TB, Germann A, von Weymarn LB, Bierut LJ, Goate A, Kharasch ED, Bloom AJ  (2017) Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. The pharmacogenomics journal, ():.

 PubMed


The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic α4β2 Receptors.

Jin X, McCollum MM, Germann AL, Akk G, Steinbach JH (2017) The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic α4β2 Receptors. Molecular pharmacology, 91(2):100-109.

 PubMed


Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol.

Germann AL, Shin DJ, Manion BD, Edge CJ, Smith EH, Franks NP, Evers AS, Akk G (2016) Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol. British journal of pharmacology, 173(21):3110-3120.

 PubMed


Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.

Eaton MM, Germann AL, Arora R, Cao LQ, Gao X, Shin DJ, Wu A, Chiara DC, Cohen JB, Steinbach JH (2016) Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol. Current neuropharmacology, 14(7):772-780.

 PubMed


Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABAA Receptors.

Chakrabarti S, Qian M, Krishnan K, Covey DF, Mennerick S, Akk G (2016) Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABAA Receptors. Molecular pharmacology, 89(4):399-406.

 PubMed


Introduced Amino Terminal Epitopes Can Reduce Surface Expression of Neuronal Nicotinic Receptors.

Bracamontes JR, Akk G, Steinbach JH (2016) Introduced Amino Terminal Epitopes Can Reduce Surface Expression of Neuronal Nicotinic Receptors. PloS one, 11(3):e0151071.

 PubMed


Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.

Eaton MM, Cao LQ, Chen Z, Franks NP, Evers AS, Akk G (2015) Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors. Molecular pharmacology, 88(4):736-45.

 PubMed


Synaptic-type α1β2γ2L GABAA receptors produce large persistent currents in the presence of ambient GABA and anesthetic drugs.

Li P, Akk G (2015) Synaptic-type α1β2γ2L GABAA receptors produce large persistent currents in the presence of ambient GABA and anesthetic drugs. Molecular pharmacology, 87(5):776-81.

 PubMed


The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors.

Li P, Bracamontes JR, Manion BD, Mennerick S, Steinbach JH, Evers AS, Akk G (2014) The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors. British journal of pharmacology, 171(23):5446-57.

 PubMed


γ-aminobutyric acid type A α4, β2, and δ subunits assemble to produce more than one functionally distinct receptor type.

Eaton MM, Bracamontes J, Shu HJ, Li P, Mennerick S, Steinbach JH, Akk G (2014) γ-aminobutyric acid type A α4, β2, and δ subunits assemble to produce more than one functionally distinct receptor type. Molecular pharmacology, 86(6):647-56.

 PubMed


Modulation of the human ρ1 GABAA receptor by inhibitory steroids.

Eaton MM, Lim YB, Covey DF, Akk G (2014) Modulation of the human ρ1 GABAA receptor by inhibitory steroids. Psychopharmacology, 231(17):3467-78.

 PubMed


11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.

Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS (2014) 11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors. Psychopharmacology, 231(17):3479-91.

 PubMed


Mutations in the main cytoplasmic loop of the GABA(A) receptor α4 and δ subunits have opposite effects on surface expression.

Bracamontes JR, Li P, Akk G, Steinbach JH (2014) Mutations in the main cytoplasmic loop of the GABA(A) receptor α4 and δ subunits have opposite effects on surface expression. Molecular pharmacology, 86(1):20-7.

 PubMed


Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.

Qian M, Krishnan K, Kudova E, Li P, Manion BD, Taylor A, Elias G, Akk G, Evers AS, Zorumski CF (2014) Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone. Journal of medicinal chemistry, 57(1):171-90.

 PubMed


The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists.

Li P, Eaton MM, Steinbach JH, Akk G (2013) The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists. Anesthesiology, 118(6):1417-25.

 PubMed


Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit.

Akk G, Eaton M, Li P, Zheng S, Lo J, Steinbach JH (2013) Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit. PloS one, 8(10):e78539.

 PubMed


A neurosteroid potentiation site can be moved among GABAA receptor subunits.

Bracamontes JR, Li P, Akk G, Steinbach JH (2012) A neurosteroid potentiation site can be moved among GABAA receptor subunits. The Journal of physiology, 590(Pt 22):5739-47.

 PubMed


Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors.

Tammimäki A, Herder P, Li P, Esch C, Laughlin JR, Akk G, Stitzel JA. (2012) Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors. Neuropharmacology, 63(6):1002-11.

 PubMed


Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor.

Chen ZW, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, Sieghart W, Fuchs K, Evers AS (2012) Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. Molecular pharmacology, 82(3):408-19.

 PubMed


Agonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor.

Eaton MM, Lim YB, Bracamontes J, Steinbach JH, Akk G (2012) Agonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor. Molecular pharmacology, 82(2):255-63.

 PubMed


Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.

Shu H.-J., Bracamontes J., Taylor A., Wu K., Eaton M.M., Akk G., Manion B., Evers A.S., Krishnan K., Covey D.F., Zorumski C.F., Steinbach J.H., Mennerick S. (2012) Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes. British journal of pharmacology, 165(7):2228-43.

 PubMed


Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence.

Haller G, Druley T, Vallania FL, Mitra RD, Li P, Akk G, Steinbach JH, Breslau N, Johnson E, Hatsukami D, Stitzel J, Bierut LJ, Goate AM Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Human molecular genetics, 21(3):647-55.

 PubMed


Structural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptor.

Akk G., Steinbach J.H. (2011) Structural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptor. Anesthesiology, 115(6):1338-48.

 PubMed


Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation.

Steinbach J.H., Akk G. (2011) Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation. Anesthesiology, 115(6):1328-37.

 PubMed


Functional characterization of the α5(Asn398) variant associated with risk for nicotine dependence in the α3β4α5 nicotinic receptor.

Li P., McCollum M., Bracamontes J., Steinbach J.H., Akk G. (2011) Functional characterization of the α5(Asn398) variant associated with risk for nicotine dependence in the α3β4α5 nicotinic receptor. Molecular pharmacology, 80(5):818-27.

 PubMed


Activation and modulation of human α4β2 nicotinic acetylcholine receptors by the neonicotinoids clothianidin and imidacloprid.

Li P., Ann J., Akk G. (2011) Activation and modulation of human α4β2 nicotinic acetylcholine receptors by the neonicotinoids clothianidin and imidacloprid. Journal of neuroscience research, 89(8):1295-301.

 PubMed


Occupation of either site for the neurosteroid allopregnanolone potentiates the opening of the GABAA receptor induced from either transmitter binding site.

Bracamontes J., McCollum M., Esch C., Li P., Ann J., Steinbach J.H., Akk G. (2011) Occupation of either site for the neurosteroid allopregnanolone potentiates the opening of the GABAA receptor induced from either transmitter binding site. Molecular pharmacology, 80(1):79-86.

 PubMed


Pharmacology of structural changes at the GABA(A) receptor transmitter binding site.

Akk G., Li P., Bracamontes J., Wang M., Steinbach J.H. (2011) Pharmacology of structural changes at the GABA(A) receptor transmitter binding site. British journal of pharmacology, 162(4):840-50.

 PubMed


Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids.

Li P., Khatri A., Bracamontes J., Weiss D.S., Steinbach J.H., Akk G. (2010) Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids. Molecular pharmacology, 77(4):539-46.

 PubMed


Molecular pharmacology of the GABA(A) receptor.

Akk G Molecular pharmacology of the GABA(A) receptor. Current neuropharmacology, 8(1):1.

 PubMed


Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.

Akk G, Covey DF, Evers AS, Mennerick S, Zorumski CF, Steinbach JH Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids. Current neuropharmacology, 8(1):18-25.

 PubMed


The influence of the membrane on neurosteroid actions at GABA(A) receptors.

Akk G., Covey D.F., Evers A.S., Steinbach J.H., Zorumski C.F., Mennerick S. (2009) The influence of the membrane on neurosteroid actions at GABA(A) receptors. Psychoneuroendocrinology, 34 Suppl 1():S59-66.

 PubMed


Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation.

Li P, Bandyopadhyaya AK, Covey DF, Steinbach JH, Akk G Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation. British journal of pharmacology, 158(5):1322-9.

 PubMed


Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells.

Akk G., Li P., Bracamontes J., Steinbach J.H. (2009) Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells. Molecular pharmacology, 75(6):1400-11.

 PubMed


The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat alpha1beta2gamma2L GABA(A) receptor.

Li P., Akk G. (2008) The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat alpha1beta2gamma2L GABA(A) receptor. British journal of pharmacology, 155(5):783-94.

 PubMed


Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.

Akk G., Li P., Bracamontes J., Reichert D.E., Covey D.F., Steinbach J.H. (2008) Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Molecular pharmacology, 74(3):614-27.

 PubMed


Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies.

Militante J., Ma B.-W., Akk G., Steinbach J.H. (2008) Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies. Molecular pharmacology, 74(3):764-76.

 PubMed


Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopentaphenanthrenes and cyclopentaanthracenes.

Scaglione J.B., Jastrzebska I., Krishnan K., Li P., Akk G., Manion B.D., Benz A., Taylor A., Rath N.P., Evers A.S., Zorumski C.F., Mennerick S., Covey D.F. (2008) Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopentaphenanthrenes and cyclopentaanthracenes. Journal of medicinal chemistry, 51(5):1309-18.

 PubMed


Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate.

Li P., Reichert D.E., Rodriguez A.D., Manion B.D., Evers A.S., Eterovic V.A., Steinbach J.H., Akk G. (2008) Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate. British journal of pharmacology, 153(3):598-608.

 PubMed


Actions of anesthetics on excitatory transmitter-gated channels.

Akk G., Mennerick S., Steinbach J.H. (2008) Actions of anesthetics on excitatory transmitter-gated channels. Handbook of experimental pharmacology, (182):53-84.

 PubMed


Mode of cembranoid action on embryonic muscle acetylcholine receptor.

Ulrich H., Akk G., Nery A.A., Trujillo C.A., Rodriguez A.D., Eterovic V.A. (2008) Mode of cembranoid action on embryonic muscle acetylcholine receptor. Journal of neuroscience research, 86(1):93-107.

 PubMed


Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation.

Li P., Shu H.-J., Wang C., Mennerick S., Zorumski C.F., Covey D.F., Steinbach J.H., Akk G. (2007) Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation. The Journal of physiology, 584(Pt 3):789-800.

 PubMed


Mechanisms of neurosteroid interactions with GABA(A) receptors.

Akk G., Covey D.F., Evers A.S., Steinbach J.H., Zorumski C.F., Mennerick S. (2007) Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacology & therapeutics, 116(1):35-57.

 PubMed


Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor.

Li P., Bracamontes J., Katona B.W., Covey D.F., Steinbach J.H., Akk G. (2007) Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Molecular pharmacology, 71(6):1582-90.

 PubMed


Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.

Eisenman L.N., Shu H.-J., Akk G., Wang C., Manion B.D., Kress G.J., Evers A.S., Steinbach J.H., Covey D.F., Zorumski C.F., Mennerick S. (2007) Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. Nature neuroscience, 10(4):523-30.

 PubMed


Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor.

Akk G., Li P., Manion B.D., Evers A.S., Steinbach J.H. (2007) Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor. Molecular pharmacology, 71(2):461-72.

 PubMed


Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors.

Li P., Covey D.F., Steinbach J.H., Akk G. (2006) Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors. Molecular pharmacology, 69(6):2015-26.

 PubMed


Neurosteroid access to the GABAA receptor.

Akk G., Shu H.-J., Wang C., Steinbach J.H., Zorumski C.F., Covey D.F., Mennerick S. (2005) Neurosteroid access to the GABAA receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(50):11605-13.

 PubMed


Activation of heteroliganded mouse muscle nicotinic receptors.

Akk G., Milescu L.S., Heckmann M. (2005) Activation of heteroliganded mouse muscle nicotinic receptors. The Journal of physiology, 564(Pt 2):359-76.

 PubMed


Maximum likelihood estimation of ion channel kinetics from macroscopic currents.

Milescu L.S., Akk G., Sachs F. (2005) Maximum likelihood estimation of ion channel kinetics from macroscopic currents. Biophysical journal, 88(4):2494-515.

 PubMed


Galantamine activates muscle-type nicotinic acetylcholine receptors without binding to the acetylcholine-binding site.

Akk G., Steinbach J.H. (2005) Galantamine activates muscle-type nicotinic acetylcholine receptors without binding to the acetylcholine-binding site. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(8):1992-2001.

 PubMed


Neuroactive steroids have multiple actions to potentiate GABAA receptors.

Akk G., Bracamontes J.R., Covey D.F., Evers A., Dao T., Steinbach J.H. (2004) Neuroactive steroids have multiple actions to potentiate GABAA receptors. The Journal of physiology, 558(Pt 1):59-74.

 PubMed


Activation of GABA(A) receptors containing the alpha4 subunit by GABA and pentobarbital.

Akk G., Bracamontes J., Steinbach J.H. (2004) Activation of GABA(A) receptors containing the alpha4 subunit by GABA and pentobarbital. The Journal of physiology, 556(Pt 2):387-99.

 PubMed


Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia.

Darbandi-Tonkabon R., Manion B.D., Hastings W.R., Craigen W.J., Akk G., Bracamontes J.R., He Y., Sheiko T.V., Steinbach J.H., Mennerick S.J., Covey D.F., Evers A.S. (2004) Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. The Journal of pharmacology and experimental therapeutics, 308(2):502-11.

 PubMed


Activation and block of mouse muscle-type nicotinic receptors by tetraethylammonium.

Akk G., Steinbach J.H. (2003) Activation and block of mouse muscle-type nicotinic receptors by tetraethylammonium. The Journal of physiology, 551(Pt 1):155-68.

 PubMed


Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain.

Darbandi-Tonkabon R., Hastings W.R., Zeng C.-M., Akk G., Manion B.D., Bracamontes J.R., Steinbach J.H., Mennerick S.J., Covey D.F., Evers A.S. (2003) Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. The Journal of biological chemistry, 278(15):13196-206.

 PubMed


Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function.

Akk G., Steinbach J.H. (2003) Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function. The Journal of physiology, 546(Pt 3):641-6.

 PubMed


Contributions of the non-alpha subunit residues (loop D) to agonist binding and channel gating in the muscle nicotinic acetylcholine receptor.

Akk G. (2002) Contributions of the non-alpha subunit residues (loop D) to agonist binding and channel gating in the muscle nicotinic acetylcholine receptor. The Journal of physiology, 544(Pt 3):695-705.

 PubMed


Modulation of GABA(A) receptor channel gating by pentobarbital.

Steinbach J.H., Akk G. (2001) Modulation of GABA(A) receptor channel gating by pentobarbital. The Journal of physiology, 537(Pt 3):715-33.

 PubMed


Kinetic and pharmacological properties of GABA(A) receptors in single thalamic neurons and GABA(A) subunit expression.

Browne S.H., Kang J., Akk G., Chiang L.W., Schulman H., Huguenard J.R., Prince D.A. (2001) Kinetic and pharmacological properties of GABA(A) receptors in single thalamic neurons and GABA(A) subunit expression. Journal of neurophysiology, 86(5):2312-22.

 PubMed


Aromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the alphaY93 and alphaW149 residues.

Akk G. (2001) Aromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the alphaY93 and alphaW149 residues. The Journal of physiology, 535(Pt 3):729-40.

 PubMed


Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit.

Akk G., Bracamontes J., Steinbach J.H. (2001) Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit. The Journal of physiology, 532(Pt 3):673-84.

 PubMed


Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons.

Sun Q.-Q., Akk G., Huguenard J.R., Prince D.A. (2001) Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons. The Journal of physiology, 531(Pt 1):81-94.

 PubMed


Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision.

Akk G., Steinbach J.H. (2000) Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision. The Journal of physiology, 527 Pt 3():405-17.

 PubMed


Activation and block of recombinant GABA(A) receptors by pentobarbitone: a single-channel study.

Akk G., Steinbach J.H. (2000) Activation and block of recombinant GABA(A) receptors by pentobarbitone: a single-channel study. British journal of pharmacology, 130(2):249-58.

 PubMed


Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists.

Akk G., Auerbach A. (1999) Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists. British journal of pharmacology, 128(7):1467-76.

 PubMed


A mutational analysis of the acetylcholine receptor channel transmitter binding site.

Akk G., Zhou M., Auerbach A. (1999) A mutational analysis of the acetylcholine receptor channel transmitter binding site. Biophysical journal, 76(1 Pt 1):207-18.

 PubMed


Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism.

Auerbach A., Akk G. (1998) Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism. The Journal of general physiology, 112(2):181-97.

 PubMed


Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors.

Akk G., Sine S., Auerbach A. (1996) Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors. The Journal of physiology, 496 ( Pt 1)():185-96.

 PubMed


Voltage dependence of mouse acetylcholine receptor gating: different charge movements in di-, mono- and unliganded receptors.

Auerbach A., Sigurdson W., Chen J., Akk G. (1996) Voltage dependence of mouse acetylcholine receptor gating: different charge movements in di-, mono- and unliganded receptors. The Journal of physiology, 494 ( Pt 1)():155-70.

 PubMed


Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors.

Akk G., Auerbach A. (1996) Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors. Biophysical journal, 70(6):2652-8.

 PubMed


Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating.

Chen J., Zhang Y., Akk G., Sine S., Auerbach A. (1995) Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating. Biophysical journal, 69(3):849-59.

 PubMed